Data-driven gating (DDG)-based motion match for improved CTAC registration

Background Respiratory motion artefacts are a pitfall in thoracic PET/CT imaging. A source of these motion artefacts within PET images is the CT used for attenuation correction of the images. The arbitrary respiratory phase in which the helical CT ( CT helical ) is acquired often causes misregistrat...

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Vydáno v:EJNMMI physics Ročník 11; číslo 1; s. 42 - 13
Hlavní autoři: Cook, Ella L., Su, Kuan-Hao, Higgins, Geoff S., Johnsen, Robert, Bouhnik, Jean-Paul, McGowan, Daniel R.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cham Springer International Publishing 01.05.2024
Springer Nature B.V
SpringerOpen
Témata:
4DCT
Algorithms
Applied and Technical Physics
Attenuation
Computational Mathematics and Numerical Analysis
Computed tomography
Data-driven gating
Engineering
Image acquisition
Imaging
Lesions
Liver
Medicine
Medicine & Public Health
Motion effects
Nuclear Medicine
Original Research
Phase matching
Positron emission
Radiology
Respiratory motion
4DCT
Data-driven gating
Respiratory motion
ISSN:2197-7364, 2197-7364
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Shrnutí:Background Respiratory motion artefacts are a pitfall in thoracic PET/CT imaging. A source of these motion artefacts within PET images is the CT used for attenuation correction of the images. The arbitrary respiratory phase in which the helical CT ( CT helical ) is acquired often causes misregistration between PET and CT images, leading to inaccurate attenuation correction of the PET image. As a result, errors in tumour delineation or lesion uptake values can occur. To minimise the effect of motion in PET/CT imaging, a data-driven gating (DDG)-based motion match (MM) algorithm has been developed that estimates the phase of the CT helical , and subsequently warps this CT to a given phase of the respiratory cycle, allowing it to be phase-matched to the PET. A set of data was used which had four-dimensional CT (4DCT) acquired alongside PET/CT. The 4DCT allowed ground truth CT phases to be generated and compared to the algorithm-generated motion match CT (MMCT). Measurements of liver and lesion margin positions were taken across CT images to determine any differences and establish how well the algorithm performed concerning warping the CT helical to a given phase (end-of-expiration, EE). Results Whilst there was a minor significance in the liver measurement between the 4DCT and MMCT ( p = 0.045 ), no significant differences were found between the 4DCT or MMCT for lesion measurements ( p = 1.0 ). In all instances, the CT helical was found to be significantly different from the 4DCT ( p < 0.001 ). Consequently, the 4DCT and MMCT can be considered equivalent with respect to warped CT generation, showing the DDG-based MM algorithm to be successful. Conclusion The MM algorithm successfully enables the phase-matching of a CT helical to the EE of a ground truth 4DCT. This would reduce the motion artefacts caused by PET/CT registration without requiring additional patient dose (required for a 4DCT).
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ISSN:2197-7364
2197-7364
DOI:10.1186/s40658-024-00644-0