Cachexia induced by cancer and chemotherapy yield distinct perturbations to energy metabolism

Background Cancer cachexia is a metabolic disorder involving perturbed energy balance and altered mitochondrial function. Chemotherapy is a primary treatment option for many types of cancer, but there is substantial evidence that some chemotherapeutic agents can also lead to the development and prog...

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Bibliographic Details
Published in:	Journal of cachexia, sarcopenia and muscle Vol. 10; no. 1; pp. 140 - 154
Main Authors:	Pin, Fabrizio, Barreto, Rafael, Couch, Marion E., Bonetto, Andrea, O'Connell, Thomas M.
Format:	Journal Article
Language:	English
Published:	Germany John Wiley & Sons, Inc 01.02.2019 John Wiley and Sons Inc Wiley
Subjects:	Animals Anorexia Antineoplastic Agents - adverse effects Antineoplastic Combined Chemotherapy Protocols - adverse effects Cachexia Cachexia - chemically induced Cachexia - metabolism Cachexia - pathology Camptothecin - adverse effects Camptothecin - analogs & derivatives Cancer Cancer therapies Cell Line, Tumor Chemotherapy Dehydrogenases Energy Metabolism Fluorouracil - adverse effects Glucose - metabolism Laboratory animals Leucovorin - adverse effects Lipids Liver Liver - drug effects Liver - metabolism Male Metabolism Metabolites Metabolomics Mice Muscle Strength Muscle wasting Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Musculoskeletal system Neoplasms - chemically induced Neoplasms - metabolism Neoplasms - pathology Nitrogen NMR Nuclear magnetic resonance Original Oxidative stress Reactive Oxygen Species - metabolism Receptors, LDL - metabolism Studies United States > US Metabolomics Chemotherapy Cachexia Metabolism Muscle wasting Cancer
ISSN:	2190-5991, 2190-6009, 2190-6009
Online Access:	Get full text
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