The functional roles of the circRNA/Wnt axis in cancer

CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway. Aberrant Wnt pathway activation is involved in the development of various types of cancers. Accumulating evidence indicate...

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Bibliographic Details
Published in:Molecular cancer Vol. 21; no. 1; pp. 108 - 24
Main Authors: Xue, Chen, Li, Ganglei, Zheng, Qiuxian, Gu, Xinyu, Bao, Zhengyi, Lu, Juan, Li, Lanjuan
Format: Journal Article
Language:English
Published: London BioMed Central 05.05.2022
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Animals
Biomarker
Biomedical and Life Sciences
Biomedicine
Bladder cancer
Cancer
Cancer Research
Carcinogenesis - genetics
Cell growth
circRNA
Development and progression
Gene expression
Genes
Genetic aspects
Genomes
Humans
Insects
Kinases
Mammals
Mammals - genetics
Mechanism
Medical diagnosis
Medical research
Metastasis
MicroRNAs
Neoplasms - genetics
Oncology
Prognosis
Proteins
Review
RNA, Circular - genetics
RNA, Untranslated
Tumorigenesis
Wnt
Wnt protein
Wnt Signaling Pathway
Biomarker
cancer
circRNA
Wnt
Mechanism
ISSN:1476-4598, 1476-4598
Online Access:Get full text
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Summary:CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway. Aberrant Wnt pathway activation is involved in the development of various types of cancers. Accumulating evidence indicates that the circRNA/Wnt axis modulates the expression of cancer-associated genes and then regulates cancer progression. Wnt pathway-related circRNA expression is obviously associated with many clinical characteristics. CircRNAs could regulate cell biological functions by interacting with the Wnt pathway. Moreover, Wnt pathway-related circRNAs are promising potential biomarkers for cancer diagnosis, prognosis evaluation, and treatment. In our review, we summarized the recent research progress on the role and clinical application of Wnt pathway-related circRNAs in tumorigenesis and progression.
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ISSN:1476-4598
1476-4598
DOI:10.1186/s12943-022-01582-0