Regulation of Trophoblast Invasion — A Workshop Report

Trophoblast invasion during placental development helps to establish efficient physiological exchange between maternal and fetal circulatory systems. Trophoblast stem cells differentiate into multiple subtypes, including some that are highly invasive. Signalling to the trophoblast from decidua, uter...

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Bibliographic Details
Published in:Placenta (Eastbourne) Vol. 29; no. Suppl A; pp. 26 - 28
Main Authors: Knöfler, M., Simmons, D.G., Lash, G.E., Harris, L.K., Armant, D.R.
Format: Journal Article Conference Proceeding
Language:English
Published: Oxford Elsevier Ltd 01.03.2008
Elsevier
Subjects:
Biological and medical sciences
Education
Embryology: invertebrates and vertebrates. Teratology
Extravillous trophoblast
Female
Fundamental and applied biological sciences. Psychology
Humans
Internal Medicine
Invasion
Obstetrics and Gynecology
Placental Circulation - physiology
Pregnancy
Signal Transduction - physiology
Spiral artery
Trophoblast giant cells
Trophoblasts - cytology
Trophoblasts - physiology
Uterine NK cell
Trophoblast giant cells
Extravillous trophoblast
Uterine NK cell
Spiral artery
Invasion
Trophoblaste
Vertebrata
Regulation(control)
Mammalia
Fetal membrane
ISSN:0143-4004, 1532-3102
Online Access:Get full text
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Summary:Trophoblast invasion during placental development helps to establish efficient physiological exchange between maternal and fetal circulatory systems. Trophoblast stem cells differentiate into multiple subtypes, including some that are highly invasive. Signalling to the trophoblast from decidua, uterine natural killer cells and vascular smooth muscle can regulate extravillous trophoblast differentiation. Important questions remain about how these cellular interactions promote trophoblast invasion and the signalling pathways that are involved. New and established biological models are being used to experimentally examine these interactions and the underlying molecular mechanisms.
Bibliography:SourceType-Scholarly Journals-1
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ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2007.11.008