Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients
Background Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study is to investigate the use and effect of prone position in this population during the first 2020 pandemic wave. Methods Retrospecti...
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| Published in: | Critical care (London, England) Vol. 25; no. 1; pp. 128 - 11 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
London
BioMed Central
06.04.2021
BioMed Central Ltd Springer Nature B.V BMC |
| Subjects: | |
| ISSN: | 1364-8535, 1466-609X, 1364-8535, 1466-609X, 1366-609X |
| Online Access: | Get full text |
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| Abstract | Background
Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study is to investigate the use and effect of prone position in this population during the first 2020 pandemic wave.
Methods
Retrospective, multicentre, national cohort study conducted between February 24 and June 14, 2020, in 24 Italian Intensive Care Units (ICU) on adult patients needing invasive mechanical ventilation for respiratory failure caused by COVID-19. Clinical data were collected on the day of ICU admission. Information regarding the use of prone position was collected daily. Follow-up for patient outcomes was performed on July 15, 2020. The respiratory effects of the
first
prone position were studied in a subset of 78 patients. Patients were classified as
Oxygen Responders
if the PaO
2
/FiO
2
ratio increased ≥ 20 mmHg during prone position and as
Carbon Dioxide Responders
if the ventilatory ratio was reduced during prone position.
Results
Of 1057 included patients, mild, moderate and severe ARDS was present in 15, 50 and 35% of patients, respectively, and had a resulting mortality of 25, 33 and 41%. Prone position was applied in 61% of the patients. Patients placed prone had a more severe disease and died significantly more (45% vs. 33%,
p
< 0.001). Overall, prone position induced a significant increase in PaO
2
/FiO
2
ratio, while no change in respiratory system compliance or ventilatory ratio was observed. Seventy-eight % of the subset of 78 patients were
Oxygen Responders
. Non-Responders had a more severe respiratory failure and died more often in the ICU (65% vs
.
38%,
p
= 0.047). Forty-seven % of patients were defined as
Carbon Dioxide Responders
. These patients were older and had more comorbidities; however, no difference in terms of ICU mortality was observed (51% vs
.
37%,
p
= 0.189 for
Carbon Dioxide Responders
and
Non-Responders
, respectively).
Conclusions
During the COVID-19 pandemic, prone position has been widely adopted to treat mechanically ventilated patients with respiratory failure. The majority of patients improved their oxygenation during prone position, most likely due to a better ventilation perfusion matching.
Trial registration
: clinicaltrials.gov number: NCT04388670 |
|---|---|
| AbstractList | Abstract Background Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study is to investigate the use and effect of prone position in this population during the first 2020 pandemic wave. Methods Retrospective, multicentre, national cohort study conducted between February 24 and June 14, 2020, in 24 Italian Intensive Care Units (ICU) on adult patients needing invasive mechanical ventilation for respiratory failure caused by COVID-19. Clinical data were collected on the day of ICU admission. Information regarding the use of prone position was collected daily. Follow-up for patient outcomes was performed on July 15, 2020. The respiratory effects of the first prone position were studied in a subset of 78 patients. Patients were classified as Oxygen Responders if the PaO2/FiO2 ratio increased ≥ 20 mmHg during prone position and as Carbon Dioxide Responders if the ventilatory ratio was reduced during prone position. Results Of 1057 included patients, mild, moderate and severe ARDS was present in 15, 50 and 35% of patients, respectively, and had a resulting mortality of 25, 33 and 41%. Prone position was applied in 61% of the patients. Patients placed prone had a more severe disease and died significantly more (45% vs. 33%, p < 0.001). Overall, prone position induced a significant increase in PaO2/FiO2 ratio, while no change in respiratory system compliance or ventilatory ratio was observed. Seventy-eight % of the subset of 78 patients were Oxygen Responders. Non-Responders had a more severe respiratory failure and died more often in the ICU (65% vs. 38%, p = 0.047). Forty-seven % of patients were defined as Carbon Dioxide Responders. These patients were older and had more comorbidities; however, no difference in terms of ICU mortality was observed (51% vs. 37%, p = 0.189 for Carbon Dioxide Responders and Non-Responders, respectively). Conclusions During the COVID-19 pandemic, prone position has been widely adopted to treat mechanically ventilated patients with respiratory failure. The majority of patients