Integration of genetic colocalizations with physiological and pharmacological perturbations identifies cardiometabolic disease genes

Background Identification of causal genes for polygenic human diseases has been extremely challenging, and our understanding of how physiological and pharmacological stimuli modulate genetic risk at disease-associated loci is limited. Specifically, insulin resistance (IR), a common feature of cardio...

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Bibliographic Details
Published in:	Genome medicine Vol. 14; no. 1; pp. 31 - 16
Main Authors:	Gloudemans, Michael J., Balliu, Brunilda, Nachun, Daniel, Schnurr, Theresia M., Durrant, Matthew G., Ingelsson, Erik, Wabitsch, Martin, Quertermous, Thomas, Montgomery, Stephen B., Knowles, Joshua W., Carcamo-Orive, Ivan
Format:	Journal Article
Language:	English
Published:	London BioMed Central 15.03.2022 BioMed Central Ltd BMC
Subjects:	Analysis Bioinformatics Biomedical and Life Sciences Biomedicine Body mass index Cancer Research Cardiovascular Diseases - genetics Colocalization Dextrose Diabetes Mellitus, Type 2 - genetics Differential expression Genes Genetic research Genetic transcription Genome-wide association studies Genome-Wide Association Study Genomics Glucose Human Genetics Humans Insulin Insulin resistance Insulin Resistance - genetics Integrative gene prioritization Liver Medicine/Public Health Metabolomics Muscles Perturbation experiments Physiological aspects Protein-protein interactions Quantitative genetics Quantitative Trait Loci Systems Biology Type 2 diabetes Colocalization Type 2 diabetes Cardiometabolic disease Genome-wide association studies Perturbation experiments Integrative gene prioritization Insulin resistance Differential expression
ISSN:	1756-994X, 1756-994X
Online Access:	Get full text
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