Human RPA activates BLM’s bidirectional DNA unwinding from a nick

BLM is a multifunctional helicase that plays critical roles in maintaining genome stability. It processes distinct DNA substrates, but not nicked DNA, during many steps in DNA replication and repair. However, how BLM prepares itself for diverse functions remains elusive. Here, using a combined singl...

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Veröffentlicht in:	eLife Jg. 9
Hauptverfasser:	Qin, Zhenheng, Bi, Lulu, Hou, Xi-Miao, Zhang, Siqi, Zhang, Xia, Lu, Ying, Li, Ming, Modesti, Mauro, Xi, Xu-Guang, Sun, Bo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England eLife Science Publications, Ltd 26.02.2020 eLife Sciences Publications Ltd eLife Sciences Publication eLife Sciences Publications, Ltd
Schlagworte:	BLM Cellular Biology Deoxyribonucleic acid DNA DNA biosynthesis DNA Breaks, Single-Stranded DNA damage DNA helicase DNA repair DNA replication DNA Topoisomerases, Type I - metabolism DNA unwinding DNA, Single-Stranded - metabolism Genomes Genomics helicase Life Sciences Microscopy Novels optical tweezers Proteins RecQ Helicases - metabolism Replication protein A Replication Protein A - metabolism RPA single molecule Structural Biology and Molecular Biophysics Unwinding single molecule BLM RPA chicken optical tweezers structural biology helicase molecular biophysics DNA unwinding
ISSN:	2050-084X, 2050-084X
Online-Zugang:	Volltext
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