Systematic analysis of barrier-forming FG hydrogels from Xenopus nuclear pore complexes

Nuclear pore complexes (NPCs) control the traffic between cell nucleus and cytoplasm. While facilitating translocation of nuclear transport receptors (NTRs) and NTR·cargo complexes, they suppress passive passage of macromolecules ⩾30 kDa. Previously, we reconstituted the NPC barrier as hydrogels com...

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Veröffentlicht in:	The EMBO journal Jg. 32; H. 2; S. 204 - 218
Hauptverfasser:	Labokha, Aksana A, Gradmann, Sabine, Frey, Steffen, Hülsmann, Bastian B, Urlaub, Henning, Baldus, Marc, Görlich, Dirk
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Chichester, UK John Wiley & Sons, Ltd 23.01.2013 Nature Publishing Group UK Springer Nature B.V Nature Publishing Group
Schlagworte:	Active Transport, Cell Nucleus Amino Acid Sequence Animals beta Karyopherins - analysis beta Karyopherins - metabolism Cell Nucleus - chemistry Cell Nucleus - metabolism Cell Nucleus - ultrastructure Cells EMBO20 EMBO31 exportin FG hydrogel Glycine - chemistry Glycine - metabolism Hydrogels Hydrogels - analysis Hydrogels - chemistry Hydrogels - metabolism importin Membrane Microdomains - chemistry Membrane Microdomains - metabolism Membrane Microdomains - physiology Molecular Sequence Data Neurons Nuclear Pore - chemistry Nuclear Pore - metabolism Nuclear Pore - physiology nuclear pore complex Nuclear Pore Complex Proteins - analysis Nuclear Pore Complex Proteins - chemistry Nuclear Pore Complex Proteins - metabolism O-glycosylation Permeability Phenylalanine - chemistry Phenylalanine - metabolism Repetitive Sequences, Amino Acid Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - metabolism Spectroscopy Translocation Xenopus - metabolism nuclear pore complex importin O‐glycosylation exportin FG hydrogel
ISSN:	0261-4189, 1460-2075, 1460-2075
Online-Zugang:	Volltext
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