Use of MRI in the diagnosis of fetal brain abnormalities in utero (MERIDIAN): a multicentre, prospective cohort study

In-utero MRI (iuMRI) has shown promise as an adjunct to ultrasound but the comparative diagnostic performance has been poorly defined. We aimed to assess whether the diagnostic accuracy and confidence of the prenatal diagnosis of fetal brain abnormalities is improved with iuMRI and assess the clinic...

Full description

Saved in:

Bibliographic Details
Published in:	The Lancet (British edition) Vol. 389; no. 10068; pp. 538 - 546
Main Authors:	Griffiths, Paul D, Bradburn, Michael, Campbell, Michael J, Cooper, Cindy L, Graham, Ruth, Jarvis, Deborah, Kilby, Mark D, Mason, Gerald, Mooney, Cara, Robson, Stephen C, Wailoo, Allan
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 04.02.2017 Elsevier Limited
Subjects:	Abnormalities Acceptability Accuracy Age Anomalies Brain Brain - abnormalities Brain - diagnostic imaging Brain research Clinical trials Cohort analysis Confidence Diagnosis Diagnostic systems Ethics Female Fetal Diseases - diagnostic imaging Fetuses Gestation Gestational Age Humans Internal Medicine Magnetic Resonance Imaging Male Management Medical diagnosis Neuropathology NMR Nuclear magnetic resonance Predictive Value of Tests Pregnancy Prenatal Diagnosis Prospective Studies Technology assessment Ultrasonic imaging Ultrasound United Kingdom Womens health United Kingdom > UK
ISSN:	0140-6736, 1474-547X, 1474-547X
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	In-utero MRI (iuMRI) has shown promise as an adjunct to ultrasound but the comparative diagnostic performance has been poorly defined. We aimed to assess whether the diagnostic accuracy and confidence of the prenatal diagnosis of fetal brain abnormalities is improved with iuMRI and assess the clinical impact and patient acceptability of iuMRI. We did a multicentre, prospective, cohort study in the UK, at 16 fetal medicine centres, of pregnant women aged 16 years or older whose fetus had a brain abnormality detected by ultrasound at a gestational age of 18 weeks or more, had no contraindications to iuMRI, and consented to enter the study. Women carrying a fetus suspected of having a brain anomaly on ultrasound had iuMRI done within 14 days of ultrasound. The findings were reviewed by two independent panels and used to estimate diagnostic accuracy and confidence by comparison with outcome diagnoses. Changes in diagnosis, prognosis, and clinical management brought about by iuMRI and patient acceptability were assessed. Participants were recruited between July 29, 2011, and Aug 31, 2014. The cohort was subdivided by gestation into the 18 weeks to less than 24 weeks fetus cohort (n=369) and into the 24 weeks or older fetus cohort (n=201). Diagnostic accuracy was improved by 23% (95% CI 18–27) in the 18 weeks to less than 24 weeks group and 29% (23–36) in the 24 weeks and older group (p<0·0001 for both groups). The overall diagnostic accuracy was 68% for ultrasound and 93% for iuMRI (difference 25%, 95% CI 21–29). Dominant diagnoses were reported with high confidence on ultrasound in 465 (82%) of 570 cases compared with 544 (95%) of 570 cases on iuMRI. IuMRI provided additional diagnostic information in 387 (49%) of 783 cases, changed prognostic information in at least 157 (20%), and led to changes in clinical management in more than one in three cases. IuMRI also had high patient acceptability with at least 95% of women saying they would have an iuMRI study if a future pregnancy were complicated by a fetal brain abnormality. iuMRI improves diagnostic accuracy and confidence for fetal brain anomalies and leads to management changes in a high proportion of cases. This finding, along with the high patient acceptability, leads us to propose that any fetus with a suspected brain abnormality on ultrasound should have iuMRI to better inform counselling and management decisions. National Institute for Health Research Health Technology Assessment programme.
AbstractList	Summary Background In-utero MRI (iuMRI) has shown promise as an adjunct to ultrasound but the comparative diagnostic performance has been poorly defined. We aimed to assess whether the diagnostic accuracy and confidence of the prenatal diagnosis of fetal brain abnormalities is improved with iuMRI and assess the clinical impact and patient acceptability of iuMRI. Methods We did a multicentre, prospective, cohort study in the UK, at 16 fetal medicine centres, of pregnant women aged 16 years or older whose fetus had a brain abnormality detected by ultrasound at a gestational age of 18 weeks or more, had no contraindications to iuMRI, and consented to enter the study. Women carrying a fetus suspected of having a brain anomaly on ultrasound had iuMRI done within 14 days of ultrasound. The findings were reviewed by two independent panels and used to estimate diagnostic accuracy and confidence by comparison with outcome diagnoses. Changes in diagnosis, prognosis, and clinical management brought about by iuMRI and patient acceptability were assessed. Findings Participants were recruited between July 29, 2011, and Aug 31, 2014. The cohort was subdivided by gestation into the 18 weeks to less than 24 weeks fetus cohort (n=369) and into the 24 weeks or older fetus cohort (n=201). Diagnostic accuracy was improved by 23% (95% CI 18–27) in the 18 weeks to less than 24 weeks group and 29% (23–36) in the 24 weeks and older group (p<0·0001 for both groups). The overall diagnostic accuracy was 68% for ultrasound and 93% for iuMRI (difference 25%, 95% CI 21–29). Dominant diagnoses were reported with high confidence on ultrasound in 465 (82%) of 570 cases compared with 544 (95%) of 570 cases on iuMRI. IuMRI provided additional diagnostic information in 387 (49%) of 783 cases, changed prognostic information in at least 157 (20%), and led to changes in clinical management in more than one in three cases. IuMRI also had high patient acceptability with at least 95% of women saying they would have an iuMRI study if a future pregnancy were complicated by a fetal brain abnormality. Interpretation iuMRI improves diagnostic accuracy and confidence for fetal brain anomalies and leads to management changes in a high proportion of cases. This finding, along with the high patient acceptability, leads us to propose that any fetus with a suspected brain abnormality on ultrasound should have iuMRI to better inform counselling and management decisions. Funding National Institute for Health Research Health Technology Assessment programme. In-utero MRI (iuMRI) has shown promise as an adjunct to ultrasound but the comparative diagnostic performance has been poorly defined. We aimed to assess whether the diagnostic accuracy and confidence of the prenatal diagnosis of fetal brain abnormalities is improved with iuMRI and assess the clinical impact and patient acceptability of iuMRI. We did a multicentre, prospective, cohort study in the UK, at 16 fetal medicine centres, of pregnant women aged 16 years or older whose fetus had a brain abnormality detected by ultrasound at a gestational age of 18 weeks or more, had no contraindications to iuMRI, and consented to enter the study. Women carrying a fetus suspected of having a brain anomaly on ultrasound had iuMRI done within 14 days of ultrasound. The findings were reviewed by two independent panels and used to estimate diagnostic accuracy and confidence by comparison with outcome diagnoses. Changes in diagnosis, prognosis, and clinical management brought about by iuMRI and patient acceptability were assessed. Participants were recruited between July 29, 2011, and Aug 31, 2014. The cohort was subdivided by gestation into the 18 weeks to less than 24 weeks fetus cohort (n=369) and into the 24 weeks or older fetus cohort (n=201). Diagnostic accuracy was improved by 23% (95% CI 18–27) in the 18 weeks to less than 24 weeks group and 29% (23–36) in the 24 weeks and older group (p<0·0001 for both groups). The overall diagnostic accuracy was 68% for ultrasound and 93% for iuMRI (difference 25%, 95% CI 21–29). Dominant diagnoses were reported with high confidence on ultrasound in 465 (82%) of 570 cases compared with 544 (95%) of 570 cases on iuMRI. IuMRI provided additional diagnostic information in 387 (49%) of 783 cases, changed prognostic information in at least 157 (20%), and led to changes in clinical management in more than one in three cases. IuMRI also had high patient acceptability with at least 95% of women saying they would have an iuMRI study if a future pregnancy were complicated by a fetal brain abnormality. iuMRI improves diagnostic accuracy and confidence for fetal brain anomalies and leads to management changes in a high proportion of cases. This finding, along with the high patient acceptability, leads us to propose that any fetus with a suspected brain abnormality on ultrasound should have iuMRI to better inform counselling and management decisions. National Institute for Health Research Health Technology Assessment programme. In-utero MRI (iuMRI) has shown promise as an adjunct to ultrasound but the comparative diagnostic performance has been poorly defined. We aimed to assess whether the diagnostic accuracy and confidence of the prenatal diagnosis of fetal brain abnormalities is improved with iuMRI and assess the clinical impact and patient acceptability of iuMRI.BACKGROUNDIn-utero MRI (iuMRI) has shown promise as an adjunct to ultrasound but the comparative diagnostic performance has been poorly defined. We aimed to assess