CD105 as a tool for assessing microvessel density in renal cell carcinoma

Background: Angiogenesis plays an essential role in both tumor growth and metastasis. CD105 expression was correlated with prognosis in many tumors, but its value in renal cell carcinoma (RCC) is still questionable. Materials and Methods: The aim of this study was to evaluate microvessel density (MV...

Full description

Saved in:

Bibliographic Details
Published in:	Indian journal of pathology & microbiology Vol. 62; no. 2; pp. 239 - 243
Main Authors:	Cioca, Andreea, Muntean, Diana, Bungardean, Catalina
Format:	Journal Article
Language:	English
Published:	India Wolters Kluwer - Medknow 01.04.2019 Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd Wolters Kluwer Medknow Publications
Edition:	2
Subjects:	Adult Aged Aged, 80 and over Angiogenesis Antiangiogenics Biomarkers, Tumor - analysis Blood vessels Cancer Cancer metastasis Carcinoma Carcinoma, Renal Cell - diagnosis CD-105 CD105 antigen Clear cell-type renal cell carcinoma Density endoglin Endoglin - analysis Female Gene expression Genetic aspects Humans Immunohistochemistry Kidney cancer Kidney Neoplasms - diagnosis Male Medical prognosis Membrane proteins Metastases Metastasis Microvessels - pathology Middle Aged Neoplasm Staging Neovascularization, Pathologic - diagnosis Original Article Paraffin Embedding Patients Prognosis Renal cell carcinoma Software Staining and Labeling Statistical analysis Studies Tumors United Kingdom > UK Angiogenesis CD-105 renal cell carcinoma endoglin immunohistochemistry
ISSN:	0377-4929, 0974-5130, 0974-5130
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Background: Angiogenesis plays an essential role in both tumor growth and metastasis. CD105 expression was correlated with prognosis in many tumors, but its value in renal cell carcinoma (RCC) is still questionable. Materials and Methods: The aim of this study was to evaluate microvessel density (MVD) by using CD105 marker, in 95 cases of renal cell carcinoma. Results: CD105 showed positivity in 93 cases. The mean MVD value was significantly higher in clear cell carcinoma compared to papillary and chromophobe subtypes (P = 0.000). We noticed a significant correlation between MVD and ISUP grade (P = 0.007). The highest MVD value was observed in tumors with ISUP grade 1 and 2, while the lowest MVD value was noted in ISUP grade 3 tumors. A high vessel density was identified in tumors with a low Fuhrman grade, compared to those with a high grade (P = 0.010). MVD value was lower in tumors with a larger diameter, compared to small ones (P = 0.026). Conclusion: In conclusion, CD105 expression (MVD) is inversely related to tumor aggressiveness in clear cell RCC and can be used as a favorable prognosis marker. The vascularity differences between histological subtypes of RCCs could be useful for a better selection of patients that may benefit from anti-angiogenic therapies.
AbstractList	Background: Angiogenesis plays an essential role in both tumor growth and metastasis. CD105 expression was correlated with prognosis in many tumors, but its value in renal cell carcinoma (RCC) is still questionable. Materials and Methods: The aim of this study was to evaluate microvessel density (MVD) by using CD105 marker, in 95 cases of renal cell carcinoma. Results: CD105 showed positivity in 93 cases. The mean MVD value was significantly higher in clear cell carcinoma compared to papillary and chromophobe subtypes (P = 0.000). We noticed a significant correlation between MVD and ISUP grade (P = 0.007). The highest MVD value was observed in tumors with ISUP grade 1 and 2, while the lowest MVD value was noted in ISUP grade 3 tumors. A high vessel density was identified in tumors with a low Fuhrman grade, compared to those with a high grade (P = 0.010). MVD value was lower in tumors with a larger diameter, compared to small ones (P = 0.026). Conclusion: In conclusion, CD105 expression (MVD) is inversely related to tumor aggressiveness in clear cell RCC and can be used as a favorable prognosis marker. The vascularity differences between histological subtypes of RCCs could be useful for a better selection of patients that may benefit from anti-angiogenic therapies. Angiogenesis plays an essential role in both tumor growth and metastasis. CD105 expression was correlated with prognosis in many tumors, but its value in renal cell carcinoma (RCC) is still questionable.BACKGROUNDAngiogenesis plays an essential role in both tumor growth and metastasis. CD105 expression was correlated with prognosis in many tumors, but its value in renal cell carcinoma (RCC) is still questionable.The aim of this study was to evaluate microvessel density (MVD) by using CD105 marker, in 95 cases of renal cell carcinoma.MATERIALS AND METHODSThe aim of this study was to evaluate microvessel density (MVD) by using CD105 marker, in 95 cases of renal cell carcinoma.CD105 showed positivity in 93 cases. The mean MVD value was significantly higher in clear cell carcinoma compared to papillary and chromophobe subtypes (P = 0.000). We noticed a significant correlation between MVD and ISUP grade (P = 0.007). The highest MVD value was observed in tumors with ISUP grade 1 and 2, while the lowest MVD value was noted in ISUP grade 3 tumors. A high vessel density was identified in tumors with a low Fuhrman grade, compared to those with a high grade (P = 0.010). MVD value was lower in tumors with a larger diameter, compared to small ones (P = 0.026).RESULTSCD105 showed positivity in 93 cases. The mean MVD value was significantly higher in clear cell carcinoma compared to papillary and chromophobe subtypes (P = 0.000). We noticed a significant correlation between MVD and ISUP grade (P = 0.007). The highest MVD value was observed in tumors with ISUP grade 1 and 2, while the lowest MVD value was noted in ISUP grade 3 tumors. A high vessel density was identified in tumors with a low Fuhrman grade, compared to those with a high grade (P = 0.010). MVD value was lower in tumors with a larger diameter, compared to small ones (P = 0.026).In conclusion, CD105 expression (MVD) is inversely related to tumor aggressiveness in clear cell RCC and can be used as a favorable prognosis marker. The vascularity differences between histological subtypes of RCCs could be useful for a better selection of patients that may benefit from anti-angiogenic therapies.CONCLUSIONIn conclusion, CD105 expression (MVD) is inversely related to tumor aggressiveness in clear cell RCC and can be used as a favorable prognosis marker. The vascularity differences between histological subtypes of RCCs could be useful for a better selection of patients that may benefit from anti-angiogenic therapies. Background: Angiogenesis plays an essential role in both tumor growth and metastasis. CD105 expression was correlated with prognosis in many tumors, but its value in renal cell carcinoma (RCC) is still questionable. Materials and Methods: The aim of this study was to evaluate microvessel density (MVD) by using CD105 marker, in 95 cases of renal cell carcinoma. Results: CD105 showed positivity in 93 cases. The mean MVD value was significantly higher in clear cell carcinoma compared to papillary and chromophobe subtypes (P = 0.000). We noticed a significant correlation between MVD and ISUP grade (P = 0.007). The highest MVD value was observed in tumors with ISUP grade 1 and 2, while the lowest MVD value was noted in ISUP grade 3 tumors. A high vessel density was identified in tumors with a low Fuhrman grade, compared to those with a high grade (P = 0.010). MVD value was lower in tumors with a larger diameter, compared to small ones (P = 0.026). Conclusion: In conclusion, CD105 expression (MVD) is inversely related to tumor aggressiveness in clear cell RCC and can be used as a favorable prognosis marker. The vascularity differences between histological subtypes of RCCs could be useful for a better selection of patients that may benefit from anti-angiogenic therapies. Angiogenesis plays an essential role in both tumor growth and metastasis. CD105 expression was correlated with prognosis in many tumors, but its value in renal cell carcinoma (RCC) is still questionable. The aim of this study was to evaluate microvessel density (MVD) by using CD105 marker, in 95 cases of renal cell carcinoma. CD105 showed positivity in 93 cases. The mean MVD value was significantly higher in clear cell carcinoma compared to papillary and chromophobe subtypes (P = 0.000). We noticed a significant correlation between MVD and ISUP grade (P = 0.007). The highest MVD value was observed in tumors with ISUP grade 1 and 2, while the lowest MVD value was noted in ISUP grade 3 tumors. A high vessel density was identified in tumors with a low Fuhrman grade, compared to those with a high grade (P = 0.010). MVD value was lower in tumors with a larger diameter, compared to small ones (P = 0.026). In conclusion, CD105 expression (MVD) is inversely related to tumor aggressiveness in clear cell RCC and can be used as a favorable prognosis marker. The vascularity differences between histological subtypes of RCCs could be useful for a better selection of patients that may benefit from anti-angiogenic therapies.
