Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial
Background Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expression profiles in white adipose tissue (WAT), and an extensive blood biomarker p...
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| Veröffentlicht in: | Journal of translational medicine Jg. 22; H. 1; S. 40 - 17 |
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| Sprache: | Englisch |
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BioMed Central
09.01.2024
BioMed Central Ltd Springer Nature B.V BMC |
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| Abstract | Background
Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expression profiles in white adipose tissue (WAT), and an extensive blood biomarker profile in humans with overweight or obesity.
Methods
N = 59 participants with overweight or obesity (73% women) were randomized stratified by sex to an 8-week plant-based dietary intervention low (~ 2
g
/day, SAAR) or high (~ 5.6
g
/day, control group) in sulfur amino acids. The diets were provided in full to the participants, and both investigators and participants were blinded to the intervention. Outcome analyses were performed using linear mixed model regression adjusted for baseline values of the outcome and sex.
Results
SAAR led to a ~ 20% greater weight loss compared to controls (β 95% CI − 1.14 (− 2.04, − 0.25) kg, p = 0.013). Despite greater weight loss, resting metabolic rate remained similar between groups. Furthermore, SAAR decreased serum leptin, and increased ketone bodies compared to controls. In WAT, 20 genes were upregulated whereas 24 genes were downregulated (FDR < 5%) in the SAAR group compared to controls. Generally applicable gene set enrichment analyses revealed that processes associated with ribosomes were upregulated, whereas processes related to structural components were downregulated.
Conclusion
Our study shows that SAAR leads to greater weight loss, decreased leptin and increased ketone bodies compared to controls. Further research on SAAR is needed to investigate the therapeutic potential for metabolic conditions in humans.
Trial registration
: ClinicalTrials.gov identifier: NCT04701346, registered Jan 8th 2021,
https://www.clinicaltrials.gov/study/NCT04701346 |
|---|---|
| AbstractList | Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expression profiles in white adipose tissue (WAT), and an extensive blood biomarker profile in humans with overweight or obesity.
N = 59 participants with overweight or obesity (73% women) were randomized stratified by sex to an 8-week plant-based dietary intervention low (~ 2 g/day, SAAR) or high (~ 5.6 g/day, control group) in sulfur amino acids. The diets were provided in full to the participants, and both investigators and participants were blinded to the intervention. Outcome analyses were performed using linear mixed model regression adjusted for baseline values of the outcome and sex.
SAAR led to a ~ 20% greater weight loss compared to controls (β 95% CI - 1.14 (- 2.04, - 0.25) kg, p = 0.013). Despite greater weight loss, resting metabolic rate remained similar between groups. Furthermore, SAAR decreased serum leptin, and increased ketone bodies compared to controls. In WAT, 20 genes were upregulated whereas 24 genes were downregulated (FDR < 5%) in the SAAR group compared to controls. Generally applicable gene set enrichment analyses revealed that processes associated with ribosomes were upregulated, whereas processes related to structural components were downregulated.
Our study shows that SAAR leads to greater weight loss, decreased leptin and increased ketone bodies compared to controls. Further research on SAAR is needed to investigate the therapeutic potential for metabolic conditions in humans.
ClinicalTrials.gov identifier: NCT04701346, registered Jan 8th 2021, https://www.
