Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits

Background Increasing evidence suggests that multiple or long-time exposure to general anaesthesia (GA) could be detrimental to cognitive development in young subjects and might also contribute to accelerated neurodegeneration in the elderly. Iron is essential for normal neuronal function, and exces...

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Bibliographic Details
Published in:	Journal of neuroinflammation Vol. 17; no. 1; pp. 110 - 13
Main Authors:	Wu, Jing, Yang, Jian-Jun, Cao, Yan, Li, Huihui, Zhao, Hongting, Yang, Shuofei, Li, Kuanyu
Format:	Journal Article
Language:	English
Published:	London BioMed Central 11.04.2020 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Anesthesia Anesthesia, General - adverse effects Anesthetics, General - toxicity Animal cognition Animals Apoptosis Biomedical and Life Sciences Biomedicine Cell culture Cell death Cognition Cognitive ability Cognitive disorders Complications and side effects Development and progression Divalent metal transporter-1 Ferroptosis General anaesthesia General anesthesia Geriatrics Glutamic acid receptors Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Homeostasis Immunology Intravenous administration Iron Iron - metabolism Iron metabolism disorders Iron Overload - etiology Iron Overload - metabolism Iron Overload - pathology Ketamine Ketamine - toxicity Laboratory animals Male Mice Mice, Inbred C57BL Mitochondria Morphology N-Methyl-D-aspartic acid receptors Neurobiology Neurodegeneration Neurodegenerative diseases Neurological diseases Neurology Neurons Neurons - drug effects Neurons - metabolism Neurons - pathology Neurosciences Neurotoxicity Neurotoxicity syndromes Neurotoxicity Syndromes - metabolism Neurotoxicity Syndromes - pathology Postoperative Cognitive Complications - chemically induced Postoperative Cognitive Complications - metabolism Postoperative Cognitive Complications - pathology Proteins Rats Rats, Sprague-Dawley Risk factors Sevoflurane Sevoflurane - toxicity China United States > US Ferroptosis General anaesthesia Neurotoxicity Iron Cognition
ISSN:	1742-2094, 1742-2094
Online Access:	Get full text
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