Audience	Academic
Author	Muntean, Diana Bungardean, Catalina Cioca, Andreea
Author_xml	– sequence: 1 givenname: Andreea surname: Cioca fullname: Cioca, Andreea – sequence: 2 givenname: Diana surname: Muntean fullname: Muntean, Diana – sequence: 3 givenname: Catalina surname: Bungardean fullname: Bungardean, Catalina
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30971547$$D View this record in MEDLINE/PubMed
BookMark	eNp9kktv1DAUhSNURB-wZ4UisWEzg5-xvaxaHoOKYAFsr24cZ-Rpxi52hlH_Pc5Mh0cFlSU7tr5zruN7TqujEIOrqueUzAUl_PXiw-eP82kCpThQ9ag6IUaJmaScHJVvrtRMGGaOq9OcV4Q0gkn-pDrmhaJSqJNqcXFJiawx11iPMQ51H1PZZZezD8t67W2KP8rGDXXnQvbjbe1DnVzAobZuKBMm60Nc49PqcY9Dds_u1rPq69s3Xy7ez64-vVtcnF_NbENMmDHjhNTUydbpTmGrqLZM84YwhYxL2iNqlNLYrtOMdUK3faFkoxGN67jlZ9Vi79tFXMFN8mtMtxDRw-4gpiVgGr0dHHSdMuiMZrSVQrLGiMa2TDbcEoa6kcXr1d7rJsXvG5dHWPs8_RYGFzcZGCPKCMoEK-jLe-gqblJ5hgyc0YZRLfSDFGNSCioMbX5TSyy39KGPY0I7lYZzqUtNpsjkNf8HVUbnSltKEHpfzv8SvLgrvmnXrvv1NoduF6DZA6WpOSfXg_Ujjj6G4uwHoASmWMEuUX_EqgjJPeHB-wHJt71kG4fRpXw9bLYuQbnXdYjb_-qAcQO7TAJmQJgyCSWTcMgk_wmhJ-iY
CitedBy_id	crossref_primary_10_1007_s12094_022_02792_0 crossref_primary_10_12998_wjcc_v9_i25_7381 crossref_primary_10_1016_j_canlet_2023_216327 crossref_primary_10_1007_s00428_021_03214_2 crossref_primary_10_3892_ol_2024_14358
ContentType	Journal Article
Copyright	Copyright: © 2019 Indian Journal of Pathology and Microbiology COPYRIGHT 2019 Medknow Publications and Media Pvt. Ltd. 2019. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2019. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml	– notice: Copyright: © 2019 Indian Journal of Pathology and Microbiology – notice: COPYRIGHT 2019 Medknow Publications and Media Pvt. Ltd. – notice: 2019. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2019. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7T7 7U9 7X7 7XB 8FD 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR C1K CCPQU DWQXO FR3 FYUFA GHDGH H94 K9. M0S M7N P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 DOA
DOI	10.4103/IJPM.IJPM_773_17
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Industrial and Applied Microbiology Abstracts (Microbiology A) Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Technology Research Database Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC ProQuest Central Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts Proquest Central Premium ProQuest One Academic ProQuest Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China Environmental Sciences and Pollution Management ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) Virology and AIDS Abstracts ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic Publicly Available Content Database MEDLINE Virology and AIDS Abstracts
Database_xml	– sequence: 1 dbid: DOA name: Directory of Open Access Journals (DOAJ) url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	0974-5130
Edition	2
EndPage	243
ExternalDocumentID	oai_doaj_org_article_dd79ae9821b54526946cb2563c02a865 A582072702 30971547 10_4103_IJPM_IJPM_773_17 IJPM-62-239
Genre	Journal Article
GeographicLocations	United Kingdom--UK
GeographicLocations_xml	– name: United Kingdom--UK
GroupedDBID	--- .55 29I 2WC 36B 53G 5GY 5VS 7X7 8FI 8FJ AAWTL ABDBF ABJNI ABUWG ACGFO ACGFS ACUHS ADBBV ADJBI AENEX AFKRA ALIPV ALMA_UNASSIGNED_HOLDINGS BAWUL BCNDV BENPR C1A CCPQU DIK DU5 E3Z EAD EAP EAS EBD EBS EJD EMB EMK EMOBN EOJEC ESX F5P FYUFA GROUPED_DOAJ GX1 H13 HMCUK IAO IEA IHR IL9 INH INR ITC KQ8 MM. OBODZ OK1 OVD PHGZM PHGZT PIMPY PMFND RMW SV3 TEORI TR2 TUS UKHRP X7M AAYXX AFFHD CITATION OVT ABXLX CGR CUY CVF ECM EIF M~E NPM 3V. 7QL 7T7 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 H94 K9. M7N P64 PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 PUEGO
