The Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study

Sleep disordered breathing (SDB) is highly prevalent in older adults. Increasing evidence links SDB to the risk of dementia, mediated via a number of pathways, some of which may be attenuated by low-dose aspirin. This study will evaluate, in a healthy older cohort, the prospective relationship betwe...

Full description

Saved in:
Bibliographic Details
Published in:Contemporary Clinical Trials Vol. 64; pp. 101 - 111
Main Authors: Ward, Stephanie Alison, Storey, Elsdon, Woods, Robyn L., Hamilton, Garun S., Kawasaki, Ryo, Janke, Andrew L., Naughton, Matthew T., O'Donoghue, Fergal, Wolfe, Rory, Wong, Tien Y., Reid, Christopher M., Abhayaratna, Walter P., Stocks, Nigel, Trevaks, Ruth, Fitzgerald, Sharyn, Hodgson, Lauren A.B., Robman, Liubov, Workman, Barbara, McNeil, John J.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.01.2018
Elsevier BV
Subjects:
2736 Pharmacology (medical)
Aged
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Aspirin
Aspirin - therapeutic use
Brain magnetic resonance imaging
Cardiovascular
Cerebrovascular Circulation
Cerebrovascular Circulation - drug effects
Cognition
Cognition - drug effects
Cognitive decline
Dementia
Dose-Response Relationship, Drug
Double-Blind Method
Female
Hematology, Oncology, and Palliative Medicine
Humans
Low-dose aspirin
Male
Mental Status and Dementia Tests
Microvessels
Microvessels - drug effects
Prospective Studies
Research Design
Retina
Retina - drug effects
Retinal vascular imaging
Sleep Apnea Syndromes
Sleep Apnea Syndromes - drug therapy
Sleep Apnea Syndromes - physiopathology
Sleep disordered breathing
Cognitive decline
Retinal vascular imaging
Low-dose aspirin
Brain magnetic resonance imaging
Sleep disordered breathing
Dementia
ISSN:1551-7144, 1559-2030, 1559-2030
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Sleep disordered breathing (SDB) is highly prevalent in older adults. Increasing evidence links SDB to the risk of dementia, mediated via a number of pathways, some of which may be attenuated by low-dose aspirin. This study will evaluate, in a healthy older cohort, the prospective relationship between SDB and cognitive function, changes in retinal and cerebral microvasculature, and determine whether low-dose aspirin ameliorates the effects of SDB on these outcomes over 3years. SNORE-ASA is a sub-study of the ASPirin in Reducing Events in the Elderly (ASPREE) randomised, multi-centre, placebo-controlled trial evaluating the effect of daily 100mg aspirin on disability-free and dementia-free survival in the healthy older adult aged 70 and over. At baseline, 1400 ASPREE participants successfully underwent a home sleep study with a home sleep study screening device for SDB; and 296 underwent both 1.5 Tesla brain magnetic resonance imaging (MRI) and retinal vascular imaging (RVI). Cognitive testing, brain MRI and RVI is being repeated after 3years. Change in the modified mini-mental state examination score. Secondary outcome measures are changes in other cognitive tests, and changes in abnormal parameters on RVI and volume of white matter hyper-intensities on brain MRI. Identifying preventive therapies for delaying the onset of dementia is of paramount importance. The results of this study will help clarify the impact of the SDB on risk of cognitive decline and cerebral small vessel disease, and whether low-dose aspirin can ameliorate cognitive decline in the setting of SDB. The Principal ASPREE study is registered with the International Standardized Randomized Controlled Trials Register, ASPirin in Reducing Events in the Elderly, Number: ISRCTN83772183 and clinicaltrials.gov Number NCT01038583.
AbstractList Sleep disordered breathing (SDB) is highly prevalent in older adults. Increasing evidence links SDB to the risk of dementia, mediated via a number of pathways, some of which may be attenuated by low-dose aspirin. This study will evaluate, in a healthy older cohort, the prospective relationship between SDB and cognitive function, changes in retinal and cerebral microvasculature, and determine whether low-dose aspirin ameliorates the effects of SDB on these outcomes over 3years. SNORE-ASA is a sub-study of the ASPirin in Reducing Events in the Elderly (ASPREE) randomised, multi-centre, placebo-controlled trial evaluating the effect of daily 100mg aspirin on disability-free and dementia-free survival in the healthy older adult aged 70 and over. At baseline, 1400 ASPREE participants successfully underwent a home sleep study with a home sleep study screening device for SDB; and 296 underwent both 1.5 Tesla brain magnetic resonance imaging (MRI) and retinal vascular imaging (RVI). Cognitive testing, brain MRI and RVI is being repeated after 3years. Change in the modified mini-mental state examination score. Secondary outcome measures are changes in other cognitive tests, and changes in abnormal parameters on RVI and volume of white matter hyper-intensities on brain MRI. Identifying preventive therapies for delaying the onset of dementia is of paramount importance. The results of this study will help clarify the impact of the SDB on risk of cognitive decline and cerebral small vessel disease, and whether low-dose aspirin can ameliorate cognitive decline in the setting of SDB. The Principal ASPREE study is registered with the International Standardized Randomized Controlled Trials Register, ASPirin in Reducing Events in the Elderly, Number: ISRCTN83772183 and clinicaltrials.gov Number NCT01038583.
Sleep disordered breathing (SDB) is highly prevalent in older adults. Increasing evidence links SDB to the risk of dementia, mediated via a number of pathways, some of which may be attenuated by low-dose aspirin. This study will evaluate, in a healthy older cohort, the prospective relationship between SDB and cognitive function, changes in retinal and cerebral microvasculature, and determine whether low-dose aspirin ameliorates the effects of SDB on these outcomes over 3years.PURPOSESleep disordered breathing (SDB) is highly prevalent in older adults. Increasing evidence links SDB to the risk of dementia, mediated via a number of pathways, some of which may be attenuated by low-dose aspirin. This study will evaluate, in a healthy older cohort, the prospective relationship between SDB and cognitive function, changes in retinal and cerebral microvasculature, and determine whether low-dose aspirin ameliorates the effects of SDB on these outcomes over 3years.SNORE-ASA is a sub-study of the ASPirin in Reducing Events in the Elderly (ASPREE) randomised, multi-centre, placebo-controlled trial evaluating the effect of daily 100mg aspirin on disability-free and dementia-free survival in the healthy older adult aged 70 and over. At baseline, 1400 ASPREE participants successfully underwent a home sleep study with a home sleep study screening device for SDB; and 296 underwent both 1.5 Tesla brain magnetic resonance imaging (MRI) and retinal vascular imaging (RVI). Cognitive testing, brain MRI and RVI is being repeated after 3years.DESIGNSNORE-ASA is a sub-study of the ASPirin in Reducing Events in the Elderly (ASPREE) randomised, multi-centre, placebo-controlled trial evaluating the effect of daily 100mg aspirin on disability-free and dementia-free survival in the healthy older adult aged 70 and over. At baseline, 1400 ASPREE participants successfully underwent a home sleep study with a home sleep study screening device for SDB; and 296 underwent both 1.5 Tesla brain magnetic resonance imaging (MRI) and retinal vascular imaging (RVI). Cognitive testing, brain MRI and RVI is being repeated after 3years.Change in the modified mini-mental state examination score. Secondary outcome measures are changes in other cognitive tests, and changes in abnormal parameters on RVI and volume of white matter hyper-intensities on brain MRI.PRIMARY OUTCOME MEASURESChange in the modified mini-mental state examination score. Secondary outcome measures are changes in other cognitive tests, and changes in abnormal parameters on RVI and volume of white matter hyper-intensities on brain MRI.Identifying preventive therapies for delaying the onset of dementia is of paramount importance. The results of this study will help clarify the impact of the SDB on risk of cognitive decline and cerebral small vessel disease, and whether low-dose aspirin can ameliorate cognitive decline in the setting of SDB.CONCLUSIONIdentifying preventive therapies for delaying the onset of dementia is of paramount importance. The results of this study will help clarify the impact of the SDB on risk of cognitive decline and cerebral small vessel disease, and whether low-dose aspirin can ameliorate cognitive decline in the setting of SDB.ACTRN12612000891820: The Principal ASPREE study is registered with the International Standardized Randomized Controlled Trials Register, ASPirin in Reducing Events in the Elderly, Number: ISRCTN83772183 and clinicaltrials.gov Number NCT01038583.SNORE-ASA TRIAL REGISTRATIONACTRN12612000891820: The Principal ASPREE study is registered with the International Standardized Randomized Controlled Trials Register, ASPirin in Reducing Events in the Elderly, Number: ISRCTN83772183 and clinicaltrials.gov Number NCT01038583.
Sleep disordered breathing (SDB) is highly prevalent in older adults. Increasing evidence links SDB to the risk of dementia, mediated via a number of pathways, some of which may be attenuated by low-dose aspirin. This study will evaluate, in a healthy older cohort, the prospective relationship between SDB and cognitive function, changes in retinal and cerebral microvasculature, and determine whether low-dose aspirin ameliorates the effects of SDB on these outcomes over 3years. SNORE-ASA is a sub-study of the ASPirin in Reducing Events in the Elderly (ASPREE) randomised, multi-centre, placebo-controlled trial evaluating the effect of daily 100mg aspirin on disability-free and dementia-free survival in the healthy older adult aged 70 and over. At baseline, 1400 ASPREE participants successfully underwent a home sleep study with a home sleep study screening device for SDB; and 296 underwent both 1.5 Tesla brain magnetic resonance imaging (MRI) and retinal vascular imaging (RVI). Cognitive testing, brain MRI and RVI is being repeated after 3years. Change in the modified mini-mental state examination score. Secondary outcome measures are changes in other cognitive tests, and changes in abnormal parameters on RVI and volume of white matter hyper-intensities on brain MRI. Identifying preventive therapies for delaying the onset of dementia is of paramount importance. The results of this study will help clarify the impact of the SDB on risk of cognitive decline and cerebral small vessel disease, and whether low-dose aspirin can ameliorate cognitive decline in the setting of SDB. ACTRN12612000891820: The Principal ASPREE study is registered with the International Standardized Randomized Controlled Trials Register, ASPirin in Reducing Events in the Elderly, Number: ISRCTN83772183 and clinicaltrials.gov Number NCT01038583.
AbstractPurposeSleep disordered breathing (SDB) is highly prevalent in older adults. Increasing evidence links SDB to the risk of dementia, mediated via a number of pathways, some of which may be attenuated by low-dose aspirin. This study will evaluate, in a healthy older cohort, the prospective relationship between SDB and cognitive function, changes in retinal and cerebral microvasculature, and determine whether low-dose aspirin ameliorates the effects of SDB on these outcomes over 3 years. DesignSNORE-ASA is a sub-study of the ASPirin in Reducing Events in the Elderly (ASPREE) randomised, multi-centre, placebo-controlled trial evaluating the effect of daily 100 mg aspirin on disability-free and dementia-free survival in the healthy older adult aged 70 and over. At baseline, 1400 ASPREE participants successfully underwent a home sleep study with a home sleep study screening device for SDB; and 296 underwent both 1.5 Tesla brain magnetic resonance imaging (MRI) and retinal vascular imaging (RVI). Cognitive testing, brain MRI and RVI is being repeated after 3 years. Primary outcome measuresChange in the modified mini-mental state examination score. Secondary outcome measures are changes in other cognitive tests, and changes in abnormal parameters on RVI and volume of white matter hyper-intensities on brain MRI. ConclusionIdentifying preventive therapies for delaying the onset of dementia is of paramount importance. The results of this study will help clarify the impact of the SDB on risk of cognitive decline and cerebral small vessel disease, and whether low-dose aspirin can ameliorate cognitive decline in the setting of SDB. SNORE-ASA trial registration: ACTRN12612000891820The Principal ASPREE study is registered with the International Standardized Randomized Controlled Trials Register, ASPirin in Reducing Events in the Elderly, Number: ISRCTN83772183 and clinicaltrials.gov Number NCT01038583.
Author Ward, Stephanie Alison
Kawasaki, Ryo
O'Donoghue, Fergal
Trevaks, Ruth
Woods, Robyn L.
Abhayaratna, Walter P.
Reid, Christopher M.
McNeil, John J.
Wong, Tien Y.
Workman, Barbara
Wolfe, Rory
Stocks, Nigel
Fitzgerald, Sharyn
Hodgson, Lauren A.B.
Hamilton, Garun S.
Storey, Elsdon
Robman, Liubov
Naughton, Matthew T.
Janke, Andrew L.