improved their oxygenation during prone position, most likely due to a better ventilation perfusion matching. Trial registration: clinicaltrials.gov number: NCT04388670 Background Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study is to investigate the use and effect of prone position in this population during the first 2020 pandemic wave. Methods Retrospective, multicentre, national cohort study conducted between February 24 and June 14, 2020, in 24 Italian Intensive Care Units (ICU) on adult patients needing invasive mechanical ventilation for respiratory failure caused by COVID-19. Clinical data were collected on the day of ICU admission. Information regarding the use of prone position was collected daily. Follow-up for patient outcomes was performed on July 15, 2020. The respiratory effects of the first prone position were studied in a subset of 78 patients. Patients were classified as Oxygen Responders if the PaO.sub.2/FiO.sub.2 ratio increased [greater than or equai to] 20 mmHg during prone position and as Carbon Dioxide Responders if the ventilatory ratio was reduced during prone position. Results Of 1057 included patients, mild, moderate and severe ARDS was present in 15, 50 and 35% of patients, respectively, and had a resulting mortality of 25, 33 and 41%. Prone position was applied in 61% of the patients. Patients placed prone had a more severe disease and died significantly more (45% vs. 33%, p < 0.001). Overall, prone position induced a significant increase in PaO.sub.2/FiO.sub.2 ratio, while no change in respiratory system compliance or ventilatory ratio was observed. Seventy-eight % of the subset of 78 patients were Oxygen Responders. Non-Responders had a more severe respiratory failure and died more often in the ICU (65% vs. 38%, p = 0.047). Forty-seven % of patients were defined as Carbon Dioxide Responders. These patients were older and had more comorbidities; however, no difference in terms of ICU mortality was observed (51% vs. 37%, p = 0.189 for Carbon Dioxide Responders and Non-Responders, respectively). Conclusions During the COVID-19 pandemic, prone position has been widely adopted to treat mechanically ventilated patients with respiratory failure. The majority of patients improved their oxygenation during prone position, most likely due to a better ventilation perfusion matching. Trial registration: clinicaltrials.gov number: NCT04388670 Keywords: COVID-19, Mechanical ventilation, Prone positioning, Refractory hypoxemia Background Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study is to investigate the use and effect of prone position in this population during the first 2020 pandemic wave. Methods Retrospective, multicentre, national cohort study conducted between February 24 and June 14, 2020, in 24 Italian Intensive Care Units (ICU) on adult patients needing invasive mechanical ventilation for respiratory failure caused by COVID-19. Clinical data were collected on the day of ICU admission. Information regarding the use of prone position was collected daily. Follow-up for patient outcomes was performed on July 15, 2020. The respiratory effects of the first prone position were studied in a subset of 78 patients. Patients were classified as Oxygen Responders if the PaO 2 /FiO 2 ratio increased ≥ 20 mmHg during prone position and as Carbon Dioxide Responders if the ventilatory ratio was reduced during prone position. Results Of 1057 included patients, mild, moderate and severe ARDS was present in 15, 50 and 35% of patients, respectively, and had a resulting mortality of 25, 33 and 41%. Prone position was applied in 61% of the patients. Patients placed prone had a more severe disease and died significantly more (45% vs. 33%, p < 0.001). Overall, prone position induced a significant increase in PaO 2 /FiO 2 ratio, while no change in respiratory system compliance or ventilatory ratio was observed. Seventy-eight % of the subset of 78 patients were Oxygen Responders . Non-Responders had a more severe respiratory failure and died more often in the ICU (65% vs . 38%, p = 0.047). Forty-seven % of patients were defined as Carbon Dioxide Responders . These patients were older and had more comorbidities; however, no difference in terms of ICU mortality was observed (51% vs . 