ID	FETCH-LOGICAL-c609n-29e4581e5be8d7ab718c2836027a2351faa8a559cdd822d48bf7ab568aa9ed3c3
IEDL.DBID	BENPR
ISICitedReferencesCount	8
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000464366400011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0377-4929 0974-5130
IngestDate	Fri Oct 03 12:51:00 EDT 2025 Fri Sep 05 13:15:24 EDT 2025 Tue Oct 07 06:58:15 EDT 2025 Tue Oct 07 07:11:25 EDT 2025 Tue Nov 11 10:17:59 EST 2025 Tue Nov 04 17:47:33 EST 2025 Thu Jan 02 22:54:20 EST 2025 Tue Nov 18 22:44:09 EST 2025 Sat Nov 29 03:11:04 EST 2025 Thu Jun 12 06:10:21 EDT 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	2
Keywords	Angiogenesis CD-105 renal cell carcinoma endoglin immunohistochemistry
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c609n-29e4581e5be8d7ab718c2836027a2351faa8a559cdd822d48bf7ab568aa9ed3c3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
OpenAccessLink	https://www.proquest.com/docview/2255414916?pq-origsite=%requestingapplication%
PMID	30971547
PQID	2255414916
PQPubID	2049580
PageCount	5
ParticipantIDs	doaj_primary_oai_doaj_org_article_dd79ae9821b54526946cb2563c02a865 proquest_miscellaneous_2207941242 proquest_journals_3216218482 proquest_journals_2255414916 gale_infotracmisc_A582072702 gale_infotracacademiconefile_A582072702 pubmed_primary_30971547 crossref_citationtrail_10_4103_IJPM_IJPM_773_17 crossref_primary_10_4103_IJPM_IJPM_773_17 wolterskluwer_medknow_10_4103_IJPM_IJPM_773_17_239_CD105_as_a_tool_for_assessin
PublicationCentury	2000
PublicationDate	2019-04-01
PublicationDateYYYYMMDD	2019-04-01
PublicationDate_xml	– month: 04 year: 2019 text: 2019-04-01 day: 01
PublicationDecade	2010
PublicationPlace	India
PublicationPlace_xml	– name: India – name: Mumbai
PublicationTitle	Indian journal of pathology & microbiology
PublicationTitleAlternate	Indian J Pathol Microbiol
PublicationYear	2019
Publisher	Wolters Kluwer - Medknow Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd Wolters Kluwer Medknow Publications
Publisher_xml	– name: Wolters Kluwer - Medknow – name: Medknow Publications and Media Pvt. Ltd – name: Medknow Publications & Media Pvt. Ltd – name: Wolters Kluwer Medknow Publications
References	Yao (key-10.4103/0377-4929.255845-11) 2007 Bhattacharyya (key-10.4103/0377-4929.255845-3) 2008 Hemmerlein (key-10.4103/0377-4929.255845-30) 2001 Delahunt (key-10.4103/0377-4929.255845-24) 1997 Weidner (key-10.4103/0377-4929.255845-6) 1991 Zhang (key-10.4103/0377-4929.255845-14) 2014 Hanahan (key-10.4103/0377-4929.255845-16) 1996 Frank (key-10.4103/0377-4929.255845-4) 2002 Volpe (key-10.4103/0377-4929.255845-5) 2010 Saroufim (key-10.4103/0377-4929.255845-23) 2014 Denekamp (key-10.4103/0377-4929.255845-8) 1990 Kumar (key-10.4103/0377-4929.255845-18) 1996 Sandlund (key-10.4103/0377-4929.255845-22) 2006 Weidner (key-10.4103/0377-4929.255845-15) 1995 Siegel (key-10.4103/0377-4929.255845-1) 2015 Wang (key-10.4103/0377-4929.255845-19) 1995 Dubinski (key-10.4103/0377-4929.255845-25) 2012 Yao (key-10.4103/0377-4929.255845-10) 2005 Yao (key-10.4103/0377-4929.255845-27) 2007 Dallas (key-10.4103/0377-4929.255845-7) 2008 Kumar (key-10.4103/0377-4929.255845-13) 1999 Matsuno (key-10.4103/0377-4929.255845-20) 1999 Tanaka (key-10.4103/0377-4929.255845-9) 2001 Qian (key-10.4103/0377-4929.255845-28) 2009 Yagasaki (key-10.4103/0377-4929.255845-21) 2003 Sudarshan (key-10.4103/0377-4929.255845-17) 2013 Ferician (key-10.4103/0377-4929.255845-29) 2016 Choueiri (key-10.4103/0377-4929.255845-2) 2017 Rubatt (key-10.4103/0377-4929.255845-12) 2009 Bauman (key-10.4103/0377-4929.255845-26) 2016
