Gold nanoparticles enlighten the future of cancer theranostics

Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bio-imaging and phototherapy due to their...

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Bibliographic Details
Published in:International journal of nanomedicine Vol. 12; pp. 6131 - 6152
Main Authors: Guo, Jianfeng, Rahme, Kamil, He, Yan, Li, Lin-Lin, Holmes, Justin, O'Driscoll, Caitriona
Format: Journal Article
Language:English
Published: New Zealand Dove Medical Press Limited 01.01.2017
Taylor & Francis Ltd
Dove Medical Press
Subjects:
Acids
Biomedical materials
cancer bioimaging
Cancer diagnosis
cancer photothermal and photodynamic therapy
Cancer therapies
Drug delivery systems
Gold
Gold - chemistry
Humans
Metal Nanoparticles - administration & dosage
Metal Nanoparticles - chemistry
Multifunctional gold nanoparticles
Nanomaterials
Nanoparticles
Neoplasms - diagnosis
Neoplasms - therapy
Particle size
Photochemotherapy
Photochemotherapy - methods
Photodynamic therapy
Phototherapy - methods
Polyethylene glycol
Quantum dots
Review
Seeds
Silver
Surface Plasmon Resonance
Surfactants
Theranostic Nanomedicine - methods
University colleges
Ireland
China
cancer bioimaging
multifunctional gold nanoparticles
cancer photothermal and photodynamic therapy
ISSN:1178-2013, 1176-9114, 1178-2013
Online Access:Get full text
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Summary:Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bio-imaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed "theranostics," multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. In this review, the important properties of AuNPs relevant to diagnostic and phototherapeutic applications such as structure, shape, optics, and surface chemistry are described. Barriers for translational development of theranostic AuNPs and recent advances in the application of AuNPs for cancer diagnosis, photothermal, and photodynamic therapy are discussed.
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ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S140772