gov/study/NCT04701346. Background Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expression profiles in white adipose tissue (WAT), and an extensive blood biomarker profile in humans with overweight or obesity. Methods N = 59 participants with overweight or obesity (73% women) were randomized stratified by sex to an 8-week plant-based dietary intervention low (~ 2 g /day, SAAR) or high (~ 5.6 g /day, control group) in sulfur amino acids. The diets were provided in full to the participants, and both investigators and participants were blinded to the intervention. Outcome analyses were performed using linear mixed model regression adjusted for baseline values of the outcome and sex. Results SAAR led to a ~ 20% greater weight loss compared to controls (β 95% CI − 1.14 (− 2.04, − 0.25) kg, p = 0.013). Despite greater weight loss, resting metabolic rate remained similar between groups. Furthermore, SAAR decreased serum leptin, and increased ketone bodies compared to controls. In WAT, 20 genes were upregulated whereas 24 genes were downregulated (FDR < 5%) in the SAAR group compared to controls. Generally applicable gene set enrichment analyses revealed that processes associated with ribosomes were upregulated, whereas processes related to structural components were downregulated. Conclusion Our study shows that SAAR leads to greater weight loss, decreased leptin and increased ketone bodies compared to controls. Further research on SAAR is needed to investigate the therapeutic potential for metabolic conditions in humans. Trial registration : ClinicalTrials.gov identifier: NCT04701346, registered Jan 8th 2021, https://www.clinicaltrials.gov/study/NCT04701346 Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expression profiles in white adipose tissue (WAT), and an extensive blood biomarker profile in humans with overweight or obesity. N = 59 participants with overweight or obesity (73% women) were randomized stratified by sex to an 8-week plant-based dietary intervention low (~ 2 g/day, SAAR) or high (~ 5.6 g/day, control group) in sulfur amino acids. The diets were provided in full to the participants, and both investigators and participants were blinded to the intervention. Outcome analyses were performed using linear mixed model regression adjusted for baseline values of the outcome and sex. SAAR led to a ~ 20% greater weight loss compared to controls ([beta] 95% CI - 1.14 (- 2.04, - 0.25) kg, p = 0.013). Despite greater weight loss, resting metabolic rate remained similar between groups. Furthermore, SAAR decreased serum leptin, and increased ketone bodies compared to controls. In WAT, 20 genes were upregulated whereas 24 genes were downregulated (FDR < 5%) in the SAAR group compared to controls. Generally applicable gene set enrichment analyses revealed that processes associated with ribosomes were upregulated, whereas processes related to structural components were downregulated. Our study shows that SAAR leads to greater weight loss, decreased leptin and increased ketone bodies compared to controls. Further research on SAAR is needed to investigate the therapeutic potential for metabolic conditions in humans. Abstract Background Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expression profiles in white adipose tissue (WAT), and an extensive blood biomarker profile in humans with overweight or obesity. Methods N = 59 participants with overweight or obesity (73% women) were randomized stratified by sex to an 8-week plant-based dietary intervention low (~ 2 g/day, SAAR) or high (~ 5.6 g/day, control group) in sulfur amino acids. The diets were provided in full to the participants, and both investigators and participants were blinded to the intervention. Outcome analyses were performed using linear mixed model regression adjusted for baseline values of the outcome and sex. Results SAAR led to a ~ 20% greater weight loss compared to controls (β 95% CI − 1.14 (− 2.04, − 0.25) kg, p = 0.013). Despite greater weight loss, resting metabolic rate remained similar between groups. Furthermore, SAAR decreased serum leptin, and increased ketone bodies compared to controls. In WAT, 20 genes were upregulated whereas 24 genes were downregulated (FDR < 5%) in the SAAR group compared to controls. Generally applicable gene set enrichment analyses revealed that processes associated with ribosomes were upregulated, whereas processes related to structural components were downregulated. Conclusion Our study shows that SAAR leads to greater weight loss, decreased leptin and increased ketone bodies compared to controls. Further research on SAAR is needed to investigate the therapeutic potential for metabolic conditions in humans. Trial registration: ClinicalTrials.gov identifier: NCT04701346, registered Jan 8th 2021, https://www.clinicaltrials.gov/study/NCT04701346 Background Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expression profiles in white adipose tissue (WAT), and an extensive blood biomarker profile in humans with overweight or obesity. Methods N = 59 participants with overweight or obesity (73% women) were randomized stratified by sex to an 8-week plant-based dietary intervention low (~ 2 g/day, SAAR) or high (~ 5.6 g/day, control group) in sulfur amino acids. The diets were provided in full to the participants, and both investigators and participants were blinded to the intervention. Outcome analyses were performed using linear mixed model regression adjusted for baseline values of the outcome and sex. Results SAAR led to a ~ 20% greater weight loss compared to controls ([beta] 95% CI - 1.14 (- 2.04, - 0.25) kg, p = 0.013). Despite greater weight loss, resting metabolic rate remained similar between