A principal component analysis is conducted for a case series quality appraisal checklist

Because of a lack of a control group, a case-series study is considered one of the weaker study designs from which to obtain evidence on treatment effectiveness. Under certain circumstances, however, this is the only available evidence to inform health-care decisions. This study's intent was to...

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Vydané v:	Journal of clinical epidemiology Ročník 69; s. 199 - 207.e2
Hlavní autori:	Guo, Bing, Moga, Carmen, Harstall, Christa, Schopflocher, Don
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Elsevier Inc 01.01.2016 Elsevier Limited
Predmet:	Bias Case series Checklist - standards Confidence intervals Delphi Epidemiology Experimental design Internal Medicine Intervention Practice Guidelines as Topic Principal Component Analysis Principal components analysis Quality Quality appraisal Quality Assurance, Health Care - methods Research Design Research evidence Studies Surveys and Questionnaires Treatment intervention Validation Validation Quality appraisal Treatment intervention Case series Research evidence Delphi
ISSN:	0895-4356, 1878-5921, 1878-5921
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Abstract	Because of a lack of a control group, a case-series study is considered one of the weaker study designs from which to obtain evidence on treatment effectiveness. Under certain circumstances, however, this is the only available evidence to inform health-care decisions. This study's intent was to develop and validate a quality appraisal checklist specifically for case-series studies. A modified Delphi process was used to develop the checklist, which was then used by multiple researchers to appraise a random sample of 105 case-series studies. A principal component analysis of these appraisals was conducted to further refine the checklist. The modified Delphi process resulted in a 20-criterion checklist. The principal component analysis of the appraisals for the 105 case-series studies revealed two components. The first component (10 criteria) indicated the extent to which a case series presented traditional features of a statistical hypothesis-testing paradigm. The second component (seven criteria) indicated whether detailed descriptions of the subjects' characteristics that might feature in the experimental design were present, particularly in judgments about the likelihood of confounding. This quality appraisal checklist may be useful in assessing case-series studies, but further validation of the checklist is required.
AbstractList	Objective Because of a lack of a control group, a case-series study is considered one of the weaker study designs from which to obtain evidence on treatment effectiveness. Under certain circumstances, however, this is the only available evidence to inform health-care decisions. This study's intent was to develop and validate a quality appraisal checklist specifically for case-series studies. Study design and setting A modified Delphi process was used to develop the checklist, which was then used by multiple researchers to appraise a random sample of 105 case-series studies. A principal component analysis of these appraisals was conducted to further refine the checklist. Results The modified Delphi process resulted in a 20-criterion checklist. The principal component analysis of the appraisals for the 105 case-series studies revealed two components. The first component (10 criteria) indicated the extent to which a case series presented traditional features of a statistical hypothesis-testing paradigm. The second component (seven criteria) indicated whether detailed descriptions of the subjects' characteristics that might feature in the experimental design were present, particularly in judgments about the likelihood of confounding. Conclusion This quality appraisal checklist may be useful in assessing case-series studies, but further validation of the checklist is required. Abstract Objective Because of a lack of a control group, a case-series study is considered one of the weaker study designs from which to obtain evidence on treatment effectiveness. Under certain circumstances, however, this is the only available evidence to inform health-care decisions. This study's intent was to develop and validate a quality appraisal checklist specifically for case-series studies. Study design and setting A modified Delphi process was used to develop the checklist, which was then used by multiple researchers to appraise a random sample of 105 case-series studies. A principal component analysis of these appraisals was conducted to further refine the checklist. Results The modified Delphi process resulted in a 20-criterion checklist. The principal component analysis of the appraisals for the 105 case-series studies revealed two components. The first component (10 criteria) indicated the extent to which a case series presented traditional features of a statistical hypothesis-testing paradigm. The second component (seven criteria) indicated whether detailed descriptions of the subjects' characteristics that might feature in the experimental design were present, particularly in judgments about the likelihood of confounding. Conclusion This quality appraisal checklist may be useful in assessing case-series studies, but further validation of the checklist is required. Because of a lack of a control group, a case-series study is considered one of the weaker study designs from which to obtain evidence on treatment effectiveness. Under certain circumstances, however, this is the only available evidence to inform health-care decisions. This study's intent was to develop and validate a quality appraisal checklist specifically for case-series studies. A modified Delphi process was used to develop