References_xml	– start-page: 319 volume-title: Prognostic factors in renal cell carcinoma year: 2010 ident: key-10.4103/0377-4929.255845-5 publication-title: World J Urol – start-page: 267 volume-title: Vascular attack as a therapeutic strategy for cancer year: 1990 ident: key-10.4103/0377-4929.255845-8 publication-title: Cancer Metastasis Rev – start-page: 856 volume-title: Breast carcinoma: Vascular density determined using CD105 antibody correlates with tumor prognosis year: 1999 ident: key-10.4103/0377-4929.255845-13 publication-title: Cancer Res – start-page: 1 volume-title: Tumor angiogenesis and metastasis – Correlation in invasive breast carcinoma year: 1991 ident: key-10.4103/0377-4929.255845-6 publication-title: N Engl J Med – start-page: 645 volume-title: Vascular endothelial growth factor expression, angiogenesis and necrosis in renal cell carcinoma year: 2001 ident: key-10.4103/0377-4929.255845-30 publication-title: Virchows Arch – start-page: 39 volume-title: Endoglin (CD105) expression in angiogenesis of primary hepatocellular carcinomas: Analysis using tissue microarrays and comparisons with CD34 and VEGF year: 2007 ident: key-10.4103/0377-4929.255845-11 publication-title: Ann Clin Lab Sci – start-page: 706 volume-title: Endoglin (CD105) expression in human renal cell carcinoma year: 2006 ident: key-10.4103/0377-4929.255845-22 publication-title: BJU Int – start-page: 469 volume-title: Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study year: 2009 ident: key-10.4103/0377-4929.255845-12 publication-title: Gynecol Oncol – start-page: 2282 volume-title: Complexity of tumor vasculature in clear cell renal cell carcinoma year: 2009 ident: key-10.4103/0377-4929.255845-28 publication-title: Cancer – start-page: 1037 volume-title: Assessment of the prognostic significance of endoglin (CD105) in clear cell renal cell carcinoma using automated image analysis year: 2012 ident: key-10.4103/0377-4929.255845-25 publication-title: Hum Pathol – start-page: 2769 volume-title: Lack of association of microvessel density with prognosis of renal cell carcinoma: Evidence from meta-analysis year: 2014 ident: key-10.4103/0377-4929.255845-14 publication-title: Tumour Biol – start-page: 98 volume-title: Neovascularity as a prognosis marker in renal cell carcinoma year: 2016 ident: key-10.4103/0377-4929.255845-26 publication-title: Hum Pathol – start-page: 220 volume-title: Histopathological analysis of angiogenic factors in renal cell carcinoma year: 2003 ident: key-10.4103/0377-4929.255845-21 publication-title: Int J Urol – start-page: 5 volume-title: Cancer statistics year: 2015 ident: key-10.4103/0377-4929.255845-1 publication-title: CA Cancer J Clin – start-page: 1778 volume-title: Tumoral CD105 is a novel independent prognostic marker for prognosis in clear-cell renal cell carcinoma year: 2014 ident: key-10.4103/0377-4929.255845-23 publication-title: Br J Cancer – start-page: 354 volume-title: Systemic therapy for metastatic renal-cell carcinoma year: 2017 ident: key-10.4103/0377-4929.255845-2 publication-title: N Engl J Med – start-page: 401 volume-title: Prognostic significance of microscopic