Polymorphisms in glutathione-related genes modify mercury concentrations and antioxidant status in subjects environmentally exposed to methylmercury

Methylmercury (MeHg) toxicity may vary widely despite similar levels of exposure. This is hypothetically related to genetic differences in enzymes metabolizing MeHg. MeHg causes oxidative stress in experimental models but little is known about its effects on humans. The aims of the present study was...

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Bibliographic Details
Published in:	The Science of the total environment Vol. 463-464; pp. 319 - 325
Main Authors:	Barcelos, Gustavo Rafael Mazzaron, Grotto, Denise, de Marco, Kátia Cristina, Valentini, Juliana, Lengert, André van Helvoort, Oliveira, Andréia Ávila Soares de, Garcia, Solange Cristina, Braga, Gilberto Úbida Leite, Schläwicke Engström, Karin, Cólus, Ilce Mara de Syllos, Broberg, Karin, Barbosa, Fernando
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.10.2013
Subjects:	Adult adverse effects analysis antioxidant activity Antioxidant status blood Brazil chemistry chronic exposure Cross-Sectional Studies drug effects Earth and Related Environmental Sciences Environmental Exposure Environmental Exposure - adverse effects Environmental Sciences enzymes Female fish fish consumption Fish intake gender genes genetics Gene–environment interactions genotype Genotyping Techniques Geovetenskap och relaterad miljövetenskap Glutamate-Cysteine Ligase Glutamate-Cysteine Ligase - genetics Glutathione Glutathione - blood Glutathione - genetics Glutathione S-Transferase pi Glutathione S-Transferase pi - genetics Glutathione Transferase Glutathione Transferase - genetics Hair Hair - chemistry Humans linear models Male mercury Mercury Poisoning Mercury Poisoning - blood Mercury Poisoning - genetics Metabolism Methylmercury methylmercury compounds Methylmercury Compounds - analysis Methylmercury Compounds - blood Miljövetenskap Multiplex Polymerase Chain Reaction Natural Sciences Naturvetenskap Oxidation-Reduction Oxidation-Reduction - drug effects oxidative stress people polymerase chain reaction Polymorphism, Genetic Polymorphism, Genetic - genetics Polymorphisms toxicity Brazil Antioxidant status Gene–environment interactions Fish intake Metabolism Polymorphisms Methylmercury
ISSN:	0048-9697, 1879-1026, 1879-1026
Online Access:	Get full text
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