the checklist, which was then used by multiple researchers to appraise a random sample of 105 case-series studies. A principal component analysis of these appraisals was conducted to further refine the checklist. The modified Delphi process resulted in a 20-criterion checklist. The principal component analysis of the appraisals for the 105 case-series studies revealed two components. The first component (10 criteria) indicated the extent to which a case series presented traditional features of a statistical hypothesis-testing paradigm. The second component (seven criteria) indicated whether detailed descriptions of the subjects' characteristics that might feature in the experimental design were present, particularly in judgments about the likelihood of confounding. This quality appraisal checklist may be useful in assessing case-series studies, but further validation of the checklist is required. Because of a lack of a control group, a case-series study is considered one of the weaker study designs from which to obtain evidence on treatment effectiveness. Under certain circumstances, however, this is the only available evidence to inform health-care decisions. This study's intent was to develop and validate a quality appraisal checklist specifically for case-series studies.OBJECTIVEBecause of a lack of a control group, a case-series study is considered one of the weaker study designs from which to obtain evidence on treatment effectiveness. Under certain circumstances, however, this is the only available evidence to inform health-care decisions. This study's intent was to develop and validate a quality appraisal checklist specifically for case-series studies.A modified Delphi process was used to develop the checklist, which was then used by multiple researchers to appraise a random sample of 105 case-series studies. A principal component analysis of these appraisals was conducted to further refine the checklist.STUDY DESIGN AND SETTINGA modified Delphi process was used to develop the checklist, which was then used by multiple researchers to appraise a random sample of 105 case-series studies. A principal component analysis of these appraisals was conducted to further refine the checklist.The modified Delphi process resulted in a 20-criterion checklist. The principal component analysis of the appraisals for the 105 case-series studies revealed two components. The first component (10 criteria) indicated the extent to which a case series presented traditional features of a statistical hypothesis-testing paradigm. The second component (seven criteria) indicated whether detailed descriptions of the subjects' characteristics that might feature in the experimental design were present, particularly in judgments about the likelihood of confounding.RESULTSThe modified Delphi process resulted in a 20-criterion checklist. The principal component analysis of the appraisals for the 105 case-series studies revealed two components. The first component (10 criteria) indicated the extent to which a case series presented traditional features of a statistical hypothesis-testing paradigm. The second component (seven criteria) indicated whether detailed descriptions of the subjects' characteristics that might feature in the experimental design were present, particularly in judgments about the likelihood of confounding.This quality appraisal checklist may be useful in assessing case-series studies, but further validation of the checklist is required.CONCLUSIONThis quality appraisal checklist may be useful in assessing case-series studies, but further validation of the checklist is required.
Author	Guo, Bing Harstall, Christa Moga, Carmen Schopflocher, Don
Author_xml	– sequence: 1 givenname: Bing surname: Guo fullname: Guo, Bing email: bguo@ihe.ca organization: Health Technology Assessment Program, Institute of Health Economics, #1200 10405 Jasper Avenue, Edmonton, Alberta T5J 3N4, Canada – sequence: 2 givenname: Carmen surname: Moga fullname: Moga, Carmen organization: Health Technology Assessment Program, Institute of Health Economics, #1200 10405 Jasper Avenue, Edmonton, Alberta T5J 3N4, Canada – sequence: 3 givenname: Christa surname: Harstall fullname: Harstall, Christa organization: Health Technology Assessment Program, Institute of Health Economics, #1200 10405 Jasper Avenue, Edmonton, Alberta T5J 3N4, Canada – sequence: 4 givenname: Don surname: Schopflocher fullname: Schopflocher, Don organization: School of Public Health & Faculty of Nursing, University of Alberta, 3-291 Edmonton Clinic Health Academy, 11405-87 Avenue, Edmonton, Alberta T6G 1C9, Canada
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26307459$$D View this record in MEDLINE/PubMed
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Snippet	Because of a lack of a control group, a case-series study is considered one of the weaker study designs from which to obtain evidence on treatment... Abstract Objective Because of a lack of a control group, a case-series study is considered one of the weaker study designs from which to obtain evidence on... Objective Because of a lack of a control group, a case-series study is considered one of the weaker study designs from which to obtain evidence on treatment...
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SubjectTerms	Bias Case series Checklist - standards Confidence intervals Delphi Epidemiology Experimental design Internal Medicine Intervention Practice Guidelines as Topic Principal Component Analysis Principal components analysis Quality Quality appraisal Quality Assurance, Health Care - methods Research Design Research evidence Studies Surveys and Questionnaires Treatment intervention Validation
Title	A principal component analysis is conducted for a case series quality appraisal checklist
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