vascularity for clear cell renal cell carcinoma year: 1997 ident: key-10.4103/0377-4929.255845-24 publication-title: Br J Urol – start-page: 363 volume-title: CD 105 and angiogenesis year: 1996 ident: key-10.4103/0377-4929.255845-18 publication-title: J Pathol – start-page: 791 volume-title: Irradiation induces up-regulation of E9 protein (CD105) in human vascular endothelial cells year: 1995 ident: key-10.4103/0377-4929.255845-19 publication-title: Int J Cancer – start-page: 2395 volume-title: An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: The SSIGN score year: 2002 ident: key-10.4103/0377-4929.255845-4 publication-title: J Urol – start-page: 244 volume-title: Metabolism of kidney cancer: From the lab to clinical practice year: 2013 ident: key-10.4103/0377-4929.255845-17 publication-title: Eur Urol – start-page: 3410 volume-title: Evaluation of Angiogenesis in Non-small Cell Lung Cancer: Comparison between anti-CD34 and anti-CD105 antibody year: 2001 ident: key-10.4103/0377-4929.255845-9 publication-title: Clin Cancer Res – start-page: 371 volume-title: Induction of lasting complete regression of performed distinct solid tumors by targeting the tumor vasculature using two new anti-endoglin monoclonal antibodies year: 1999 ident: key-10.4103/0377-4929.255845-20 publication-title: Clin Cancer Res – start-page: 17 issn: 0377-4929 volume-title: Kundu AK.A study of proliferative activity, angiogenesis and nuclear grading in renal cell carcinoma year: 2008 ident: key-10.4103/0377-4929.255845-3 publication-title: Indian J Pathol Microbiol – start-page: 201 volume-title: Prognostic significance of microvessel density determined by an anti-CD105/endoglin monoclonal antibody in astrocytic tumors: Comparison with an anti-CD31 monoclonal antibody year: 2005 ident: key-10.4103/0377-4929.255845-10 publication-title: Neuropathology – start-page: 169 volume-title: Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors year: 1995 ident: key-10.4103/0377-4929.255845-15 publication-title: Breast Cancer Res Treat – start-page: 161 volume-title: Two distinct types of blood vessels in clear cell renal cell carcinoma have contrasting prognostic implications year: 2007 ident: key-10.4103/0377-4929.255845-27 publication-title: Clin Cancer Res – start-page: 353 volume-title: Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis year: 1996 ident: key-10.4103/0377-4929.255845-16 publication-title: Cell – start-page: 1931 volume-title: Endoglin (CD105): A marker of tumor vasculature and potential target for therapy.Clin year: 2008 ident: key-10.4103/0377-4929.255845-7 publication-title: Cancer Res – start-page: 46 volume-title: Heterogeneous vascular patterns in renal cell carcinomas year: 2016 ident: key-10.4103/0377-4929.255845-29 publication-title: Pol J Pathol
SSID	ssj0064253
Score	2.180928
Snippet	Background: Angiogenesis plays an essential role in both tumor growth and metastasis. CD105 expression was correlated with prognosis in many tumors, but its... Angiogenesis plays an essential role in both tumor growth and metastasis. CD105 expression was correlated with prognosis in many tumors, but its value in renal... Background: Angiogenesis plays an essential role in both tumor growth and metastasis. CD105 expression was correlated with prognosis in many tumors, but its... Background:Angiogenesis plays an essential role in both tumor growth and metastasis. CD105 expression was correlated with prognosis in many tumors, but its...
