Excessive reactive oxygen species induce transcription-dependent replication stress

Elevated levels of reactive oxygen species (ROS) reduce replication fork velocity by causing dissociation of the TIMELESS-TIPIN complex from the replisome. Here, we show that ROS generated by exposure of human cells to the ribonucleotide reductase inhibitor hydroxyurea (HU) promote replication fork...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; pp. 1791 - 15
Main Authors:	Andrs, Martin, Stoy, Henriette, Boleslavska, Barbora, Chappidi, Nagaraja, Kanagaraj, Radhakrishnan, Nascakova, Zuzana, Menon, Shruti, Rao, Satyajeet, Oravetzova, Anna, Dobrovolna, Jana, Surendranath, Kalpana, Lopes, Massimo, Janscak, Pavel
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 30.03.2023 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/106 13/109 13/51 14/28 14/35 14/63 38/22 38/77 631/337/1427 631/337/151/2356 Aphidicolin Cancer Chromosome rearrangements Deoxyribonucleic acid Depletion DNA DNA damage DNA polymerase DNA Replication DNA-Binding Proteins - metabolism DNA-directed DNA polymerase Humanities and Social Sciences Humans Hybrids Hydroxyurea Hydroxyurea - pharmacology multidisciplinary Oxidative stress Oxygen R-loops Reactive Oxygen Species Reductases Replication S Phase - genetics Science Science (multidisciplinary) Stalling Transcription
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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