whether the diagnostic accuracy and confidence of the prenatal diagnosis of fetal brain abnormalities is improved with iuMRI and assess the clinical impact and patient acceptability of iuMRI.We did a multicentre, prospective, cohort study in the UK, at 16 fetal medicine centres, of pregnant women aged 16 years or older whose fetus had a brain abnormality detected by ultrasound at a gestational age of 18 weeks or more, had no contraindications to iuMRI, and consented to enter the study. Women carrying a fetus suspected of having a brain anomaly on ultrasound had iuMRI done within 14 days of ultrasound. The findings were reviewed by two independent panels and used to estimate diagnostic accuracy and confidence by comparison with outcome diagnoses. Changes in diagnosis, prognosis, and clinical management brought about by iuMRI and patient acceptability were assessed.METHODSWe did a multicentre, prospective, cohort study in the UK, at 16 fetal medicine centres, of pregnant women aged 16 years or older whose fetus had a brain abnormality detected by ultrasound at a gestational age of 18 weeks or more, had no contraindications to iuMRI, and consented to enter the study. Women carrying a fetus suspected of having a brain anomaly on ultrasound had iuMRI done within 14 days of ultrasound. The findings were reviewed by two independent panels and used to estimate diagnostic accuracy and confidence by comparison with outcome diagnoses. Changes in diagnosis, prognosis, and clinical management brought about by iuMRI and patient acceptability were assessed.Participants were recruited between July 29, 2011, and Aug 31, 2014. The cohort was subdivided by gestation into the 18 weeks to less than 24 weeks fetus cohort (n=369) and into the 24 weeks or older fetus cohort (n=201). Diagnostic accuracy was improved by 23% (95% CI 18-27) in the 18 weeks to less than 24 weeks group and 29% (23-36) in the 24 weeks and older group (p<0·0001 for both groups). The overall diagnostic accuracy was 68% for ultrasound and 93% for iuMRI (difference 25%, 95% CI 21-29). Dominant diagnoses were reported with high confidence on ultrasound in 465 (82%) of 570 cases compared with 544 (95%) of 570 cases on iuMRI. IuMRI provided additional diagnostic information in 387 (49%) of 783 cases, changed prognostic information in at least 157 (20%), and led to changes in clinical management in more than one in three cases. IuMRI also had high patient acceptability with at least 95% of women saying they would have an iuMRI study if a future pregnancy were complicated by a fetal brain abnormality.FINDINGSParticipants were recruited between July 29, 2011, and Aug 31, 2014. The cohort was subdivided by gestation into the 18 weeks to less than 24 weeks fetus cohort (n=369) and into the 24 weeks or older fetus cohort (n=201). Diagnostic accuracy was improved by 23% (95% CI 18-27) in the 18 weeks to less than 24 weeks group and 29% (23-36) in the 24 weeks and older group (p<0·0001 for both groups). The overall diagnostic accuracy was 68% for ultrasound and 93% for iuMRI (difference 25%, 95% CI 21-29). Dominant diagnoses were reported with high confidence on ultrasound in 465 (82%) of 570 cases compared with 544 (95%) of 570 cases on iuMRI. IuMRI provided additional diagnostic information in 387 (49%) of 783 cases, changed prognostic information in at least 157 (20%), and led to changes in clinical management in more than one in three cases. IuMRI also had high patient acceptability with at least 95% of women saying they would have an iuMRI study if a future pregnancy were complicated by a fetal brain abnormality.iuMRI improves diagnostic accuracy and confidence for fetal brain anomalies and leads to management changes in a high proportion of cases. This finding, along with the high patient acceptability, leads us to propose that any fetus with a suspected brain abnormality on ultrasound should have iuMRI to better inform counselling and management decisions.INTERPRETATIONiuMRI improves diagnostic accuracy and confidence for fetal brain anomalies and leads to management changes in a high proportion of cases. This finding, along with the high patient acceptability, leads us to propose that any fetus with a suspected brain abnormality on ultrasound should have iuMRI to better inform counselling and management decisions.National Institute for Health Research Health Technology Assessment programme.FUNDINGNational Institute for Health Research Health Technology Assessment programme. Background In-utero MRI (iuMRI) has shown promise as an adjunct to ultrasound but the comparative diagnostic performance has been poorly defined. We aimed to assess whether the diagnostic accuracy and confidence of the prenatal diagnosis of fetal brain abnormalities is improved with iuMRI and assess the clinical impact and patient acceptability of iuMRI. Methods We did a multicentre, prospective, cohort study in the UK, at 16 fetal medicine centres, of pregnant women aged 16 years or older whose fetus had a brain abnormality detected by ultrasound at a gestational age of 18 weeks or more, had no contraindications to iuMRI, and consented to enter the study. Women carrying a fetus suspected of having a brain anomaly on ultrasound had iuMRI done within 14 days of ultrasound. The findings were reviewed by two independent panels and used to estimate diagnostic accuracy and confidence by comparison with outcome diagnoses. Changes in diagnosis, prognosis, and clinical management brought about by iuMRI and patient acceptability were assessed. Findings Participants were recruited between July 29, 2011, and Aug 31, 2014. The cohort was subdivided by gestation into the 18 weeks to less than 24 weeks fetus cohort (n=369) and into the 24 weeks or older fetus cohort (n=201). Diagnostic accuracy was improved by 23% (95% CI 18-27) in the 18 weeks to less than 24 weeks group and 29% (23-36) in the 24 weeks and older group (p<0.0001 for both groups). The overall diagnostic accuracy was 68% for ultrasound and 93% for iuMRI (difference 25%, 95% CI 21-29). Dominant diagnoses were reported with high confidence on ultrasound in 465 (82%) of 570 cases compared with 544 (95%) of 570 cases on iuMRI. IuMRI provided additional diagnostic information in 387 (49%) of 783 cases, changed prognostic information in at least 157 (20%), and led to changes in clinical management in more than one in three cases. IuMRI also had high patient acceptability with at least 95% of women saying they would have an iuMRI study if a future pregnancy were complicated by a fetal brain abnormality. Interpretation iuMRI improves diagnostic accuracy and confidence for fetal brain anomalies and leads to management changes in a high proportion of cases. This finding, along with the high patient acceptability, leads us to propose that any fetus with a suspected brain abnormality on ultrasound should have iuMRI to better inform counselling and management decisions. Funding National Institute for Health Research Health Technology Assessment programme. In-utero MRI (iuMRI) has shown promise as an adjunct to ultrasound but the comparative diagnostic performance has been poorly defined. We aimed to assess whether the diagnostic accuracy and confidence of the prenatal diagnosis of fetal brain abnormalities is improved with iuMRI and assess the clinical impact and patient acceptability of iuMRI. Methods We did a multicentre, prospective, cohort study in the UK, at 16 fetal medicine centres, of pregnant women aged 16 years or older whose fetus had a brain abnormality detected by ultrasound at a gestational age of 18 weeks or more, had no contraindications to iuMRI, and consented to enter the study. Women carrying a fetus suspected of having a brain anomaly on ultrasound had iuMRI done within 14 days of ultrasound. The findings were reviewed by two independent panels and used to estimate diagnostic accuracy and confidence by comparison with outcome diagnoses. Changes in diagnosis, prognosis, and clinical management brought about by iuMRI and patient acceptability were assessed. Findings Participants were recruited between July 29, 2011, and Aug 31, 2014. The cohort was subdivided by gestation into the 18 weeks to less than 24 weeks fetus cohort (n=369) and into the 24 weeks or older fetus cohort (n=201). Diagnostic accuracy was improved by 23% (95% CI 18-27) in the 18 weeks to less than 24 weeks group and 29% (23-36) in the 24 weeks and older group (p<0·0001 for both groups). The overall diagnostic accuracy was 68% for ultrasound and 93% for iuMRI (difference 25%, 95% CI 21-29). Dominant diagnoses were reported with high confidence on ultrasound in 465 (82%) of 570 cases compared with 544 (95%) of 570 cases on iuMRI. IuMRI provided additional diagnostic information in 387 (49%) of 783 cases, changed prognostic information in at least 157 (20%), and led to changes in clinical management in more than one in three cases. IuMRI also had high patient acceptability with at least 95% of women saying they would have an iuMRI study if a future pregnancy were complicated by a fetal brain abnormality. Interpretation iuMRI improves diagnostic accuracy and confidence for fetal brain anomalies and leads to management changes in a high proportion of cases. This finding, along with the high patient acceptability, leads us to propose that any fetus with a suspected brain abnormality on ultrasound should have iuMRI to better inform counselling and management decisions. Funding National Institute for Health Research Health Technology Assessment programme.