AuthorAffiliation The ASPREE Study Group, Australia, USA
AuthorAffiliation_xml – name: The ASPREE Study Group, Australia, USA
– name: b Monash Ageing Research Centre (MONARC), Monash University, The Kingston Centre, Warrigal Rd, Cheltenham 3192, Australia
– name: d Department of Lung and Sleep Medicine, Monash Health, 246 Clayton Rd, Clayton, Vic 3168, Australia
– name: j Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Vic, Australia
– name: a Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia
– name: e School of Clinical Sciences, Monash University, 246 Clayton Rd, Clayton, Vic 3168, Australia
– name: o Discipline of General Practice, Adelaide Medical School, University of Adelaide, Corner of North Terrace and George St, Adelaide, SA 5000, Australia
– name: k Singapore Eye Research Institute, Singapore National Eye Center, 11 Third Hospital Avenue, 168751, Singapore
– name: g Centre for Advanced Imaging, University of Queensland, Building 57, Research Rd, The University of Queensland, St Lucia, QLD 4072, Australia
– name: n College of Medicine, Biology and Environment, Australian National University, Building 4, The Canberra Hospital, Hospital Rd, Garran ACT, Canberra 2605, Australia
– name: i Institute for Breathing and Sleep, Austin Health, Heidelberg, VIC 3084, Australia
– name: p Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Department of Surgery (Opthalmology), University of Melbourne, 32 Gisborne St, East Melbourne, VIC 3002, Australia
– name: q The ASPREE Study Group, Australia, USA
– name: f Department of Vision Informatics (Topcon),Osaka University Graduate School of Medicine, E7 2-2 Yamada-oka, Suita-city, Osaka 565-1871, Japan
– name: l Duke-NUS Medical School, National University of Singapore, 8 College Rd, 169857, Singapore
– name: m School of Public Health, Curtin University, Kent St, Bentley, Perth, WA 6102, Australia
– name: c Department of Neuroscience (Medicine), Monash University, The Alfred Hospital, Commercial Rd, Melbourne 3004, Australia
– name: h The Department of Allergy, Immunology & Respiratory Medicine, Alfred Hospital, The Central Clinical School, Monash University, Commercial Rd, Melbourne, VIC 3004, Australia
Author_xml – sequence: 1
  givenname: Stephanie Alison
  surname: Ward
  fullname: Ward, Stephanie Alison
  email: Stephanie.Ward@monash.edu
  organization: Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia
– sequence: 2
  givenname: Elsdon
  surname: Storey
  fullname: Storey, Elsdon
  email: elsdon.storey@monash.edu
  organization: Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia
– sequence: 3
  givenname: Robyn L.
  surname: Woods
  fullname: Woods, Robyn L.
  email: Robyn.Woods@monash.edu
  organization: Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia
– sequence: 4
  givenname: Garun S.
  surname: Hamilton
  fullname: Hamilton, Garun S.
  email: Garun.Hamilton@monash.edu
  organization: Department of Lung and Sleep Medicine, Monash Health, 246 Clayton Rd, Clayton, Vic 3168, Australia
– sequence: 5
  givenname: Ryo
  surname: Kawasaki
  fullname: Kawasaki, Ryo
  email: ryo.kawasaki@ophthal.med.osakau.ac.jp
  organization: Department of Vision Informatics (Topcon),Osaka University Graduate School of Medicine, E7 2-2 Yamada-oka, Suita-city, Osaka 565-1871, Japan
– sequence: 6
  givenname: Andrew L.
  surname: Janke
  fullname: Janke, Andrew L.
  email: Andrew.janke@cai.uq.edu.au
  organization: Centre for Advanced Imaging, University of Queensland, Building 57, Research Rd, The University of Queensland, St Lucia, QLD 4072, Australia
– sequence: 7
  givenname: Matthew T.
  surname: Naughton
  fullname: Naughton, Matthew T.
  email: M.Naughton@alfred.org.au
  organization: The Department of Allergy, Immunology & Respiratory Medicine, Alfred Hospital, The Central Clinical School, Monash University, Commercial Rd, Melbourne, VIC 3004, Australia
– sequence: 8
  givenname: Fergal
  surname: O'Donoghue
  fullname: O'Donoghue, Fergal
  email: Fergal.ODonoghue@austin.org.au
  organization: Institute for Breathing and Sleep, Austin Health, Heidelberg, VIC 3084, Australia
– sequence: 9
  givenname: Rory
  surname: Wolfe
  fullname: Wolfe, Rory
  email: rory.wolfe@monash.edu
  organization: Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia
– sequence: 10
  givenname: Tien Y.
  surname: Wong
  fullname: Wong, Tien Y.
  email: Tien_yin_wong@nuhs.edu.sg
  organization: Singapore Eye Research Institute, Singapore National Eye Center, 11 Third Hospital Avenue, 168751, Singapore
– sequence: 11
  givenname: Christopher M.
  orcidid: 0000-0001-9173-3944
  surname: Reid
  fullname: Reid, Christopher M.
  email: chris.reid@monash.edu
  organization: Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia
– sequence: 12
  givenname: Walter P.
  surname: Abhayaratna
  fullname: Abhayaratna, Walter P.
  email: Walter.P.Abhayaratna@act.gov.au
  organization: College of Medicine, Biology and Environment, Australian National University, Building 4, The Canberra Hospital, Hospital Rd, Garran ACT, Canberra 2605, Australia
– sequence: 13
  givenname: Nigel
  surname: Stocks
  fullname: Stocks, Nigel
  email: Nigel.stocks@adelaide.edu.au
  organization: Discipline of General Practice, Adelaide Medical School, University of Adelaide, Corner of North Terrace and George St, Adelaide, SA 5000, Australia
– sequence: 14
  givenname: Ruth
  surname: Trevaks
  fullname: Trevaks, Ruth
  email: ruth.trevaks@monash.edu
  organization: Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia
– sequence: 15
  givenname: Sharyn
  surname: Fitzgerald
  fullname: Fitzgerald, Sharyn
  email: sharyn.fitzgerald@monash.edu
  organization: Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia
– sequence: 16
  givenname: Lauren A.B.
  surname: Hodgson
  fullname: Hodgson, Lauren A.B.
  email: labh@unimelb.edu.au
  organization: Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Department of Surgery (Opthalmology), University of Melbourne, 32 Gisborne St, East Melbourne, VIC 3002, Australia
– sequence: 17
  givenname: Liubov
  surname: Robman
  fullname: Robman, Liubov
  email: liubov.robman@monash.edu
  organization: Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia
– sequence: 18
  givenname: Barbara
  orcidid: 0000-0001-6520-9276
  surname: Workman
  fullname: Workman, Barbara
  email: Barbara.Workman@monashhealth.org
  organization: Monash Ageing Research Centre (MONARC), Monash University, The Kingston Centre, Warrigal Rd, Cheltenham 3192, Australia
– sequence: 19
  givenname: John J.
  surname: McNeil
  fullname: McNeil, John J.
  email: john.mcneil@monash.edu
  organization: Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia
BackLink https://cir.nii.ac.jp/crid/1873679867427460864$$DView record in CiNii
https://www.ncbi.nlm.nih.gov/pubmed/29097299$$D View this record in MEDLINE/PubMed
BookMark eNqFUltr2zAUNqNjvWw_YC_DD3vYw5zpYksWg0Io2QVKC0n3LGT5OFHmSJkkB_I79ocnJ-3YCutAWMfH38Wc75xnJ9ZZyLLXGE0wwuzDeqJ1nBCEeXqfpM6z7AxXlSgIoujkUOOC47I8zc5DWCNEWcWqF9kpEUhwIsRZ9vNuBfkiDu0-d11-A4N32i2tiWYH-e0QtdtAeJ_PVWtc75ZGqz5Xts3nEI1N9azrQMcwkqdha7yxeTqLHmCbT7fWgSpyr6JxCQwH5gbiyrWj2MEyjv43t_NZMV1M8zD-ycvseaf6AK_u74vs26fZ3dWX4vr289er6XWhGapj0VJGBSFUc11r1mjCMNe0qUpcUVWC4k1Zd7rjNW-A1C0SLQdW46ohXDNGgF5kl0fd7dBsoNVgo1e93HqzUX4vnTLy7y_WrOTS7STjFa0pTgLv7gW8-zFAiHJjgoa-VxbcECQWjBIueF0l6Js_vX6bPCSRAPwI0N6F4KGT2sTD4JK16SVGcsxcrmXKXI6Zj63USUz8iPkg_hTn7ZFjjUlG4xPXnDIuasZLwss0YVYm2McjDFIMOwNeBm3AamiNT7HL1pknTS4fsXWfrNIKfYc9hLUbfNqKNCYZiERyMa7ruK2YU1SW5Tg08W-B_5j_Ah5e97w
CitedBy_id crossref_primary_10_1371_journal_pone_0294743
crossref_primary_10_1097_WCO_0000000000000779
crossref_primary_10_1093_sleep_zsae204
crossref_primary_10_1111_resp_14299
crossref_primary_10_1097_MCP_0000000000000623
crossref_primary_10_1111_resp_14279
crossref_primary_10_1038_s41433_023_02754_y
crossref_primary_10_1007_s12630_022_02302_4
crossref_primary_10_1177_23969873211012132
crossref_primary_10_1016_j_conctc_2020_100667
crossref_primary_10_1183_16000617_0162_2024
crossref_primary_10_1183_23120541_00581_2024
crossref_primary_10_1093_ije_dyy279
crossref_primary_10_1111_resp_13728
Cites_doi 10.1016/S0140-6736(01)06253-5
10.1111/j.1532-5415.2007.01506.x
10.1371/journal.pone.0079521
10.1016/j.neurobiolaging.2015.05.004
10.1111/jsr.12034
10.3233/JAD-130419
10.1155/2016/9626831
10.1016/j.jagp.2015.08.004
10.1016/S0140-6736(15)60461-5
10.1111/j.1532-5415.2011.03731.x
10.1136/thx.2009.126730
10.1056/NEJMoa1606599
10.1093/sleep/34.1.111
10.1183/09031936.00133011
10.5665/sleep.2644
10.1586/17476348.2.3.349
10.1038/jcbfm.2013.58
10.1093/sleep/33.4.515
10.1001/jamaneurol.2017.2180
10.5664/jcsm.26861
10.1076/ceyr.27.3.143.16049
10.1016/j.ophtha.2008.05.029
10.1111/jgs.13321
10.1016/j.smrv.2015.03.002
10.1111/j.1440-1843.2010.01797.x
10.1001/jamaneurol.2013.4215
10.1371/journal.pone.0012065
10.1111/j.1532-5415.2008.01934.x
10.1016/j.jalz.2012.11.007
10.1016/S1474-4422(11)70072-2
10.3233/JAD-131046
10.1164/rccm.201005-0693OC
10.1136/jnnp-2013-307544
10.5665/sleep.5042
10.1167/iovs.09-3442
10.1164/rccm.200608-1141OC
10.1136/bmjopen-2012-001288
10.5665/sleep.2632
10.1016/j.brainres.2014.11.035
10.1111/j.1442-9071.2012.02768.x
10.1001/jama.2016.20325
10.5665/sleep.4392
10.1161/JAHA.116.003598
10.1016/j.neuroimage.2005.09.068
10.1007/s12272-015-0648-x
10.5664/jcsm.26311
10.1016/S0140-6736(09)60503-1
10.1016/j.ophtha.2007.06.036
10.1212/WNL.0b013e31821a7d7d
10.1016/S1474-4422(04)00682-9
10.1046/j.1365-2869.2002.00289.x
10.1001/jama.2011.1115
10.1212/WNL.0000000000001163
10.1002/jnr.23634
10.1046/j.1365-2869.2002.00308.x
10.1212/WNL.0000000000001566
10.5665/sleep.1582
10.1212/WNL.0000000000003557
10.1016/j.chest.2017.01.020
10.1136/thx.2010.152801
10.5665/sleep.2228
10.1136/thoraxjnl-2015-206970
10.5664/jcsm.4694
10.1093/sleep/27.3.467
10.1093/sleep/30.3.291
10.1016/j.ajo.2005.07.030
10.5665/sleep.5434
10.5665/sleep.2226
10.3233/JAD-141596
10.1111/jgs.14883
10.1080/AC.71.3.3152087
10.1016/S1474-4422(09)70131-0
10.1378/chest.103.1.30
10.1016/j.cct.2013.09.014
10.1097/IAE.0b013e318259568b
10.1016/j.sleep.2006.02.005
10.1093/brain/awq127
10.1371/journal.pone.0078655
10.1371/journal.pone.0147160
10.1007/s11325-015-1177-z
10.1126/science.1180962
10.1001/jama.288.1.67
10.1126/science.1241224
10.1016/S0161-6420(99)90525-0
10.1016/S2213-2600(14)70172-9
ContentType Journal Article
Copyright 2017 Elsevier Inc.
