Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system

Remyelination following CNS demyelination restores rapid signal propagation and protects axons; however, its efficiency declines with increasing age. Both intrinsic changes in the oligodendrocyte progenitor cell population and extrinsic factors in the lesion microenvironment of older subjects contri...

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Veröffentlicht in:	Acta neuropathologica Jg. 139; H. 5; S. 893 - 909
Hauptverfasser:	Rawji, Khalil S., Young, Adam M.H., Ghosh, Tanay, Michaels, Nathan J., Mirzaei, Reza, Kappen, Janson, Kolehmainen, Kathleen L., Alaeiilkhchi, Nima, Lozinski, Brian, Mishra, Manoj K., Pu, Annie, Tang, Weiwen, Zein, Salma, Kaushik, Deepak K., Keough, Michael B., Plemel, Jason R., Calvert, Fiona, Knights, Andrew J., Gaffney, Daniel J., Tetzlaff, Wolfram, Franklin, Robin J. M., Yong, V. Wee
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2020 Springer Springer Nature B.V
Schlagworte:	Aging Aging - physiology Animals Axons Axons - pathology CD36 antigen Cell culture Cell fate Central nervous system Demyelinating diseases Demyelinating Diseases - pathology Demyelination Fate maps Gene mapping Growth factors Humans Lesions Macrophages Macrophages - pathology Medicine Medicine & Public Health Mice, Transgenic Microglia Microglia - metabolism Microglia - pathology Monocytes Multiple sclerosis Multiple Sclerosis - pathology Myelin Myelination Neurosciences Niacin Niacin - metabolism Nicotinic acid Original Paper Pathology Phagocytes Phagocytosis Phagocytosis - physiology Progenitor cells Propagation Rejuvenation - physiology Remyelination - physiology Scavenger receptors Vitamin B Aging Oligodendrocyte progenitor cells Macrophages Remyelination Phagocytosis Microglia
ISSN:	0001-6322, 1432-0533, 1432-0533
Online-Zugang:	Volltext
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