Viral infections and molecular mimicry in type 1 diabetes

Type 1 diabetes (T1D) is a disease characterized by inflammation of pancreatic islets associated with autoimmunity against insulin‐producing beta cells, leading to their progressive destruction. The condition constitutes a significant and worldwide problem to human health, particularly because of it...

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Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica Vol. 120; no. 12; pp. 941 - 949
Main Authors: Coppieters, Ken T., Wiberg, Anna, von Herrath, Matthias G.
Format: Journal Article
Language:English
Published: Oxford Blackwell Publishing Ltd 01.12.2012
Blackwell
Wiley Subscription Services, Inc
Subjects:
Animals
Autoimmunity
Biological and medical sciences
Bystander Effect
Diabetes
Diabetes Mellitus, Type 1 - immunology
Diabetes Mellitus, Type 1 - virology
Environmental factors
Epitopes - immunology
Fundamental and applied biological sciences. Psychology
Humans
infection
Infectious diseases
Insulin-Secreting Cells - immunology
Insulin-Secreting Cells - virology
Medical sciences
Mice
Microbiology
mimicry
Molecular Mimicry
Pancreas
Rats
T cells
T-Lymphocytes - immunology
Type 1 diabetes
Viral infections
Virus Diseases - immunology
Virus Diseases - virology
viruses
Endocrinopathy
Infection
Autoimmunity
Immunopathology
viruses
Immunology
Type 1 diabetes
Viral disease
T-Lymphocyte
mimicry
Autoimmune disease
T cells
ISSN:0903-4641, 1600-0463, 1600-0463
Online Access:Get full text
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Summary:Type 1 diabetes (T1D) is a disease characterized by inflammation of pancreatic islets associated with autoimmunity against insulin‐producing beta cells, leading to their progressive destruction. The condition constitutes a significant and worldwide problem to human health, particularly because of its rapid, but thus far unexplained, increase in incidence. Environmental factors such as viral infections are thought to account for this trend. While there is no lack of reports associating viral infections toT1D, it has proven difficult to establish which immunological processes link viral infections to disease onset or progression. One of the commonly discussed pathways is molecular mimicry, a mechanism that encompasses cross‐reactive immunity against epitopes shared between viruses and beta cells. In this review, we will take a closer look at mechanistic evidence for a potential role of viruses in T1D, with a special focus on molecular mimicry.
Bibliography:ark:/67375/WNG-3LW6PV5M-L
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ArticleID:APM12011
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Coppieters KT, Wiberg A, von Herrath MG. Viral infections and molecular mimicry in type 1 diabetes. APMIS 2013.
ISSN:0903-4641
1600-0463
1600-0463
DOI:10.1111/apm.12011