Author	Griffiths, Paul D Campbell, Michael J Kilby, Mark D Robson, Stephen C Cooper, Cindy L Mason, Gerald Graham, Ruth Jarvis, Deborah Mooney, Cara Bradburn, Michael Wailoo, Allan
Author_xml	– sequence: 1 givenname: Paul D surname: Griffiths fullname: Griffiths, Paul D organization: Academic Unit of Radiology, University of Sheffield, Sheffield, UK – sequence: 2 givenname: Michael surname: Bradburn fullname: Bradburn, Michael organization: Clinical Trials Research Unit, School of Health and Related Research, University of Sheffield, Sheffield, UK – sequence: 3 givenname: Michael J surname: Campbell fullname: Campbell, Michael J organization: Clinical Trials Research Unit, School of Health and Related Research, University of Sheffield, Sheffield, UK – sequence: 4 givenname: Cindy L surname: Cooper fullname: Cooper, Cindy L organization: Clinical Trials Research Unit, School of Health and Related Research, University of Sheffield, Sheffield, UK – sequence: 5 givenname: Ruth surname: Graham fullname: Graham, Ruth organization: Newcastle University, Newcastle upon Tyne, UK – sequence: 6 givenname: Deborah surname: Jarvis fullname: Jarvis, Deborah organization: Academic Unit of Radiology, University of Sheffield, Sheffield, UK – sequence: 7 givenname: Mark D surname: Kilby fullname: Kilby, Mark D organization: Centre for Women's and Newborn Health, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK – sequence: 8 givenname: Gerald surname: Mason fullname: Mason, Gerald organization: Leeds Teaching Hospitals NHS Trust, Leeds, UK – sequence: 9 givenname: Cara surname: Mooney fullname: Mooney, Cara email: c.d.mooney@sheffield.ac.uk organization: Clinical Trials Research Unit, School of Health and Related Research, University of Sheffield, Sheffield, UK – sequence: 10 givenname: Stephen C surname: Robson fullname: Robson, Stephen C organization: Newcastle University, Newcastle upon Tyne, UK – sequence: 11 givenname: Allan surname: Wailoo fullname: Wailoo, Allan organization: Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, Sheffield, UK
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27988140$$D View this record in MEDLINE/PubMed
BookMark	eNqNkmFrFDEQhoNU7LX6E5SAX67garLZJLuKSqlVD1qFasFvIZudtam7mzPJFu7fm72rFQ70_JKQzDNvJvPOAdob3AAIPabkOSVUvPhCaEEyIZmYU3HEqMxZVt5DM1rIIuOF_LaHZnfIPjoI4ZoQUgjCH6D9XFZlmYIzNF4GwK7F5xcLbAccrwA3Vn8fXLBhum8h6g7XXqegrgfne93ZaCFM9BjBOzw_P71YvFscfzp6iTXuxy5aA0P08AwvvQtLMNHeADbuyvmIQxyb1UN0v9VdgEe3-yG6fH_69eRjdvb5w-Lk-CwzgpKY1UIbWWoiSlEQ2eTAdd3qWghuTENbYJwR2RatpFXDdAUtY9Q0hEotKtZyzg7RfKObCvk5Qoiqt8FA1-kB3BgULUXJWEnTshvlNK-E5DKhT7fQazf6IX1E5cmIkstKiH9R6VmeMylymqgnt9RY99Copbe99iv126EE8A1gUi-Dh_YOoURNk6DWk6Amm1U6rSdBlSnv1VaesVFH65Iz2nY7s99usiG5c2PBq2AsDAYa65OfqnF2p8KbLQXT2cEa3f2AFYQ_vVAhV2QjMmlQsVaYBF7_XeA_CvgFetfxxw
CODEN	LANCAO
CitedBy_id	crossref_primary_10_1038_s41372_019_0407_9 crossref_primary_10_1002_uog_23581 crossref_primary_10_1016_j_pnpbp_2021_110277 crossref_primary_10_1097_GRF_0000000000000307 crossref_primary_10_1136_archdischild_2024_328310 crossref_primary_10_1038_s41598_023_43867_4 crossref_primary_10_1002_pd_5722 crossref_primary_10_1002_mgg3_70016 crossref_primary_10_1007_s00234_020_02364_5 crossref_primary_10_3390_jcm12010058 crossref_primary_10_1007_s00429_021_02303_x crossref_primary_10_1097_MD_0000000000036623 crossref_primary_10_1002_pd_5042 crossref_primary_10_1038_s41390_025_04000_5 crossref_primary_10_3390_diagnostics15020208 crossref_primary_10_1002_pd_5399 crossref_primary_10_1111_dmcn_15528 crossref_primary_10_3389_fnins_2022_886083 crossref_primary_10_1002_uog_21943 crossref_primary_10_1007_s00330_022_09173_9 crossref_primary_10_1159_000512534 crossref_primary_10_1080_14767058_2025_2521796 crossref_primary_10_1002_uog_17485 crossref_primary_10_1002_uog_22155 crossref_primary_10_1159_000496202 crossref_primary_10_1136_archdischild_2021_321984 crossref_primary_10_1111_tog_12740 crossref_primary_10_1002_uog_29310 crossref_primary_10_1080_14767058_2018_1480605 crossref_primary_10_1007_s00247_018_4261_2 crossref_primary_10_3171_2022_4_PEDS2269 crossref_primary_10_1002_jmri_26316 crossref_primary_10_1002_jmri_27526 crossref_primary_10_1016_j_ajog_2018_04_039 crossref_primary_10_1002_uog_17475 crossref_primary_10_3390_jcm14196690 crossref_primary_10_1002_uog_21974 crossref_primary_10_1002_uog_22145 crossref_primary_10_2967_jnumed_116_184028 crossref_primary_10_1111_aogs_13687 crossref_primary_10_1080_15513815_2025_2529888 crossref_primary_10_1002_jmri_29140 crossref_primary_10_1016_j_neuroimage_2020_117316 crossref_primary_10_1016_j_mric_2024_02_008 crossref_primary_10_1007_s00234_019_02218_9 crossref_primary_10_1007_s00234_023_03193_y crossref_primary_10_1136_archdischild_2018_316733 crossref_primary_10_1007_s00234_019_02184_2 crossref_primary_10_3390_genes13091517 crossref_primary_10_1111_dmcn_16301 crossref_primary_10_1007_s42058_021_00082_2 crossref_primary_10_1016_j_crad_2017_09_007 crossref_primary_10_1007_s00330_020_07125_9 crossref_primary_10_1016_j_nic_2019_03_001 crossref_primary_10_1177_20584601241248820 crossref_primary_10_1016_j_pediatrneurol_2023_02_013 crossref_primary_10_23736_S2724_606X_24_05641_0 crossref_primary_10_1002_jmri_29057 crossref_primary_10_1016_j_gim_2023_100915 crossref_primary_10_1016_j_siny_2024_101555 crossref_primary_10_1136_archdischild_2023_326747 crossref_primary_10_1186_s12880_024_01286_5 crossref_primary_10_3390_diagnostics10010027 crossref_primary_10_1007_s00381_020_04633_3 crossref_primary_10_1016_j_ejogrb_2020_04_032 crossref_primary_10_1016_j_ejpn_2018_08_007 crossref_primary_10_3390_biomedicines12122929 crossref_primary_10_1111_1471_0528_16533 crossref_primary_10_1080_14767058_2017_1342801 crossref_primary_10_1016_j_neubiorev_2018_06_001 crossref_primary_10_1093_brain_awaf094 crossref_primary_10_1016_j_ejogrb_2018_05_044 crossref_primary_10_1002_pd_5591 crossref_primary_10_1159_000516378 crossref_primary_10_3390_children11091094 crossref_primary_10_3390_diagnostics15101295 