Moderation of Adult Depression by a Polymorphism in the FKBP5 Gene and Childhood Physical Abuse in the General Population

Childhood maltreatment and depressive disorders have both been associated with a dysregulation of the hypothalamic–pituitary–adrenal axis. The FKBP5 gene codes for a co-chaperone regulating the glucocorticoid-receptor sensitivity. Previous evidence suggests that subjects carrying the TT genotype of...

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Bibliographic Details
Published in:	Neuropsychopharmacology Vol. 36; no. 10; pp. 1982 - 1991
Main Authors:	Appel, Katja, Schwahn, Christian, Mahler, Jessie, Schulz, Andrea, Spitzer, Carsten, Fenske, Kristin, Stender, Jan, Barnow, Sven, John, Ulrich, Teumer, Alexander, Biffar, Reiner, Nauck, Matthias, Völzke, Henry, Freyberger, Harald J, Grabe, Hans J
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01.09.2011 Nature Publishing Group
Subjects:	631/208/726/649 631/208/727/2000 692/699/476/1414 Adult Adult and adolescent clinical studies Adult Survivors of Child Abuse - psychology Aged Behavioral Sciences Biological and medical sciences Biological Psychology Child Child abuse & neglect Clinical psychology Depression Depressive Disorder, Major - genetics Depressive Disorder, Major - psychology Female Genes Genetic Predisposition to Disease Genotype & phenotype Hormones Humans Male Medical sciences Medicine Medicine & Public Health Mental depression Middle Aged Models, Genetic Mood disorders Neurosciences Original original-article Pharmacotherapy Polymorphism Polymorphism, Single Nucleotide - genetics Population Surveillance - methods Post traumatic stress disorder Predictive Value of Tests Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychotherapy Registries Surveys and Questionnaires Tacrolimus Binding Proteins - genetics Victimology Young Adult Germany CTQ gene–environment interaction childhood abuse general population gene major depression Human Mood disorder Violence gene-environment interaction Depression Victimology Child abuse Gene Genotype environment interaction FKBP5 gene Genetics Adult Polymorphism childhood maltreatment gene environment interaction Epidemiology sexual abuse Bipolar Unipolar Mood Development Developmental Disorders Anxiety depression Stress Disorders FKBP5
ISSN:	0893-133X, 1740-634X, 1740-634X, 0007-0920
Online Access:	Get full text
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