Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

Adipose tissue inflammation and dysfunction are associated with obesity‐related insulin resistance and diabetes, but mechanisms underlying this relationship are unclear. Although senescent cells accumulate in adipose tissue of obese humans and rodents, a direct pathogenic role for these cells in the...

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Published in:	Aging cell Vol. 18; no. 3; pp. e12950 - n/a
Main Authors:	Palmer, Allyson K., Xu, Ming, Zhu, Yi, Pirtskhalava, Tamar, Weivoda, Megan M., Hachfeld, Christine M., Prata, Larissa G., Dijk, Theo H., Verkade, Esther, Casaclang‐Verzosa, Grace, Johnson, Kurt O., Cubro, Hajrunisa, Doornebal, Ewald J., Ogrodnik, Mikolaj, Jurk, Diana, Jensen, Michael D., Chini, Eduardo N., Miller, Jordan D., Matveyenko, Aleksey, Stout, Michael B., Schafer, Marissa J., White, Thomas A., Hickson, LaTonya J., Demaria, Marco, Garovic, Vesna, Grande, Joseph, Arriaga, Edgar A., Kuipers, Folkert, Zglinicki, Thomas, LeBrasseur, Nathan K., Campisi, Judith, Tchkonia, Tamar, Kirkland, James L.
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01.06.2019 Anatomical Society - Wiley John Wiley and Sons Inc
Subjects:	Adipocytes - cytology Adipocytes - drug effects Adipocytes - metabolism Adipogenesis Adipogenesis - drug effects Adipogenesis - physiology Adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Adipose tissues aging Aging - metabolism Aging - pathology Animals BASIC BIOLOGICAL SCIENCES Cell Death - drug effects Cell Death - genetics Cell Death - physiology Cell Line cellular senescence Cellular Senescence - drug effects Cellular Senescence - genetics Cellular Senescence - physiology Cyclin-Dependent Kinase Inhibitor p16 - metabolism dasatinib Dasatinib - pharmacology Development and progression Dextrose Diabetes Diabetes mellitus Female Ganciclovir - pharmacology Glucose Glucose - metabolism Glucose tolerance Humans Immunological tolerance Inflammation Inflammation - metabolism INK4a protein Insulin Insulin resistance Insulin Resistance - physiology Leukocyte migration Macrophages Macrophages - drug effects Macrophages - metabolism Male Metabolism Mice Mice, Inbred C57BL Mice, Transgenic Monocytes Obesity Obesity - metabolism Original p16 Protein quercetin Quercetin - pharmacology Renal function Senescence senolytics Suicide Suicide genes Type 2 diabetes adipogenesis cellular senescence dasatinib type 2 diabetes senolytics quercetin aging
ISSN:	1474-9718, 1474-9726, 1474-9726
Online Access:	Get full text
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