Elsevier Inc.
Copyright © 2017 Elsevier Inc. All rights reserved.
Copyright_xml – notice: 2017 Elsevier Inc.
– notice: Elsevier Inc.
– notice: Copyright © 2017 Elsevier Inc. All rights reserved.
CorporateAuthor The ASPREE Study Group
ASPREE Study Group
CorporateAuthor_xml – name: The ASPREE Study Group
– name: ASPREE Study Group
DBID RYH
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOI 10.1016/j.cct.2017.10.016
DatabaseName CiNii Complete
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList

MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1559-2030
EndPage 111
ExternalDocumentID PMC6753831
29097299
10_1016_j_cct_2017_10_016
S1551714417304445
1_s2_0_S1551714417304445
Genre Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIA NIH HHS
  grantid: U01 AG029824
GroupedDBID ---
--K
--M
.1-
.FO
.GJ
.~1
0R~
1B1
1P~
1~.
1~5
4.4
457
4G.
53G
5GY
5VS
7-5
71M
8P~
AAEDT
AAEDW
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AATTM
AAXKI
AAXUO
AAYWO
ABBQC
ABFNM
ABJNI
ABLJU
ABMAC
ABMZM
ABWVN
ABXDB
ACDAQ
ACGFS
ACIEU
ACIUM
ACLOT
ACRLP
ACRPL
ACVFH
ADBBV
ADCNI
ADEZE
ADMUD
ADNMO
AEBSH
AEIPS
AEKER
AENEX
AEUPX
AEVXI
AFJKZ
AFPUW
AFRHN
AFTJW
AFXIZ
AGHFR
AGUBO
AGYEJ
AIEXJ
AIGII
AIIUN
AIKHN
AITUG
AJRQY
AJUYK
AKBMS
AKRWK
AKYEP
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ANKPU
ANZVX
APXCP
AXJTR
BKOJK
BLXMC
BNPGV
CS3
DU5
EBS
EFJIC
EFKBS
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FIRID
FNPLU
FYGXN
G-Q
GBLVA
HVGLF
HZ~
IHE
J1W
KOM
M41
MO0
N9A
O-L
O9-
OAUVE
OA~
OL0
OZT
P-8
P-9
PC.
Q38
ROL
RPZ
SCC
SDF
SDG
SEL
SES
SEW
SPCBC
SSH
SSZ
T5K
UAP
Z5R
~G-
~HD
AACTN
AFCTW
AFKWA
AJOXV
AMFUW
RIG
AAIAV
ABLVK
ABYKQ
AJBFU
LCYCR
RYH
9DU
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
ID FETCH-LOGICAL-c608t-d3639223c7c8c6bc2617c3b54153a4ea7b48fcf787be28d09d7e6815b27c662e3
ISICitedReferencesCount 15
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000423647200014&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1551-7144
1559-2030
IngestDate Tue Sep 30 15:31:38 EDT 2025
Sat Sep 27 18:17:55 EDT 2025
Thu Apr 03 07:01:39 EDT 2025
Tue Nov 18 22:35:05 EST 2025
Sat Nov 29 07:00:10 EST 2025
Mon Nov 10 09:11:58 EST 2025
Fri Feb 23 02:45:26 EST 2024
Sun Feb 23 10:18:49 EST 2025
Tue Oct 14 19:34:57 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords Cognitive decline
Retinal vascular imaging
Low-dose aspirin
Brain magnetic resonance imaging
Sleep disordered breathing
Dementia
Language English
License Copyright © 2017 Elsevier Inc. All rights reserved.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c608t-d3639223c7c8c6bc2617c3b54153a4ea7b48fcf787be28d09d7e6815b27c662e3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
Author’s contributions
SW was responsible for project inception, design, funding, supervision of project manager, and first draft of manuscript. ES, RLW, BW, JM were involved in project inception, funding and leadership, and ES in training field staff in the cognitive testing. GH, MN and FO’D were involved in project inception, funding and design especially related to measures of sleep apnoea and reporting of sleep studies. TW, RK, LH and LR were involved in design of the retinal imaging sub-study. AJ was involved in design of MRI analyses and sub-study, and attracting funding. WA and NS were involved in leadership of the project at other sites. RW provided sample size and statistical analysis plans. CR has had input into study design and operation. RT and SF provide important input into study operations and recruitment. All authors have read and contributed to the manuscript.
ORCID 0000-0001-6520-9276
0000-0001-9173-3944
0000-0003-1249-6149
0000-0002-1049-5129
0000-0002-8448-1264
0000-0003-1840-6079
0000-0003-0547-5171
0000-0002-7492-6303
0000-0002-9018-0361
0000-0002-4908-0641
0000-0002-2126-1045
0000-0002-1439-3373
0000-0002-1744-2839
OpenAccessLink https://cir.nii.ac.jp/crid/1873679867427460864
PMID 29097299
PQID 1963279785
PQPubID 23479
PageCount 11
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_6753831
proquest_miscellaneous_1963279785
pubmed_primary_29097299
crossref_citationtrail_10_1016_j_cct_2017_10_016
crossref_primary_10_1016_j_cct_2017_10_016
nii_cinii_1873679867427460864
elsevier_sciencedirect_doi_10_1016_j_cct_2017_10_016
elsevier_clinicalkeyesjournals_1_s2_0_S1551714417304445
elsevier_clinicalkey_doi_10_1016_j_cct_2017_10_016
PublicationCentury 2000
PublicationDate 2018-01-01
PublicationDateYYYYMMDD 2018-01-01
PublicationDate_xml – month: 01
  year: 2018
  text: 2018-01-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Contemporary Clinical Trials
PublicationTitleAlternate Contemp Clin Trials
PublicationYear 2018
Publisher Elsevier Inc
Elsevier BV
Publisher_xml – name: Elsevier Inc
– name: Elsevier BV
References Wong, Barr, Tapp, Harper, Taylor, Zimmet (bb0345) 2005; 140
Weaver, Laizner, Evans, Maislin, Chugh, Lyon (bb0420) 1997; 20
Morrell, Jackson, Twigg, Ghiassi, McRobbie, Quest (bb0200) 2010; 65
Iqbal, Kinoshita, Noda, Friedman, Yesavage, Zeitzer (bb0015) 2016; 24
Canessa, Castronovo, Cappa, Aloia, Marelli, Falini (bb0205) 2011; 183
Ryan, Taylor, McNicholas (bb0140) 2009; 64
Martin, Sforza, Roche, Barthelemy, Thomas-Anterion (bb0230) 2015; 38
Boland, Shahar, Iber, Knopman, Kuo, Nieto (bb0455) 2002; 11
Beebe, Gozal (bb0110) 2002; 11
Martinez-Ceron, Fernandez-Navarro, Garcia-Rio (bb0255) 2016; 25
Stranks, Crowe (bb0095) 2016; 31
Zhou, Chen, Peng, Ouyang (bb0120) 2016; 2016
Chew, Xie, Klein, Klein, Cotch, Redline (bb0375) 2016; 20
Kern, Skoog, Ostling, Kern, Borjesson-Hanson (bb0300) 2012; 2
Ancoli-Israel, Palmer, Cooke, Corey-Bloom, Fiorentino, Natarajan (bb0265) 2008; 56
Kuhn, Schwarz, Bratton, Rossi, Kohler (bb0245) 2017; 151
Liew, Wang, Cheung, Zhang, Hsu, Lee (bb0440) 2008; 115
Lindley, Wang, Wong, Mitchell, Liew, Hand (bb0325) 2009; 8
(bb0065) 2013; 36
Kang, Lim, Bateman, Lee, Smyth, Cirrito (bb0175) 2009; 326
Spira, Gamaldo, An, MN, Simonsick, Bilgel (bb0195) 2013; 70
Sun, Huang, Sun, Qiu, Zhou, Zhou (bb0250) 2016; 71
Heringa, Bouvy, van den Berg, Moll, Kappelle, Biessels (bb0350) 2013; 33
Quan, Wright, Baldwin, Kaemingk, Goodwin, Kuo (bb0450) 2006; 7
Veronese, Stubbs, Maggi, Thompson, Schofield, Muller (bb0295) 2017; 65
Macey, Kumar, Woo, Valladares, Yan-Go, Harper (bb0215) 2008; 31
Daulatzai (bb0045) 2015; 93
Baigent, Blackwell, Collins, Emberson, Godwin, Peto (bb0290) 2009; 373
Evans (bb0425) 2006; 30
Khandgave, Puthran, Ingole, Nicholson (bb0385) 2013; 7
Gantner, Ge, Li, Antic, Windler, Wong (bb0410) 2010; 15
Erman, Stewart, Einhorn, Gordon, Casal (bb0400) 2007; 3
Knudtson, Lee, Hubbard, Wong, Klein, Klein (bb0435) 2003; 27
Hubbard, Brothers, King, Clegg, Klein, Cooper (bb0430) 1999; 106
Osorio, Gumb, Pirraglia, Varga, SE, Lim (bb0035) 2015; 84
Kushida, Nichols, Holmes, Quan, Walsh, Gottlieb (bb0280) 2012; 35
Blackwell, Yaffe, Ancoli-Israel, Redline, Ensrud, Stefanick (bb0100) 2011; 59
Naidu, Ismail, Amiel, Kohli, Crosby-Nwaobi, Sivaprasad (bb0355) 2016; 11
McMillan, Bratton, Faria, Laskawiec-Szkonter, Griffin, Davies (bb0285) 2014; 2
Cheung, Ong, Ikram, Chen, Wong (bb0360) 2014; 42
Lin, Redline, Klein, Colangelo, Cotch, Wong (bb0370) 2016; 5
Chang, Liu, Chang, Yang, YC, Pai (bb0030) 2013; 8
Gelber, Redline, Ross, Petrovitch, Sonnen, Zarow (bb0160) 2015; 84
Faridi, Park, Liebmann, Ritch (bb0380) 2012; 40
Banerjee, Leong, Arora, Nolen, Punamiya, Grunstein (bb0390) 2013; 8
Yaffe, Laffan, Harrison, Redline, Spira, Ensrud (bb0025) 2011; 306
Caples, Garcia-Touchard, Somers (bb0085) 2007; 30
Cheung, Mosley, Islam, Kawasaki, Sharrett, Klein (bb0310) 2010; 133
Mason, West, Kiire, Groves, Lipinski, Jaycock (bb0395) 2012; 32
Antic, Catcheside, Buchan, Hensley, Naughton, Rowland (bb0275) 2011; 34
Chai-Coetzer, Antic, Rowland, Catcheside, Esterman, Reed (bb0405) 2011; 66
Buratti, Viticchi, Falsetti, Cagnetti, Luzzi, Bartolini (bb0155) 2014; 38
Cho, Kim, Seo, Suh, Lee, Shin (bb0170) 2013; 22
Troussiere, Charley, Salleron, Richard, Delbeuck, Derambure (bb0270) 2014; 85
de Jong, Vernooij, Ikram, Ikram, Hofman, Krestin (bb0335) 2008; 115
Sprecher, Bendlin, Racine, Okonkwo, Christian, Koscik (bb0185) 2015; 36
Leng, McEvoy, Allen, Yaffe (bb0240) 2017; 74
Force, Bibbins-Domingo, Grossman, Curry, Davidson, Epling (bb0020) 2017; 317
Minoguchi, Yokoe, Tazaki, Minoguchi, Oda, Tanaka (bb0150) 2007; 175
Wong (bb0305) 2004; 3
Sforza, Roche, Thomas-Anterion, Kerleroux, Beauchet, Celle (bb0005) 2010; 33
Boland, Shahar, Wong, Klein, Punjabi, Robbins (bb0365) 2004; 27
Lutsey, Bengtson, Punjabi, Shahar, Mosley, Gottesman (bb0235) 2016; 39
O'Donoghue, Wellard, Rochford, Dawson, Barnes, Ruehland (bb0210) 2012; 35
Wong, Klein, Sharrett, Couper, Klein, Liao (bb0330) 2002; 288
Molnar, Mucsi, Novak, Szabo, Freire, Huch (bb0090) 2015; 70
Sforza, Gauthier, Crawford-Achour, Pichot, Maudoux, Barthelemy (bb0105) 2012; 40
Yuan, Guo, Deng, Zhu, Shang, Liu (bb0115) 2015; 1596
Xie, Kang, Xu, Chen, Liao, Thiyagarajan (bb0180) 2013; 342