crossref_primary_10_3174_ajnr_A8742 crossref_primary_10_3390_diagnostics12030764 crossref_primary_10_1016_j_jksuci_2023_101647 crossref_primary_10_1007_s00330_020_06899_2 crossref_primary_10_1016_j_pediatrneurol_2025_05_014 crossref_primary_10_1002_pd_5229 crossref_primary_10_3390_diagnostics14222535 crossref_primary_10_1016_S0140_6736_18_32490_5 crossref_primary_10_1136_archdischild_2019_317517 crossref_primary_10_3390_brainsci9090231 crossref_primary_10_1002_uog_26301 crossref_primary_10_1017_S0954579420000218 crossref_primary_10_1111_dmcn_16071 crossref_primary_10_1016_j_nicl_2023_103357 crossref_primary_10_1002_pd_5579 crossref_primary_10_1002_pd_5210 crossref_primary_10_1016_j_siny_2024_101525 crossref_primary_10_1007_s00330_018_5508_x crossref_primary_10_1016_j_gofs_2024_07_005 crossref_primary_10_1016_j_mric_2021_06_007 crossref_primary_10_1097_GRF_0000000000000820 crossref_primary_10_1002_uog_20111 crossref_primary_10_1002_uog_17502 crossref_primary_10_1111_dmcn_14160 crossref_primary_10_1016_j_yacr_2019_05_003 crossref_primary_10_3390_children10061015 crossref_primary_10_3390_jimaging7100200 crossref_primary_10_1016_j_tjog_2024_07_020 crossref_primary_10_1016_j_ajogmf_2023_101198 crossref_primary_10_1016_j_crad_2020_03_035 crossref_primary_10_1016_j_patcog_2022_109029 crossref_primary_10_1111_1471_0528_15530 crossref_primary_10_1002_mrm_30094 crossref_primary_10_1002_uog_23612 crossref_primary_10_1002_jum_15313 crossref_primary_10_1016_j_crad_2019_03_010 crossref_primary_10_1891_0730_0832_37_6_358 crossref_primary_10_3174_ajnr_A8728 crossref_primary_10_1111_1471_0528_16609 crossref_primary_10_1016_j_ccr_2021_214068 crossref_primary_10_1016_j_nic_2022_04_009 crossref_primary_10_1002_pd_5558 crossref_primary_10_1016_j_ejogrb_2025_01_027 crossref_primary_10_2147_CLEP_S256297 crossref_primary_10_1002_pd_5674 crossref_primary_10_1007_s00247_017_3982_y crossref_primary_10_1016_j_clp_2022_05_001 crossref_primary_10_3389_fped_2024_1354475 crossref_primary_10_1177_03000605241301879 crossref_primary_10_1148_radiol_2019181976 crossref_primary_10_1016_j_ejogrb_2025_01_020 crossref_primary_10_1016_j_pediatrneurol_2025_01_022 crossref_primary_10_1002_uog_24856 crossref_primary_10_1002_uog_23762 crossref_primary_10_1002_uog_24853 crossref_primary_10_1111_dmcn_14260 crossref_primary_10_1002_acn3_51484 crossref_primary_10_1259_bjr_20220071 crossref_primary_10_18621_eurj_899462 crossref_primary_10_1016_j_media_2023_102793 crossref_primary_10_3390_genes12101598 crossref_primary_10_1007_s00247_020_04696_z crossref_primary_10_1093_cercor_bhab030 crossref_primary_10_1136_archdischild_2025_328547 crossref_primary_10_1177_87564793231167429 crossref_primary_10_1186_s42492_025_00197_8 crossref_primary_10_1007_s00330_020_07452_x crossref_primary_10_1177_2329048X231157147 crossref_primary_10_1002_pd_5416 crossref_primary_10_1038_s41372_017_0040_4 crossref_primary_10_1007_s00247_019_04537_8 crossref_primary_10_1080_14767058_2017_1338258 crossref_primary_10_1002_pd_5096 crossref_primary_10_1007_s00330_018_5938_5 crossref_primary_10_1186_s12880_022_00929_9 crossref_primary_10_1007_s00234_023_03242_6 crossref_primary_10_1080_14767058_2021_1910657 crossref_primary_10_1007_s00381_017_3595_7 crossref_primary_10_1177_1049732318764390 crossref_primary_10_1159_000488674 crossref_primary_10_1016_j_jpeds_2019_01_051 crossref_primary_10_1007_s00247_021_05137_1 crossref_primary_10_1016_j_ajogmf_2021_100501 crossref_primary_10_1016_j_pediatrneurol_2023_04_016 crossref_primary_10_1016_j_pediatrneurol_2024_12_014 crossref_primary_10_1007_s43441_022_00433_w crossref_primary_10_1002_uog_17538 crossref_primary_10_1111_aogs_14711 crossref_primary_10_1007_s13312_023_3007_x crossref_primary_10_1016_j_artmed_2023_102608 crossref_primary_10_1038_s41598_022_05468_5 crossref_primary_10_1002_pd_5874 crossref_primary_10_1002_mrm_29106 crossref_primary_10_1016_j_crad_2019_02_017 crossref_primary_10_1002_uog_29309 crossref_primary_10_1002_jcu_23157 crossref_primary_10_1002_jcu_23158 crossref_primary_10_12968_hmed_2017_78_3_128 crossref_primary_10_1080_07853890_2021_1969590 crossref_primary_10_1016_j_ejrad_2020_109369 crossref_primary_10_1186_s13293_023_00497_9 crossref_primary_10_1186_s12880_020_00525_9 crossref_primary_10_1212_NXG_0000000000200171 crossref_primary_10_1016_S0140_6736_17_31337_5 crossref_primary_10_1002_ijgo_16079 crossref_primary_10_1016_j_ejogrb_2020_05_013 crossref_primary_10_1148_radiol_2018171267 crossref_primary_10_3389_fneur_2024_1358741 crossref_primary_10_1016_j_ajog_2018_11_1088 crossref_primary_10_1002_jum_15626 crossref_primary_10_1038_s41372_018_0208_6 crossref_primary_10_1111_dmcn_15022 crossref_primary_10_1016_j_mric_2024_03_004 crossref_primary_10_1016_j_pediatrneurol_2025_02_009 crossref_primary_10_1002_uog_22102 crossref_primary_10_3390_diagnostics11091723 crossref_primary_10_1016_S2352_4642_19_30387_6 crossref_primary_10_1007_s00381_019_04384_w crossref_primary_10_1111_dmcn_16471 crossref_primary_10_1016_S2352_4642_19_30349_9 crossref_primary_10_1109_TMI_2022_3208277 crossref_primary_10_1007_s12021_023_09635_5 crossref_primary_10_1016_j_mjafi_2021_12_002 crossref_primary_10_1002_ana_27072 crossref_primary_10_1111_1471_0528_15620 crossref_primary_10_1002_ccr3_9684 crossref_primary_10_1016_j_ejpn_2020_08_009 crossref_primary_10_1007_s00330_018_5878_0
Cites_doi	10.1136/adc.67.7_Spec_No.770 10.1016/j.ejogrb.2009.02.045 10.1136/bmj.37939.570104.EE 10.1016/j.mri.2004.01.047 10.1515/JPM.2008.005 10.1148/radiol.10092366 10.1002/pd.1710 10.1002/uog.13429 10.1259/bjr/64096611 10.1046/j.1469-0705.2000.00199.x 10.1111/j.1471-0528.2005.00660.x 10.3109/14767058.2015.1109621 10.1007/s100249900101 10.1080/00016340600880886 10.1016/S0002-9378(99)70577-6
ContentType	Journal Article
Copyright	2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license. Published by Elsevier Ltd.. All rights reserved. Copyright Elsevier Limited Feb 4, 2017 2017. The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license.
