Growth of ovarian cancer xenografts causes loss of muscle and bone mass: a new model for the study of cancer cachexia

Background Cachexia frequently occurs in women with advanced ovarian cancer (OC), along with enhanced inflammation. Despite being responsible for one third of all cancer deaths, cachexia is generally under‐studied in OC due to a limited number of pre‐clinical animal models. We aimed to address this...

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Bibliographic Details
Published in:	Journal of cachexia, sarcopenia and muscle Vol. 9; no. 4; pp. 685 - 700
Main Authors:	Pin, Fabrizio, Barreto, Rafael, Kitase, Yukiko, Mitra, Sumegha, Erne, Carlie E., Novinger, Leah J., Zimmers, Teresa A., Couch, Marion E., Bonewald, Lynda F., Bonetto, Andrea
Format:	Journal Article
Language:	English
Published:	Germany John Wiley & Sons, Inc 01.08.2018 John Wiley and Sons Inc Wiley
Subjects:	Animal model Animals Biomarkers Body Composition Bone and Bones - diagnostic imaging Bone and Bones - pathology Bone Density Cachexia - diagnosis Cachexia - etiology Cancer cachexia Cancer therapies Cell Line, Tumor Chemotherapy Cytokines Disease Models, Animal Energy Metabolism ES‐2 Ethanol Female Heterografts Histology Humans IL‐6 Laboratory animals Medical prognosis Mice Mitochondria - metabolism Muscle Strength Muscular Atrophy - diagnostic imaging Muscular Atrophy - metabolism Muscular Atrophy - pathology Musculoskeletal system Mutation Organ Size Original Ovarian cancer Ovarian Neoplasms - complications Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Penicillin Quality of life Sarcopenia Signal Transduction Skeletal muscle X-Ray Microtomography United States > US Animal model Cancer cachexia ES-2 IL-6 Skeletal muscle Ovarian cancer
ISSN:	2190-5991, 2190-6009, 2190-6009
Online Access:	Get full text
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