Innate immunity receptors in depression and suicide: upregulated NOD-like receptors containing pyrin (NLRPs) and hyperactive inflammasomes in the postmortem brains of people who were depressed and died by suicide
Abnormalities of inflammation have been implicated in the pathophysiology of depression and suicide, based on observations of increased levels of proinflammatory cytokines in the serum of people who were depressed and died by suicide. More recently, abnormalities in cytokines and innate immunity rec...
Gespeichert in:
| Veröffentlicht in: | Journal of psychiatry & neuroscience Jg. 46; H. 5; S. E538 - E547 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Canada
Canadian Medical Association
01.09.2021
NRC Research Press CMA Joule Inc |
| Schlagworte: | |
| ISSN: | 1180-4882, 1488-2434, 1488-2434 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Abnormalities of inflammation have been implicated in the pathophysiology of depression and suicide, based on observations of increased levels of proinflammatory cytokines in the serum of people who were depressed and died by suicide. More recently, abnormalities in cytokines and innate immunity receptors such as toll-like receptors have also been observed in the postmortem brains of people who were depressed and died by suicide. In addition to toll-like receptors, another subfamily of innate immunity receptors known as NOD-like receptors containing pyrin (NLRPs) are the most widely present NOD-like receptors in the central nervous system. NLRPs also form inflammasomes that play an important role in brain function. We studied the role of NLRPs in depression and suicide.
We determined the protein and mRNA expression of NLRP1, NLRP3 and NLRP6 and the components of their inflammasomes (i.e., adaptor molecule apoptosis-associated speck-like protein [ASC], caspase1, caspase3, interleukin [IL]-1β and IL-18) postmortem in the prefrontal cortex of people who were depressed and died by suicide, and in healthy controls. We determined mRNA levels using quantitative polymerase chain reaction, and we determined protein expression using Western blot immunolabelling.
We found that the protein and mRNA expression levels of NLRP1, NLRP3, NLRP6, caspase3 and ASC were significantly increased in people who were depressed and died by suicide compared to healthy controls.
Some people who were depressed and died by suicide were taking antidepressant medication at the time of their death.
Similar to toll-like receptors, NLRP and its inflammasomes were upregulated in people who were depressed and died by suicide compared to healthy controls. Innate immunity receptors in general — and NLRPs and inflammasomes in particular — may play an important role in the pathophysiology of depression and suicide. |
|---|---|
| AbstractList | ABSTRACTBackgroundAbnormalities of inflammation have been implicated in the pathophysiology of depression and suicide, based on observations of increased levels of proinflammatory cytokines in the serum of people who were depressed and died by suicide. More recently, abnormalities in cytokines and innate immunity receptors such as toll-like receptors have also been observed in the postmortem brains of people who were depressed and died by suicide. In addition to toll-like receptors, another subfamily of innate immunity receptors known as NOD-like receptors containing pyrin (NLRPs) are the most widely present NOD-like receptors in the central nervous system. NLRPs also form inflammasomes that play an important role in brain function. We studied the role of NLRPs in depression and suicide. MethodsWe determined the protein and mRNA expression of NLRP1, NLRP3 and NLRP6 and the components of their inflammasomes (i.e., adaptor molecule apoptosis-associated speck-like protein [ASC], caspase1, caspase3, interleukin [IL]-1β and IL-18) postmortem in the prefrontal cortex of people who were depressed and died by suicide, and in healthy controls. We determined mRNA levels using quantitative polymerase chain reaction, and we determined protein expression using Western blot immunolabelling. ResultsWe found that the protein and mRNA expression levels of NLRP1, NLRP3, NLRP6, caspase3 and ASC were significantly increased in people who were depressed and died by suicide compared to healthy controls. LimitationsSome people who were depressed and died by suicide were taking antidepressant medication at the time of their death. ConclusionSimilar to toll-like receptors, NLRP and its inflammasomes were upregulated in people who were depressed and died by suicide compared to healthy controls. Innate immunity receptors in general — and NLRPs and inflammasomes in particular — may play an important role in the pathophysiology of depression and suicide. Abnormalities of inflammation have been implicated in the pathophysiology of depression and suicide, based on observations of increased levels of proinflammatory cytokines in the serum of people who were depressed and died by suicide. More recently, abnormalities in cytokines and innate immunity receptors such as toll-like receptors have also been observed in the postmortem brains of people who were depressed and died by suicide. In addition to toll-like receptors, another subfamily of innate immunity receptors known as NOD-like receptors containing pyrin (NLRPs) are the most widely present NOD-like receptors in the central nervous system. NLRPs also form inflammasomes that play an important role in brain function. We studied the role of NLRPs in depression and suicide. We determined the protein and mRNA expression of NLRP1, NLRP3 and NLRP6 and the components of their inflammasomes (i.e., adaptor molecule apoptosis-associated speck-like protein [ASC], caspase1, caspase3, interleukin [IL]-1β and IL-18) postmortem in the prefrontal cortex of people who were depressed and died by suicide, and in healthy controls. We determined mRNA levels using quantitative polymerase chain reaction, and we determined protein expression using Western blot immunolabelling. We found that the protein and mRNA expression levels of NLRP1, NLRP3, NLRP6, caspase3 and ASC were significantly increased in people who were depressed and died by suicide compared to healthy controls. Some people who were depressed and died by suicide were taking antidepressant medication at the time of their death. Similar to toll-like receptors, NLRP and its