Vaccination and the risk of systemic lupus erythematosus: a meta-analysis of observational studies

Objective This meta-analysis aims to explore the potential link between vaccines and systemic lupus erythematosus (SLE). Methods We systematically searched PubMed, Cochrane Library, and Embase for observational studies from inception to September 3, 2023, using medical subject headings (MeSH) and ke...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Arthritis research & therapy Ročník 26; číslo 1; s. 60 - 11
Hlavní autoři: Wang, Meijiao, Gu, Huanpeng, Zhai, Yingqi, Li, Xuanlin, Huang, Lin, Li, Haichang, Xie, Zhijun, Wen, Chengping
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 04.03.2024
BioMed Central Ltd
Springer Nature B.V
BMC
Témata:
Autoimmune diseases
B cells
Care and treatment
Cohort analysis
Complications and side effects
Coronaviruses
COVID-19 Vaccines
Diagnosis
Dosage and administration
Hepatitis B
Human papillomavirus
Humans
Immunosuppression
Infections
Influenza
Influenza Vaccines
Lupus
Lupus Erythematosus, Systemic - epidemiology
Medicine
Medicine & Public Health
Meta-analysis
Observational studies
Observational Studies as Topic
Orthopedics
Patient outcomes
Review
Rheumatology
Risk
Risk factors
Sensitivity analysis
Systemic lupus erythematosus
Vaccination
Vaccination - adverse effects
Viral vaccines
Asia
North America
China
Risk
Systemic lupus erythematosus
Vaccination
Meta-analysis
ISSN:1478-6362, 1478-6354, 1478-6362
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Objective This meta-analysis aims to explore the potential link between vaccines and systemic lupus erythematosus (SLE). Methods We systematically searched PubMed, Cochrane Library, and Embase for observational studies from inception to September 3, 2023, using medical subject headings (MeSH) and keywords. Study quality was assessed using the NOS scale. Statistical analyses were conducted using STATA software (version 14.0). Publication bias was evaluated using funnel plots and Egger’s regression. Results The meta-analysis incorporated 17 studies, encompassing 45,067,349 individuals with follow-up periods ranging from 0.5 to 2 years. The pooled analysis revealed no significant association between vaccinations and an increased risk of SLE [OR = 1.14, 95% CI (0.86–1.52), I 2  = 78.1%, P  = 0.348]. Subgroup analyses indicated that HBV vaccination was significantly associated with an elevated risk of SLE [OR =2.11, 95% CI (1.11-4.00), I 2  = 63.3%, P  = 0.02], HPV vaccination was slightly associated with an increased risk of SLE [OR = 1.43, 95% CI (0.88–2.31), I 2  = 72.4%, P  = 0.148], influenza vaccination showed no association with an increased risk of SLE [OR = 0.96, 95% CI (0.82–1.12), I 2  = 0.0%, P  = 0.559], and COVID-19 vaccine was marginally associated with a decreased risk of SLE [OR = 0.44, 95% CI (0.18–1.21), I 2  = 91.3%, P  = 0.118]. Conclusions This study suggests that vaccinations are not linked to an increased risk of SLE. Our meta-analysis results provide valuable insights, alleviating concerns about SLE risk post-vaccination and supporting further vaccine development efforts.
Bibliografie:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 14
ObjectType-Feature-3
ObjectType-Evidence Based Healthcare-1
ObjectType-Feature-1
ObjectType-Review-4
content type line 23
ObjectType-Undefined-3
ISSN:1478-6362
1478-6354
1478-6362
DOI:10.1186/s13075-024-03296-8