Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19
Background COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. Case presentation We describe a 78-year old immunocompromised...
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| Vydáno v: | BMC neurology Ročník 20; číslo 1; s. 248 - 5 |
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| Médium: | Journal Article |
| Jazyk: | angličtina |
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London
BioMed Central
18.06.2020
BioMed Central Ltd Springer Nature B.V BMC |
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| ISSN: | 1471-2377, 1471-2377 |
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| Abstract | Background
COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients.
Case presentation
We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion.
Conclusion
Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease. |
|---|---|
| AbstractList | Background
COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients.
Case presentation
We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion.
Conclusion
Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease. COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion. Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease. Abstract Background COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. Case presentation We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion. Conclusion Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease. COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients.BACKGROUNDCOVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients.We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion.CASE PRESENTATIONWe describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion.Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease.CONCLUSIONOur findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease. Background COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. Case presentation We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion. Conclusion Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease. Keywords: COVID-19, SARS-CoV-2, Neuroinflammation COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease. Background COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. Case presentation We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion. Conclusion Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease. |
| ArticleNumber | 248 |
| Audience | Academic |
| Author | Grubaugh, Nathan D. Vogels, Chantal B. F. Casanovas-Massana, Arnau Farhadian, Shelli Odio, Camila Steinle, Matthew Wyllie, Anne L. Thomas, Jared Chiarella, Jennifer Geng, Bertie Spudich, Serena Glick, Laura R. Bermejo, Santos Ko, Albert I. Alpert, Tara Wilen, Craig MacKay, Sean Barakat, Lydia Aoun Zhou, Jing Paczkowski, Patrick Vijayakumar, Pavithra Dela Cruz, Charles Fournier, John Turcotte, Cynthia Fauver, Joseph R. |
| Author_xml | – sequence: 1 givenname: Shelli orcidid: 0000-0001-7230-1409 surname: Farhadian fullname: Farhadian, Shelli email: shelli.farhadian@yale.edu organization: Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, Department of Neurology, Yale School of Medicine – sequence: 2 givenname: Laura R. surname: Glick fullname: Glick, Laura R. organization: Department of Internal Medicine, Yale School of Medicine – sequence: 3 givenname: Chantal B. F. surname: Vogels fullname: Vogels, Chantal B. F. organization: Department of Epidemiology of Microbial Diseases, Yale School of Public Health – sequence: 4 givenname: Jared surname: Thomas fullname: Thomas, Jared organization: Department of Internal Medicine, Yale School of Medicine – sequence: 5 givenname: Jennifer surname: Chiarella fullname: Chiarella, Jennifer organization: Department of Neurology, Yale School of Medicine – sequence: 6 givenname: Arnau surname: Casanovas-Massana fullname: Casanovas-Massana, Arnau organization: Department of Epidemiology of Microbial Diseases, Yale School of Public Health – sequence: 7 givenname: Jing surname: Zhou fullname: Zhou, Jing organization: Isoplexis – sequence: 8 givenname: Camila surname: Odio fullname: Odio, Camila organization: Department of Internal Medicine, Yale School of Medicine – sequence: 9 givenname: Pavithra surname: Vijayakumar fullname: Vijayakumar, Pavithra organization: Department of Internal Medicine, Yale School of Medicine – sequence: 10 givenname: Bertie surname: Geng fullname: Geng, Bertie organization: Department of Internal Medicine, Yale School of Medicine – sequence: 11 givenname: John surname: Fournier fullname: Fournier, John organization: Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine – sequence: 12 givenname: Santos surname: Bermejo fullname: Bermejo, Santos organization: Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine – sequence: 13 givenname: Joseph R. surname: Fauver fullname: Fauver, Joseph R. organization: Department of Epidemiology of Microbial Diseases, Yale School of Public Health – sequence: 14 givenname: Tara surname: Alpert fullname: Alpert, Tara organization: Department of Epidemiology of Microbial Diseases, Yale School of Public Health – sequence: 15 givenname: Anne L. surname: Wyllie fullname: Wyllie, Anne L. organization: Department of Epidemiology of Microbial Diseases, Yale School of Public Health – sequence: 16 givenname: Cynthia surname: Turcotte fullname: Turcotte, Cynthia