inflammasomes were upregulated in people who were depressed and died by suicide compared to healthy controls. Innate immunity receptors in general - and NLRPs and inflammasomes in particular - may play an important role in the pathophysiology of depression and suicide. Abnormalities of inflammation have been implicated in the pathophysiology of depression and suicide, based on observations of increased levels of proinflammatory cytokines in the serum of people who were depressed and died by suicide. More recently, abnormalities in cytokines and innate immunity receptors such as toll-like receptors have also been observed in the postmortem brains of people who were depressed and died by suicide. In addition to toll-like receptors, another subfamily of innate immunity receptors known as NOD-like receptors containing pyrin (NLRPs) are the most widely present NOD-like receptors in the central nervous system. NLRPs also form inflammasomes that play an important role in brain function. We studied the role of NLRPs in depression and suicide.BACKGROUNDAbnormalities of inflammation have been implicated in the pathophysiology of depression and suicide, based on observations of increased levels of proinflammatory cytokines in the serum of people who were depressed and died by suicide. More recently, abnormalities in cytokines and innate immunity receptors such as toll-like receptors have also been observed in the postmortem brains of people who were depressed and died by suicide. In addition to toll-like receptors, another subfamily of innate immunity receptors known as NOD-like receptors containing pyrin (NLRPs) are the most widely present NOD-like receptors in the central nervous system. NLRPs also form inflammasomes that play an important role in brain function. We studied the role of NLRPs in depression and suicide.We determined the protein and mRNA expression of NLRP1, NLRP3 and NLRP6 and the components of their inflammasomes (i.e., adaptor molecule apoptosis-associated speck-like protein [ASC], caspase1, caspase3, interleukin [IL]-1β and IL-18) postmortem in the prefrontal cortex of people who were depressed and died by suicide, and in healthy controls. We determined mRNA levels using quantitative polymerase chain reaction, and we determined protein expression using Western blot immunolabelling.METHODSWe determined the protein and mRNA expression of NLRP1, NLRP3 and NLRP6 and the components of their inflammasomes (i.e., adaptor molecule apoptosis-associated speck-like protein [ASC], caspase1, caspase3, interleukin [IL]-1β and IL-18) postmortem in the prefrontal cortex of people who were depressed and died by suicide, and in healthy controls. We determined mRNA levels using quantitative polymerase chain reaction, and we determined protein expression using Western blot immunolabelling.We found that the protein and mRNA expression levels of NLRP1, NLRP3, NLRP6, caspase3 and ASC were significantly increased in people who were depressed and died by suicide compared to healthy controls.RESULTSWe found that the protein and mRNA expression levels of NLRP1, NLRP3, NLRP6, caspase3 and ASC were significantly increased in people who were depressed and died by suicide compared to healthy controls.Some people who were depressed and died by suicide were taking antidepressant medication at the time of their death.LIMITATIONSSome people who were depressed and died by suicide were taking antidepressant medication at the time of their death.Similar to toll-like receptors, NLRP and its inflammasomes were upregulated in people who were depressed and died by suicide compared to healthy controls. Innate immunity receptors in general - and NLRPs and inflammasomes in particular - may play an important role in the pathophysiology of depression and suicide.CONCLUSIONSimilar to toll-like receptors, NLRP and its inflammasomes were upregulated in people who were depressed and died by suicide compared to healthy controls. Innate immunity receptors in general - and NLRPs and inflammasomes in particular - may play an important role in the pathophysiology of depression and suicide. Background: Abnormalities of inflammation have been implicated in the pathophysiology of depression and suicide, based on observations of increased levels of proinflammatory cytokines in the serum of people who were depressed and died by suicide. More recently, abnormalities in cytokines and innate immunity receptors such as toll-like receptors have also been observed in the postmortem brains of people who were depressed and died by suicide. In addition to toll-like receptors, another subfamily of innate immunity receptors known as NOD-like receptors containing pyrin (NLRPs) are the most widely present NOD-like receptors in the central nervous system. NLRPs also form inflammasomes that play an important role in brain function. We studied the role of NLRPs in depression and suicide. Methods: We determined the protein and mRNA expression of NLRP1, NLRP3 and NLRP6 and the components of their inflammasomes (i.e., adaptor molecule apoptosis-associated speck-like protein [ASC], caspase1, caspase3, interleukin [IL]-1 p and IL-18) postmortem in the prefrontal cortex of people who were depressed and died by suicide, and in healthy controls. We determined mRNA levels using quantitative polymerase chain reaction, and we determined protein expression using Western blot immunolabelling. Results: We found that the protein and mRNA expression levels of NLRP1, NLRP3, NLRP6, caspase3 and ASC were significantly increased in people who were depressed and died by suicide compared to healthy controls. Limitations: Some people who were depressed and died by suicide were taking antidepressant medication at the time of their death. Conclusion: Similar to toll-like receptors, NLRP and its inflammasomes were upregulated in people who were depressed and died by suicide compared to healthy controls. Innate immunity receptors in general--and NLRPs and inflammasomes in particular--may play an important role in the pathophysiology of depression and suicide. |
| Audience | Academic |
| Author | Ren, Xinguo Zhang, Hui Sharma, Anuradha Pandey, Ghanshyam N. |
