The impact of physical exercise on the fatigue symptoms in patients with multiple sclerosis: a systematic review and meta-analysis

Background Despite many benefits of the physical activity on physical and mental health of patients with Multiple Sclerosis (MS), the activity level in these patients is still very limited, and they continue to suffer from impairment in functioning ability. The main aim of this study is thus to clos...

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Veröffentlicht in:BMC neurology Jg. 20; H. 1; S. 93 - 11
Hauptverfasser: Razazian, Nazanin, Kazeminia, Mohsen, Moayedi, Hossein, Daneshkhah, Alireza, Shohaimi, Shamarina, Mohammadi, Masoud, Jalali, Rostam, Salari, Nader
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 13.03.2020
BioMed Central Ltd
Springer Nature B.V
BMC
Schlagworte:
Bias
Care and treatment
Chronic illnesses
Diagnosis
Disease
Employment
Exercise
Exercise Therapy
Fatigue
Fatigue - etiology
Fatigue - therapy
Flexibility
Health aspects
Humans
Iran
Keywords
Medical research
Medicine
Medicine & Public Health
Mental health
Meta-analysis
Multiple sclerosis
Multiple Sclerosis - complications
Multiple Sclerosis - rehabilitation
Neurochemistry
Neurology
Neuromuscular disorders and peripheral neurology
Neurosurgery
Patients
Pharmaceuticals
Physical activity
Physical exercise
Physical fitness
Physical training
Rehabilitation
Research Article
Retirement benefits
Studies
Systematic review
Iran
Physical exercise
Fatigue
Multiple sclerosis
ISSN:1471-2377, 1471-2377
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Zusammenfassung:Background Despite many benefits of the physical activity on physical and mental health of patients with Multiple Sclerosis (MS), the activity level in these patients is still very limited, and they continue to suffer from impairment in functioning ability. The main aim of this study is thus to closely examine exercise’s effect on fatigue of patients with MS worldwide, with particular interest on Iran based on a comprehensive systematic review and meta-analysis. Methods The studies used in this systematic review were selected from the articles published from 1996 to 2019, in national and international databases including SID, Magiran, Iranmedex, Irandoc, Google Scholar, Cochrane, Embase, ScienceDirect, Scopus, PubMed and Web of Science (ISI). These databases were thoroughly searched, and the relevant ones were selected based on some plausible keywords to the aim of this study. Heterogeneity index between studies was determined using Cochran’s test and I 2 . Due to heterogeneity in studies, the random effects model was used to estimate standardized mean difference. Results From the systematic review, a meta-analysis was performed on 31 articles which were fulfilled the inclusion criteria. The sample including of 714 subjects was selected from the intervention group, and almost the same sample size of 720 individuals were selected in the control group. Based on the results derived from this meta-analysis, the standardized mean difference between the intervention group before and after the intervention was respectively estimated to be 23.8 ± 6.2 and 16.9 ± 3.2, which indicates that the physical exercise reduces fatigue in patients with MS. Conclusion The results of this study extracted from a detailed meta-analysis reveal and confirm that physical exercise significantly reduces fatigue in patients with MS. As a results, a regular exercise program is strongly recommended to be part of a rehabilitation program for these patients.
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ISSN:1471-2377
1471-2377
DOI:10.1186/s12883-020-01654-y