Uncovering the mechanism of resveratrol in the treatment of diabetic kidney disease based on network pharmacology, molecular docking, and experimental validation

Background Diabetic kidney disease (DKD) has been the leading cause of chronic kidney disease in developed countries. Evidence of the benefits of resveratrol (RES) for the treatment of DKD is accumulating. However, comprehensive therapeutic targets and underlying mechanisms through which RES exerts...

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Bibliographic Details
Published in:	Journal of translational medicine Vol. 21; no. 1; pp. 380 - 14
Main Authors:	Chen, Shengnan, Li, Bo, Chen, Lei, Jiang, Hongli
Format:	Journal Article
Language:	English
Published:	London BioMed Central 12.06.2023 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	AKT1 protein Aldehyde Reductase Analysis Association analysis Bioinformatics Biomedical and Life Sciences Biomedicine Care and treatment Computer simulation Diabetes Diabetes Mellitus Diabetic kidney disease Diabetic Nephropathies Diabetic nephropathy Diagnosis Dietary supplements Dosage and administration ESR1 protein Experimental validation Gelatinase A Gelatinase B Gene expression Gene set enrichment analysis Genes Genomics Glucose Humans Kidney diseases Matrix Metalloproteinase 9 Medicine/Public Health Molecular docking Molecular Docking Simulation Network Pharmacology Nutrition & metabolism Peroxisome proliferator-activated receptors Pharmacology Phytochemicals PPAR gamma Proteins Reproducibility of Results Resveratrol Software Therapeutic applications Therapeutic targets China United States > US Experimental validation Network pharmacology Molecular docking Resveratrol Diabetic kidney disease
ISSN:	1479-5876, 1479-5876
Online Access:	Get full text
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