Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19

Background COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. Case presentation We describe a 78-year old immunocompromised...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	BMC neurology Ročník 20; číslo 1; s. 248 - 5
Hlavní autoři:	Farhadian, Shelli, Glick, Laura R., Vogels, Chantal B. F., Thomas, Jared, Chiarella, Jennifer, Casanovas-Massana, Arnau, Zhou, Jing, Odio, Camila, Vijayakumar, Pavithra, Geng, Bertie, Fournier, John, Bermejo, Santos, Fauver, Joseph R., Alpert, Tara, Wyllie, Anne L., Turcotte, Cynthia, Steinle, Matthew, Paczkowski, Patrick, Dela Cruz, Charles, Wilen, Craig, Ko, Albert I., MacKay, Sean, Grubaugh, Nathan D., Spudich, Serena, Barakat, Lydia Aoun
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 18.06.2020 BioMed Central Ltd Springer Nature B.V BMC
Témata:	Acute Disease Age Aged Betacoronavirus Biomarkers - cerebrospinal fluid Blood Case Report Central nervous system Cerebrospinal fluid Coronavirus Infections Coronaviruses COVID-19 Cytokines Cytokines - cerebrospinal fluid Diagnosis Disease Encephalitis, Viral Encephalopathy Female Health aspects Hospitals Humans Illnesses Infections Inflammation Invasiveness Laboratories Magnetic resonance imaging Medicine Medicine & Public Health Metabolism Nervous system Neurochemistry Neurocritical care Neuroinflammation Neurological complications Neurology Neurosurgery Pandemics Patients Plasma Pneumonia, Viral Proteins SARS-CoV-2 Seizures Seizures (Medicine) Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 China COVID-19 Neuroinflammation SARS-CoV-2
ISSN:	1471-2377, 1471-2377
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Background COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. Case presentation We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion. Conclusion Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Report-3 ObjectType-Case Study-4 ObjectType-Case Study-2 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1471-2377 1471-2377
DOI:	10.1186/s12883-020-01812-2