Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes

Parkinson's disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are Lewy bodies and Lewy neurites: neuronal inclusions immunopositive for the protein α-synuclein. In-depth ultrastructural analy...

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Veröffentlicht in:	Nature neuroscience Jg. 22; H. 7; S. 1099 - 1109
Hauptverfasser:	Shahmoradian, Sarah H, Lewis, Amanda J, Genoud, Christel, Hench, Jürgen, Moors, Tim E, Navarro, Paula P, Castaño-Díez, Daniel, Schweighauser, Gabriel, Graff-Meyer, Alexandra, Goldie, Kenneth N, Sütterlin, Rosmarie, Huisman, Evelien, Ingrassia, Angela, Gier, Yvonne de, Rozemuller, Annemieke J M, Wang, Jing, Paepe, Anne De, Erny, Johannes, Staempfli, Andreas, Hoernschemeyer, Joerg, Großerüschkamp, Frederik, Niedieker, Daniel, El-Mashtoly, Samir F, Quadri, Marialuisa, Van IJcken, Wilfred F J, Bonifati, Vincenzo, Gerwert, Klaus, Bohrmann, Bernd, Frank, Stephan, Britschgi, Markus, Stahlberg, Henning, Van de Berg, Wilma D J, Lauer, Matthias E
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Nature Publishing Group 01.07.2019
Schlagworte:	Age alpha-Synuclein - analysis Alzheimer Disease - metabolism Alzheimer Disease - pathology Autopsy Axons Brain Coherent scattering Correlation Depletion Electron microscopy Etiology Filaments Fourier transforms Hippocampus - chemistry Hippocampus - ultrastructure Humans Image resolution Imaging, Three-Dimensional Inclusions Infrared imaging Intracellular Membranes - ultrastructure Lewy bodies Lewy Bodies - chemistry Lewy Bodies - ultrastructure Lewy Body Disease - metabolism Lewy Body Disease - pathology Lipid membranes Lipids Medical imaging Membrane Lipids - analysis Membranes Mesencephalon - chemistry Mesencephalon - ultrastructure Microscopy Microscopy, Confocal Microscopy, Electron - methods Microscopy, Fluorescence Movement disorders Neurodegenerative diseases Neuroimaging Neurological diseases Organelles Organelles - ultrastructure Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Pathogenesis Pathology Proteins Raman spectra Stimulated emission Substantia Nigra - chemistry Substantia Nigra - ultrastructure Synuclein Whole Exome Sequencing
ISSN:	1097-6256, 1546-1726, 1546-1726
Online-Zugang:	Volltext
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