Copyright_xml	– notice: 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license – notice: The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license – notice: Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license. Published by Elsevier Ltd.. All rights reserved. – notice: Copyright Elsevier Limited Feb 4, 2017 – notice: 2017. The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license.
CorporateAuthor	MERIDIAN collaborative group
CorporateAuthor_xml	– name: MERIDIAN collaborative group
DBID	6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QP 7RV 7TK 7U7 7U9 7X7 7XB 88A 88C 88E 88G 88I 8AF 8AO 8C1 8C2 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AEUYN AFKRA AN0 ASE AZQEC BBNVY BEC BENPR BHPHI C1K CCPQU DWQXO FPQ FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K6X K9- K9. KB0 KB~ LK8 M0R M0S M0T M1P M2M M2O M2P M7N M7P MBDVC NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ Q9U S0X 7X8
DOI	10.1016/S0140-6736(16)31723-8
DatabaseName	ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Nursing & Allied Health Database Neurosciences Abstracts Toxicology Abstracts Virology and AIDS Abstracts ProQuest_Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Healthcare Administration Database (Alumni) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection Public Health Database Lancet Titles ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni Edition) ProQuest One Sustainability ProQuest Central UK/Ireland British Nursing Database British Nursing Index ProQuest Central Essentials Biological Science Collection ProQuest eLibrary (NC LIVE) ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea British Nursing Index (BNI) (1985 to Present) Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection British Nursing Index Consumer Health Database (Alumni Edition) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) ProQuest Newsstand Professional ProQuest Biological Science Collection Consumer Health Database Health & Medical Collection (Alumni Edition) Healthcare Administration Database Medical Database ProQuest Psychology Database (NC LIVE) ProQuest Research Library (NC LIVE) Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Research Library (Corporate) Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic SIRS Editorial MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology Research Library Prep ProQuest Central Student ProQuest Central Essentials Lancet Titles elibrary ProQuest AP Science SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Newsstand Professional Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Family Health ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition ProQuest Health Management (Alumni Edition) ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest One Academic Middle East (New) SIRS Editorial ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Family Health (Alumni Edition) ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Public Health ProQuest Central Basic Toxicology Abstracts ProQuest Science Journals British Nursing Index with Full Text ProQuest Health Management British Nursing Index ProQuest Nursing & Allied Health Source ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection ProQuest Medical Library ProQuest Psychology Journals ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic ProQuest One Psychology Neurosciences Abstracts ProQuest One Psychology MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1474-547X
EndPage	546
ExternalDocumentID	4312279621 27988140 10_1016_S0140_6736_16_31723_8 S0140673616317238 1_s2_0_S0140673616317238
Genre	Multicenter Study Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GeographicLocations	United Kingdom--UK
GeographicLocations_xml	– name: United Kingdom--UK
GrantInformation	National Institute for Health Research Health Technology Assessment programme.
GroupedDBID	--- --K --M .1- .55 .CO .FO 0R~ 123 1B1 1P~ 1RT 1~5 29L 4.4 457 4G. 53G 5VS 7-5 71M 7RV 7X7 88E 88I 8AF 8AO 8C1 8C2 8FE 8FH 8FI 8FJ 8G5 9JM AABNK AAEDT AAEDW AAFWJ AAIKJ AAKOC AALRI AAMRU AAQFI AAQQT AATTM AAXKI AAXUO AAYWO ABBQC ABCQX ABFNM ABIVO ABJNI ABLJU ABMAC ABMZM ABOCM ABUFD ABUWG ACGFS ACGOD ACIEU ACIUM ACLOT ACPRK ACRLP ACVFH ADBBV ADCNI AEIPS AEKER AENEX AEUPX AEUYN AEVXI AFKRA AFPUW AFRAH AFRHN AFTJW AFXIZ AGAPS AGHFR AHMBA AIIUN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ AN0 ANZVX APXCP AQUVI AXJTR AZQEC BBNVY BCU BEC BENPR BHPHI BKEYQ BKNYI BKOJK BKOMP BNPGV BNQBC BPHCQ BVXVI CCPQU CS3 DU5 DWQXO EAU EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 EWM EX3 F5P FD8 FDB FIRID FNPLU FYGXN FYUFA G-2 G-Q GBLVA GNUQQ GUQSH HCIFZ HMCUK IHE J1W K-O K9- KOM L7B LK8 LZ2 M0R M0T M1P M2M M2O M2P M7P MJL MO0 N9A NAPCQ O-L O9- OD. OO~ OZT P-8 P-9 P2P PC. PHGZM PHGZT PJZUB PPXIY PQGLB PQQKQ PRG PROAC PSQYO PSYQQ R2- ROL RPZ S0X SAD SDG SEL SES SJFOW SJN SPCBC SSH SSZ T5K TLN TWZ UAP UBE UKHRP UV1 WOW X7M XAX XDU YYM Z5R ZMT ~HD .GJ 04C 3EH 3O- 3V. 41~ 88A 8WZ A6W AACTN AAEJM AAKAS AAQXK AAYOK ABDBF ABTAH ABWVN ACRPL ACRZS ACUHS ADMUD ADNMO ADZCM AFCTW AFFNX AFKWA AHHHB AHQJS AJJEV AJOXV AKVCP ALIPV AMFUW ARTTT ASPBG AVWKF AZFZN D0S EAP EAS EAZ EBC EBD EBU EGS EHN EIHBH EMB EMK EMOBN ENC EPL EPS EPT ESX EVS FEDTE FGOYB HVGLF HZ~ J5H M0L M41 MVM OVD PKN Q~Q RIG SDF SV3 TEORI TH9 UHU UQL WOQ WUQ XPP YYQ ZGI ZXP ZY4 ~G0 6I. AAFTH ABLVK ABYKQ AHPSJ AJBFU XFK ZA5 9DU AAYXX ADXHL AFFHD AGQPQ AIGII CITATION AGCQF AGRNS CGR CUY CVF ECM EIF NPM 7QL 7QP 7TK 7U7 7U9 7XB 8FK ASE C1K FPQ H94 K6X K9. KB~ M7N MBDVC PKEHL PQEST PQUKI PRINS Q9U 7X8 PUEGO
ID	FETCH-LOGICAL-c610t-b6ac78a0686407d2e5abfab665ccd1fe35307f4f719d3a9ef331cd017a693f553
IEDL.DBID	M7P
ISICitedReferencesCount	248
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000393283400036&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0140-6736 1474-547X
IngestDate	Sun Sep 28 06:09:49 EDT 2025 Sun Sep 28 10:43:07 EDT 2025 Tue Oct 07 07:36:12 EDT 2025 Tue Oct 07 06:47:50 EDT 2025 Mon Jul 21 06:05:56 EDT 2025 Sat Nov 29 05:12:46 EST 2025 Tue Nov 18 22:41:08 EST 2025 Fri Feb 23 02:32:32 EST 2024 Tue Feb 25 20:10:34 EST 2025 Tue Oct 14 19:40:38 EDT 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	10068
Language	English
License	This is an open access article under the CC BY license. Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license. Published by Elsevier Ltd.. All rights reserved.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c610t-b6ac78a0686407d2e5abfab665ccd1fe35307f4f719d3a9ef331cd017a693f553
