Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer

Research about the role of gut microbiome in colorectal cancer (CRC) is a newly emerging field of study. Gut microbiota modulation, with the aim to reverse established microbial dysbiosis, is a novel strategy for prevention and treatment of CRC. Different strategies including probiotics, prebiotics,...

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Vydáno v:Oncogene Ročník 39; číslo 26; s. 4925 - 4943
Hlavní autoři: Fong, Winnie, Li, Qing, Yu, Jun
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York Nature Publishing Group 25.06.2020
Témata:
Antibiotics
Colonization
Colorectal cancer
Colorectal carcinoma
Cytotoxicity
Dysbacteriosis
Fecal microflora
Gut microbiota
Immune system
Innate immunity
Intestinal microflora
Microbiomes
Microbiota
Probiotics
Transplantation
Tumor cells
ISSN:0950-9232, 1476-5594, 1476-5594
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Shrnutí:Research about the role of gut microbiome in colorectal cancer (CRC) is a newly emerging field of study. Gut microbiota modulation, with the aim to reverse established microbial dysbiosis, is a novel strategy for prevention and treatment of CRC. Different strategies including probiotics, prebiotics, postbiotics, antibiotics, and fecal microbiota transplantation (FMT) have been employed. Although these strategies show promising results, mechanistically by correcting microbiota composition, modulating innate immune system, enhancing gut barrier function, preventing pathogen colonization and exerting selective cytotoxicity against tumor cells, it should be noted that they are accompanied by risks and controversies that can potentially introduce clinical complications. During bench-to-bedside translation, evaluation of risk-and-benefit ratio, as well as patient selection, should be carefully performed. In view of the individualized host response to gut microbiome intervention, developing personalized microbiome therapy may be the key to successful clinical treatment.
Bibliografie:ObjectType-Article-1
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ISSN:0950-9232
1476-5594
1476-5594
DOI:10.1038/s41388-020-1341-1