The Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study

Sleep disordered breathing (SDB) is highly prevalent in older adults. Increasing evidence links SDB to the risk of dementia, mediated via a number of pathways, some of which may be attenuated by low-dose aspirin. This study will evaluate, in a healthy older cohort, the prospective relationship betwe...

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Veröffentlicht in:	Contemporary Clinical Trials Jg. 64; S. 101 - 111
Hauptverfasser:	Ward, Stephanie Alison, Storey, Elsdon, Woods, Robyn L., Hamilton, Garun S., Kawasaki, Ryo, Janke, Andrew L., Naughton, Matthew T., O'Donoghue, Fergal, Wolfe, Rory, Wong, Tien Y., Reid, Christopher M., Abhayaratna, Walter P., Stocks, Nigel, Trevaks, Ruth, Fitzgerald, Sharyn, Hodgson, Lauren A.B., Robman, Liubov, Workman, Barbara, McNeil, John J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.01.2018 Elsevier BV
Schlagworte:	2736 Pharmacology (medical) Aged Aged, 80 and over Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Aspirin Aspirin - therapeutic use Brain magnetic resonance imaging Cardiovascular Cerebrovascular Circulation Cerebrovascular Circulation - drug effects Cognition Cognition - drug effects Cognitive decline Dementia Dose-Response Relationship, Drug Double-Blind Method Female Hematology, Oncology, and Palliative Medicine Humans Low-dose aspirin Male Mental Status and Dementia Tests Microvessels Microvessels - drug effects Prospective Studies Research Design Retina Retina - drug effects Retinal vascular imaging Sleep Apnea Syndromes Sleep Apnea Syndromes - drug therapy Sleep Apnea Syndromes - physiopathology Sleep disordered breathing Cognitive decline Retinal vascular imaging Low-dose aspirin Brain magnetic resonance imaging Sleep disordered breathing Dementia
ISSN:	1551-7144, 1559-2030, 1559-2030
Online-Zugang:	Volltext
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