Lee, Nagubadi, Kryger, Mokhlesi (bb0010) 2008; 2
Lim, Yu, Kowgier, Schneider, Buchman, Bennett (bb0190) 2013; 70
Robbins, Redline, Ervin, Walsleben, Ding, Nieto (bb0165) 2005; 1
McEvoy, Antic, Heeley, Luo, Ou, Zhang (bb0445) 2016; 375
Kawasaki, Che Azemin, Kumar, Tan, Liew, Wong (bb0320) 2011; 76
Kim, Yun, Thomas, Lee, Seo, Cho (bb0060) 2013; 36
Crawford-Achour, Dauphinot, Martin, Tardy, Gonthier, Barthelemy (bb0260) 2015; 11
Ngandu, Lehtisalo, Solomon, Levalahti, Ahtiluoto, Antikainen (bb0080) 2015; 385
Johns (bb0415) 1993; 103
Chami, Fontes, Vasan, Keaney, O'Connor, Larson (bb0050) 2013; 36
Prince, Bryce, Albanese, Wimo, Ribeiro, Ferri (bb0070) 2013; 9
Shiota, Takekawa, Matsumoto, Takeda, Nurwidya, Yoshioka (bb0125) 2013; 37
X-L, Liu, Wang, Jiao, Zeng, Yao (bb0130) 2015; 5
Blackwell, Yaffe, Laffan, Redline, Ancoli-Israel, Ensrud (bb0040) 2015; 63
Haba-Rubio, Marti-Soler, Tobback, Andries, Marques-Vidal, Waeber (bb0225) 2017; 88
Spira, Blackwell, Stone, Redline, Cauley, Ancoli-Israel (bb0460) 2008; 56
Barnes, Yaffe (bb0075) 2011; 10
Sapin, Peyron, Roche, Gay, Carcenac, Savasta (bb0135) 2015; 38
Drager, Lopes, Maki-Nunes, Trombetta, Toschi-Dias, Alves (bb0055) 2010; 5
Macey, Kumar, Yan-Go, Woo, Harper (bb0220) 2012; 35
Nguyen, Kawasaki, Kreis, Wang, Shaw, Vilser (bb0340) 2009; 50
Shadfar, Hwang, Lim, Choi, Hong (bb0145) 2015; 38
Wong, Klein, Couper, Cooper, Shahar, Hubbard (bb0315) 2001; 358
Daulatzai (10.1016/j.cct.2017.10.016_bb0045) 2015; 93
Cheung (10.1016/j.cct.2017.10.016_bb0310) 2010; 133
McMillan (10.1016/j.cct.2017.10.016_bb0285) 2014; 2
Prince (10.1016/j.cct.2017.10.016_bb0070) 2013; 9
Morrell (10.1016/j.cct.2017.10.016_bb0200) 2010; 65
Buratti (10.1016/j.cct.2017.10.016_bb0155) 2014; 38
(10.1016/j.cct.2017.10.016_bb0065) 2013; 36
Blackwell (10.1016/j.cct.2017.10.016_bb0100) 2011; 59
Boland (10.1016/j.cct.2017.10.016_bb0455) 2002; 11
Quan (10.1016/j.cct.2017.10.016_bb0450) 2006; 7
Drager (10.1016/j.cct.2017.10.016_bb0055) 2010; 5
Macey (10.1016/j.cct.2017.10.016_bb0220) 2012; 35
Spira (10.1016/j.cct.2017.10.016_bb0195) 2013; 70
Ancoli-Israel (10.1016/j.cct.2017.10.016_bb0265) 2008; 56
Wong (10.1016/j.cct.2017.10.016_bb0330) 2002; 288
Liew (10.1016/j.cct.2017.10.016_bb0440) 2008; 115
Wong (10.1016/j.cct.2017.10.016_bb0345) 2005; 140
Heringa (10.1016/j.cct.2017.10.016_bb0350) 2013; 33
Shiota (10.1016/j.cct.2017.10.016_bb0125) 2013; 37
Sun (10.1016/j.cct.2017.10.016_bb0250) 2016; 71
Beebe (10.1016/j.cct.2017.10.016_bb0110) 2002; 11
Leng (10.1016/j.cct.2017.10.016_bb0240) 2017; 74
Chew (10.1016/j.cct.2017.10.016_bb0375) 2016; 20
Faridi (10.1016/j.cct.2017.10.016_bb0380) 2012; 40
Hubbard (10.1016/j.cct.2017.10.016_bb0430) 1999; 106
Caples (10.1016/j.cct.2017.10.016_bb0085) 2007; 30
Kang (10.1016/j.cct.2017.10.016_bb0175) 2009; 326
Blackwell (10.1016/j.cct.2017.10.016_bb0040) 2015; 63
Veronese (10.1016/j.cct.2017.10.016_bb0295) 2017; 65
Martin (10.1016/j.cct.2017.10.016_bb0230) 2015; 38
Sapin (10.1016/j.cct.2017.10.016_bb0135) 2015; 38
Wong (10.1016/j.cct.2017.10.016_bb0305) 2004; 3
Wong (10.1016/j.cct.2017.10.016_bb0315) 2001; 358
Chai-Coetzer (10.1016/j.cct.2017.10.016_bb0405) 2011; 66
Lutsey (10.1016/j.cct.2017.10.016_bb0235) 2016; 39
Kawasaki (10.1016/j.cct.2017.10.016_bb0320) 2011; 76
Nguyen (10.1016/j.cct.2017.10.016_bb0340) 2009; 50
Zhou (10.1016/j.cct.2017.10.016_bb0120) 2016; 2016
Sprecher (10.1016/j.cct.2017.10.016_bb0185) 2015; 36
Spira (10.1016/j.cct.2017.10.016_bb0460) 2008; 56
Kim (10.1016/j.cct.2017.10.016_bb0060) 2013; 36
Chami (10.1016/j.cct.2017.10.016_bb0050) 2013; 36
X-L (10.1016/j.cct.2017.10.016_bb0130) 2015; 5
Weaver (10.1016/j.cct.2017.10.016_bb0420) 1997; 20
Martinez-Ceron (10.1016/j.cct.2017.10.016_bb0255) 2016; 25
Haba-Rubio (10.1016/j.cct.2017.10.016_bb0225) 2017; 88
Khandgave (10.1016/j.cct.2017.10.016_bb0385) 2013; 7
Boland (10.1016/j.cct.2017.10.016_bb0365) 2004; 27
Lin (10.1016/j.cct.2017.10.016_bb0370) 2016; 5
Robbins (10.1016/j.cct.2017.10.016_bb0165) 2005; 1
Naidu (10.1016/j.cct.2017.10.016_bb0355) 2016; 11
Ngandu (10.1016/j.cct.2017.10.016_bb0080) 2015; 385
Kuhn (10.1016/j.cct.2017.10.016_bb0245) 2017; 151
Force (10.1016/j.cct.2017.10.016_bb0020) 2017; 317
Chang (10.1016/j.cct.2017.10.016_bb0030) 2013; 8
O'Donoghue (10.1016/j.cct.2017.10.016_bb0210) 2012; 35
de Jong (10.1016/j.cct.2017.10.016_bb0335) 2008; 115
Antic (10.1016/j.cct.2017.10.016_bb0275) 2011; 34
Banerjee (10.1016/j.cct.2017.10.016_bb0390) 2013; 8
Sforza (10.1016/j.cct.2017.10.016_bb0005) 2010; 33
Canessa (10.1016/j.cct.2017.10.016_bb0205) 2011; 183
Kushida (10.1016/j.cct.2017.10.016_bb0280) 2012; 35
Yuan (10.1016/j.cct.2017.10.016_bb0115) 2015; 1596
Shadfar (10.1016/j.cct.2017.10.016_bb0145) 2015; 38
Kern (10.1016/j.cct.2017.10.016_bb0300) 2012; 2
Macey (10.1016/j.cct.2017.10.016_bb0215) 2008; 31
Sforza (10.1016/j.cct.2017.10.016_bb0105) 2012; 40
Lim (10.1016/j.cct.2017.10.016_bb0190) 2013; 70
Troussiere (10.1016/j.cct.2017.10.016_bb0270) 2014; 85
Lee (10.1016/j.cct.2017.10.016_bb0010) 2008; 2
Minoguchi (10.1016/j.cct.2017.10.016_bb0150) 2007; 175
Evans (10.1016/j.cct.2017.10.016_bb0425) 2006; 30
McEvoy (10.1016/j.cct.2017.10.016_bb0445) 2016; 375
Yaffe (10.1016/j.cct.2017.10.016_bb0025) 2011; 306
Ryan (10.1016/j.cct.2017.10.016_bb0140) 2009; 64
Baigent (10.1016/j.cct.2017.10.016_bb0290) 2009; 373
Lindley (10.1016/j.cct.2017.10.016_bb0325) 2009; 8
Cheung (10.1016/j.cct.2017.10.016_bb0360) 2014; 42
Iqbal (10.1016/j.cct.2017.10.016_bb0015) 2016; 24
Molnar (10.1016/j.cct.2017.10.016_bb0090) 2015; 70
Gelber (10.1016/j.cct.2017.10.016_bb0160) 2015; 84
Barnes (10.1016/j.cct.2017.10.016_bb0075) 2011; 10
Erman (10.1016/j.cct.2017.10.016_bb0400) 2007; 3
Stranks (10.1016/j.cct.2017.10.016_bb0095) 2016; 31
Crawford-Achour (10.1016/j.cct.2017.10.016_bb0260) 2015; 11
Johns (10.1016/j.cct.2017.10.016_bb0415) 1993; 103
Osorio (10.1016/j.cct.2017.10.016_bb0035) 2015; 84
Cho (10.1016/j.cct.2017.10.016_bb0170) 2013; 22
Xie (10.1016/j.cct.2017.10.016_bb0180) 2013; 342
Gantner (10.1016/j.cct.2017.10.016_bb0410) 2010; 15
Mason (10.1016/j.cct.2017.10.016_bb0395) 2012; 32
Knudtson (10.1016/j.cct.2017.10.016_bb0435) 2003; 27
References_xml – volume: 5
  start-page: e12065
  year: 2010
  ident: bb0055
  article-title: The impact of obstructive sleep apnea on metabolic and inflammatory markers in consecutive patients with metabolic syndrome
  publication-title: PLoS One
– volume: 35
  start-page: 1593
  year: 2012
  end-page: 1602
  ident: bb0280
  article-title: Effects of continuous positive airway pressure on neurocognitive function in obstructive sleep apnea patients: The Apnea Positive Pressure Long-term Efficacy Study (APPLES)
  publication-title: Sleep
– volume: 140
  start-page: 1157
  year: 2005
  end-page: 1159
  ident: bb0345
  article-title: Retinopathy in persons with impaired glucose metabolism: the Australian Diabetes Obesity and Lifestyle (AusDiab) study
  publication-title: Am J. Ophthalmol.
– volume: 31
  start-page: 186
  year: 2016
  end-page: 193
  ident: bb0095
  article-title: The cognitive effects of obstructive sleep apnea: an updated meta-analysis
  publication-title: Arch. Clin. Neuropsychol.
– volume: 35
  start-page: 1603
  year: 2012
  end-page: 1613
  ident: bb0220
  article-title: Sex differences in white matter alterations accompanying obstructive sleep apnea
  publication-title: Sleep
– volume: 32
  start-page: 1791
  year: 2012
  end-page: 1798
  ident: bb0395
  article-title: High prevalence of sleep disordered breathing in patients with diabetic macular edema
  publication-title: Retina
– volume: 133
  start-page: 1987
  year: 2010
  end-page: 1993
  ident: bb0310
  article-title: Retinal microvascular abnormalities and subclinical magnetic resonance imaging brain infarct: a prospective study
  publication-title: Brain
– volume: 115
  start-page: 1951
  year: 2008
  end-page: 1956
  ident: bb0440
  article-title: The retinal vasculature as a fractal: methodology, reliability, and relationship to blood pressure
  publication-title: Ophthalmology
– volume: 56
  start-page: 2076
  year: 2008
  end-page: 2081
  ident: bb0265
  article-title: Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study
  publication-title: J. Am. Geriatr. Soc.
– volume: 36
  start-page: 2568
  year: 2015
  end-page: 2576
  ident: bb0185
  article-title: Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults
  publication-title: Neurobiol. Aging
– volume: 11
  start-page: 519
  year: 2015
  end-page: 524
  ident: bb0260
  article-title: Protective effect of long-term CPAP therapy on cognitive performance in elderly patients with severe OSA: The PROOF study
  publication-title: J. Clin. Sleep Med.
– volume: 25
  start-page: 121
  year: 2016
  end-page: 130
  ident: bb0255
  article-title: Effects of continuous positive airway pressure treatment on glucose metabolism in patients with obstructive sleep apnea
  publication-title: Sleep Med. Rev.