SourceID	doaj proquest gale pubmed crossref wolterskluwer
SourceType	Open Website Aggregation Database Index Database Enrichment Source Publisher
StartPage	239
SubjectTerms	Adult Aged Aged, 80 and over Angiogenesis Antiangiogenics Biomarkers, Tumor - analysis Blood vessels Cancer Cancer metastasis Carcinoma Carcinoma, Renal Cell - diagnosis CD-105 CD105 antigen Clear cell-type renal cell carcinoma Density endoglin Endoglin - analysis Female Gene expression Genetic aspects Humans Immunohistochemistry Kidney cancer Kidney Neoplasms - diagnosis Male Medical prognosis Membrane proteins Metastases Metastasis Microvessels - pathology Middle Aged Neoplasm Staging Neovascularization, Pathologic - diagnosis Original Article Paraffin Embedding Patients Prognosis Renal cell carcinoma Software Staining and Labeling Statistical analysis Studies Tumors
SummonAdditionalLinks	– databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3di9QwEA9yiAgifrvnKREE8aFum48mfTxPD0-88x4U7m1I0xQOd1vZ7t3hf-9M0l138evFl0KbNLTTSeY3zcxvGHtRVUEXsi4zrfBAyY-ZFcFlyrk2FNY01kUS14_m5MSenVWnG6W-KCYs0QMnwU2bxhB_tBVFncphq9LXaKelz4WzZWQvRdSzcqbSGoygOvFPSmMyhQggbVCqIpfTow-nx6_pAMZIiIXKfhqkyNv_6-q8YZ5uXfW0jT18jVHsG7bo8A67PYJIvp8e_i67Frp77MbxuE1-nx0dvEVAw93AHV_2_YwjMsUz2t5FS8XnFIR3SaThM95QAPvyOz_v-CLQoPQnn3uqMNT1c_eAfTl89_ngfTbWTMh8mVddJqqgtC2CroNtjKvR9HhBiRrCOCF10TpnHXoRvmkQGjTK1i320qV1rgqN9PIh2-n6LjxmvNBBEmuoVq1XeYuuoA1StLWohVO61hM2XQkO_EgoTnUtZoCOBYkaopQ3RD1hr9Z3fEtkGn_p-4a-xbof0WDHC6gcMCoH_Es5JuwlfUmgyYqP5t2Yc4AvSLRXsK8RABlKyZuwva2eOMn8dvNKF2Cc5APgUkhF1BFg_7ZZiqIkB9ri3c_XzTQwxbV1ob-gIXJcEBFjYZ9HScXWbyyJ3ksrlMSnLZ2DeUqU_KPoQMgKoqKBG8ABKRqgosFK0Xb_h2yfsJsIHqsUxbTHdpaLi_CUXfeXy_Nh8SxOxx9gXjNG priority: 102 providerName: Directory of Open Access Journals
Title	CD105 as a tool for assessing microvessel density in renal cell carcinoma
URI	https://doi.org/10.4103/IJPM.IJPM_773_17 https://www.ncbi.nlm.nih.gov/pubmed/30971547 https://www.proquest.com/docview/2255414916 https://www.proquest.com/docview/3216218482 https://www.proquest.com/docview/2207941242 https://doaj.org/article/dd79ae9821b54526946cb2563c02a865
Volume	62
WOSCitedRecordID	wos000464366400011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: Directory of Open Access Journals (DOAJ) customDbUrl: eissn: 0974-5130 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0064253 issn: 0377-4929 databaseCode: DOA dateStart: 20080101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 0974-5130 dateEnd: 20231231 omitProxy: false ssIdentifier: ssj0064253 issn: 0377-4929 databaseCode: 7X7 dateStart: 20180101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 0974-5130 dateEnd: 20231231 omitProxy: false ssIdentifier: ssj0064253 issn: 0377-4929 databaseCode: BENPR dateStart: 20180101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 0974-5130 dateEnd: 20231231 omitProxy: false ssIdentifier: ssj0064253 issn: 0377-4929 databaseCode: PIMPY dateStart: 20180101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELdYhxAS4vujMCojISEesjb-iJ0ntI1NFNFSIZDKk-U4Dppok9F0Q_z33CVu1wrYCy-WEjtWbJ_PP_vOvyPkZZp6GfMsiaSABC8_Rpp5GwlrCx9rlWvbkLh-UOOxnk7TSThwq4Nb5UonNoo6rxyekfdB7jBiNaCZN2c_IowahdbVEEJjh-wiU5nokN3D4_Hk00oXA7hueSi5UpEAJNAaKkU84P3h-8loHxOjFDdNwLLLhanh7_9TS28sU7d-VmjOrr833uwba9LJnf9tzV1yO6BRetCKzz1yzZf3yY1RsLc_IMOjt4CMqK2ppcuqmlGAuPCEdmJY8ugcvfkukH18RnP0hF_-oqclXXisFE0C1GGoorKa24fky8nx56N3UQi-ELlkkJYRS72QOvYy8zpXNoM1zDG88cGUZVzGhbXawnbE5TlgjFzorIBSMtHWpj7njj8inbIq_RNCY-k50o9KUTgxKGBPqT1nRcYyZoXMZJf0Vz1vXGAmxwAZMwM7FBwr0wzTxlh1yev1F2ctK8cVZQ9xMNflkE-7eVEtvpkwPU2eK2Qp1yzO2qDrInEZoEHuBszqBH7xFYqCwVkPv-ZsuLwADUT-LHMgAUkpvNvXJXtbJWG2uu3slUCYoC1qcykNf83mLE5wJ67h6xfrbKwYHeRKX51jFQPQrADWoMzjVkbXLebIEyYF9MTHLaE18_bG5T-7zjCemkbQjK2NNShoBgTNrATt6dWteUZuAr5MW0enPdJZLs79c3LdXSxP60WP7KipalLdC_O21xyJwNNkOJp8_Q01dUgR
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLbGQICEuF8KA4wEQjyENr7EzgNCY2NaWTv2sEl9M47joIk2GU23aX-K38g5uXStgL3tgZdIrR0rdj6f8znnRsjrOPYy5EkUSAEXDH4MNPM2ENZmPtQq1bZK4jpQu7t6NIr3VsivNhYG3SpbmVgJ6rRw-I28C7jDitXAZj4e_QywahRaV9sSGjUsdvzZKRzZyg_9TXi_bxjb-ry_sR00VQUCF_XiPGCxF1KHXiZep8omIJwdw1AGpizjMsys1RZ4tktTUJ6p0EkGvWSkrY19yh2Hca-QqyDHFbqQqdH8gAdUvs56yZUKBPCO2iwqwh7v9r_sDd_jxSjFTVUe7VwNVtUC_tQJC0rx1mmBxvPyR-U7v6ABt-78b2t3l9xuuDZdrzfHPbLi8_vk-rDxJnhA-hubwPuoLamls6IYUyDw8Aut4KDQ6QR9FU8wt_qYpujnPzujhzmdehwUDR7UYSGmvJjYh-TgUibyiKzmRe6fEBpKzzG5qhSZE70MTszac5YlLGFWyER2SLd908Y1edex_MfYwPkLsWEqWCxgo0Peze84qnOOXND3E4Jn3g-zhVd_FNPvphE-Jk0V5mDXLEzqkvIicglwXe56zOoIHvEtQs-gTINHc7YJzYAJYnYwsy6BJyqMXOyQtaWeIIvccnMLQNPIwtKco--vzZyFEX5n0HD3q3kzDozuf7kvjnGIHugNoKLQ53G9J-Yz5pgFTQpYia9Lm8RM6njSfy6dYTw2FdCMLY01CDQDQDMt0J5ePJuX5Mb2_nBgBv3dnWfkJjDpuHbpWiOrs-mxf06uuZPZYTl9UUkJSr5d9tb6DV2VoA0
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=CD105+as+a+tool+for+assessing+microvessel+density+in+renal+cell+carcinoma&rft.jtitle=Indian+journal+of+pathology+%26+microbiology&rft.au=Cioca%2C+Andreea&rft.au=Muntean%2C+Diana&rft.au=Bungardean%2C+Catalina&rft.date=2019-04-01&rft.issn=0377-4929&rft.volume=62&rft.issue=2&rft.spage=239&rft_id=info:doi/10.4103%2FIJPM.IJPM_773_17&rft.externalDBID=n%2Fa&rft.externalDocID=10_4103_IJPM_IJPM_773_17
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0377-4929&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0377-4929&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0377-4929&client=summon