organization: Isoplexis – sequence: 17 givenname: Matthew surname: Steinle fullname: Steinle, Matthew organization: Isoplexis – sequence: 18 givenname: Patrick surname: Paczkowski fullname: Paczkowski, Patrick organization: Isoplexis – sequence: 19 givenname: Charles surname: Dela Cruz fullname: Dela Cruz, Charles organization: Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine – sequence: 20 givenname: Craig surname: Wilen fullname: Wilen, Craig organization: Department of Laboratory Medicine, Yale School of Medicine – sequence: 21 givenname: Albert I. surname: Ko fullname: Ko, Albert I. organization: Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, Department of Epidemiology of Microbial Diseases, Yale School of Public Health – sequence: 22 givenname: Sean surname: MacKay fullname: MacKay, Sean organization: Isoplexis – sequence: 23 givenname: Nathan D. surname: Grubaugh fullname: Grubaugh, Nathan D. organization: Department of Epidemiology of Microbial Diseases, Yale School of Public Health – sequence: 24 givenname: Serena surname: Spudich fullname: Spudich, Serena organization: Department of Neurology, Yale School of Medicine – sequence: 25 givenname: Lydia Aoun surname: Barakat fullname: Barakat, Lydia Aoun organization: Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine |
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| Cites_doi | 10.1148/radiol.2020201187 10.1007/s15010-015-0720-y 10.1038/s41591-020-0901-9 10.1016/S0042-6822(03)00323-4 10.4049/jimmunol.163.5.2953 10.1056/NEJMc2008597 10.1007/s00018-013-1459-1 10.1046/j.1365-2249.1998.00698.x 10.1128/JVI.00737-08 10.1056/NEJMoa2012410 10.1016/j.ijid.2020.03.062 10.1016/S1044-5323(02)00125-2 10.1128/JVI.73.4.3338-3350.1999 10.1056/NEJMc2011400 10.1086/444461 |
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| References | L Mao (1812_CR8) 2020; 1 T Moriguchi (1812_CR11) 2020; 94 Y Wu (1812_CR5) 2020; S0889-1591 JM Weiss (1812_CR14) 1999; 163 Y Arabi (1812_CR4) 2015; 43 N Arbour (1812_CR2) 1999; 73 H Jacomy (1812_CR3) 2003; 315 1812_CR1 J Xu (1812_CR7) 2005; 41 Y Yao (1812_CR13) 2014; 71 1812_CR9 1812_CR17 DJ Mahad (1812_CR15) 2003; 15 CM Mastroianni (1812_CR16) 1998; 114 1812_CR10 J Netland (1812_CR6) 2008; 82 1812_CR12 32702723 - Res Sq. 2020 May 12:rs.3.rs-28583. doi: 10.21203/rs.3.rs-28583/v1 |
| References_xml | – volume: S0889-1591 start-page: 30357 issue: 20 year: 2020 ident: 1812_CR5 publication-title: Brain Behav Immun – ident: 1812_CR10 doi: 10.1148/radiol.2020201187 – volume: 43 start-page: 495 issue: 4 year: 2015 ident: 1812_CR4 publication-title: Infection. doi: 10.1007/s15010-015-0720-y – ident: 1812_CR17 doi: 10.1038/s41591-020-0901-9 – volume: 315 start-page: 20 issue: 1 year: 2003 ident: 1812_CR3 publication-title: Virology. doi: 10.1016/S0042-6822(03)00323-4 – volume: 163 start-page: 2953 issue: 5 year: 1999 ident: 1812_CR14 publication-title: J Immunol doi: 10.4049/jimmunol.163.5.2953 – ident: 1812_CR9 doi: 10.1056/NEJMc2008597 – volume: 71 start-page: 683 year: 2014 ident: 1812_CR13 publication-title: Cell Mol Life Sci doi: 10.1007/s00018-013-1459-1 – volume: 114 start-page: 210 year: 1998 ident: 1812_CR16 publication-title: Clin Exp Immunol doi: 10.1046/j.1365-2249.1998.00698.x – volume: 1 start-page: e201127 year: 2020 ident: 1812_CR8 publication-title: JAMA Neurol – volume: 82 start-page: 7264 issue: 15 year: 2008 ident: 1812_CR6 publication-title: J Virol doi: 10.1128/JVI.00737-08 – ident: 1812_CR1 doi: 10.1056/NEJMoa2012410 – volume: 94 start-page: 55 year: 2020 ident: 1812_CR11 publication-title: Int J Infect Dis doi: 10.1016/j.ijid.2020.03.062 – volume: 15 start-page: 23 year: 2003 ident: 1812_CR15 publication-title: Semin Immunol doi: 10.1016/S1044-5323(02)00125-2 – volume: 73 start-page: 3338 issue: 4 year: 1999 ident: 1812_CR2 publication-title: J Virol doi: 10.1128/JVI.73.4.3338-3350.1999 – ident: 1812_CR12 doi: 10.1056/NEJMc2011400 – volume: 41 start-page: 1089 issue: 8 year: 2005 ident: 1812_CR7 publication-title: Clin Infect Dis doi: 10.1086/444461 – reference: 32702723 - Res Sq. 2020 May 12:rs.3.rs-28583. doi: 10.21203/rs.3.rs-28583/v1 |
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COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic... COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications... Background COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic... Abstract Background COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but... |
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| SubjectTerms | Acute Disease Age Aged Betacoronavirus Biomarkers - cerebrospinal fluid Blood Case Report Central nervous system Cerebrospinal fluid Coronavirus Infections Coronaviruses COVID-19 Cytokines Cytokines - cerebrospinal fluid Diagnosis Disease Encephalitis, Viral Encephalopathy Female Health aspects Hospitals Humans Illnesses Infections Inflammation Invasiveness Laboratories Magnetic resonance imaging Medicine Medicine & Public Health Metabolism Nervous system Neurochemistry Neurocritical care Neuroinflammation Neurological complications Neurology Neurosurgery Pandemics Patients Plasma Pneumonia, Viral Proteins SARS-CoV-2 Seizures Seizures (Medicine) Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 |
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| Title | Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19 |
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