– volume: 71
  start-page: 275
  year: 2016
  end-page: 280
  ident: bb0250
  article-title: CPAP therapy reduces blood pressure for patients with obstructive sleep apnoea: an update meta-analysis of randomized clinical trials
  publication-title: Acta Cardiol.
– volume: 1
  start-page: 159
  year: 2005
  end-page: 165
  ident: bb0165
  article-title: Associations of sleep-disordered breathing and cerebral changes on MRI
  publication-title: J. Clin. Sleep Med.
– volume: 38
  start-page: 2106
  year: 2015
  end-page: 2119
  ident: bb0145
  article-title: Involvement of inflammation in Alzheimer's disease pathogenesis and therapeutic potential of anti-inflammatory agents
  publication-title: Arch. Pharm. Res.
– volume: 151
  start-page: 786
  year: 2017
  end-page: 794
  ident: bb0245
  article-title: Effects of CPAP and mandibular advancement devices on health-related quality of life in OSA: a systematic review and meta-analysis
  publication-title: Chest
– volume: 3
  start-page: 179
  year: 2004
  end-page: 183
  ident: bb0305
  article-title: Is retinal photography useful in the measurement of stroke risk?
  publication-title: Lancet Neurol.
– volume: 5
  year: 2016
  ident: bb0370
  article-title: Sex-specific association of obstructive sleep apnea with retinal microvascular signs: the multi-ethnic study of atherosclerosis
  publication-title: J. Am. Heart Assoc.
– volume: 40
  start-page: 408
  year: 2012
  end-page: 419
  ident: bb0380
  article-title: Glaucoma and obstructive sleep apnoea syndrome
  publication-title: Clin. Exp. Ophthalmol.
– volume: 183
  start-page: 1419
  year: 2011
  end-page: 1426
  ident: bb0205
  article-title: Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment
  publication-title: Am. J. Respir. Crit. Care Med.
– volume: 373
  start-page: 1849
  year: 2009
  end-page: 1860
  ident: bb0290
  article-title: Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials
  publication-title: Lancet
– volume: 326
  start-page: 1005
  year: 2009
  end-page: 1007
  ident: bb0175
  article-title: Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle
  publication-title: Science
– volume: 317
  start-page: 407
  year: 2017
  end-page: 414
  ident: bb0020
  article-title: Screening for obstructive sleep apnea in adults: US preventive services task force recommendation statement
  publication-title: JAMA
– volume: 30
  start-page: 184
  year: 2006
  end-page: 202
  ident: bb0425
  article-title: The NIH MRI study of normal brain development
  publication-title: NeuroImage
– volume: 38
  start-page: 179
  year: 2015
  end-page: 187
  ident: bb0230
  article-title: Sleep breathing disorders and cognitive function in the elderly: an 8-year follow-up study. The proof-synapse cohort
  publication-title: Sleep
– volume: 70
  start-page: 1544
  year: 2013
  end-page: 1551
  ident: bb0190
  article-title: Modification of the relationship of the apolipoprotein E epsilon4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep
  publication-title: JAMA Neurol.
– volume: 93
  start-page: 1778
  year: 2015
  end-page: 1794
  ident: bb0045
  article-title: Evidence of neurodegeneration in obstructive sleep apnea: relationship between obstructive sleep apnea and cognitive dysfunction in the elderly
  publication-title: J. Neurosci. Res.
– volume: 70
  start-page: 1537
  year: 2013
  end-page: 1543
  ident: bb0195
  article-title: Self-reported sleep and beta-amyloid deposition in community-dwelling older adults
  publication-title: JAMA Neurol.
– volume: 24
  start-page: 170
  year: 2016
  end-page: 173
  ident: bb0015
  article-title: Ubiquity of undiagnosed sleep disordered breathing in community-dwelling older male veterans
  publication-title: Am. J. Geriatr. Psychiatry
– volume: 84
  start-page: 296
  year: 2015
  end-page: 303
  ident: bb0160
  article-title: Associations of brain lesions at autopsy with polysomnography features before death
  publication-title: Neurology
– volume: 11
  start-page: 1
  year: 2002
  end-page: 16
  ident: bb0110
  article-title: Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits
  publication-title: J. Sleep Res.
– volume: 20
  start-page: 835
  year: 1997
  end-page: 843
  ident: bb0420
  article-title: An instrument to measure functional status outcomes for disorders of excessive sleepiness
  publication-title: Sleep
– volume: 27
  start-page: 143
  year: 2003
  end-page: 149
  ident: bb0435
  article-title: Revised formulas for summarizing retinal vessel diameters
  publication-title: Curr. Eye Res.
– volume: 2
  year: 2012
  ident: bb0300
  article-title: Does low-dose acetylsalicylic acid prevent cognitive decline in women with high cardiovascular risk? A 5-year follow-up of a non-demented population-based cohort of Swedish elderly women
  publication-title: BMJ Open
– volume: 59
  start-page: 2217
  year: 2011
  end-page: 2225
  ident: bb0100
  article-title: Associations between sleep architecture and sleep-disordered breathing and cognition in older community-dwelling men: the Osteoporotic Fractures in Men Sleep Study
  publication-title: J. Am. Geriatr. Soc.
– volume: 33
  start-page: 983
  year: 2013
  end-page: 995
  ident: bb0350
  article-title: Associations between retinal microvascular changes and dementia, cognitive functioning, and brain imaging abnormalities: a systematic review
  publication-title: J. Cereb. Blood Flow Metab.
– volume: 31
  start-page: 967
  year: 2008
  end-page: 977
  ident: bb0215
  article-title: Brain structural changes in obstructive sleep apnea
  publication-title: Sleep
– volume: 64
  start-page: 631
  year: 2009
  end-page: 636
  ident: bb0140
  article-title: Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome?
  publication-title: Thorax
– volume: 2
  start-page: 349
  year: 2008
  end-page: 364
  ident: bb0010
  article-title: Epidemiology of obstructive sleep apnea: a population-based perspective
  publication-title: Expert Rev. Respir. Med.
– volume: 1596
  start-page: 48
  year: 2015
  end-page: 57
  ident: bb0115
  article-title: Chronic intermittent hypoxia-induced neuronal apoptosis in the hippocampus is attenuated by telmisartan through suppression of iNOS/NO and inhibition of lipid peroxidation and inflammatory responses
  publication-title: Brain Res.
– volume: 8
  year: 2013
  ident: bb0030
  article-title: Sleep apnea and the risk of dementia: a population-based 5-year follow-up study in Taiwan
  publication-title: PLoS One
– volume: 3
  start-page: 387
  year: 2007
  end-page: 392
  ident: bb0400
  article-title: Validation of the ApneaLink for the screening of sleep apnea: a novel and simple single-channel recording device
  publication-title: J. Clin. Sleep Med.
– volume: 37
  start-page: 325
  year: 2013
  end-page: 333
  ident: bb0125
  article-title: Chronic intermittent hypoxia/reoxygenation facilitate amyloid-beta generation in mice
  publication-title: J. Alzheimer's Dis.
– volume: 2016
  year: 2016
  ident: bb0120
  article-title: Role of oxidative stress in the neurocognitive dysfunction of obstructive sleep apnea syndrome
  publication-title: Oxidative Med. Cell. Longev.
– volume: 56
  start-page: 45
  year: 2008
  end-page: 50
  ident: bb0460
  article-title: Sleep-disordered breathing and cognition in older women
  publication-title: J. Am. Geriatr. Soc.
– volume: 175
  start-page: 612
  year: 2007
  end-page: 617
  ident: bb0150
  article-title: Silent brain infarction and platelet activation in obstructive sleep apnea
  publication-title: Am. J. Respir. Crit. Care Med.
– volume: 70
  start-page: 888
  year: 2015
  end-page: 895
  ident: bb0090
  article-title: Association of incident obstructive sleep apnoea with outcomes in a large cohort of US veterans
  publication-title: Thorax
– volume: 63
  start-page: 453
  year: 2015
  end-page: 461
  ident: bb0040
  article-title: Associations between sleep-disordered breathing, nocturnal hypoxemia, and subsequent cognitive decline in older community-dwelling men: the Osteoporotic Fractures in Men Sleep Study
  publication-title: J. Am. Geriatr. Soc.
– volume: 36
  start-page: 555
  year: 2013
  end-page: 564
  ident: bb0065
  publication-title: Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial
– volume: 38
  start-page: 445
  year: 2014
  end-page: 453
  ident: bb0155
  article-title: Vascular impairment in Alzheimer's disease: the role of obstructive sleep apnea
  publication-title: J. Alzheimers Dis.
– volume: 34
  start-page: 111
  year: 2011
  end-page: 119
  ident: bb0275
  article-title: The effect of CPAP in normalizing daytime sleepiness, quality of life, and neurocognitive function in patients with moderate to severe OSA
  publication-title: Sleep
– volume: 65
  start-page: 1763
  year: 2017
  end-page: 1768
  ident: bb0295
  article-title: Low-dose aspirin use and cognitive function in older age: a systematic review and meta-analysis
  publication-title: J. Am. Geriatr. Soc.
– volume: 7
  start-page: 1391
  year: 2013
  end-page: 1393
  ident: bb0385
  article-title: The assessment of sleep apnoea as a risk factor in glaucoma
  publication-title: J. Clin. Diagn. Res.
– volume: 33
  start-page: 515
  year: 2010
  end-page: 521
  ident: bb0005
  article-title: Cognitive function and sleep related breathing disorders in a healthy elderly population: the SYNAPSE study
  publication-title: Sleep
– volume: 39
  start-page: 309
  year: 2016
  end-page: 316
  ident: bb0235
  article-title: Obstructive sleep apnea and 15-year cognitive decline: the atherosclerosis risk in communities (ARIC) study
  publication-title: Sleep
– volume: 85
  start-page: 1405
  year: 2014
  end-page: 1408
  ident: bb0270
  article-title: Treatment of sleep apnoea syndrome decreases cognitive decline in patients with Alzheimer's disease
  publication-title: J. Neurol. Neurosurg. Psychiatry
– volume: 2
  start-page: 804
  year: 2014
  end-page: 812
  ident: bb0285
  article-title: Continuous positive airway pressure in older people with obstructive sleep apnoea syndrome (PREDICT): a 12-month, multicentre, randomised trial
  publication-title: Lancet Respir. Med.
– volume: 5
  year: 2015
  ident: bb0130
  article-title: Serum amyloid-beta levels are increased in patients with obstructive sleep apnea syndrome
  publication-title: Sci. Rep.
– volume: 65
  start-page: 908
  year: 2010
  end-page: 914
  ident: bb0200
  article-title: Changes in brain morphology in patients with obstructive sleep apnoea
  publication-title: Thorax
– volume: 306
  start-page: 613
  year: 2011
  end-page: 619
  ident: bb0025
  article-title: Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women
  publication-title: JAMA
– volume: 35
  start-page: 41
  year: 2012
  end-page: 48
  ident: bb0210
  article-title: Magnetic resonance spectroscopy and neurocognitive dysfunction in obstructive sleep apnea before and after CPAP treatment
  publication-title: Sleep
– volume: 103
  start-page: 30
  year: 1993
  end-page: 36
  ident: bb0415
  article-title: Daytime sleepiness, snoring, and obstructive sleep apnea. The Epworth Sleepiness Scale
  publication-title: Chest
– volume: 106
  start-page: 2269
  year: 1999
  end-page: 2280
  ident: bb0430
  article-title: Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study
  publication-title: Ophthalmology
– volume: 9
  start-page: 63
  year: 2013
  end-page: 75
  ident: bb0070
  article-title: The global prevalence of dementia: a systematic review and metaanalysis
  publication-title: Alzheimers Dement.
– volume: 8
  start-page: 628
  year: 2009
  end-page: 634
  ident: bb0325
  article-title: Retinal microvasculature in acute lacunar stroke: a cross-sectional study
  publication-title: Lancet Neurol.
– volume: 15
  start-page: 952
  year: 2010
  end-page: 960
  ident: bb0410
  article-title: Diagnostic accuracy of a questionnaire and simple home monitoring device in detecting obstructive sleep apnoea in a Chinese population at high cardiovascular risk
  publication-title: Respirology
– volume: 385
  start-page: 2255
  year: 2015
  end-page: 2263
  ident: bb0080
  article-title: A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
  publication-title: Lancet
– volume: 38
  start-page: 1537
  year: 2015
  end-page: 1546
  ident: bb0135
  article-title: Chronic intermittent hypoxia induces chronic low-grade neuroinflammation in the dorsal hippocampus of mice
  publication-title: Sleep
– volume: 50
  start-page: 5609
  year: 2009
  end-page: 5613
  ident: bb0340
  article-title: Correlation of light-flicker-induced retinal vasodilation and retinal vascular caliber measurements in diabetes
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 22
  start-page: 452
  year: 2013
  end-page: 458
  ident: bb0170
  article-title: Obstructive sleep apnea as a risk factor for silent cerebral infarction
  publication-title: J. Sleep Res.