| Author_xml | – sequence: 1 givenname: Ghanshyam N. surname: Pandey fullname: Pandey, Ghanshyam N. email: gnpandey@uic.edu – sequence: 2 givenname: Hui surname: Zhang fullname: Zhang, Hui – sequence: 3 givenname: Anuradha surname: Sharma fullname: Sharma, Anuradha – sequence: 4 givenname: Xinguo surname: Ren fullname: Ren, Xinguo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34588173$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1k9tq3DAQhk1JaQ7tTR-giPYmLTiV5MPKuSiE9BQISenhWmjl8a4SWXIkecO-Zx-os9lsScoWgy3J_3wzjP7Zz3acd5BlLxk9YhUt3l8N7ogzSln9JNtjpRA5L4tyB9dM0Bz3fDfbj_GKUsopq55lu0VZCcEmxV72-8w5lYCYvh-dSUsSQMOQfIjEONLCECBG4x1RriVxNNq0cExGPJ6NFgNbcnH5MbfmGh5Eau-SMs64GRmWATmHF-ffv8W3d5D5coCgdDILzOo6q_peRd_DXcI0BzL4mHofEvRkGhATie_IAH6wQG7nntxCgE1lmH_FbA0upstNgc-zp52yEV7cfw-yX58__Tz9mp9ffjk7PTnPdU1FyjnXmgmhsBvlhCmmS90UtSqaqpw2k6JrhYayU12Bby4Ym5aNogXqmloXdALFQfZhzR3GaQ-tBpeCsnIIpldhKb0y8vEfZ-Zy5hdSVLxmXCDg8B4Q_M0IMcneRA3WKgd-jJJXE8Eq3jQUpW_W0pmyILFxHol6JZcnNRYnyrJaqfItqhk4bLlF13QGjx_pX2_R68HcyIeioy0ifFrojd5KffWwL38bsrEdCuhaoIOPMUAntUkqoc-QbKxkVK6cLdHZcu1sDHn3T8iGulV8fzGAt78wEKS26Eet7DUsIV75MTg0hmQycknlj9WgrOaEFzgjNS0RwP8PkK0327L-Ae5JIic |
| CitedBy_id | crossref_primary_10_2147_PRBM_S463316 crossref_primary_10_1016_j_pnpbp_2025_111325 crossref_primary_10_1016_j_bbih_2024_100853 crossref_primary_10_1186_s12906_025_04939_2 crossref_primary_10_3389_fphar_2024_1381523 crossref_primary_10_1080_14728222_2023_2225216 crossref_primary_10_1016_j_brainresbull_2025_111405 crossref_primary_10_1016_j_intimp_2023_111030 crossref_primary_10_1007_s11033_024_09293_z crossref_primary_10_1007_s11064_024_04323_5 crossref_primary_10_3389_fcell_2022_842320 crossref_primary_10_1016_j_phymed_2025_156394 crossref_primary_10_1016_j_brainres_2023_148644 crossref_primary_10_1038_s41380_025_02951_z crossref_primary_10_3389_fimmu_2025_1642001 crossref_primary_10_1016_j_bbr_2024_115413 crossref_primary_10_1038_s41423_025_01275_w crossref_primary_10_1007_s12035_024_04284_4 crossref_primary_10_3390_brainsci12081057 crossref_primary_10_1016_j_expneurol_2024_114937 crossref_primary_10_1016_j_exger_2024_112451 crossref_primary_10_1176_appi_focus_20220078 crossref_primary_10_1016_j_brainresbull_2024_111056 crossref_primary_10_1016_j_jad_2023_06_050 crossref_primary_10_1016_j_cytogfr_2024_10_004 crossref_primary_10_3389_fncel_2022_863426 crossref_primary_10_1007_s12035_022_03199_2 crossref_primary_10_1016_j_jad_2024_08_144 crossref_primary_10_3389_fimmu_2024_1479471 crossref_primary_10_1016_j_neurot_2023_10_010 crossref_primary_10_1016_j_bbi_2025_04_015 crossref_primary_10_3390_ijms25189776 crossref_primary_10_3390_ijms24010133 crossref_primary_10_3390_ph18060867 crossref_primary_10_1016_j_neuroscience_2023_11_029 crossref_primary_10_1503_jpn_220206 crossref_primary_10_2147_JIR_S501652 crossref_primary_10_1016_j_phrs_2022_106625 crossref_primary_10_1089_ars_2022_0180 |
| Cites_doi | 10.1016/j.coph.2011.07.002 10.1016/j.bbi.2012.12.008 10.1016/j.cell.2010.01.040 10.3109/08830185.2010.529976 10.1111/j.1471-4159.2011.07481.x 10.1016/j.biopsych.2009.09.033 10.1164/rccm.200808-1274OC 10.1503/jpn.170192 10.1016/j.psyneuen.2008.10.006 10.1016/j.bbi.2013.10.017 10.1016/S1359-6101(98)00004-5 10.1038/ni.1980 10.1016/j.biopsych.2014.10.014 10.1016/j.coi.2008.01.003 10.1016/j.gene.2004.05.002 10.1016/j.jpsychires.2015.10.015 10.4049/jimmunol.0901363 10.1111/bpa.12478 10.1126/science.1184003 10.1038/s41577-019-0165-0 10.1038/nature02664 10.1016/j.pnpbp.2004.11.003 10.1016/j.bbi.2018.09.024 10.1038/nature09663 10.1371/journal.ppat.0030111 10.1038/nature11729 10.1016/j.neurobiolaging.2007.06.006 10.1038/ni.1703 10.1038/jcbfm.2013.227 10.1038/nature04516 10.1016/j.jpsychires.2014.01.021 10.1016/S1097-2765(02)00599-3 10.1016/S0021-9258(19)52451-6 10.1007/s12026-012-8272-z 10.1016/j.neubiorev.2008.10.005 10.1016/j.cell.2010.02.016 10.1007/s12035-015-9408-7 10.1001/archgenpsychiatry.2010.22 10.1038/ni.3333 10.1111/j.1600-0447.2007.01128.x 10.1016/j.neuron.2013.04.005 10.1016/j.neuron.2018.08.001 10.1016/j.tcb.2014.12.009 10.1038/nrmicro2070 10.1016/j.jpsychires.2011.08.006 10.1016/j.immuni.2009.04.012 10.1016/j.cell.2010.01.022 10.1016/j.immuni.2013.08.001 10.1016/S0893-133X(01)00327-X 10.4049/jimmunol.0713552 10.1038/nrn.2016.69 10.1038/ni.2237 10.1016/j.bbi.2014.04.007 10.1016/j.euroneuro.2013.06.002 10.1016/S1074-7613(04)00046-9 |
| ContentType | Journal Article |
| Copyright | 2021 CMA Joule Inc. or its licensors CMA Joule Inc. or its licensors 2021 CMA Joule Inc. or its licensors. COPYRIGHT 2021 NRC Research Press 2021 CMA Joule Inc. or its licensors 2021 |
| Copyright_xml | – notice: 2021 CMA Joule Inc. or its licensors – notice: CMA Joule Inc. or its licensors – notice: 2021 CMA Joule Inc. or its licensors. – notice: COPYRIGHT 2021 NRC Research Press – notice: 2021 CMA Joule Inc. or its licensors 2021 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1503/jpn.210016 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1488-2434 |
| EndPage | E547 |
| ExternalDocumentID | PMC8526128 A681184450 34588173 10_1503_jpn_210016 1_s2_0_S1180488223000604 S1180488223000604 |
| Genre | Journal Article |
| GeographicLocations | United States |
| GeographicLocations_xml | – name: United States |
| GroupedDBID | --- .1- .FO 1P~ 29L 2WC 36B 4.4 5GY 5RS 6PF 7RV 7X7 88E 88I 8AF 8AO 8FI 8FJ 8FQ 8G5 AAFWJ AAWTL ABIVO ABUWG ACGFO ACGOD ACHQT ACPRK ADBBV AENEX AEVXI AFKRA AFRHN AHMBA AJUYK ALMA_UNASSIGNED_HOLDINGS AN0 AZQEC BAWUL BENPR BKEYQ BLC BNQBC BPHCQ BVXVI CCPQU DIK DU5 DWQXO E3Z EBD EBS EMB EMOBN EX3 F5P FEDTE FYUFA GNUQQ GUQSH GX1 HCIFZ HMCUK HVGLF HYE IAO ICQ IEA IHR IHW INH INR IOF IPO IPY ISN ISR ITC M1P M2M M2O M2P M2Q M3G M5~ NAPCQ OH0 OK1 OU- OVD OVT PHGZM PHGZT PIMPY PJZUB PPXIY PQQKQ PROAC PSQYO PSYQQ PV9 Q2X RDH RNS RPM RWL RXW RZL SV3 TAE TR2 UKHRP W2D WOW XSB Z5R 3V. 53G AAKAS ADZCM AFCTW ALIPV BCGST BCR EJD M~E RHF TEORI WOQ ZXP AAYXX AFFHD BAIFH BBTPI CITATION CGR CUY CVF ECM EIF NPM 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c608t-22cc188a345471a1c4c936a3954b973fd8ce4faf3e4f2811b49a03a1c96c307e3 |
| ISICitedReferencesCount | 44 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000708626700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1180-4882 1488-2434 |
| IngestDate | Tue Nov 04 01:42:13 EST 2025 Fri Sep 05 09:52:53 EDT 2025 Tue Nov 11 10:45:56 EST 2025 Mon Nov 24 15:49:38 EST 2025 Wed Aug 20 01:30:39 EDT 2025 Tue Nov 04 18:10:50 EST 2025 Thu Apr 03 07:05:08 EDT 2025 Sat Nov 29 07:38:54 EST 2025 Tue Nov 18 20:40:04 EST 2025 Sun Feb 23 10:19:00 EST 2025 Tue Oct 14 19:34:21 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Language | English |
