The NICU Antibiotics and Outcomes (NANO) trial: a randomized multicenter clinical trial assessing empiric antibiotics and clinical outcomes in newborn preterm infants

Background Early-onset sepsis is an important cause of neonatal morbidity and mortality in the preterm population. Infants perceived to be at increased risk for early-onset sepsis are often treated empirically with broad-spectrum antibiotics while awaiting confirmatory blood cultures, despite an ove...

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Bibliographic Details
Published in:	Current controlled trials in cardiovascular medicine Vol. 23; no. 1; pp. 428 - 16
Main Authors:	Morowitz, Michael J., Katheria, Anup C., Polin, Richard A., Pace, Elizabeth, Huang, David T., Chang, Chung-Chou H., Yabes, Johathan G.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 23.05.2022 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Anti-Bacterial Agents - adverse effects Antibiotics Biomedicine Birth weight Cesarean Section Childbirth & labor Clinical outcomes Clinical trials Critical care Diagnosis Dosage and administration Drug therapy Early-onset neonatal sepsis Enterocolitis, Necrotizing - diagnosis Enterocolitis, Necrotizing - epidemiology Extremely-low-birthweight Female Gastrointestinal diseases Gestational age Health Sciences Hemodynamics Humans Induced labor Infant Infant, Newborn Infant, Premature Infants (Premature) Infections Intensive care Intensive Care Units, Neonatal Internal medicine Late-onset neonatal sepsis Medicine Medicine & Public Health Microbial colonization Microbiota Necrosis Necrotizing enterocolitis Neonatal care Newborn babies Pediatrics Penicillin Pregnancy Premature babies Premature birth Prematurity Prospective Studies Sepsis Sepsis - diagnosis Sepsis - drug therapy Sepsis - epidemiology Statistics for Life Sciences Study Protocol Testing Thoracic surgery Ventilators Canada United States United States > US Microbial colonization Late-onset neonatal sepsis Prematurity Mortality Extremely-low-birthweight Necrotizing enterocolitis Early-onset neonatal sepsis Morbidity
ISSN:	1745-6215, 1745-6215
Online Access:	Get full text
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