– volume: 40
  start-page: 665
  year: 2012
  end-page: 672
  ident: bb0105
  article-title: A 3-year longitudinal study of sleep disordered breathing in the elderly
  publication-title: Eur. Respir. J.
– volume: 76
  start-page: 1766
  year: 2011
  end-page: 1767
  ident: bb0320
  article-title: Fractal dimension of the retinal vasculature and risk of stroke: a nested case-control study
  publication-title: Neurology
– volume: 11
  year: 2016
  ident: bb0355
  article-title: Associations between retinal markers of microvascular disease and cognitive impairment in newly diagnosed type 2 diabetes mellitus: a case control study
  publication-title: PLoS One
– volume: 115
  start-page: 887
  year: 2008
  end-page: 892
  ident: bb0335
  article-title: Arteriolar oxygen saturation, cerebral blood flow, and retinal vessel diameters. The Rotterdam Study
  publication-title: Ophthalmology
– volume: 20
  start-page: 15
  year: 2016
  end-page: 23
  ident: bb0375
  article-title: Sleep apnea and retinal signs in cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis
  publication-title: Sleep Breath.
– volume: 288
  start-page: 67
  year: 2002
  end-page: 74
  ident: bb0330
  article-title: Cerebral white matter lesions, retinopathy, and incident clinical stroke
  publication-title: JAMA
– volume: 342
  start-page: 373
  year: 2013
  end-page: 377
  ident: bb0180
  article-title: Sleep drives metabolite clearance from the adult brain
  publication-title: Science
– volume: 36
  start-page: 763
  year: 2013
  end-page: 768
  ident: bb0050
  article-title: Vascular inflammation and sleep disordered breathing in a community-based cohort
  publication-title: Sleep
– volume: 88
  start-page: 463
  year: 2017
  end-page: 469
  ident: bb0225
  article-title: Sleep characteristics and cognitive impairment in the general population: The HypnoLaus study
  publication-title: Neurology
– volume: 358
  start-page: 1134
  year: 2001
  end-page: 1140
  ident: bb0315
  article-title: Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study
  publication-title: Lancet
– volume: 74
  start-page: 1237
  year: 2017
  end-page: 1245
  ident: bb0240
  article-title: Association of sleep-disordered breathing with cognitive function and risk of cognitive impairment: a systematic review and meta-analysis
  publication-title: JAMA Neurol.
– volume: 42
  start-page: S339
  year: 2014
  end-page: 52
  ident: bb0360
  article-title: Retinal microvasculature in Alzheimer's disease
  publication-title: J. Alzheimers Dis.
– volume: 84
  start-page: 1
  year: 2015
  end-page: 8
  ident: bb0035
  article-title: Sleep-disordered breathing advances cognitive decline in the elderly
  publication-title: Neurology
– volume: 36
  start-page: 709
  year: 2013
  end-page: 715
  ident: bb0060
  article-title: Obstructive sleep apnea as a risk factor for cerebral white matter change in a middle-aged and older general population
  publication-title: Sleep
– volume: 27
  start-page: 467
  year: 2004
  end-page: 473
  ident: bb0365
  article-title: Sleep-disordered breathing is not associated with the presence of retinal microvascular abnormalities: the Sleep Heart Health Study
  publication-title: Sleep
– volume: 375
  start-page: 919
  year: 2016
  end-page: 931
  ident: bb0445
  article-title: CPAP for prevention of cardiovascular events in obstructive sleep apnea
  publication-title: N. Engl. J. Med.
– volume: 8
  year: 2013
  ident: bb0390
  article-title: The potential association between obstructive sleep apnea and diabetic retinopathy in severe obesity-the role of hypoxemia
  publication-title: PLoS One
– volume: 11
  start-page: 265
  year: 2002
  end-page: 272
  ident: bb0455
  article-title: Measures of cognitive function in persons with varying degrees of sleep-disordered breathing: the Sleep Heart Health Study
  publication-title: J. Sleep Res.
– volume: 10
  start-page: 819
  year: 2011
  end-page: 828
  ident: bb0075
  article-title: The projected effect of risk factor reduction on Alzheimer's disease prevalence
  publication-title: Lancet Neurol.
– volume: 7
  start-page: 498
  year: 2006
  end-page: 507
  ident: bb0450
  article-title: Obstructive sleep apnea-hypopnea and neurocognitive functioning in the Sleep Heart Health Study
  publication-title: Sleep Med.
– volume: 66
  start-page: 213
  year: 2011
  end-page: 219
  ident: bb0405
  article-title: A simplified model of screening questionnaire and home monitoring for obstructive sleep apnoea in primary care
  publication-title: Thorax
– volume: 30
  start-page: 291
  year: 2007
  end-page: 303
  ident: bb0085
  article-title: Sleep-disordered breathing and cardiovascular risk
  publication-title: Sleep
– volume: 358
  start-page: 1134
  issue: 9288
  year: 2001
  ident: 10.1016/j.cct.2017.10.016_bb0315
  article-title: Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study
  publication-title: Lancet
  doi: 10.1016/S0140-6736(01)06253-5
– volume: 56
  start-page: 45
  issue: 1
  year: 2008
  ident: 10.1016/j.cct.2017.10.016_bb0460
  article-title: Sleep-disordered breathing and cognition in older women
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/j.1532-5415.2007.01506.x
– volume: 8
  issue: 11
  year: 2013
  ident: 10.1016/j.cct.2017.10.016_bb0390
  article-title: The potential association between obstructive sleep apnea and diabetic retinopathy in severe obesity-the role of hypoxemia
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0079521
– volume: 36
  start-page: 2568
  issue: 9
  year: 2015
  ident: 10.1016/j.cct.2017.10.016_bb0185
  article-title: Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults
  publication-title: Neurobiol. Aging
  doi: 10.1016/j.neurobiolaging.2015.05.004
– volume: 31
  start-page: 967
  issue: 7
  year: 2008
  ident: 10.1016/j.cct.2017.10.016_bb0215
  article-title: Brain structural changes in obstructive sleep apnea
  publication-title: Sleep
– volume: 22
  start-page: 452
  issue: 4
  year: 2013
  ident: 10.1016/j.cct.2017.10.016_bb0170
  article-title: Obstructive sleep apnea as a risk factor for silent cerebral infarction
  publication-title: J. Sleep Res.
  doi: 10.1111/jsr.12034
– volume: 37
  start-page: 325
  issue: 2
  year: 2013
  ident: 10.1016/j.cct.2017.10.016_bb0125
  article-title: Chronic intermittent hypoxia/reoxygenation facilitate amyloid-beta generation in mice
  publication-title: J. Alzheimer's Dis.
  doi: 10.3233/JAD-130419
– volume: 2016
  year: 2016
  ident: 10.1016/j.cct.2017.10.016_bb0120
  article-title: Role of oxidative stress in the neurocognitive dysfunction of obstructive sleep apnea syndrome
  publication-title: Oxidative Med. Cell. Longev.
  doi: 10.1155/2016/9626831
– volume: 24
  start-page: 170
  issue: 2
  year: 2016
  ident: 10.1016/j.cct.2017.10.016_bb0015
  article-title: Ubiquity of undiagnosed sleep disordered breathing in community-dwelling older male veterans
  publication-title: Am. J. Geriatr. Psychiatry
  doi: 10.1016/j.jagp.2015.08.004
– volume: 385
  start-page: 2255
  issue: 9984
  year: 2015
  ident: 10.1016/j.cct.2017.10.016_bb0080
  article-title: A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(15)60461-5
– volume: 59
  start-page: 2217
  issue: 12
  year: 2011
  ident: 10.1016/j.cct.2017.10.016_bb0100
  article-title: Associations between sleep architecture and sleep-disordered breathing and cognition in older community-dwelling men: the Osteoporotic Fractures in Men Sleep Study
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/j.1532-5415.2011.03731.x
– volume: 65
  start-page: 908
  issue: 10
  year: 2010
  ident: 10.1016/j.cct.2017.10.016_bb0200
  article-title: Changes in brain morphology in patients with obstructive sleep apnoea
  publication-title: Thorax
  doi: 10.1136/thx.2009.126730
– volume: 375
  start-page: 919
  issue: 10
  year: 2016
  ident: 10.1016/j.cct.2017.10.016_bb0445
  article-title: CPAP for prevention of cardiovascular events in obstructive sleep apnea
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1606599
– volume: 34
  start-page: 111
  issue: 1
  year: 2011
  ident: 10.1016/j.cct.2017.10.016_bb0275
  article-title: The effect of CPAP in normalizing daytime sleepiness, quality of life, and neurocognitive function in patients with moderate to severe OSA
  publication-title: Sleep
  doi: 10.1093/sleep/34.1.111
– volume: 40
  start-page: 665
  issue: 3
  year: 2012
  ident: 10.1016/j.cct.2017.10.016_bb0105
  article-title: A 3-year longitudinal study of sleep disordered breathing in the elderly
  publication-title: Eur. Respir. J.
  doi: 10.1183/09031936.00133011
– volume: 36
  start-page: 763
  issue: 5
  year: 2013
  ident: 10.1016/j.cct.2017.10.016_bb0050
  article-title: Vascular inflammation and sleep disordered breathing in a community-based cohort
  publication-title: Sleep
  doi: 10.5665/sleep.2644
– volume: 2
  start-page: 349
  issue: 3
  year: 2008
  ident: 10.1016/j.cct.2017.10.016_bb0010
  article-title: Epidemiology of obstructive sleep apnea: a population-based perspective
  publication-title: Expert Rev. Respir. Med.
  doi: 10.1586/17476348.2.3.349
– volume: 33
  start-page: 983
  issue: 7
  year: 2013
  ident: 10.1016/j.cct.2017.10.016_bb0350
  article-title: Associations between retinal microvascular changes and dementia, cognitive functioning, and brain imaging abnormalities: a systematic review
  publication-title: J. Cereb. Blood Flow Metab.
  doi: 10.1038/jcbfm.2013.58
– volume: 33
  start-page: 515
  issue: 4
  year: 2010
  ident: 10.1016/j.cct.2017.10.016_bb0005
  article-title: Cognitive function and sleep related breathing disorders in a healthy elderly population: the SYNAPSE study
  publication-title: Sleep
  doi: 10.1093/sleep/33.4.515
– volume: 74
  start-page: 1237
  issue: 10
  year: 2017
  ident: 10.1016/j.cct.2017.10.016_bb0240
  article-title: Association of sleep-disordered breathing with cognitive function and risk of cognitive impairment: a systematic review and meta-analysis
  publication-title: JAMA Neurol.
  doi: 10.1001/jamaneurol.2017.2180
– volume: 3
  start-page: 387
  issue: 4
  year: 2007
  ident: 10.1016/j.cct.2017.10.016_bb0400
  article-title: Validation of the ApneaLink for the screening of sleep apnea: a novel and simple single-channel recording device
  publication-title: J. Clin. Sleep Med.
  doi: 10.5664/jcsm.26861
– volume: 27
  start-page: 143
  issue: 3
  year: 2003
  ident: 10.1016/j.cct.2017.10.016_bb0435
  article-title: Revised formulas for summarizing retinal vessel diameters
  publication-title: Curr. Eye Res.
  doi: 10.1076/ceyr.27.3.143.16049
– volume: 115
  start-page: 1951
  issue: 11
  year: 2008
  ident: 10.1016/j.cct.2017.10.016_bb0440
  article-title: The retinal vasculature as a fractal: methodology, reliability, and relationship to blood pressure
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2008.05.029
– volume: 63
  start-page: 453
  issue: 3
  year: 2015
  ident: 10.1016/j.cct.2017.10.016_bb0040
  article-title: Associations between sleep-disordered breathing, nocturnal hypoxemia, and subsequent cognitive decline in older community-dwelling men: the Osteoporotic Fractures in Men Sleep Study
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/jgs.13321
– volume: 31
  start-page: 186
  issue: 2
  year: 2016
  ident: 10.1016/j.cct.2017.10.016_bb0095
  article-title: The cognitive effects of obstructive sleep apnea: an updated meta-analysis
  publication-title: Arch. Clin. Neuropsychol.
