Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis

Background Endometrial cancer is the most common gynaecological cancer in high-income countries. Elevated body mass index (BMI) is an established modifiable risk factor for this condition and is estimated to confer a larger effect on endometrial cancer risk than any other cancer site. However, the m...

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Bibliographic Details
Published in:	BMC medicine Vol. 20; no. 1; pp. 125 - 24
Main Authors:	Hazelwood, Emma, Sanderson, Eleanor, Tan, Vanessa Y., Ruth, Katherine S., Frayling, Timothy M., Dimou, Niki, Gunter, Marc J., Dossus, Laure, Newton, Claire, Ryan, Neil, Pournaras, Dimitri J., O’Mara, Tracy A., Davey Smith, George, Martin, Richard M., Yarmolinsky, James
Format:	Journal Article
Language:	English
Published:	London BioMed Central 19.04.2022 BioMed Central Ltd BMC
Subjects:	Bioavailable testosterone Biological markers Biomedicine Body Mass Index Complications and side effects Endometrial cancer Endometrial Neoplasms - epidemiology Endometrial Neoplasms - genetics Fasting insulin Female Genetic aspects Genome-Wide Association Study Health aspects Hormones Humans Insulin Medicine Medicine & Public Health Mendelian randomization Mendelian Randomization Analysis Obesity Polymorphism, Single Nucleotide - genetics Prevention Research Article Risk Factors Sex hormone-binding globulin Testosterone United Kingdom Body mass index Bioavailable testosterone Sex hormone-binding globulin Mendelian randomization Endometrial cancer Fasting insulin
ISSN:	1741-7015, 1741-7015
Online Access:	Get full text
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