| License | http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining 2021 CMA Joule Inc. or its licensors. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY-NC-ND 4.0) licence, which permits use, distribution and reproduction in any medium, provided that the original publication is properly cited, the use is noncommercial (i.e., research or educational use), and no modifications or adaptations are made. See: https://creativecommons.org/licenses/by-nc-nd/4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c608t-22cc188a345471a1c4c936a3954b973fd8ce4faf3e4f2811b49a03a1c96c307e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC8526128 |
| PMID | 34588173 |
| PQID | 2578152990 |
| PQPubID | 23479 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_8526128 proquest_miscellaneous_2578152990 gale_infotracmisc_A681184450 gale_infotracgeneralonefile_A681184450 gale_infotraccpiq_681184450 gale_infotracacademiconefile_A681184450 pubmed_primary_34588173 crossref_citationtrail_10_1503_jpn_210016 crossref_primary_10_1503_jpn_210016 elsevier_clinicalkeyesjournals_1_s2_0_S1180488223000604 elsevier_clinicalkey_doi_10_1503_jpn_210016 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-Sep |
| PublicationDateYYYYMMDD | 2021-09-01 |
| PublicationDate_xml | – month: 09 year: 2021 text: 2021-Sep |
| PublicationDecade | 2020 |
| PublicationPlace | Canada |
| PublicationPlace_xml | – name: Canada |
| PublicationTitle | Journal of psychiatry & neuroscience |
| PublicationTitleAlternate | J Psychiatry Neurosci |
| PublicationYear | 2021 |
| Publisher | Canadian Medical Association NRC Research Press CMA Joule Inc |
| Publisher_xml | – name: Canadian Medical Association – name: NRC Research Press – name: CMA Joule Inc |
| References | Lampron, Elali, Rivest (bb0060) 2013; 78 Alcocer-Gomez, Ulecia-Moron, Marin-Aguilar (bb0190) 2016; 53 Ye, Ting (bb0070) 2008; 20 Mariathasan, Newton, Monack (bb0225) 2004; 430 Iyer, He, Janczy (bb0230) 2013; 39 Heneka, Kummer, Stutz (bb0285) 2013; 493 Schroder, Zhou, Tschopp (bb0155) 2010; 327 Xu, Murphy, Kochanek (bb0010) 2020 Rathinam, Vanaja, Fitzgerald (bb0080) 2012; 13 Serafini, Pompili, Elena Seretti (bb0035) 2013; 23 Kim, Andreazza, Elmi (bb0175) 2016; 72 White, Lawrence, Brough (bb0305) 2017; 27 Zhou, Yazdi, Menu (bb0235) 2011; 469 Griffith, Sun, McIntosh (bb0250) 2009; 183 Bauernfeind, Horvath, Stutz (bb0210) 2009; 183 Franchi, Eigenbrod, Munoz-Planillo (bb0065) 2009; 10 Schroder, Tschopp (bb0100) 2010; 140 Pandey, Rizavi, Zhang (bb0050) 2018; 43 Tonelli, Stiller, Rujescu (bb0040) 2008; 117 Wohleb, Franklin, Iwata (bb0025) 2016; 17 Vanaja, Rathinam, Fitzgerald (bb0205) 2015; 25 McAfoose, Baune (bb0275) 2009; 33 McAfoose, Koerner, Baune (bb0280) 2009; 34 de Rivero Vaccari, Dietrich, Keane (bb0170) 2014; 34 Pan, Chen, Zhang (bb0195) 2014; 41 Zhou, Shi, Wang (bb0150) 2016; 2016 Martinon, Burns, Tschopp (bb0105) 2002; 10 Franchi, Park, Shaw (bb0240) 2008; 10 Ojala, Alafuzoff, Herukka (bb0300) 2009; 30 Bergsbaken, Fink, Cookson (bb0290) 2009; 7 Pandey, Rizavi, Ren (bb0095) 2014; 53 Shi, Wang, Li (bb0200) 2016; 17 Lowry, Rosebrough, Farr (bb0125) 1951; 193 Schiepers, Wichers, Maes (bb0020) 2005; 29 Nakahira, Haspel, Rathinam (bb0260) 2011; 12 Kumar, Kawai, Akira (bb0085) 2011; 30 Hanamsagar, Torres, Kielian (bb0115) 2011; 119 Alcocer-Gomez, de Miguel, Casas-Barquero (bb0180) 2014; 36 Song, Pei, Yao (bb0160) 2017; 11 Suzuki, Franchi, Toma (bb0295) 2007; 3 Iwata, Ota, Duman (bb0270) 2013; 31 Rosenzweig, Planck, Rosenbaum (bb0055) 2011; 11 Swanson, Deng, Ting (bb0145) 2019; 19 Pandey, Dwivedi, SridharaRao (bb0130) 2002; 26 Andreazza, Shao, Wang (bb0265) 2010; 67 Glass, Saijo, Winner (bb0165) 2010; 140 Martinon, Petrilli, Mayor (bb0255) 2006; 440 Pandey, Rizavi, Bhaumik (bb0090) 2019; 75 Anderson, Mueller, Rosengren (bb0140) 2004; 338 First, Spitzer, Gibbon (bb0120) 1997 Gillespie, Horwood (bb0135) 1998; 9 Syed, Beurel, Loewenstein (bb0185) 2018; 99 Meng, Zhang, Fuss (bb0220) 2009; 30 Takeuchi, Akira (bb0075) 2010; 140 Black, Miller (bb0015) 2015; 78 Agostini, Martinon, Burns (bb0110) 2004; 20 Gasse, Riteau, Charron (bb0245) 2009; 179 Pandey, Rizavi, Ren (bb0045) 2012; 46 Dowlati, Herrmann, Swardfager (bb0030) 2010; 67 Zambetti, Laudisi, Licandro (bb0215) 2012; 53 Takeuchi O (b14-46-5-e538/b14-46-5-e538_1) 2010; 140 McAfoose J (b54-46-5-e538/b54-46-5-e538_1) 2009; 33 Song L (b31-46-5-e538/b31-46-5-e538_1) 2017; 11 Alcocer-Gomez E (b37-46-5-e538/b37-46-5-e538_1) 2016; 53 McAfoose J (b55-46-5-e538/b55-46-5-e538_1) 2009; 34 Pandey GN (b25-46-5-e538/b25-46-5-e538_1) 2002; 26 Vanaja SK (b40-46-5-e538/b40-46-5-e538_1) 2015; 25 Xu J (b1-46-5-e538/b1-46-5-e538_1) 2020 Pandey GN (b8-46-5-e538/b8-46-5-e538_1) 2012; 46 Suzuki T (b58-46-5-e538/b58-46-5-e538_1) 2007; 3 Hanamsagar R (b22-46-5-e538/b22-46-5-e538_1) 2011; 119 Andreazza AC (b52-46-5-e538/b52-46-5-e538_1) 2010; 67 Martinon F (b20-46-5-e538/b20-46-5-e538_1) 2002; 10 First MB (b23-46-5-e538/b23-46-5-e538_1) 1997 Heneka MT (b56-46-5-e538/b56-46-5-e538_1) 2013; 493 Griffith JW (b49-46-5-e538/b49-46-5-e538_1) 2009; 183 Zhou K (b29-46-5-e538/b29-46-5-e538_1) 2016; 2016 Kumar H (b16-46-5-e538/b16-46-5-e538_1) 2011; 30 Schroder K (b30-46-5-e538/b30-46-5-e538_1) 2010; 327 Swanson KV (b28-46-5-e538/b28-46-5-e538_1) 2019; 19 Mariathasan S (b44-46-5-e538/b44-46-5-e538_1) 2004; 430 Martinon F (b50-46-5-e538/b50-46-5-e538_1) 2006; 440 Pandey GN (b18-46-5-e538/b18-46-5-e538_1) 2014; 53 Franchi L (b47-46-5-e538/b47-46-5-e538_1) 2008; 10 Syed SA (b36-46-5-e538/b36-46-5-e538_1) 2018; 99 Gasse P (b48-46-5-e538/b48-46-5-e538_1) 2009; 179 Pan Y (b38-46-5-e538/b38-46-5-e538_1) 2014; 41 Gillespie MT (b26-46-5-e538/b26-46-5-e538_1) 1998; 9 de Rivero Vaccari JP (b33-46-5-e538/b33-46-5-e538_1) 2014; 34 Shi H (b39-46-5-e538/b39-46-5-e538_1) 2016; 17 Franchi L (b12-46-5-e538/b12-46-5-e538_1) 2009; 10 Iyer SS (b45-46-5-e538/b45-46-5-e538_1) 2013; 39 White CS (b60-46-5-e538/b60-46-5-e538_1) 2017; 27 Lowry OH (b24-46-5-e538/b24-46-5-e538_1) 1951; 193 Meng G (b43-46-5-e538/b43-46-5-e538_1) 2009; 30 Schiepers OJ (b3-46-5-e538/b3-46-5-e538_1) 2005; 29 Zambetti LP (b42-46-5-e538/b42-46-5-e538_1) 2012; 53 Wohleb ES (b4-46-5-e538/b4-46-5-e538_1) 2016; 17 Lampron A (b11-46-5-e538/b11-46-5-e538_1) 2013; 78 Pandey GN (b17-46-5-e538/b17-46-5-e538_1) 2019; 75 Kim HK (b34-46-5-e538/b34-46-5-e538_1) 2016; 72 Rosenzweig HL (b10-46-5-e538/b10-46-5-e538_1) 2011; 11 Serafini G (b6-46-5-e538/b6-46-5-e538_1) 2013; 23 Ye Z (b13-46-5-e538/b13-46-5-e538_1) 2008; 20 Ojala J (b59-46-5-e538/b59-46-5-e538_1) 2009; 30 Schroder K (b19-46-5-e538/b19-46-5-e538_1) 2010; 140 Bauernfeind FG (b41-46-5-e538/b41-46-5-e538_1) 2009; 183 Rathinam VA (b15-46-5-e538/b15-46-5-e538_1) 2012; 13 Bergsbaken T (b57-46-5-e538/b57-46-5-e538_1) 2009; 7 Zhou R (b46-46-5-e538/b46-46-5-e538_1) 2011; 469 Nakahira K (b51-46-5-e538/b51-46-5-e538_1) 2011; 12 Pandey GN (b9-46-5-e538/b9-46-5-e538_1) 2018; 43 Dowlati Y (b5-46-5-e538/b5-46-5-e538_1) 2010; 67 Agostini L (b21-46-5-e538/b21-46-5-e538_1) 2004; 20 Iwata M (b53-46-5-e538/b53-46-5-e538_1) 2013; 31 Glass CK (b32-46-5-e538/b32-46-5-e538_1) 2010; 140 Black C (b2-46-5-e538/b2-46-5-e538_1) 2015; 78 Anderson JP (b27-46-5-e538/b27-46-5-e538_1) 2004; 338 Tonelli LH (b7-46-5-e538/b7-46-5-e538_1) 2008; 117 Alcocer-Gomez E (b35-46-5-e538/b35-46-5-e538_1) 2014; 36 |