– volume: 25
  start-page: 121
  year: 2016
  ident: 10.1016/j.cct.2017.10.016_bb0255
  article-title: Effects of continuous positive airway pressure treatment on glucose metabolism in patients with obstructive sleep apnea
  publication-title: Sleep Med. Rev.
  doi: 10.1016/j.smrv.2015.03.002
– volume: 15
  start-page: 952
  issue: 6
  year: 2010
  ident: 10.1016/j.cct.2017.10.016_bb0410
  article-title: Diagnostic accuracy of a questionnaire and simple home monitoring device in detecting obstructive sleep apnoea in a Chinese population at high cardiovascular risk
  publication-title: Respirology
  doi: 10.1111/j.1440-1843.2010.01797.x
– volume: 70
  start-page: 1544
  issue: 12
  year: 2013
  ident: 10.1016/j.cct.2017.10.016_bb0190
  article-title: Modification of the relationship of the apolipoprotein E epsilon4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep
  publication-title: JAMA Neurol.
  doi: 10.1001/jamaneurol.2013.4215
– volume: 5
  start-page: e12065
  issue: 8
  year: 2010
  ident: 10.1016/j.cct.2017.10.016_bb0055
  article-title: The impact of obstructive sleep apnea on metabolic and inflammatory markers in consecutive patients with metabolic syndrome
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0012065
– volume: 56
  start-page: 2076
  issue: 11
  year: 2008
  ident: 10.1016/j.cct.2017.10.016_bb0265
  article-title: Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/j.1532-5415.2008.01934.x
– volume: 9
  start-page: 63
  issue: 1
  year: 2013
  ident: 10.1016/j.cct.2017.10.016_bb0070
  article-title: The global prevalence of dementia: a systematic review and metaanalysis
  publication-title: Alzheimers Dement.
  doi: 10.1016/j.jalz.2012.11.007
– volume: 10
  start-page: 819
  issue: 9
  year: 2011
  ident: 10.1016/j.cct.2017.10.016_bb0075
  article-title: The projected effect of risk factor reduction on Alzheimer's disease prevalence
  publication-title: Lancet Neurol.
  doi: 10.1016/S1474-4422(11)70072-2
– volume: 38
  start-page: 445
  issue: 2
  year: 2014
  ident: 10.1016/j.cct.2017.10.016_bb0155
  article-title: Vascular impairment in Alzheimer's disease: the role of obstructive sleep apnea
  publication-title: J. Alzheimers Dis.
  doi: 10.3233/JAD-131046
– volume: 183
  start-page: 1419
  issue: 10
  year: 2011
  ident: 10.1016/j.cct.2017.10.016_bb0205
  article-title: Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201005-0693OC
– volume: 85
  start-page: 1405
  issue: 12
  year: 2014
  ident: 10.1016/j.cct.2017.10.016_bb0270
  article-title: Treatment of sleep apnoea syndrome decreases cognitive decline in patients with Alzheimer's disease
  publication-title: J. Neurol. Neurosurg. Psychiatry
  doi: 10.1136/jnnp-2013-307544
– volume: 38
  start-page: 1537
  issue: 10
  year: 2015
  ident: 10.1016/j.cct.2017.10.016_bb0135
  article-title: Chronic intermittent hypoxia induces chronic low-grade neuroinflammation in the dorsal hippocampus of mice
  publication-title: Sleep
  doi: 10.5665/sleep.5042
– volume: 50
  start-page: 5609
  issue: 12
  year: 2009
  ident: 10.1016/j.cct.2017.10.016_bb0340
  article-title: Correlation of light-flicker-induced retinal vasodilation and retinal vascular caliber measurements in diabetes
  publication-title: Invest. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.09-3442
– volume: 175
  start-page: 612
  issue: 6
  year: 2007
  ident: 10.1016/j.cct.2017.10.016_bb0150
  article-title: Silent brain infarction and platelet activation in obstructive sleep apnea
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.200608-1141OC
– volume: 2
  issue: 5
  year: 2012
  ident: 10.1016/j.cct.2017.10.016_bb0300
  article-title: Does low-dose acetylsalicylic acid prevent cognitive decline in women with high cardiovascular risk? A 5-year follow-up of a non-demented population-based cohort of Swedish elderly women
  publication-title: BMJ Open
  doi: 10.1136/bmjopen-2012-001288
– volume: 36
  start-page: 709
  issue: 5
  year: 2013
  ident: 10.1016/j.cct.2017.10.016_bb0060
  article-title: Obstructive sleep apnea as a risk factor for cerebral white matter change in a middle-aged and older general population
  publication-title: Sleep
  doi: 10.5665/sleep.2632
– volume: 1596
  start-page: 48
  year: 2015
  ident: 10.1016/j.cct.2017.10.016_bb0115
  article-title: Chronic intermittent hypoxia-induced neuronal apoptosis in the hippocampus is attenuated by telmisartan through suppression of iNOS/NO and inhibition of lipid peroxidation and inflammatory responses
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2014.11.035
– volume: 40
  start-page: 408
  issue: 4
  year: 2012
  ident: 10.1016/j.cct.2017.10.016_bb0380
  article-title: Glaucoma and obstructive sleep apnoea syndrome
  publication-title: Clin. Exp. Ophthalmol.
  doi: 10.1111/j.1442-9071.2012.02768.x
– volume: 317
  start-page: 407
  issue: 4
  year: 2017
  ident: 10.1016/j.cct.2017.10.016_bb0020
  article-title: Screening for obstructive sleep apnea in adults: US preventive services task force recommendation statement
  publication-title: JAMA
  doi: 10.1001/jama.2016.20325
– volume: 38
  start-page: 179
  issue: 2
  year: 2015
  ident: 10.1016/j.cct.2017.10.016_bb0230
  article-title: Sleep breathing disorders and cognitive function in the elderly: an 8-year follow-up study. The proof-synapse cohort
  publication-title: Sleep
  doi: 10.5665/sleep.4392
– volume: 64
  start-page: 631
  issue: 7
  year: 2009
  ident: 10.1016/j.cct.2017.10.016_bb0140
  article-title: Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome?
  publication-title: Thorax
– volume: 5
  issue: 7
  year: 2016
  ident: 10.1016/j.cct.2017.10.016_bb0370
  article-title: Sex-specific association of obstructive sleep apnea with retinal microvascular signs: the multi-ethnic study of atherosclerosis
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.116.003598
– volume: 30
  start-page: 184
  issue: 1
  year: 2006
  ident: 10.1016/j.cct.2017.10.016_bb0425
  article-title: The NIH MRI study of normal brain development
  publication-title: NeuroImage
  doi: 10.1016/j.neuroimage.2005.09.068
– volume: 38
  start-page: 2106
  issue: 12
  year: 2015
  ident: 10.1016/j.cct.2017.10.016_bb0145
  article-title: Involvement of inflammation in Alzheimer's disease pathogenesis and therapeutic potential of anti-inflammatory agents
  publication-title: Arch. Pharm. Res.
  doi: 10.1007/s12272-015-0648-x
– volume: 1
  start-page: 159
  issue: 2
  year: 2005
  ident: 10.1016/j.cct.2017.10.016_bb0165
  article-title: Associations of sleep-disordered breathing and cerebral changes on MRI
  publication-title: J. Clin. Sleep Med.
  doi: 10.5664/jcsm.26311
– volume: 373
  start-page: 1849
  issue: 9678
  year: 2009
  ident: 10.1016/j.cct.2017.10.016_bb0290
  article-title: Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials
  publication-title: Lancet
  doi: 10.1016/S0140-6736(09)60503-1
– volume: 115
  start-page: 887
  issue: 5
  year: 2008
  ident: 10.1016/j.cct.2017.10.016_bb0335
  article-title: Arteriolar oxygen saturation, cerebral blood flow, and retinal vessel diameters. The Rotterdam Study
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2007.06.036
– volume: 76
  start-page: 1766
  issue: 20
  year: 2011
  ident: 10.1016/j.cct.2017.10.016_bb0320
  article-title: Fractal dimension of the retinal vasculature and risk of stroke: a nested case-control study
  publication-title: Neurology
  doi: 10.1212/WNL.0b013e31821a7d7d
– volume: 3
  start-page: 179
  issue: 3
  year: 2004
  ident: 10.1016/j.cct.2017.10.016_bb0305
  article-title: Is retinal photography useful in the measurement of stroke risk?
  publication-title: Lancet Neurol.
  doi: 10.1016/S1474-4422(04)00682-9
– volume: 11
  start-page: 1
  issue: 1
  year: 2002
  ident: 10.1016/j.cct.2017.10.016_bb0110
  article-title: Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits
  publication-title: J. Sleep Res.
  doi: 10.1046/j.1365-2869.2002.00289.x
– volume: 306
  start-page: 613
  issue: 6
  year: 2011
  ident: 10.1016/j.cct.2017.10.016_bb0025
  article-title: Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women
  publication-title: JAMA
  doi: 10.1001/jama.2011.1115
– volume: 84
  start-page: 296
  issue: 3
  year: 2015
  ident: 10.1016/j.cct.2017.10.016_bb0160
  article-title: Associations of brain lesions at autopsy with polysomnography features before death
  publication-title: Neurology
  doi: 10.1212/WNL.0000000000001163
– volume: 93
  start-page: 1778
  issue: 12
  year: 2015
  ident: 10.1016/j.cct.2017.10.016_bb0045
  article-title: Evidence of neurodegeneration in obstructive sleep apnea: relationship between obstructive sleep apnea and cognitive dysfunction in the elderly
  publication-title: J. Neurosci. Res.
  doi: 10.1002/jnr.23634
– volume: 11
  start-page: 265
  issue: 3
  year: 2002
  ident: 10.1016/j.cct.2017.10.016_bb0455
  article-title: Measures of cognitive function in persons with varying degrees of sleep-disordered breathing: the Sleep Heart Health Study
  publication-title: J. Sleep Res.
  doi: 10.1046/j.1365-2869.2002.00308.x
– volume: 84
  start-page: 1
  year: 2015
  ident: 10.1016/j.cct.2017.10.016_bb0035
  article-title: Sleep-disordered breathing advances cognitive decline in the elderly
  publication-title: Neurology
  doi: 10.1212/WNL.0000000000001566
– volume: 35
  start-page: 41
  issue: 1
  year: 2012
  ident: 10.1016/j.cct.2017.10.016_bb0210
  article-title: Magnetic resonance spectroscopy and neurocognitive dysfunction in obstructive sleep apnea before and after CPAP treatment
  publication-title: Sleep
  doi: 10.5665/sleep.1582
– volume: 88
  start-page: 463
  issue: 5
  year: 2017
  ident: 10.1016/j.cct.2017.10.016_bb0225
  article-title: Sleep characteristics and cognitive impairment in the general population: The HypnoLaus study
  publication-title: Neurology
  doi: 10.1212/WNL.0000000000003557
– volume: 151
  start-page: 786
  issue: 4
  year: 2017
  ident: 10.1016/j.cct.2017.10.016_bb0245
  article-title: Effects of CPAP and mandibular advancement devices on health-related quality of life in OSA: a systematic review and meta-analysis
  publication-title: Chest
  doi: 10.1016/j.chest.2017.01.020
– volume: 5
  year: 2015
  ident: 10.1016/j.cct.2017.10.016_bb0130
  article-title: Serum amyloid-beta levels are increased in patients with obstructive sleep apnea syndrome
  publication-title: Sci. Rep.