groups. Furthermore, SAAR decreased serum leptin, and increased ketone bodies compared to controls. In WAT, 20 genes were upregulated whereas 24 genes were downregulated (FDR < 5%) in the SAAR group compared to controls. Generally applicable gene set enrichment analyses revealed that processes associated with ribosomes were upregulated, whereas processes related to structural components were downregulated. Conclusion Our study shows that SAAR leads to greater weight loss, decreased leptin and increased ketone bodies compared to controls. Further research on SAAR is needed to investigate the therapeutic potential for metabolic conditions in humans. Trial registration: ClinicalTrials.gov identifier: NCT04701346, registered Jan 8th 2021, Keywords: Sulfur amino acid restriction, Methionine restriction, Cysteine, Overweight, Obesity, Randomized controlled trial, Dietary intervention, Weight loss, Leptin Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expression profiles in white adipose tissue (WAT), and an extensive blood biomarker profile in humans with overweight or obesity.BACKGROUNDDietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expression profiles in white adipose tissue (WAT), and an extensive blood biomarker profile in humans with overweight or obesity.N = 59 participants with overweight or obesity (73% women) were randomized stratified by sex to an 8-week plant-based dietary intervention low (~ 2 g/day, SAAR) or high (~ 5.6 g/day, control group) in sulfur amino acids. The diets were provided in full to the participants, and both investigators and participants were blinded to the intervention. Outcome analyses were performed using linear mixed model regression adjusted for baseline values of the outcome and sex.METHODSN = 59 participants with overweight or obesity (73% women) were randomized stratified by sex to an 8-week plant-based dietary intervention low (~ 2 g/day, SAAR) or high (~ 5.6 g/day, control group) in sulfur amino acids. The diets were provided in full to the participants, and both investigators and participants were blinded to the intervention. Outcome analyses were performed using linear mixed model regression adjusted for baseline values of the outcome and sex.SAAR led to a ~ 20% greater weight loss compared to controls (β 95% CI - 1.14 (- 2.04, - 0.25) kg, p = 0.013). Despite greater weight loss, resting metabolic rate remained similar between groups. Furthermore, SAAR decreased serum leptin, and increased ketone bodies compared to controls. In WAT, 20 genes were upregulated whereas 24 genes were downregulated (FDR < 5%) in the SAAR group compared to controls. Generally applicable gene set enrichment analyses revealed that processes associated with ribosomes were upregulated, whereas processes related to structural components were downregulated.RESULTSSAAR led to a ~ 20% greater weight loss compared to controls (β 95% CI - 1.14 (- 2.04, - 0.25) kg, p = 0.013). Despite greater weight loss, resting metabolic rate remained similar between groups. Furthermore, SAAR decreased serum leptin, and increased ketone bodies compared to controls. In WAT, 20 genes were upregulated whereas 24 genes were downregulated (FDR < 5%) in the SAAR group compared to controls. Generally applicable gene set enrichment analyses revealed that processes associated with ribosomes were upregulated, whereas processes related to structural components were downregulated.Our study shows that SAAR leads to greater weight loss, decreased leptin and increased ketone bodies compared to controls. Further research on SAAR is needed to investigate the therapeutic potential for metabolic conditions in humans.CONCLUSIONOur study shows that SAAR leads to greater weight loss, decreased leptin and increased ketone bodies compared to controls. Further research on SAAR is needed to investigate the therapeutic potential for metabolic conditions in humans.ClinicalTrials.gov identifier: NCT04701346, registered Jan 8th 2021, https://www.TRIAL REGISTRATIONClinicalTrials.gov identifier: NCT04701346, registered Jan 8th 2021, https://www.gov/study/NCT04701346.CLINICALTRIALSgov/study/NCT04701346. BackgroundDietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expression profiles in white adipose tissue (WAT), and an extensive blood biomarker profile in humans with overweight or obesity.MethodsN = 59 participants with overweight or obesity (73% women) were randomized stratified by sex to an 8-week plant-based dietary intervention low (~ 2 g/day, SAAR) or high (~ 5.6 g/day, control group) in sulfur amino acids. The diets were provided in full to the participants, and both investigators and participants were blinded to the intervention. Outcome analyses were performed using linear mixed model regression adjusted for baseline values of the outcome and sex.ResultsSAAR led to a ~ 20% greater weight loss compared to controls (β 95% CI − 1.14 (− 2.04, − 0.25) kg, p = 0.013). Despite greater weight loss, resting metabolic rate remained similar between groups. Furthermore, SAAR decreased serum leptin, and increased ketone bodies compared to controls. In WAT, 20 genes were upregulated whereas 24 genes were downregulated (FDR < 5%) in the SAAR group compared to controls. Generally applicable gene set enrichment analyses revealed that processes associated with ribosomes were upregulated, whereas processes related to structural components were downregulated.ConclusionOur study shows that SAAR leads to greater weight loss, decreased leptin and increased ketone bodies compared to controls. Further research on SAAR is needed to investigate the therapeutic potential for metabolic conditions in humans.Trial registration: ClinicalTrials.gov identifier: NCT04701346, registered Jan 8th 2021, https://www.clinicaltrials.gov/study/NCT04701346 |
