Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry

Glycosylated α-dystroglycan (α-DG) serves as cellular entry receptor for multiple pathogens, and defects in its glycosylation cause hereditary Walker-Warburg syndrome (WWS). At least eight proteins are critical to glycosylate α-DG, but many genes mutated in WWS remain unknown. To identify modifiers...

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Vydané v:	Science (American Association for the Advancement of Science) Ročník 340; číslo 6131; s. 479
Hlavní autori:	Jae, Lucas T, Raaben, Matthijs, Riemersma, Moniek, van Beusekom, Ellen, Blomen, Vincent A, Velds, Arno, Kerkhoven, Ron M, Carette, Jan E, Topaloglu, Haluk, Meinecke, Peter, Wessels, Marja W, Lefeber, Dirk J, Whelan, Sean P, van Bokhoven, Hans, Brummelkamp, Thijn R
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 26.04.2013
Predmet:	Amino Acid Sequence Cell Line Dystroglycans - metabolism Female Glycosylation Haploidy Host-Pathogen Interactions - genetics Humans Infant Lassa Fever - genetics Lassa Fever - virology Lassa virus - physiology Male Membrane Proteins - genetics Molecular Sequence Data Mutation Pedigree Proteome - metabolism Virus Internalization Walker-Warburg Syndrome - genetics
ISSN:	1095-9203, 1095-9203
On-line prístup:	Zistit podrobnosti o prístupe
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