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
OpenAccessLink	https://www.clinicalkey.es/playcontent/1-s2.0-S0140673616317238
PMID	27988140
PQID	1865237621
PQPubID	40246
PageCount	9
ParticipantIDs	proquest_miscellaneous_1868338183 proquest_miscellaneous_1851296757 proquest_journals_2317857966 proquest_journals_1865237621 pubmed_primary_27988140 crossref_primary_10_1016_S0140_6736_16_31723_8 crossref_citationtrail_10_1016_S0140_6736_16_31723_8 elsevier_sciencedirect_doi_10_1016_S0140_6736_16_31723_8 elsevier_clinicalkeyesjournals_1_s2_0_S0140673616317238 elsevier_clinicalkey_doi_10_1016_S0140_6736_16_31723_8
PublicationCentury	2000
PublicationDate	2017-02-04
PublicationDateYYYYMMDD	2017-02-04
PublicationDate_xml	– month: 02 year: 2017 text: 2017-02-04 day: 04
PublicationDecade	2010
PublicationPlace	England
PublicationPlace_xml	– name: England – name: London
PublicationTitle	The Lancet (British edition)
PublicationTitleAlternate	Lancet
PublicationYear	2017
Publisher	Elsevier Ltd Elsevier Limited
Publisher_xml	– name: Elsevier Ltd – name: Elsevier Limited
References	Congenital anomalies. Kok, de Vries, Heerschap, van den Berg (bib21) 2004; 22 (bib15) 1992; 67 Richmond, Atkins (bib14) 2005; 112 Rossi, Prefumo (bib4) 2014; 44 (bib18) 2010 Likert (bib16) 1932; 22 Sun, Grumbach, DeCosta, Meyers, Dungan (bib8) 1999; 2 Ng, Palmer (bib17) 2007; 80 Reeves, Brandreth, Whitby (bib20) 2010; 257 (accessed Nov 10, 2016). Carroll, Porter, Abdel-Fattah, Kyle, Soothill (bib7) 2000; 16 Akgun, Basbug, Ozgun (bib9) 2007; 27 Antonsson, Sundberg, Kublickas (bib6) 2008; 36 Van Doorn, Oude Rengerink, Newsum, Reneman, Majoie, Pajkrt (bib5) 2015; 23 (bib19) 2008 bib1 Fadda, Capobianco, Balata (bib12) 2009; 144 Mundy, Hiller, Braunack-Mayer, Merlin (bib3) 2007 Boyd, Tondi, Hicks, Chamberlain (bib11) 2004; 328 Grandjean, Larroque, Levi (bib13) 1999; 181 Amini, Antonsson, Papadogiannakis (bib10) 2006; 85 Reeves (10.1016/S0140-6736(16)31723-8_bib20) 2010; 257 Likert (10.1016/S0140-6736(16)31723-8_bib16) 1932; 22 Ng (10.1016/S0140-6736(16)31723-8_bib17) 2007; 80 Carroll (10.1016/S0140-6736(16)31723-8_bib7) 2000; 16 10.1016/S0140-6736(16)31723-8_bib2 Sun (10.1016/S0140-6736(16)31723-8_bib8) 1999; 2 Amini (10.1016/S0140-6736(16)31723-8_bib10) 2006; 85 Boyd (10.1016/S0140-6736(16)31723-8_bib11) 2004; 328 Fadda (10.1016/S0140-6736(16)31723-8_bib12) 2009; 144 (10.1016/S0140-6736(16)31723-8_bib18) 2010 Grandjean (10.1016/S0140-6736(16)31723-8_bib13) 1999; 181 (10.1016/S0140-6736(16)31723-8_bib15) 1992; 67 Rossi (10.1016/S0140-6736(16)31723-8_bib4) 2014; 44 Van Doorn (10.1016/S0140-6736(16)31723-8_bib5) 2015; 23 Antonsson (10.1016/S0140-6736(16)31723-8_bib6) 2008; 36 Akgun (10.1016/S0140-6736(16)31723-8_bib9) 2007; 27 Richmond (10.1016/S0140-6736(16)31723-8_bib14) 2005; 112 (10.1016/S0140-6736(16)31723-8_bib19) 2008 Kok (10.1016/S0140-6736(16)31723-8_bib21) 2004; 22 Mundy (10.1016/S0140-6736(16)31723-8_bib3) 2007 28561003 - Lancet. 2017 May 27;389(10084):2103 31273009 - Arch Dis Child Fetal Neonatal Ed. 2020 Jan;105(1):109-110 27988139 - Lancet. 2017 Feb 4;389(10068):483-485 28568972 - Ultrasound Obstet Gynecol. 2017 Dec;50(6):679-680
References_xml	– volume: 80 start-page: 152 year: 2007 end-page: 160 ident: bib17 article-title: Analysis of diagnostic confidence and diagnostic accuracy: a unified framework publication-title: Br J Radiol – volume: 85 start-page: 1208 year: 2006 end-page: 1216 ident: bib10 article-title: Comparison of ultrasound and autopsy findings in pregnancies terminated due to fetal anomalies publication-title: Acta Obstet Gynecol Scand – volume: 2 start-page: 131 year: 1999 end-page: 142 ident: bib8 article-title: Correlation of prenatal ultrasound diagnosis and pathologic findings in fetal anomalies publication-title: Pediatr Dev Pathol – volume: 328 start-page: 137 year: 2004 ident: bib11 article-title: Autopsy after termination of pregnancy for fetal anomaly: retrospective cohort study publication-title: BMJ – volume: 36 start-page: 59 year: 2008 end-page: 69 ident: bib6 article-title: Correlation between ultrasound and autopsy findings after 2nd trimester terminations of pregnancy publication-title: J Perinat Med – reference: (accessed Nov 10, 2016). – year: 2007 ident: bib3 publication-title: MRI for the detection of foetal abnormalities – volume: 27 start-page: 457 year: 2007 end-page: 462 ident: bib9 article-title: Correlation between prenatal ultrasound and fetal autopsy findings in fetal anomalies terminated in the second trimester publication-title: Prenat Diagn – volume: 181 start-page: 446 year: 1999 end-page: 454 ident: bib13 article-title: The performance of routine ultrasonographic screening of pregnancies in the Eurofetus Study publication-title: Am J Obstet Gynecol – volume: 112 start-page: 1349 year: 2005 end-page: 1357 ident: bib14 article-title: A population-based study of the prenatal diagnosis of congenital malformation over 16 years publication-title: BJOG – volume: 67 start-page: 770 year: 1992 end-page: 774 ident: bib15 article-title: Fetal abnormality: an audit of its recognition and management publication-title: Arch Dis Child – volume: 44 start-page: 388 year: 2014 end-page: 393 ident: bib4 article-title: Additional value of fetal magnetic resonance imaging in the prenatal diagnosis of central nervous system anomalies: a systematic review of the literature publication-title: Ultrasound Obstet Gynecol – volume: 22 start-page: 1 year: 1932 end-page: 55 ident: bib16 article-title: A technique for the measurement of attitudes publication-title: Arch Psychol – volume: 16 start-page: 149 year: 2000 end-page: 153 ident: bib7 article-title: Correlation of prenatal ultrasound diagnosis and pathologic findings in fetal brain abnormalities publication-title: Ultrasound Obstet Gynecol – volume: 144 start-page: 110 year: 2009 end-page: 114 ident: bib12 article-title: Routine second trimester ultrasound screening for prenatal detection of fetal malformations in Sassari University Hospital, Italy: 23 years of experience in 42 256 pregnancies publication-title: Eur J Obstet Gynecol Reprod Biol – year: 2008 ident: bib19 publication-title: Particular requirements for the safety of magnetic resonance equipment