Regulation of Trophoblast Invasion — A Workshop Report

Trophoblast invasion during placental development helps to establish efficient physiological exchange between maternal and fetal circulatory systems. Trophoblast stem cells differentiate into multiple subtypes, including some that are highly invasive. Signalling to the trophoblast from decidua, uter...

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Vydáno v:	Placenta (Eastbourne) Ročník 29; číslo Suppl A; s. 26 - 28
Hlavní autoři:	Knöfler, M., Simmons, D.G., Lash, G.E., Harris, L.K., Armant, D.R.
Médium:	Journal Article Konferenční příspěvek
Jazyk:	angličtina
Vydáno:	Oxford Elsevier Ltd 01.03.2008 Elsevier
Témata:	Biological and medical sciences Education Embryology: invertebrates and vertebrates. Teratology Extravillous trophoblast Female Fundamental and applied biological sciences. Psychology Humans Internal Medicine Invasion Obstetrics and Gynecology Placental Circulation - physiology Pregnancy Signal Transduction - physiology Spiral artery Trophoblast giant cells Trophoblasts - cytology Trophoblasts - physiology Uterine NK cell Trophoblast giant cells Extravillous trophoblast Uterine NK cell Spiral artery Invasion Trophoblaste Vertebrata Regulation(control) Mammalia Fetal membrane
ISSN:	0143-4004, 1532-3102
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Abstract	Trophoblast invasion during placental development helps to establish efficient physiological exchange between maternal and fetal circulatory systems. Trophoblast stem cells differentiate into multiple subtypes, including some that are highly invasive. Signalling to the trophoblast from decidua, uterine natural killer cells and vascular smooth muscle can regulate extravillous trophoblast differentiation. Important questions remain about how these cellular interactions promote trophoblast invasion and the signalling pathways that are involved. New and established biological models are being used to experimentally examine these interactions and the underlying molecular mechanisms.
AbstractList	Trophoblast invasion during placental development helps to establish efficient physiological exchange between maternal and fetal circulatory systems. Trophoblast stem cells differentiate into multiple subtypes, including some that are highly invasive. Signalling to the trophoblast from decidua, uterine natural killer cells and vascular smooth muscle can regulate extravillous trophoblast differentiation. Important questions remain about how these cellular interactions promote trophoblast invasion and the signalling pathways that are involved. New and established biological models are being used to experimentally examine these interactions and the underlying molecular mechanisms. Trophoblast invasion during placental development helps to establish efficient physiological exchange between maternal and fetal circulatory systems. Trophoblast stem cells differentiate into multiple subtypes, including some that are highly invasive. Signalling to the trophoblast from decidua, uterine natural killer cells and vascular smooth muscle can regulate extravillous trophoblast differentiation. Important questions remain about how these cellular interactions promote trophoblast invasion and the signalling pathways that are involved. New and established biological models are being used to experimentally examine these interactions and the underlying molecular mechanisms.Trophoblast invasion during placental development helps to establish efficient physiological exchange between maternal and fetal circulatory systems. Trophoblast stem cells differentiate into multiple subtypes, including some that are highly invasive. Signalling to the trophoblast from decidua, uterine natural killer cells and vascular smooth muscle can regulate extravillous trophoblast differentiation. Important questions remain about how these cellular interactions promote trophoblast invasion and the signalling pathways that are involved. New and established biological models are being used to experimentally examine these interactions and the underlying molecular mechanisms. Abstract Trophoblast invasion during placental development helps to establish efficient physiological exchange between maternal and fetal circulatory systems. Trophoblast stem cells differentiate into multiple subtypes, including some that are highly invasive. Signalling to the trophoblast from decidua, uterine natural killer cells and vascular smooth muscle can regulate extravillous trophoblast differentiation. Important questions remain about how these cellular interactions promote trophoblast invasion and the signalling pathways that are involved. New and established biological models are being used to experimentally examine these interactions and the underlying molecular mechanisms.
Author	Lash, G.E. Harris, L.K. Armant, D.R. Simmons, D.G. Knöfler, M.
AuthorAffiliation	c Uterine Cell Signalling Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK e C.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA a Department of Obstetrics and Fetal–Maternal Medicine, Reproductive Biology Unit, Medical University of Vienna, Austria f Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA d Maternal and Fetal Health Research Group, University of Manchester, UK b Department of Comparative Biology and Experimental Medicine, University of Calgary, Canada
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Cites_doi	10.1016/j.ydbio.2007.01.009 10.4049/jimmunol.177.12.8522 10.1016/S0140-6736(02)11283-9 10.1038/nm1452 10.1042/bj3610641 10.2353/ajpath.2006.050686 10.1016/j.ydbio.2003.09.026 10.1016/j.yexcr.2004.08.024
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SubjectTerms	Biological and medical sciences Education Embryology: invertebrates and vertebrates. Teratology Extravillous trophoblast Female Fundamental and applied biological sciences. Psychology Humans Internal Medicine Invasion Obstetrics and Gynecology Placental Circulation - physiology Pregnancy Signal Transduction - physiology Spiral artery Trophoblast giant cells Trophoblasts - cytology Trophoblasts - physiology Uterine NK cell
Title	Regulation of Trophoblast Invasion — A Workshop Report
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