Neuroprotective effects of vinpocetine, as a phosphodiesterase 1 inhibitor, on long-term potentiation in a rat model of Alzheimer’s disease

Background Vinpocetine (Vin) is known as a phosphodiesterase 1 inhibitor (PDE1-I) drug with multilateral effects, including antioxidant and anti-inflammatory activity. In this research, we investigated the neuroprotective and therapeutic effects of Vin through hippocampal synaptic plasticity on a ra...

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Bibliographic Details
Published in:	BMC neuroscience Vol. 24; no. 1; pp. 20 - 10
Main Authors:	Shekarian, Meysam, Salehi, Iraj, Raoufi, Safoura, Asadbegi, Masoumeh, Kourosh-Arami, Masoumeh, Komaki, Alireza
Format:	Journal Article
Language:	English
Published:	London BioMed Central 16.03.2023 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - metabolism Animal cognition Animal Models Animals Anti-inflammatory agents Beta-amyloid Biomedical and Life Sciences Biomedicine Brain Care and treatment Dentate gyrus Development and progression Drug dosages Electrodes Excitatory postsynaptic potentials Hippocampal plasticity Hippocampus Hippocampus - metabolism Inflammation Kinases Long-Term Potentiation Male Memory Neurobiology Neurodegenerative diseases Neuroprotection Neuroprotective agents Neuroprotective Agents - pharmacology Neurosciences Oral administration Oxidative stress Peptide Fragments - pharmacology Peptides Phosphodiesterase Phosphodiesterase1 inhibitor Phosphoric Diester Hydrolases - adverse effects Phosphoric Diester Hydrolases - metabolism Proteins Rats Rats, Wistar Stereotaxic surgery Surveillance Synaptic plasticity Testing Vinpocetine β-Amyloid Iran United States > US Phosphodiesterase1 inhibitor Alzheimer’s disease Long-term potentiation Hippocampus Beta-amyloid Vinpocetine
ISSN:	1471-2202, 1471-2202
Online Access:	Get full text
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