for medical diagnosis IEC 60601-2-33, edn 2.2, consolidated with amendments 1 and 2 – start-page: 10 year: 2010 ident: bib18 publication-title: ACR-SPR Practice guideline for the safe and optimal performance of fetal magnetic resonance imaging (MRI), resolution 13 – ident: bib1 article-title: European anomaly registers – reference: . Congenital anomalies. – volume: 23 start-page: 1 year: 2015 end-page: 13 ident: bib5 article-title: Added value of fetal MRI in foetuses with suspected brain abnormalities on neurosonography: a systematic review and meta-analysis publication-title: J Matern Fetal Neonatal Med – volume: 257 start-page: 802 year: 2010 end-page: 809 ident: bib20 article-title: Neonatal cochlear function: measurement after exposure to acoustic noise during in utero MR imaging publication-title: Radiology – volume: 22 start-page: 851 year: 2004 end-page: 854 ident: bib21 article-title: Absence of harmful effects of magnetic resonance exposure at 1.5 T in utero during the third trimester of pregnancy: a follow-up study publication-title: Magn Reson Imaging – volume: 67 start-page: 770 year: 1992 ident: 10.1016/S0140-6736(16)31723-8_bib15 article-title: Fetal abnormality: an audit of its recognition and management publication-title: Arch Dis Child doi: 10.1136/adc.67.7_Spec_No.770 – volume: 144 start-page: 110 year: 2009 ident: 10.1016/S0140-6736(16)31723-8_bib12 article-title: Routine second trimester ultrasound screening for prenatal detection of fetal malformations in Sassari University Hospital, Italy: 23 years of experience in 42 256 pregnancies publication-title: Eur J Obstet Gynecol Reprod Biol doi: 10.1016/j.ejogrb.2009.02.045 – start-page: 10 year: 2010 ident: 10.1016/S0140-6736(16)31723-8_bib18 – volume: 328 start-page: 137 year: 2004 ident: 10.1016/S0140-6736(16)31723-8_bib11 article-title: Autopsy after termination of pregnancy for fetal anomaly: retrospective cohort study publication-title: BMJ doi: 10.1136/bmj.37939.570104.EE – volume: 22 start-page: 851 year: 2004 ident: 10.1016/S0140-6736(16)31723-8_bib21 article-title: Absence of harmful effects of magnetic resonance exposure at 1.5 T in utero during the third trimester of pregnancy: a follow-up study publication-title: Magn Reson Imaging doi: 10.1016/j.mri.2004.01.047 – volume: 36 start-page: 59 year: 2008 ident: 10.1016/S0140-6736(16)31723-8_bib6 article-title: Correlation between ultrasound and autopsy findings after 2nd trimester terminations of pregnancy publication-title: J Perinat Med doi: 10.1515/JPM.2008.005 – volume: 257 start-page: 802 year: 2010 ident: 10.1016/S0140-6736(16)31723-8_bib20 article-title: Neonatal cochlear function: measurement after exposure to acoustic noise during in utero MR imaging publication-title: Radiology doi: 10.1148/radiol.10092366 – volume: 27 start-page: 457 year: 2007 ident: 10.1016/S0140-6736(16)31723-8_bib9 article-title: Correlation between prenatal ultrasound and fetal autopsy findings in fetal anomalies terminated in the second trimester publication-title: Prenat Diagn doi: 10.1002/pd.1710 – year: 2007 ident: 10.1016/S0140-6736(16)31723-8_bib3 – volume: 22 start-page: 1 year: 1932 ident: 10.1016/S0140-6736(16)31723-8_bib16 article-title: A technique for the measurement of attitudes publication-title: Arch Psychol – volume: 44 start-page: 388 year: 2014 ident: 10.1016/S0140-6736(16)31723-8_bib4 article-title: Additional value of fetal magnetic resonance imaging in the prenatal diagnosis of central nervous system anomalies: a systematic review of the literature publication-title: Ultrasound Obstet Gynecol doi: 10.1002/uog.13429 – volume: 80 start-page: 152 year: 2007 ident: 10.1016/S0140-6736(16)31723-8_bib17 article-title: Analysis of diagnostic confidence and diagnostic accuracy: a unified framework publication-title: Br J Radiol doi: 10.1259/bjr/64096611 – ident: 10.1016/S0140-6736(16)31723-8_bib2 – volume: 16 start-page: 149 year: 2000 ident: 10.1016/S0140-6736(16)31723-8_bib7 article-title: Correlation of prenatal ultrasound diagnosis and pathologic findings in fetal brain abnormalities publication-title: Ultrasound Obstet Gynecol doi: 10.1046/j.1469-0705.2000.00199.x – volume: 112 start-page: 1349 year: 2005 ident: 10.1016/S0140-6736(16)31723-8_bib14 article-title: A population-based study of the prenatal diagnosis of congenital malformation over 16 years publication-title: BJOG doi: 10.1111/j.1471-0528.2005.00660.x – volume: 23 start-page: 1 year: 2015 ident: 10.1016/S0140-6736(16)31723-8_bib5 article-title: Added value of fetal MRI in foetuses with suspected brain abnormalities on neurosonography: a systematic review and meta-analysis publication-title: J Matern Fetal Neonatal Med doi: 10.3109/14767058.2015.1109621 – year: 2008 ident: 10.1016/S0140-6736(16)31723-8_bib19 – volume: 2 start-page: 131 year: 1999 ident: 10.1016/S0140-6736(16)31723-8_bib8 article-title: Correlation of prenatal ultrasound diagnosis and pathologic findings in fetal anomalies publication-title: Pediatr Dev Pathol doi: 10.1007/s100249900101 – volume: 85 start-page: 1208 year: 2006 ident: 10.1016/S0140-6736(16)31723-8_bib10 article-title: Comparison of ultrasound and autopsy findings in pregnancies terminated due to fetal anomalies publication-title: Acta Obstet Gynecol Scand doi: 10.1080/00016340600880886 – volume: 181 start-page: 446 year: 1999 ident: 10.1016/S0140-6736(16)31723-8_bib13 article-title: The performance of routine ultrasonographic screening of pregnancies in the Eurofetus Study publication-title: Am J Obstet Gynecol doi: 10.1016/S0002-9378(99)70577-6 – reference: 28561003 - Lancet. 2017 May 27;389(10084):2103 – reference: 31273009 - Arch Dis Child Fetal Neonatal Ed. 2020 Jan;105(1):109-110 – reference: 27988139 - Lancet. 2017 Feb 4;389(10068):483-485 – reference: 28568972 - Ultrasound Obstet Gynecol. 2017 Dec;50(6):679-680
SSID	ssj0004605
Score	2.6319218
Snippet	In-utero MRI (iuMRI) has shown promise as an adjunct to ultrasound but the comparative diagnostic performance has been poorly defined. We aimed to assess... Summary Background In-utero MRI (iuMRI) has shown promise as an adjunct to ultrasound but the comparative diagnostic performance has been poorly defined. We... Background In-utero MRI (iuMRI) has shown promise as an adjunct to ultrasound but the comparative diagnostic performance has been poorly defined. We aimed to...
