Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer’s disease

Stroke and late-onset Alzheimer’s disease (AD) are risk factors for each other; the comorbidity of these brain disorders in aging individuals represents a significant challenge in basic research and clinical practice. The similarities and differences between stroke and AD in terms of pathogenesis an...

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Bibliographic Details
Published in:	Molecular neurodegeneration Vol. 18; no. 1; pp. 43 - 29
Main Authors:	Yu, Shan P., Jiang, Michael Q., Shim, Seong S., Pourkhodadad, Soheila, Wei, Ling
Format:	Journal Article
Language:	English
Published:	London BioMed Central 03.07.2023 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Advertising executives Aging Alzheimer Disease - metabolism Alzheimer's disease Animal models Animals Antagonists Apoptosis Biomedical and Life Sciences Biomedicine Brain research Calcium homeostasis Calcium influx Cell survival Clinical trials Comorbidity Cytotoxicity Dementia Dementia disorders Development and progression Drug approval Drug dosages Drug therapy Excitotoxicity Extrasynaptic NMDARs GluN2B subunit GluN3A subunit Glutamate Glutamatergic transmission Glutamic acid receptors Glutamic acid receptors (ionotropic) Homeostasis Hyperactivity Hypotheses Ischemia Ischemic Stroke - drug therapy Levetiracetam Medical research Medical treatment Medicine, Experimental Medicine, Preventive Memantine Memantine - pharmacology Memantine - therapeutic use Metabolism Molecular Medicine Mortality N-Methyl-D-aspartic acid receptors Neurodegenerative diseases Neurological disorders Neurology Neurons Neurophysiology Neuroprotection Neurosciences NMDA receptors Pathogenesis Pathology Pathophysiology Patients Preventive health services Receptors, N-Methyl-D-Aspartate - metabolism Review Risk factors Stroke Stroke (Disease) Transient receptor potential proteins homeostasis Memantine Alzheimer’s disease Excitotoxicity GluN2B subunit Extrasynaptic NMDARs Ischemic stroke Glutamate NMDA receptors Ca GluN3A subunit Ca2+ homeostasis
ISSN:	1750-1326, 1750-1326
Online Access:	Get full text
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