– volume: 66
  start-page: 213
  issue: 3
  year: 2011
  ident: 10.1016/j.cct.2017.10.016_bb0405
  article-title: A simplified model of screening questionnaire and home monitoring for obstructive sleep apnoea in primary care
  publication-title: Thorax
  doi: 10.1136/thx.2010.152801
– volume: 35
  start-page: 1603
  issue: 12
  year: 2012
  ident: 10.1016/j.cct.2017.10.016_bb0220
  article-title: Sex differences in white matter alterations accompanying obstructive sleep apnea
  publication-title: Sleep
  doi: 10.5665/sleep.2228
– volume: 70
  start-page: 888
  issue: 9
  year: 2015
  ident: 10.1016/j.cct.2017.10.016_bb0090
  article-title: Association of incident obstructive sleep apnoea with outcomes in a large cohort of US veterans
  publication-title: Thorax
  doi: 10.1136/thoraxjnl-2015-206970
– volume: 11
  start-page: 519
  issue: 5
  year: 2015
  ident: 10.1016/j.cct.2017.10.016_bb0260
  article-title: Protective effect of long-term CPAP therapy on cognitive performance in elderly patients with severe OSA: The PROOF study
  publication-title: J. Clin. Sleep Med.
  doi: 10.5664/jcsm.4694
– volume: 27
  start-page: 467
  issue: 3
  year: 2004
  ident: 10.1016/j.cct.2017.10.016_bb0365
  article-title: Sleep-disordered breathing is not associated with the presence of retinal microvascular abnormalities: the Sleep Heart Health Study
  publication-title: Sleep
  doi: 10.1093/sleep/27.3.467
– volume: 30
  start-page: 291
  issue: 3
  year: 2007
  ident: 10.1016/j.cct.2017.10.016_bb0085
  article-title: Sleep-disordered breathing and cardiovascular risk
  publication-title: Sleep
  doi: 10.1093/sleep/30.3.291
– volume: 140
  start-page: 1157
  issue: 6
  year: 2005
  ident: 10.1016/j.cct.2017.10.016_bb0345
  article-title: Retinopathy in persons with impaired glucose metabolism: the Australian Diabetes Obesity and Lifestyle (AusDiab) study
  publication-title: Am J. Ophthalmol.
  doi: 10.1016/j.ajo.2005.07.030
– volume: 20
  start-page: 835
  issue: 10
  year: 1997
  ident: 10.1016/j.cct.2017.10.016_bb0420
  article-title: An instrument to measure functional status outcomes for disorders of excessive sleepiness
  publication-title: Sleep
– volume: 39
  start-page: 309
  issue: 2
  year: 2016
  ident: 10.1016/j.cct.2017.10.016_bb0235
  article-title: Obstructive sleep apnea and 15-year cognitive decline: the atherosclerosis risk in communities (ARIC) study
  publication-title: Sleep
  doi: 10.5665/sleep.5434
– volume: 35
  start-page: 1593
  issue: 12
  year: 2012
  ident: 10.1016/j.cct.2017.10.016_bb0280
  article-title: Effects of continuous positive airway pressure on neurocognitive function in obstructive sleep apnea patients: The Apnea Positive Pressure Long-term Efficacy Study (APPLES)
  publication-title: Sleep
  doi: 10.5665/sleep.2226
– volume: 42
  start-page: S339
  issue: Suppl. 4
  year: 2014
  ident: 10.1016/j.cct.2017.10.016_bb0360
  article-title: Retinal microvasculature in Alzheimer's disease
  publication-title: J. Alzheimers Dis.
  doi: 10.3233/JAD-141596
– volume: 70
  start-page: 1537
  issue: 12
  year: 2013
  ident: 10.1016/j.cct.2017.10.016_bb0195
  article-title: Self-reported sleep and beta-amyloid deposition in community-dwelling older adults
  publication-title: JAMA Neurol.
– volume: 65
  start-page: 1763
  issue: 8
  year: 2017
  ident: 10.1016/j.cct.2017.10.016_bb0295
  article-title: Low-dose aspirin use and cognitive function in older age: a systematic review and meta-analysis
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/jgs.14883
– volume: 71
  start-page: 275
  issue: 3
  year: 2016
  ident: 10.1016/j.cct.2017.10.016_bb0250
  article-title: CPAP therapy reduces blood pressure for patients with obstructive sleep apnoea: an update meta-analysis of randomized clinical trials
  publication-title: Acta Cardiol.
  doi: 10.1080/AC.71.3.3152087
– volume: 8
  start-page: 628
  issue: 7
  year: 2009
  ident: 10.1016/j.cct.2017.10.016_bb0325
  article-title: Retinal microvasculature in acute lacunar stroke: a cross-sectional study
  publication-title: Lancet Neurol.
  doi: 10.1016/S1474-4422(09)70131-0
– volume: 103
  start-page: 30
  issue: 1
  year: 1993
  ident: 10.1016/j.cct.2017.10.016_bb0415
  article-title: Daytime sleepiness, snoring, and obstructive sleep apnea. The Epworth Sleepiness Scale
  publication-title: Chest
  doi: 10.1378/chest.103.1.30
– volume: 36
  start-page: 555
  issue: 2
  year: 2013
  ident: 10.1016/j.cct.2017.10.016_bb0065
  publication-title: Contemp. Clin. Trials
  doi: 10.1016/j.cct.2013.09.014
– volume: 32
  start-page: 1791
  issue: 9
  year: 2012
  ident: 10.1016/j.cct.2017.10.016_bb0395
  article-title: High prevalence of sleep disordered breathing in patients with diabetic macular edema
  publication-title: Retina
  doi: 10.1097/IAE.0b013e318259568b
– volume: 7
  start-page: 498
  issue: 6
  year: 2006
  ident: 10.1016/j.cct.2017.10.016_bb0450
  article-title: Obstructive sleep apnea-hypopnea and neurocognitive functioning in the Sleep Heart Health Study
  publication-title: Sleep Med.
  doi: 10.1016/j.sleep.2006.02.005
– volume: 133
  start-page: 1987
  issue: Pt 7
  year: 2010
  ident: 10.1016/j.cct.2017.10.016_bb0310
  article-title: Retinal microvascular abnormalities and subclinical magnetic resonance imaging brain infarct: a prospective study
  publication-title: Brain
  doi: 10.1093/brain/awq127
– volume: 8
  issue: 10
  year: 2013
  ident: 10.1016/j.cct.2017.10.016_bb0030
  article-title: Sleep apnea and the risk of dementia: a population-based 5-year follow-up study in Taiwan
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0078655
– volume: 11
  issue: 1
  year: 2016
  ident: 10.1016/j.cct.2017.10.016_bb0355
  article-title: Associations between retinal markers of microvascular disease and cognitive impairment in newly diagnosed type 2 diabetes mellitus: a case control study
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0147160
– volume: 7
  start-page: 1391
  issue: 7
  year: 2013
  ident: 10.1016/j.cct.2017.10.016_bb0385
  article-title: The assessment of sleep apnoea as a risk factor in glaucoma
  publication-title: J. Clin. Diagn. Res.
– volume: 20
  start-page: 15
  issue: 1
  year: 2016
  ident: 10.1016/j.cct.2017.10.016_bb0375
  article-title: Sleep apnea and retinal signs in cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis
  publication-title: Sleep Breath.
  doi: 10.1007/s11325-015-1177-z
– volume: 326
  start-page: 1005
  issue: 5955
  year: 2009
  ident: 10.1016/j.cct.2017.10.016_bb0175
  article-title: Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle
  publication-title: Science
  doi: 10.1126/science.1180962
– volume: 288
  start-page: 67
  issue: 1
  year: 2002
  ident: 10.1016/j.cct.2017.10.016_bb0330
  article-title: Cerebral white matter lesions, retinopathy, and incident clinical stroke
  publication-title: JAMA
  doi: 10.1001/jama.288.1.67
– volume: 342
  start-page: 373
  issue: 6156
  year: 2013
  ident: 10.1016/j.cct.2017.10.016_bb0180
  article-title: Sleep drives metabolite clearance from the adult brain
  publication-title: Science
  doi: 10.1126/science.1241224
– volume: 106
  start-page: 2269
  issue: 12
  year: 1999
  ident: 10.1016/j.cct.2017.10.016_bb0430
  article-title: Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study
  publication-title: Ophthalmology
  doi: 10.1016/S0161-6420(99)90525-0
– volume: 2
  start-page: 804
  issue: 10
  year: 2014
  ident: 10.1016/j.cct.2017.10.016_bb0285
  article-title: Continuous positive airway pressure in older people with obstructive sleep apnoea syndrome (PREDICT): a 12-month, multicentre, randomised trial
  publication-title: Lancet Respir. Med.
  doi: 10.1016/S2213-2600(14)70172-9
SSID ssj0036565
Score 2.2174845
Snippet Sleep disordered breathing (SDB) is highly prevalent in older adults. Increasing evidence links SDB to the risk of dementia, mediated via a number of pathways,...
AbstractPurposeSleep disordered breathing (SDB) is highly prevalent in older adults. Increasing evidence links SDB to the risk of dementia, mediated via a...
SourceID pubmedcentral
proquest
pubmed
crossref
nii
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 101
SubjectTerms 2736 Pharmacology (medical)
Aged
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Aspirin
Aspirin - therapeutic use
Brain magnetic resonance imaging
Cardiovascular
Cerebrovascular Circulation
Cerebrovascular Circulation - drug effects
Cognition
Cognition - drug effects
Cognitive decline
Dementia
Dose-Response Relationship, Drug
Double-Blind Method
Female
Hematology, Oncology, and Palliative Medicine
Humans
Low-dose aspirin
Male
Mental Status and Dementia Tests
Microvessels
Microvessels - drug effects
Prospective Studies
Research Design
Retina
Retina - drug effects
Retinal vascular imaging
Sleep Apnea Syndromes
Sleep Apnea Syndromes - drug therapy
Sleep Apnea Syndromes - physiopathology
Sleep disordered breathing
Title The Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study
URI https://www.clinicalkey.com/#!/content/1-s2.0-S1551714417304445
https://www.clinicalkey.es/playcontent/1-s2.0-S1551714417304445
https://dx.doi.org/10.1016/j.cct.2017.10.016
https://cir.nii.ac.jp/crid/1873679867427460864
https://www.ncbi.nlm.nih.gov/pubmed/29097299
https://www.proquest.com/docview/1963279785
https://pubmed.ncbi.nlm.nih.gov/PMC6753831
Volume 64
WOSCitedRecordID wos000423647200014&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVESC
  databaseName: ScienceDirect database
  customDbUrl:
  eissn: 1559-2030
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0036565
  issn: 1551-7144
  databaseCode: AIEXJ
  dateStart: 20050201
  isFulltext: true
  titleUrlDefault: https://www.sciencedirect.com
  providerName: Elsevier
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLZ2QYgXxJ0Cm4zEEyVVkzix81hNhYFgQ-tgfYsc2xWtqmRq02n8jv1hjm9pNsYGD0hVVLk5duTz9ZwTnxtCbwqRJlJJFUQc_m6godOAM0kDSQvBFeGhktw0m6AHB2w8zr5ubFz4XJizOS1Ldn6enf5XVsMYMFunzv4Du5tJYQC-A9PhCmyH618zfuRLRZvaG-sQocNVDUtayXDE5bSRfDZNsTYtsobrEI-B9sNPTTDkaK7UKRitZaV40F24M0TrfLBtqG01JxdzMDo4PBoGg9GgVcDWF0RoF8Ta85mZx2ZrmgMfHXyms9-7g7lpknjisv9tnMlSajFXVwvVeASOquJn2f3c655UlWzm-cAXK7iz193XBzm1w6A75QjZlVOOdfrN97awTsKAhrZ-pJfmKWmJ49BNYTW7E-u_KQ17fjHrCaGDa0Pa0-F-YbqJtiOaZCAqtwcfh-NPXsHHYAInpgyvW947y03Y4JVJ_mTubJbT6XUvNVdjc1vGzvEDdN-9peCBRddDtDHjj9DdLy4O4zG6AJBhAzJcTfBlkGEPsne4DTEMQMEOYthBTBM7iGH4GIhhBzHcQMxQtiCmqWq9vocYNhB7gr69Hx7v7QeuvUcg0j6rAxmDdQzWqaCCibQQujeAiIsETMqYE8VpQdhETECjFCpisp9JqlIWJkVERZpGKn6KtsqqVM8RnsRKe3hZXzJGMlZkRMSUFzEIGiqTSdZBfc-FXLja97oFyzz3QY6zHBiXa8bpIRjpoLcNyakt_HLTzZFnbe4zmkEH54Cwm4jodURq6YTJMg_zZZT385FGmgZaCOqYEJJ0EGkonaFsDeDbFtwB1MEG6GvIaKw9sCklESXAkJR00GuPxxyUjPYc8lJVK3gQUNMRzSiDpZ9ZfDabEmW6AlgGe0wvIbe5QRewv_xLOf1hCtmnFMytOHxxy3O9RPfWIuEV2qoXK7WD7oizerpc7KJNOma77j_6Cy6rD5Q
linkProvider Elsevier
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Study+of+Neurocognitive+Outcomes%2C+Radiological+and+Retinal+Effects+of+Aspirin+in+Sleep+Apnoea-+rationale+and+methodology+of+the+SNORE-ASA+study&rft.jtitle=Contemporary+Clinical+Trials&rft.au=Stephanie+Alison+Ward&rft.au=Elsdon+Storey&rft.au=Robyn+L.+Woods&rft.au=Garun+S.+Hamilton&rft.date=2018-01-01&rft.pub=Elsevier+BV&rft.issn=1551-7144&rft.volume=64&rft.spage=101&rft.epage=111&rft_id=info:doi/10.1016%2Fj.cct.2017.10.016
thumbnail_m http://cvtisr.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F15517144%2FS1551714417X00128%2Fcov150h.gif