SourceID	proquest pubmed crossref elsevier
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	538
SubjectTerms	Abnormalities Acceptability Accuracy Age Anomalies Brain Brain - abnormalities Brain - diagnostic imaging Brain research Clinical trials Cohort analysis Confidence Diagnosis Diagnostic systems Ethics Female Fetal Diseases - diagnostic imaging Fetuses Gestation Gestational Age Humans Internal Medicine Magnetic Resonance Imaging Male Management Medical diagnosis Neuropathology NMR Nuclear magnetic resonance Predictive Value of Tests Pregnancy Prenatal Diagnosis Prospective Studies Technology assessment Ultrasonic imaging Ultrasound United Kingdom Womens health
Title	Use of MRI in the diagnosis of fetal brain abnormalities in utero (MERIDIAN): a multicentre, prospective cohort study
URI	https://www.clinicalkey.com/#!/content/1-s2.0-S0140673616317238 https://www.clinicalkey.es/playcontent/1-s2.0-S0140673616317238 https://dx.doi.org/10.1016/S0140-6736(16)31723-8 https://www.ncbi.nlm.nih.gov/pubmed/27988140 https://www.proquest.com/docview/1865237621 https://www.proquest.com/docview/2317857966 https://www.proquest.com/docview/1851296757 https://www.proquest.com/docview/1868338183
Volume	389
WOSCitedRecordID	wos000393283400036&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1474-547X dateEnd: 20250908 omitProxy: false ssIdentifier: ssj0004605 issn: 0140-6736 databaseCode: M7P dateStart: 19920104 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Consumer Health Database customDbUrl: eissn: 1474-547X dateEnd: 20250908 omitProxy: false ssIdentifier: ssj0004605 issn: 0140-6736 databaseCode: M0R dateStart: 19920104 isFulltext: true titleUrlDefault: https://search.proquest.com/familyhealth providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection (ProQuest) customDbUrl: eissn: 1474-547X dateEnd: 20250908 omitProxy: false ssIdentifier: ssj0004605 issn: 0140-6736 databaseCode: 7X7 dateStart: 19920104 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Healthcare Administration Database customDbUrl: eissn: 1474-547X dateEnd: 20250908 omitProxy: false ssIdentifier: ssj0004605 issn: 0140-6736 databaseCode: M0T dateStart: 19920104 isFulltext: true titleUrlDefault: https://search.proquest.com/healthmanagement providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database (ProQuest) customDbUrl: eissn: 1474-547X dateEnd: 20250908 omitProxy: false ssIdentifier: ssj0004605 issn: 0140-6736 databaseCode: 7RV dateStart: 19920104 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1474-547X dateEnd: 20250908 omitProxy: false ssIdentifier: ssj0004605 issn: 0140-6736 databaseCode: BENPR dateStart: 19920104 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Research Library customDbUrl: eissn: 1474-547X dateEnd: 20250908 omitProxy: false ssIdentifier: ssj0004605 issn: 0140-6736 databaseCode: M2O dateStart: 19920104 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Psychology Database customDbUrl: eissn: 1474-547X dateEnd: 20250908 omitProxy: false ssIdentifier: ssj0004605 issn: 0140-6736 databaseCode: M2M dateStart: 19920104 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1474-547X dateEnd: 20250908 omitProxy: false ssIdentifier: ssj0004605 issn: 0140-6736 databaseCode: 8C1 dateStart: 19920104 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database (ProQuest) customDbUrl: eissn: 1474-547X dateEnd: 20250908 omitProxy: false ssIdentifier: ssj0004605 issn: 0140-6736 databaseCode: M2P dateStart: 19920104 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZoixAX3tCFsjISh1YiNIkT2-GCSmlFJXZZLW21t8jxQ1qpStrNLr-fGeexl22LxGWkPMa2Ymf82f5mhpCPmukoZCYMrAtdkLiEBUWsWcAzI7gpEqP81sXlTzEey9ksm7QbbnVLq-xsojfUptK4R34IOERIdJzkX69vAswahaerbQqNLbKDURKYp-5NNvlFeor72oPn8Hd_cz_iB1B2zAJ529x0G_b0c9Dp0_9t_TPypEWf9KgZLs_JA1u-II9G7fn6S7K6qC2tHB1Nz-i8pAAOqWm4ePMa7zsLWJ0WmFaCqqJEvHvlQ7Li25gcoqL7mEby-9nR-OALVdTzFT0B1H6i0ObOsZNiYt7Fkvrotq_IxenJ-fGPoE3MEGhAW8ug4EoLqdC7BNaDJrapKpwqOE-1NpGzLAXL4RInoswwlVnHWKQN_PuKZ8ylKXtNtsuqtLuEihgGhCsKGSY64SqVobNQlothaW60TAck6bok123UckyecZVvoKfBle_JXA7I517tugnbcZ8C7_o773xSwYrmMLHcpyg2Kdq6tQV1HuV1nIeNNioDAkZV0JS9Zgt3GhjzL5XudcMsX9cjeYocpzja-Hg9BAfkQ_8YjAmeEKnSVissAvEfrCHFXe9wyRDnsQF50_wN_SeOMfodtPft3Q14Rx7HiI6Q_J7ske3lYmXfk4f6z3JeL4ZkS0wvUc6ElxKkPI6GZOfbyXgyhatR2MhzlPHIy19eTobeAvwFJeVRPA
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELaqgqAX3pSFAkYCqZUITezEcZAQqihVV91dIdhWvQXHD2mlKimbXRB_it_IjJPsXrYtlx445jGJ44zHn5Nv5iPkteY6CrkJA-tCF8Qu5kHBNA9EZlJhitgo_-niZJCORvL0NPuyRv50uTBIq-xiog_UptL4jXwXcEgqMXFSfDz_EaBqFP5d7SQ0Grc4sr9_wZKt_tDfh_f7hrGDz-NPh0GrKhBogAqzoBBKp1JhagQsZgyziSqcKoRItDaRszwBt3exS6PMcJVZx3mkDTiuEhl3CapEQMi_gXX1kEI4DMer8jA9pX6ZMbT7bbFzOxI78CyMB_KiufAirOvnvIO7_1tv3SN3WnRN95rhcJ-s2fIBuTVs-QMPyfy4trRydPi1TyclBfBLTcM1nNS431lYi9ACZTOoKkrE82e-5CyejeIXFd1Gmcz9_t5o5z1V1PMxPcHVvqXQR13iKkXh4emM-uq9j8jxtTz0Y7JeVqV9QmjKwOFdUcgw1rFQiQydhWs5lkpptEx6JO5cINdtVXYUBznLV9DvYMt7Ti575N3C7LwpS3KVgej8K-9ybmGWyGHivMowXWVo6zbW1XmU1ywPG2s0BoSPpmApF5YtnGtg2r_cdKtz63x5HykS5HCxaOXhpcv3yKvFYQiW-AdMlbaa4yUQ38IaOb3sHCE54ljeI5vN6Ft0McPqftDep5c34CW5fTgeDvJBf3T0jGwwRIJI9I-3yPpsOrfPyU39czappy98_KDk-3UPwb-bpqUE
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF5VBVVcyhsCBRYJpFbCxN61d9dICFUNEVHbqAJa9WbW-5AiVXYbJyD-Gr-OGT-SS9py6YFjbH9-bGZmv7W_mSHkjeEmCrkNA-dDH8Q-5kHODA9EaqWweWx1_eri5ECOx-r0ND1aI3-6XBiUVXYxsQ7UtjT4jrwPPEQqTJwUfd_KIo4Gw0_nFwF2kMIvrV07jcZE9t3vX7B8qz6OBvBfv2Vs-Pn73peg7TAQGKANsyAX2kilMU0CFjaWuUTnXudCJMbYyDuegAv42MsotVynznMeGQtGrEXKfYIdIyD835IcrBiz1PeiVTmZtbx-mT3U_7bYuB2JHXguxgN12bx4Ge-t57_h3f955O6RzZZ1093GTe6TNVc8IBuHra7gIZkfV46Wnh5-HdFJQYEUU9toECcVbvcO1ig0x3YaVOcF8vyzuhQtHo1NMUq6je0zB6Pd8c4Hqmmt06yFr-4dhfHqElopNiSezmhd1fcROb6Rh35M1ouycE8JlQwcwee5CmMTC52o0Ds4l2dSKWtU0iNxZw6Zaau1Y9OQs2yFLA9-1VaUqR55v4CdN-VKrgOIztayLhcXZo8MJtTrgHIV0FVtDKyyKKtYFjZoBAPzRygg1QLZ0ryGvv3LRbc6E8-W11EiQW0Xi1buXpp_j7xe7IYgil_GdOHKOZ4CeS-sneVVxwjFkd_yHnnSeOJiiBlW_YP7fXb1DbwiG-B52cFovP-c3GFIEFH_H2-R9dl07l6Q2-bnbFJNX9ahhJIfN-2BfwE9F62C
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Use+of+MRI+in+the+diagnosis+of+fetal+brain+abnormalities+in+utero+%28MERIDIAN%29%3A+a+multicentre%2C+prospective+cohort+study&rft.jtitle=The+Lancet+%28British+edition%29&rft.au=Griffiths%2C+Paul+D&rft.au=Bradburn%2C+Michael&rft.au=Campbell%2C+Michael+J&rft.au=Cooper%2C+Cindy+L&rft.date=2017-02-04&rft.pub=Elsevier+Ltd&rft.issn=0140-6736&rft.volume=389&rft.issue=10068&rft.spage=538&rft.epage=546&rft_id=info:doi/10.1016%2FS0140-6736%2816%2931723-8&rft.externalDocID=S0140673616317238
thumbnail_m	http://cvtisr.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F01406736%2FS0140673617X00056%2Fcov150h.gif