Genetic and environmental determinants of human TCR repertoire diversity

T cell discrimination of self and non-self is the foundation of the adaptive immune response, and is orchestrated by the interaction between T cell receptors (TCRs) and their cognate ligands presented by major histocompatibility (MHC) molecules. However, the impact of host immunogenetic variation on...

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Bibliographic Details
Published in:	Immunity & ageing Vol. 17; no. 1; pp. 26 - 7
Main Authors:	Krishna, Chirag, Chowell, Diego, Gönen, Mithat, Elhanati, Yuval, Chan, Timothy A.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 04.09.2020 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Adaptive immunity Age Aging Analysis Antibodies Biomedical and Life Sciences Biomedicine Clinical Nutrition Cytomegalovirus Entropy Genetic aspects Geriatrics/Gerontology Health aspects Heterozygosity Heterozygote advantage Histocompatibility antigen HLA HLA antigens Hypotheses Immune response Immunogenetics Immunology Infection Infections Lymphocytes Lymphocytes T Major histocompatibility complex Peptides Polymorphism Public Health Short Report T cell receptor repertoire T cell receptors T cells Infection Aging T cell receptor repertoire Immunogenetics Major histocompatibility complex Heterozygote advantage
ISSN:	1742-4933, 1742-4933
Online Access:	Get full text
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