| ArticleNumber | 40 |
| Audience | Academic |
| Author | Stolt, Emma Tore, Elena C. Vinknes, Kathrine J. Olsen, Thomas Rising, Russell Lee-Ødegård, Sindre Doeland, Beate Elshorbagy, Amany Svendsen, Karianne Johannessen, Hanna Retterstøl, Kjetil Kožich, Viktor Øvrebø, Bente Vo, Anna A. D. Troensegaard, Hannibal Refsum, Helga Barvíková, Kristýna Dahl, Anja F. Thoresen, Magne van Greevenbroek, Marleen |
| Author_xml | – sequence: 1 givenname: Thomas orcidid: 0000-0003-1805-5221 surname: Olsen fullname: Olsen, Thomas email: thomas.olsen@medisin.uio.no organization: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo – sequence: 2 givenname: Emma surname: Stolt fullname: Stolt, Emma organization: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo – sequence: 3 givenname: Bente surname: Øvrebø fullname: Øvrebø, Bente organization: Department of Food Safety, Norwegian Institute of Public Health – sequence: 4 givenname: Amany surname: Elshorbagy fullname: Elshorbagy, Amany organization: Department of Physiology, Faculty of Medicine, University of Alexandria, Department of Pharmacology, University of Oxford – sequence: 5 givenname: Elena C. surname: Tore fullname: Tore, Elena C. organization: Department of Internal Medicine and CARIM School of Cardiovascular Diseases, Maastricht University – sequence: 6 givenname: Sindre surname: Lee-Ødegård fullname: Lee-Ødegård, Sindre organization: Department of Clinical Medicine, Faculty of Medicine, University of Oslo – sequence: 7 givenname: Hannibal surname: Troensegaard fullname: Troensegaard, Hannibal organization: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo – sequence: 8 givenname: Hanna surname: Johannessen fullname: Johannessen, Hanna organization: Department of Paedriatic Surgery, Oslo University Hospital, Rikshospitalet – sequence: 9 givenname: Beate surname: Doeland fullname: Doeland, Beate organization: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo – sequence: 10 givenname: Anna A. D. surname: Vo fullname: Vo, Anna A. D. organization: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo – sequence: 11 givenname: Anja F. surname: Dahl fullname: Dahl, Anja F. organization: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo – sequence: 12 givenname: Karianne surname: Svendsen fullname: Svendsen, Karianne organization: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, The Lipid Clinic, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital – sequence: 13 givenname: Magne surname: Thoresen fullname: Thoresen, Magne organization: Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo – sequence: 14 givenname: Helga surname: Refsum fullname: Refsum, Helga organization: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Department of Pharmacology, University of Oxford – sequence: 15 givenname: Russell surname: Rising fullname: Rising, Russell organization: D&S Consulting Services, Inc – sequence: 16 givenname: Kristýna surname: Barvíková fullname: Barvíková, Kristýna organization: Department of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital – sequence: 17 givenname: Marleen surname: van Greevenbroek fullname: van Greevenbroek, Marleen organization: Department of Internal Medicine and CARIM School of Cardiovascular Diseases, Maastricht University – sequence: 18 givenname: Viktor surname: Kožich fullname: Kožich, Viktor organization: Department of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital – sequence: 19 givenname: Kjetil surname: Retterstøl fullname: Retterstøl, Kjetil organization: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, The Lipid Clinic, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital – sequence: 20 givenname: Kathrine J. surname: Vinknes fullname: Vinknes, Kathrine J. organization: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38195568$$D View this record in MEDLINE/PubMed |
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| Keywords | Obesity Cysteine Dietary intervention Leptin Weight loss Sulfur amino acid restriction Randomized controlled trial Methionine restriction Overweight |
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| License | 2024. The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
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Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body... Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight,... Background Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body... BackgroundDietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body... Abstract Background Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary... |
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| SubjectTerms | Adipose tissue Amino acids Amino Acids, Sulfur Analysis Apolipoproteins Biomarkers Biomedical and Life Sciences Biomedicine Body composition Body fat Body weight Body weight loss Care and treatment Cholesterol Clinical trials Compliance Complications and side effects Cysteine Diabetes Diet Dosage and administration Down-regulation Exercise Female Food Gene expression Hormones Humans Insulin-like growth factors Intervention Ketone Bodies Ketones Leptin Liver Male Medicine/Public Health Metabolic rate Metabolites Methionine Methionine restriction Nutrition & metabolism Obesity Overweight Oxidation Peptides Plasma Proteins Randomized controlled trial Ribosomes Social life & customs Sulfur Sulfur amino acid restriction Triglycerides Weight control Weight Loss Womens health |
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| Title | Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial |
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