| References_xml | – volume: 75 start-page: 101 year: 2019 end-page: 111 ident: bb0090 article-title: Innate immunity in the postmortem brain of depressed and suicide subjects: role of toll-like receptors publication-title: Brain Behav Immun – volume: 10 start-page: 1 year: 2008 end-page: 8 ident: bb0240 article-title: Intracellular NOD-like receptors in innate immunity, infection and disease publication-title: Cell Microbiol – year: 2020 ident: bb0010 article-title: Mortality in the United States, 2018 publication-title: NCHS Data Brief no. 355 – volume: 67 start-page: 446 year: 2010 end-page: 457 ident: bb0030 article-title: A meta-analysis of cytokines in major depression publication-title: Biol Psychiatry – volume: 72 start-page: 43 year: 2016 end-page: 50 ident: bb0175 article-title: Nod-like receptor pyrin containing 3 (NLRP3) in the post-mortem frontal cortex from patients with bipolar disorder: a potential mediator between mitochondria and immune-activation publication-title: J Psychiatr Res – volume: 27 start-page: 223 year: 2017 end-page: 234 ident: bb0305 article-title: Inflammasomes as therapeutic targets for Alzheimer’s disease publication-title: Brain Pathol – volume: 53 start-page: 62 year: 2014 end-page: 68 ident: bb0095 article-title: Toll-like receptors in the depressed and suicide brain publication-title: J Psychiatr Res – volume: 140 start-page: 821 year: 2010 end-page: 832 ident: bb0100 article-title: The inflammasomes publication-title: Cell – volume: 11 start-page: 63 year: 2017 ident: bb0160 article-title: NLRP3 inflammasome in neurological diseases, from functions to therapies publication-title: Front Cell Neurosci – volume: 36 start-page: 111 year: 2014 end-page: 117 ident: bb0180 article-title: NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder publication-title: Brain Behav Immun – volume: 31 start-page: 105 year: 2013 end-page: 114 ident: bb0270 article-title: The inflammasome: pathways linking psychological stress, depression, and systemic illnesses publication-title: Brain Behav Immun – volume: 338 start-page: 25 year: 2004 end-page: 34 ident: bb0140 article-title: Structural, expression, and evolutionary analysis of mouse CIAS1 publication-title: Gene – volume: 12 start-page: 222 year: 2011 end-page: 230 ident: bb0260 article-title: Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome publication-title: Nat Immunol – volume: 10 start-page: 241 year: 2009 end-page: 247 ident: bb0065 article-title: The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis publication-title: Nat Immunol – volume: 440 start-page: 237 year: 2006 end-page: 241 ident: bb0255 article-title: Gout-associated uric acid crystals activate the NALP3 inflammasome publication-title: Nature – volume: 183 start-page: 5208 year: 2009 end-page: 5220 ident: bb0250 article-title: Pure hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid publication-title: J Immunol – volume: 183 start-page: 787 year: 2009 end-page: 791 ident: bb0210 article-title: Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression publication-title: J Immunol – volume: 30 start-page: 860 year: 2009 end-page: 874 ident: bb0220 article-title: A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses publication-title: Immunity – volume: 469 start-page: 221 year: 2011 end-page: 225 ident: bb0235 article-title: A role for mitochondria in NLRP3 inflammasome activation publication-title: Nature – volume: 20 start-page: 3 year: 2008 end-page: 9 ident: bb0070 article-title: NLR, the nucleotide-binding domain leucine-rich repeat containing gene family publication-title: Curr Opin Immunol – volume: 39 start-page: 311 year: 2013 end-page: 323 ident: bb0230 article-title: Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation publication-title: Immunity – volume: 140 start-page: 805 year: 2010 end-page: 820 ident: bb0075 article-title: Pattern recognition receptors and inflammation publication-title: Cell – volume: 67 start-page: 360 year: 2010 end-page: 368 ident: bb0265 article-title: Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder publication-title: Arch Gen Psychiatry – volume: 78 start-page: 28 year: 2015 end-page: 37 ident: bb0015 article-title: Meta-analysis of cytokines and chemokines in suicidality: distinguishing suicidal versus nonsuicidal patients publication-title: Biol Psychiatry – year: 1997 ident: bb0120 article-title: Structured clinical interview – volume: 140 start-page: 918 year: 2010 end-page: 934 ident: bb0165 article-title: Mechanisms underlying inflammation in neurodegeneration publication-title: Cell – volume: 99 start-page: e913 year: 2018 end-page: e924 ident: bb0185 article-title: Defective inflammatory pathways in never-treated depressed patients are associated with poor treatment response publication-title: Neuron – volume: 17 start-page: 250 year: 2016 end-page: 258 ident: bb0200 article-title: NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component publication-title: Nat Immunol – volume: 43 start-page: 376 year: 2018 end-page: 385 ident: bb0050 article-title: Abnormal protein and mRNA expression of inflammatory cytokines in the prefrontal cortex of depressed individuals who died by suicide publication-title: J Psychiatry Neurosci – volume: 327 start-page: 296 year: 2010 end-page: 300 ident: bb0155 article-title: The NLRP3 inflammasome: a sensor for metabolic danger? publication-title: Science – volume: 78 start-page: 214 year: 2013 end-page: 232 ident: bb0060 