Acetylation reprograms MITF target selectivity and residence time

The ability of transcription factors to discriminate between different classes of binding sites associated with specific biological functions underpins effective gene regulation in development and homeostasis. How this is achieved is poorly understood. The microphthalmia-associated transcription fac...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; pp. 6051 - 15
Main Authors:	Louphrasitthiphol, Pakavarin, Loffreda, Alessia, Pogenberg, Vivian, Picaud, Sarah, Schepsky, Alexander, Friedrichsen, Hans, Zeng, Zhiqiang, Lashgari, Anahita, Thomas, Benjamin, Patton, E. Elizabeth, Wilmanns, Matthias, Filippakopoulos, Panagis, Lambert, Jean-Philippe, Steingrímsson, Eiríkur, Mazza, Davide, Goding, Colin R.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 28.09.2023 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/109 14/35 38/15 38/70 38/77 631/337/2265 631/337/572 631/67/1813 82/29 82/80 Acetylation Binding sites Biological effects Cell Line, Tumor Chromatin Deoxyribonucleic acid Differentiation DNA Gene regulation Genomes Homeostasis Humanities and Social Sciences Humans Melanocytes - metabolism Melanoma Melanoma - genetics Melanoma - metabolism Microphthalmia-associated transcription factor Microphthalmia-Associated Transcription Factor - genetics Microphthalmia-Associated Transcription Factor - metabolism multidisciplinary Oncogenes Residence time distribution Science Science (multidisciplinary) Survival Transcription factors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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