Icariin improves testicular dysfunction via enhancing proliferation and inhibiting mitochondria-dependent apoptosis pathway in high-fat diet and streptozotocin-induced diabetic rats

Background Diabetes mellitus (DM), a chronic metabolic disease, severely impairs male reproductive function. However, the underpinning mechanisms are still incompletely defined, and there are no effective strategies or medicines for these reproductive lesions. Icariin (ICA), the main active componen...

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Vydané v:	Reproductive biology and endocrinology Ročník 19; číslo 1; s. 168 - 14
Hlavní autori:	He, Weiguo, Liu, Huiqing, Hu, Linlin, Wang, Yaohui, Huang, Lane, Liang, Aihong, Wang, Xuan, Zhang, Qing, Chen, Yi, Cao, Yi, Li, Suyun, Wang, Junli, Lei, Xiaocan
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London BioMed Central 09.11.2021 BioMed Central Ltd BMC
Predmet:	Animals Antigens Apoptosis Apoptosis - drug effects Apoptosis - physiology Bax protein Bcl-2 protein Bioflavonoids Blood sugar Caspase-3 Cell proliferation Cell Proliferation - drug effects Cell Proliferation - physiology Comparative analysis Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diet, High-Fat - adverse effects Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Endocrinology Epididymis Fasting Flavones Flavonoids Flavonoids - pharmacology Flavonoids - therapeutic use Gene expression Glucose Health aspects High fat diet Hyperglycemia Hypoxia-inducible factor 1 Hypoxia-inducible factor 1a Icariin Infertility Insulin Insulin resistance Male Medicine Medicine & Public Health Metabolic disorders Metformin Mitochondria Mitochondria - drug effects Mitochondria - metabolism Oxidative stress Proliferating cell nuclear antigen Proliferation Proteins Rats Rats, Sprague-Dawley Reproductive Medicine Reproductive protection RNA Rodents Seminiferous tubule Sertoli cells Signal transduction Signal Transduction - drug effects Signal Transduction - physiology SIRT1 protein Sperm Spermatocytes Spermatogenesis Spermatogonia Streptozocin Testes Testis - drug effects Testis - metabolism United Kingdom > UK United States > US China Icariin Proliferation Spermatogenesis Reproductive protection Apoptosis
ISSN:	1477-7827, 1477-7827
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