article-title: Innate immunity in the CNS: redefining the relationship between the CNS and its environment publication-title: Neuron – volume: 30 start-page: 16 year: 2011 end-page: 34 ident: bb0085 article-title: Pathogen recognition by the innate immune system publication-title: Int Rev Immunol – volume: 493 start-page: 674 year: 2013 end-page: 678 ident: bb0285 article-title: NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice publication-title: Nature – volume: 11 start-page: 423 year: 2011 end-page: 428 ident: bb0055 article-title: NLRs in immune privileged sites publication-title: Curr Opin Pharmacol – volume: 13 start-page: 333 year: 2012 end-page: 342 ident: bb0080 article-title: Regulation of inflammasome signaling publication-title: Nat Immunol – volume: 2016 start-page: 9238290 year: 2016 ident: bb0150 article-title: Recent advances of the NLRP3 inflammasome in central nervous system disorders publication-title: J Immunol Res – volume: 53 start-page: 4874 year: 2016 end-page: 4882 ident: bb0190 article-title: Stress-induced depressive behaviors require a functional NLRP3 inflammasome publication-title: Mol Neurobiol – volume: 33 start-page: 355 year: 2009 end-page: 366 ident: bb0275 article-title: Evidence for a cytokine model of cognitive function publication-title: Neurosci Biobehav Rev – volume: 30 start-page: 198 year: 2009 end-page: 209 ident: bb0300 article-title: Expression of interleukin-18 is increased in the brains of Alzheimer’s disease patients publication-title: Neurobiol Aging – volume: 34 start-page: 369 year: 2014 end-page: 375 ident: bb0170 article-title: Activation and regulation of cellular inflammasomes: gaps in our knowledge for central nervous system injury publication-title: J Cereb Blood Flow Metab – volume: 26 start-page: 216 year: 2002 end-page: 228 ident: bb0130 article-title: Protein kinase C and phospholipase C activity and expression of their specific isozymes is decreased and expression of MARCKS is increased in platelets of bipolar but not in unipolar patients publication-title: Neuropsychopharmacology – volume: 119 start-page: 736 year: 2011 end-page: 748 ident: bb0115 article-title: Inflammasome activation and IL-1beta/IL-18 processing are influenced by distinct pathways in microglia publication-title: J Neurochem – volume: 41 start-page: 90 year: 2014 end-page: 100 ident: bb0195 article-title: Microglial NLRP3 inflammasome activation mediates IL-1beta-related inflammation in prefrontal cortex of depressive rats publication-title: Brain Behav Immun – volume: 29 start-page: 201 year: 2005 end-page: 217 ident: bb0020 article-title: Cytokines and major depression publication-title: Prog Neuropsychopharmacol Biol Psychiatry – volume: 23 start-page: 1672 year: 2013 end-page: 1686 ident: bb0035 article-title: The role of inflammatory cytokines in suicidal behavior: a systematic review publication-title: Eur Neuropsychopharmacol – volume: 25 start-page: 308 year: 2015 end-page: 315 ident: bb0205 article-title: Mechanisms of inflammasome activation: recent advances and novel insights publication-title: Trends Cell Biol – volume: 17 start-page: 497 year: 2016 end-page: 511 ident: bb0025 article-title: Integrating neuroimmune systems in the neurobiology of depression publication-title: Nat Rev Neurosci – volume: 19 start-page: 477 year: 2019 end-page: 489 ident: bb0145 article-title: The NLRP3 inflammasome: molecular activation and regulation to therapeutics publication-title: Nat Rev Immunol – volume: 7 start-page: 99 year: 2009 end-page: 109 ident: bb0290 article-title: Pyroptosis: host cell death and inflammation publication-title: Nat Rev Microbiol – volume: 46 start-page: 57 year: 2012 end-page: 63 ident: bb0045 article-title: Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims publication-title: J Psychiatr Res – volume: 117 start-page: 198 year: 2008 end-page: 206 ident: bb0040 article-title: Elevated cytokine expression in the orbitofrontal cortex of victims of suicide publication-title: Acta Psychiatr Scand – volume: 20 start-page: 319 year: 2004 end-page: 325 ident: bb0110 article-title: NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder publication-title: Immunity – volume: 193 start-page: 265 year: 1951 end-page: 275 ident: bb0125 article-title: Protein measurement with the Folin phenol reagent publication-title: J Biol Chem – volume: 34 start-page: 615 year: 2009 end-page: 619 ident: bb0280 article-title: The effects of TNF deficiency on age-related cognitive performance publication-title: Psychoneuroendocrinology – volume: 430 start-page: 213 year: 2004 end-page: 218 ident: bb0225 article-title: Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf publication-title: Nature – volume: 179 start-page: 903 year: 2009 end-page: 913 ident: bb0245 article-title: Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis publication-title: Am J Respir Crit Care Med – volume: 10 start-page: 417 year: 2002 end-page: 426 ident: bb0105 article-title: The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta publication-title: Mol Cell – volume: 9 start-page: 109 year: 1998 end-page: 116 ident: bb0135 article-title: Interleukin-18: perspectives on the newest interleukin publication-title: Cytokine Growth Factor Rev – volume: 53 start-page: 78 year: 2012 end-page: 90 ident: bb0215 article-title: The rhapsody of NLRPs: master players of inflammation ... and a lot more publication-title: Immunol Res – volume: 3 start-page: e111 year: 2007 ident: bb0295 article-title: Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages publication-title: PLoS Pathog – volume: 11 start-page: 423 year: 2011 ident: b10-46-5-e538/b10-46-5-e538_1 publication-title: Curr Opin Pharmacol doi: 10.1016/j.coph.2011.07.002 – volume: 31 start-page: 105 year: 2013 ident: b53-46-5-e538/b53-46-5-e538_1 publication-title: Brain Behav Immun doi: 10.1016/j.bbi.2012.12.008 – volume: 140 start-page: 821 year: 2010 ident: b19-46-5-e538/b19-46-5-e538_1 publication-title: Cell doi: 10.1016/j.cell.2010.01.040 – volume: 30 start-page: 16 year: 2011 ident: b16-46-5-e538/b16-46-5-e538_1 publication-title: Int Rev Immunol doi: 10.3109/08830185.2010.529976 – volume: 119 start-page: 736 year: 2011 ident: b22-46-5-e538/b22-46-5-e538_1 publication-title: J Neurochem doi: 10.1111/j.1471-4159.2011.07481.x – volume: 67 start-page: 446 year: 2010 ident: b5-46-5-e538/b5-46-5-e538_1 publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2009.09.033 – volume: 179 start-page: 903 year: 2009 ident: b48-46-5-e538/b48-46-5-e538_1 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200808-1274OC – volume: 43 start-page: 376 year: 2018 ident: b9-46-5-e538/b9-46-5-e538_1 publication-title: J Psychiatry Neurosci doi: 10.1503/jpn.170192 – volume: 34 start-page: 615 year: 2009 ident: b55-46-5-e538/b55-46-5-e538_1 publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2008.10.006 – volume: 36 start-page: 111 year: 2014 ident: b35-46-5-e538/b35-46-5-e538_1 publication-title: Brain Behav Immun doi: 10.1016/j.bbi.2013.10.017 – volume: 9 start-page: 109 year: 1998 ident: b26-46-5-e538/b26-46-5-e538_1 publication-title: Cytokine Growth Factor Rev doi: 10.1016/S1359-6101(98)00004-5 – volume: 2016 start-page: 9238290 year: 2016 ident: b29-46-5-e538/b29-46-5-e538_1 publication-title: J Immunol Res – volume: 12 start-page: 222 year: 2011 ident: b51-46-5-e538/b51-46-5-e538_1 publication-title: Nat Immunol doi: 10.1038/ni.1980 – volume: 78 start-page: 28 year: 2015 ident: b2-46-5-e538/b2-46-5-e538_1 publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2014.10.014 – volume: 20 start-page: 3 year: 2008 ident: b13-46-5-e538/b13-46-5-e538_1 publication-title: Curr Opin Immunol doi: 10.1016/j.coi.2008.01.003 – volume: 338 start-page: 25 year: 2004 ident: b27-46-5-e538/b27-46-5-e538_1 publication-title: Gene doi: 10.1016/j.gene.2004.05.002 – volume: 72 start-page: 43 year: 2016 ident: b34-46-5-e538/b34-46-5-e538_1 publication-title: J Psychiatr Res doi: 10.1016/j.jpsychires.2015.10.015 – volume: 10 start-page: 1 year: 2008 ident: b47-46-5-e538/b47-46-5-e538_1 publication-title: Cell Microbiol – volume: 183 start-page: 787 year: 2009 ident: b41-46-5-e538/b41-46-5-e538_1 publication-title: J Immunol doi: 10.4049/jimmunol.0901363 – volume: 27 start-page: 223 year: 2017 ident: b60-46-5-e538/b60-46-5-e538_1 publication-title: Brain Pathol doi: 10.1111/bpa.12478 – volume: 327 start-page: 296 year: 2010 ident: b30-46-5-e538/b30-46-5-e538_1 publication-title: Science doi: 10.1126/science.1184003 – volume: 19 start-page: 477 year: 2019 ident: b28-46-5-e538/b28-46-5-e538_1 publication-title: Nat Rev Immunol doi: 10.1038/s41577-019-0165-0 – volume: 430 start-page: 213 year: 2004 ident: b44-46-5-e538/b44-46-5-e538_1 publication-title: Nature doi: 10.1038/nature02664 – volume: 29 start-page: 201 year: 2005 ident: b3-46-5-e538/b3-46-5-e538_1 publication-title: Prog Neuropsychopharmacol Biol Psychiatry doi: 10.1016/j.pnpbp.2004.11.003 – volume: 75 start-page: 101 year: 2019 ident: b17-46-5-e538/b17-46-5-e538_1 publication-title: Brain Behav Immun doi: 10.1016/j.bbi.2018.09.024 – volume: 469 start-page: 221 year: 2011 ident: b46-46-5-e538/b46-46-5-e538_1 publication-title: Nature doi: 10.1038/nature09663 – volume: 3 start-page: e111 year: 2007 ident: b58-46-5-e538/b58-46-5-e538_1 publication-title: PLoS Pathog doi: 10.1371/journal.ppat.0030111 – volume: 493 start-page: 674 year: 2013 ident: b56-46-5-e538/b56-46-5-e538_1 publication-title: Nature doi: 10.1038/nature11729 – volume: 30 start-page: 198 year: 2009 ident: b59-46-5-e538/b59-46-5-e538_1 publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2007.06.006 – volume: 10 start-page: 241 year: 2009 ident: b12-46-5-e538/b12-46-5-e538_1 publication-title: Nat Immunol doi: 10.1038/ni.1703 – volume: 34 start-page: 369 year: 2014 ident: b33-46-5-e538/b33-46-5-e538_1 publication-title: J Cereb Blood Flow Metab doi: 10.1038/jcbfm.2013.227 – volume: 440 start-page: 237 year: 2006 ident: b50-46-5-e538/b50-46-5-e538_1 publication-title: Nature doi: 10.1038/nature04516 – volume: 53 start-page: 62 year: 2014 ident: b18-46-5-e538/b18-46-5-e538_1 publication-title: J Psychiatr Res doi: 10.1016/j.jpsychires.2014.01.021 – volume-title: Mortality in the United States, 2018 year: 2020 ident: b1-46-5-e538/b1-46-5-e538_1 – volume: 10 start-page: 417 year: 2002 ident: b20-46-5-e538/b20-46-5-e538_1 publication-title: Mol Cell doi: 10.1016/S1097-2765(02)00599-3 – volume: 193 start-page: 265 year: 1951 ident: b24-46-5-e538/b24-46-5-e538_1 publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)52451-6 – volume: 53 start-page: 78 year: 2012 ident: b42-46-5-e538/b42-46-5-e538_1 publication-title: Immunol Res doi: 10.1007/s12026-012-8272-z – volume: 33 start-page: 355 year: 2009 ident: b54-46-5-e538/b54-46-5-e538_1 publication-title: Neurosci Biobehav Rev doi: 10.1016/j.neubiorev.2008.10.005 – volume: 140 start-page: 918 year: 2010 ident: b32-46-5-e538/b32-46-5-e538_1 publication-title: Cell doi: 10.1016/j.cell.2010.02.016 – volume: 53 start-page: 4874 year: 2016 ident: b37-46-5-e538/b37-46-5-e538_1 publication-title: Mol Neurobiol doi: 10.1007/s12035-015-9408-7 – volume: 67 start-page: 360 year: 2010 ident: b52-46-5-e538/b52-46-5-e538_1 publication-title: Arch Gen Psychiatry doi: 10.1001/archgenpsychiatry.2010.22 – volume: 17 start-page: 250 year: 2016 ident: b39-46-5-e538/b39-46-5-e538_1 publication-title: Nat Immunol doi: 10.1038/ni.3333 – volume: 117 start-page: 198 year: 2008 ident: b7-46-5-e538/b7-46-5-e538_1 publication-title: Acta Psychiatr Scand doi: 10.1111/j.1600-0447.2007.01128.x – volume: 78 start-page: 214 year: 2013 ident: b11-46-5-e538/b11-46-5-e538_1 publication-title: Neuron doi: 10.1016/j.neuron.2013.04.005 – volume-title: Structured clinical interview for DSM-IV axis I disorders (SCID-I) year: 1997 ident: b23-46-5-e538/b23-46-5-e538_1 – volume: 99 start-page: 914 year: 2018 ident: b36-46-5-e538/b36-46-5-e538_1 publication-title: Neuron doi: 10.1016/j.neuron.2018.08.001 – volume: 25 start-page: 308 year: 2015 ident: b40-46-5-e538/b40-46-5-e538_1 publication-title: Trends Cell Biol doi: 10.1016/j.tcb.2014.12.009 – volume: 7 start-page: 99 year: 2009 ident: b57-46-5-e538/b57-46-5-e538_1 publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro2070 – volume: 11 start-page: 63 year: 2017 ident: b31-46-5-e538/b31-46-5-e538_1 publication-title: Front Cell Neurosci – volume: 46 start-page: 57 year: 2012 ident: b8-46-5-e538/b8-46-5-e538_1 publication-title: J Psychiatr Res doi: 10.1016/j.jpsychires.2011.08.006 – volume: 30 start-page: 860 year: 2009 ident: b43-46-5-e538/b43-46-5-e538_1 publication-title: Immunity doi: 10.1016/j.immuni.2009.04.012 – volume: 140 start-page: 805 year: 2010 ident: b14-46-5-e538/b14-46-5-e538_1 publication-title: Cell doi: 10.1016/j.cell.2010.01.022 – volume: 39 start-page: 311 year: 2013 ident: b45-46-5-e538/b45-46-5-e538_1 publication-title: Immunity doi: 10.1016/j.immuni.2013.08.001 – volume: 26 start-page: 216 year: 2002 ident: b25-46-5-e538/b25-46-5-e538_1 publication-title: Neuropsychopharmacology doi: 10.1016/S0893-133X(01)00327-X – volume: 183 start-page: 5208 year: 2009 ident: b49-46-5-e538/b49-46-5-e538_1 publication-title: J Immunol doi: 10.4049/jimmunol.0713552 – volume: 17 start-page: 497 year: 2016 ident: b4-46-5-e538/b4-46-5-e538_1 publication-title: Nat Rev Neurosci doi: 10.1038/nrn.2016.69 – volume: 13 start-page: 333 year: 2012 ident: b15-46-5-e538/b15-46-5-e538_1 publication-title: Nat Immunol doi: 10.1038/ni.2237 – volume: 41 start-page: 90 year: 2014 ident: b38-46-5-e538/b38-46-5-e538_1 publication-title: Brain Behav Immun doi: 10.1016/j.bbi.2014.04.007 – volume: 23 start-page: 1672 year: 2013 ident: b6-46-5-e538/b6-46-5-e538_1 publication-title: Eur Neuropsychopharmacol doi: 10.1016/j.euroneuro.2013.06.002 – volume: 20 start-page: 319 year: 2004 ident: b21-46-5-e538/b21-46-5-e538_1 publication-title: Immunity doi: 10.1016/S1074-7613(04)00046-9 |
| SSID | ssj0002015 |
| Score | 2.516385 |
| Snippet | Abnormalities of inflammation have been implicated in the pathophysiology of depression and suicide, based on observations of increased levels of... ABSTRACTBackgroundAbnormalities of inflammation have been implicated in the pathophysiology of depression and suicide, based on observations of increased... Background: Abnormalities of inflammation have been implicated in the pathophysiology of depression and suicide, based on observations of increased levels of... |
| SourceID | pubmedcentral proquest gale pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | E538 |
| SubjectTerms | Adult Autopsy Brain Brain - metabolism Cell receptors Cellular proteins Cytokines - metabolism Depression - immunology Depression, Mental Female Humans Immunity, Innate Inflammasomes - metabolism Male NLR Proteins - immunology Physiological aspects Psychiatric/Mental Health Pyrin Research Paper RNA, Messenger Suicide Suicide, Completed Toll-Like Receptors - metabolism |
| Title | Innate immunity receptors in depression and suicide: upregulated NOD-like receptors containing pyrin (NLRPs) and hyperactive inflammasomes in the postmortem brains of people who were depressed and died by suicide |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S1180488223000604 https://www.clinicalkey.es/playcontent/1-s2.0-S1180488223000604 https://www.ncbi.nlm.nih.gov/pubmed/34588173 https://www.proquest.com/docview/2578152990 https://pubmed.ncbi.nlm.nih.gov/PMC8526128 |
| Volume | 46 |
| WOSCitedRecordID | wos000708626700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: ProQuest Canadian Business & Current Affairs Database (NC LIVE) customDbUrl: eissn: 1488-2434 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002015 issn: 1180-4882 databaseCode: 8FQ dateStart: 19990301 isFulltext: true titleUrlDefault: https://search.proquest.com/cbcacomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1488-2434 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002015 issn: 1180-4882 databaseCode: BENPR dateStart: 19990301 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Proquest Health and Medical Complete customDbUrl: eissn: 1488-2434 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002015 issn: 1180-4882 databaseCode: 7X7 dateStart: 19990301 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Nursing & Allied Health Database customDbUrl: eissn: 1488-2434 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002015 issn: 1180-4882 databaseCode: 7RV dateStart: 19990301 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Publicly Available Content customDbUrl: eissn: 1488-2434 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002015 issn: 1180-4882 databaseCode: PIMPY dateStart: 19990301 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Science Database (NC LIVE) customDbUrl: eissn: 1488-2434 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002015 issn: 1180-4882 databaseCode: M2P dateStart: 19990301 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Psychology Database customDbUrl: eissn: 1488-2434 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002015 issn: 1180-4882 databaseCode: M2M dateStart: 19990301 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1488-2434 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002015 issn: 1180-4882 databaseCode: M2O dateStart: 19990301 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLamDSFeEHfKxmQEAqEqkGtj8wZj0ybRrpSBypOVOgkNrElpml3-I3-Gf8CxnTjJ6BA88GK18Ynj5Hw5PnbO-YzQkzgMXR54gUHBGYUJShga4EZwA1yjwPLj2KQTuWvJO38wIOMxHa6t_axyYU6O_TQlZ2d0_l9VDcdA2SJ19h_UrRuFA_AblA4lqB3Kv1L8QZqC_9hNZOIHuNhg0qK53FOnGfiqYpDzIuFJKNPTC6iQ29KDBzo4fGscJ9-ixrkipF1tJtGdny8SdfoUJrEyy-pEUI_EAK5ZkGczGeOlcrCyfDmT4bzdidiLQsaNqKD17uk0655Gi6jqUyRJY7th6ROXXbvEea6DtCV2G6ycGqhDsTyu8nCmMB5Pz4NZ_d1Jr5PvF4leZJIs3irKs1gE4VSPWCNlm8dw90XWXCexLR0IVoaRjHZ0MGMrvEVYfYuYBliy1rBQrowmzQ_v0sbveoqP5rfBxzMFCcbXefrCFsxWFxi-Fclwj8DFXFesMm3YvkeFIfbHeo0AnHe56YbuUcmoC02_rBu-zIe66FQ0vKp2xG_DhTq6ga6X6sOvFWZvorUovYWu9svojtvoh4IurqCLNfxwkuIauhg0i0t8vMIN4OIKuI0za-BiCVx5cgO4uAVccSEALq6BixVwcRZjBVwMwMUCuFgDV7YpgIsn51XH7qCPe7tHO_tGuduIwXsmWRq2zblFSOAIijsrsLjLqdMLHOq5E-o7cUh45MZB7EBpgxYnLg1MB-Roj8NAGTl30XqapdF9hInJCczjHV-wQbq-TynxetSMoCmXxHTSQc8r_TFeUvGLHWGOmZiSg64Z6JopXXfQYy07VwQ0K6W6FQxYlVINTgADaK6U9ldJR3lpxnJmsdxmJvsgcChgaDuSucntoGcCY0zgHnrMgzKJB-5b8MixGt8dtNmS5PPkO2vUPm3VflEc-6ua2WoJwuDHW9WPKrAzUSUiRtMoK3ImXBGYm4Cz3UH3FPj183NEer7lO_AcWq-FFhCc--2aNJlK7n3iCc5F8uDP3dpE12oTtIXWl4sieoiu8JNlki-24Y0ffdqW770sCZRk7_022nizOxiO4F_f7svyUJZDqBke9IeffwF_ul57 |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Innate+immunity+receptors+in+depression+and+suicide%3A+upregulated+NOD-like+receptors+containing+pyrin+and+hyperactive+inflammasomes+in+the+postmortem+brains+of+people+who+were+depressed+and+died+by+suicide&rft.jtitle=Journal+of+psychiatry+%26+neuroscience&rft.au=Pandey%2C+Ghanshyam+N&rft.au=Zhang%2C+Hui&rft.au=Sharma%2C+Anuradha&rft.au=Ren%2C+Xinguo&rft.date=2021-09-01&rft.pub=NRC+Research+Press&rft.issn=1180-4882&rft.volume=46&rft.issue=5&rft.spage=E538&rft_id=info:doi/10.1503%2Fjpn.210016&rft.externalDocID=A681184450 |
| thumbnail_m | http://cvtisr.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F11804882%2FS1180488221X65006%2Fcov150h.gif |