Gold nanoparticles enlighten the future of cancer theranostics

Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bio-imaging and phototherapy due to their...

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Veröffentlicht in:	International journal of nanomedicine Jg. 12; S. 6131 - 6152
Hauptverfasser:	Guo, Jianfeng, Rahme, Kamil, He, Yan, Li, Lin-Lin, Holmes, Justin, O'Driscoll, Caitriona
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New Zealand Dove Medical Press Limited 01.01.2017 Taylor & Francis Ltd Dove Medical Press
Schlagworte:	Acids Biomedical materials cancer bioimaging Cancer diagnosis cancer photothermal and photodynamic therapy Cancer therapies Drug delivery systems Gold Gold - chemistry Humans Metal Nanoparticles - administration & dosage Metal Nanoparticles - chemistry Multifunctional gold nanoparticles Nanomaterials Nanoparticles Neoplasms - diagnosis Neoplasms - therapy Particle size Photochemotherapy Photochemotherapy - methods Photodynamic therapy Phototherapy - methods Polyethylene glycol Quantum dots Review Seeds Silver Surface Plasmon Resonance Surfactants Theranostic Nanomedicine - methods University colleges Ireland China cancer bioimaging multifunctional gold nanoparticles cancer photothermal and photodynamic therapy
ISSN:	1178-2013, 1176-9114, 1178-2013
Online-Zugang:	Volltext
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Abstract	Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bio-imaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed "theranostics," multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. In this review, the important properties of AuNPs relevant to diagnostic and phototherapeutic applications such as structure, shape, optics, and surface chemistry are described. Barriers for translational development of theranostic AuNPs and recent advances in the application of AuNPs for cancer diagnosis, photothermal, and photodynamic therapy are discussed.
AbstractList	Jianfeng Guo,1 Kamil Rahme,2-4 Yan He,1 Lin-Lin Li,5 Justin D Holmes,3,4 Caitriona M O'Driscoll6 1School of Pharmaceutical Sciences, Jilin University, Changchun, China; 2Department of Sciences, Faculty of Natural and Applied Science, Notre Dame University (Louaize), Zouk Mosbeh, Lebanon; 3Department of Chemistry, Tyndall National Institute, University College Cork, Cork, 4AMBER@CRANN, Trinity College Dublin, Dublin, Ireland; 5The First Hospital of Jilin University, Changchun, China; 6Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland Abstract: Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bioimaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed "theranostics," multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. In this review, the important properties of AuNPs relevant todiagnostic and phototherapeutic applications such as structure, shape, optics, and surface chemistry are described. Barriers for translational development of theranostic AuNPs and recent advances in the application of AuNPs for cancer diagnosis, photothermal, and photodynamic therapy are discussed. Keywords: multifunctional gold nanoparticles, cancer bioimaging, cancer photothermal and photodynamic therapy Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bio-imaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed “theranostics,” multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. In this review, the important properties of AuNPs relevant to diagnostic and phototherapeutic applications such as structure, shape, optics, and surface chemistry are described. Barriers for translational development of theranostic AuNPs and recent advances in the application of AuNPs for cancer diagnosis, photothermal, and photodynamic therapy are discussed. Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bio-imaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed "theranostics," multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. In this review, the important properties of AuNPs relevant to diagnostic and phototherapeutic applications such as structure, shape, optics, and surface chemistry are described. Barriers for translational development of theranostic AuNPs and recent advances in the application of AuNPs for cancer diagnosis, photothermal, and photodynamic therapy are discussed. Keywords: multifunctional gold nanoparticles, cancer bioimaging, cancer photothermal and photodynamic therapy Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bioimaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed “theranostics,” multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. In this review, the important properties of AuNPs relevant to diagnostic and phototherapeutic applications such as structure, shape, optics, and surface chemistry are described. Barriers for translational development of theranostic AuNPs and recent advances in the application of AuNPs for cancer diagnosis, photothermal, and photodynamic therapy are discussed. Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bio-imaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed "theranostics," multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. In this review, the important properties of AuNPs relevant to diagnostic and phototherapeutic applications such as structure, shape, optics, and surface chemistry are described. Barriers for translational development of theranostic AuNPs and recent advances in the application of AuNPs for cancer diagnosis, photothermal, and photodynamic therapy are discussed.Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bio-imaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed "theranostics," multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. In this review, the important properties of AuNPs relevant to diagnostic and phototherapeutic applications such as structure, shape, optics, and surface chemistry are described. Barriers for translational development of theranostic AuNPs and recent advances in the application of AuNPs for cancer diagnosis, photothermal, and photodynamic therapy are discussed.
Audience	Academic
Author	Holmes, Justin He, Yan Li, Lin-Lin O'Driscoll, Caitriona Guo, Jianfeng Rahme, Kamil
AuthorAffiliation	2 Department of Sciences, Faculty of Natural and Applied Science, Notre Dame University (Louaize), Zouk Mosbeh, Lebanon 5 The First Hospital of Jilin University, Changchun, China 4 AMBER@CRANN, Trinity College Dublin, Dublin, Ireland 6 Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland 1 School of Pharmaceutical Sciences, Jilin University, Changchun, China 3 Department of Chemistry, Tyndall National Institute, University College Cork, Cork
AuthorAffiliation_xml	– name: 4 AMBER@CRANN, Trinity College Dublin, Dublin, Ireland – name: 5 The First Hospital of Jilin University, Changchun, China – name: 1 School of Pharmaceutical Sciences, Jilin University, Changchun, China – name: 6 Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland – name: 3 Department of Chemistry, Tyndall National Institute, University College Cork, Cork – name: 2 Department of Sciences, Faculty of Natural and Applied Science, Notre Dame University (Louaize), Zouk Mosbeh, Lebanon
Author_xml	– sequence: 1 givenname: Jianfeng surname: Guo fullname: Guo, Jianfeng – sequence: 2 givenname: Kamil surname: Rahme fullname: Rahme, Kamil – sequence: 3 givenname: Yan surname: He fullname: He, Yan – sequence: 4 givenname: Lin-Lin surname: Li fullname: Li, Lin-Lin – sequence: 5 givenname: Justin surname: Holmes fullname: Holmes, Justin – sequence: 6 givenname: Caitriona surname: O'Driscoll fullname: O'Driscoll, Caitriona
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28883725$$D View this record in MEDLINE/PubMed
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Keywords	cancer bioimaging multifunctional gold nanoparticles cancer photothermal and photodynamic therapy
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Snippet	Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to... Jianfeng Guo,1 Kamil Rahme,2-4 Yan He,1 Lin-Lin Li,5 Justin D Holmes,3,4 Caitriona M O'Driscoll6 1School of Pharmaceutical Sciences, Jilin University,...
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SubjectTerms	Acids Biomedical materials cancer bioimaging Cancer diagnosis cancer photothermal and photodynamic therapy Cancer therapies Drug delivery systems Gold Gold - chemistry Humans Metal Nanoparticles - administration & dosage Metal Nanoparticles - chemistry Multifunctional gold nanoparticles Nanomaterials Nanoparticles Neoplasms - diagnosis Neoplasms - therapy Particle size Photochemotherapy Photochemotherapy - methods Photodynamic therapy Phototherapy - methods Polyethylene glycol Quantum dots Review Seeds Silver Surface Plasmon Resonance Surfactants Theranostic Nanomedicine - methods University colleges
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Title	Gold nanoparticles enlighten the future of cancer theranostics
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