Exploring Viral–Host Protein Interactions as Antiviral Therapies: A Computational Perspective

The interactions between human and viral proteins are pivotal in viral infection and host immune responses. These interactions traverse different stages of the viral life cycle, encompassing initial entry into host cells, replication, and the eventual deployment of immune evasion strategies. As viru...

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Bibliographic Details
Published in:Microorganisms (Basel) Vol. 12; no. 3; p. 630
Main Authors: Idrees, Sobia, Chen, Hao, Panth, Nisha, Paudel, Keshav Raj, Hansbro, Philip M.
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 21.03.2024
MDPI
Subjects:
Analysis
Antiviral agents
Antiviral drugs
antiviral proteins
antiviral therapies
Computer applications
drug development
Enzymes
Genomes
host-pathogen relationships
Host-virus relationships
hosts
humans
immune evasion
Immune response
Immunosuppressive agents
Infections
Life cycles
Mass spectrometry
Medical research
Metabolism
Pathogens
Peptides
Physiology
Protein interaction
protein-protein interactions
Proteins
Replication
Research methodology
Review
Scientific imaging
Severe acute respiratory syndrome coronavirus 2
Signal transduction
therapeutics
Viral infections
viral proteins
viral–host interactions
Virus research
Viruses
Yeast
Australia
protein–protein interactions
antiviral therapies
viral–host interactions
ISSN:2076-2607, 2076-2607
Online Access:Get full text
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Summary:The interactions between human and viral proteins are pivotal in viral infection and host immune responses. These interactions traverse different stages of the viral life cycle, encompassing initial entry into host cells, replication, and the eventual deployment of immune evasion strategies. As viruses exploit host cellular machinery for their replication and survival, targeting key protein–protein interactions offer a strategic approach for developing antiviral drugs. This review discusses how viruses interact with host proteins to develop viral–host interactions. In addition, we also highlight valuable resources that aid in identifying new interactions, incorporating high-throughput methods, and computational approaches, ultimately helping to understand how these tools can be effectively utilized to study viral–host interactions.
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ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms12030630