37%, p = 0.189 for Carbon Dioxide Responders and Non-Responders , respectively). Conclusions During the COVID-19 pandemic, prone position has been widely adopted to treat mechanically ventilated patients with respiratory failure. The majority of patients improved their oxygenation during prone position, most likely due to a better ventilation perfusion matching. Trial registration : clinicaltrials.gov number: NCT04388670 Background Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study is to investigate the use and effect of prone position in this population during the first 2020 pandemic wave. Methods Retrospective, multicentre, national cohort study conducted between February 24 and June 14, 2020, in 24 Italian Intensive Care Units (ICU) on adult patients needing invasive mechanical ventilation for respiratory failure caused by COVID-19. Clinical data were collected on the day of ICU admission. Information regarding the use of prone position was collected daily. Follow-up for patient outcomes was performed on July 15, 2020. The respiratory effects of the first prone position were studied in a subset of 78 patients. Patients were classified as Oxygen Responders if the PaO2/FiO2 ratio increased ≥ 20 mmHg during prone position and as Carbon Dioxide Responders if the ventilatory ratio was reduced during prone position. Results Of 1057 included patients, mild, moderate and severe ARDS was present in 15, 50 and 35% of patients, respectively, and had a resulting mortality of 25, 33 and 41%. Prone position was applied in 61% of the patients. Patients placed prone had a more severe disease and died significantly more (45% vs. 33%, p < 0.001). Overall, prone position induced a significant increase in PaO2/FiO2 ratio, while no change in respiratory system compliance or ventilatory ratio was observed. Seventy-eight % of the subset of 78 patients were Oxygen Responders. Non-Responders had a more severe respiratory failure and died more often in the ICU (65% vs. 38%, p = 0.047). Forty-seven % of patients were defined as Carbon Dioxide Responders. These patients were older and had more comorbidities; however, no difference in terms of ICU mortality was observed (51% vs. 37%, p = 0.189 for Carbon Dioxide Responders and Non-Responders, respectively). Conclusions During the COVID-19 pandemic, prone position has been widely adopted to treat mechanically ventilated patients with respiratory failure. The majority of patients improved their oxygenation during prone position, most likely due to a better ventilation perfusion matching. Trial registration: clinicaltrials.gov number: NCT04388670 Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study is to investigate the use and effect of prone position in this population during the first 2020 pandemic wave.BACKGROUNDLimited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study is to investigate the use and effect of prone position in this population during the first 2020 pandemic wave.Retrospective, multicentre, national cohort study conducted between February 24 and June 14, 2020, in 24 Italian Intensive Care Units (ICU) on adult patients needing invasive mechanical ventilation for respiratory failure caused by COVID-19. Clinical data were collected on the day of ICU admission. Information regarding the use of prone position was collected daily. Follow-up for patient outcomes was performed on July 15, 2020. The respiratory effects of the first prone position were studied in a subset of 78 patients. Patients were classified as Oxygen Responders if the PaO2/FiO2 ratio increased ≥ 20 mmHg during prone position and as Carbon Dioxide Responders if the ventilatory ratio was reduced during prone position.METHODSRetrospective, multicentre, national cohort study conducted between February 24 and June 14, 2020, in 24 Italian Intensive Care Units (ICU) on adult patients needing invasive mechanical ventilation for respiratory failure caused by COVID-19. Clinical data were collected on the day of ICU admission. Information regarding the use of prone position was collected daily. Follow-up for patient outcomes was performed on July 15, 2020. The respiratory effects of the first prone position were studied in a subset of 78 patients. Patients were classified as Oxygen Responders if the PaO2/FiO2 ratio increased ≥ 20 mmHg during prone position and as Carbon Dioxide Responders if the ventilatory ratio was reduced during prone position.Of 1057 included patients, mild, moderate and severe ARDS was present in 15, 50 and 35% of patients, respectively, and had a resulting mortality of 25, 33 and 41%. Prone position was applied in 61% of the patients. Patients placed prone had a more severe disease and died significantly more (45% vs. 33%, p < 0.001). Overall, prone position induced a significant increase in PaO2/FiO2 ratio, while no change in respiratory system compliance or ventilatory ratio was observed. Seventy-eight % of the subset of 78 patients were Oxygen Responders. Non-Responders had a more severe respiratory failure and died more often in the ICU (65% vs. 38%, p = 0.047). Forty-seven % of patients were defined as Carbon Dioxide Responders. These patients were older and had more comorbidities; however, no difference in terms of ICU mortality was observed (51% vs. 37%, p = 0.189 for Carbon Dioxide Responders and Non-Responders, respectively).RESULTSOf 1057 included patients, mild, moderate and severe ARDS was present in 15, 50 and 35% of patients, respectively, and had a resulting mortality of 25, 33 and 41%. Prone position was applied in 61% of the patients. Patients placed prone had a more severe disease and died significantly more (45% vs. 33%, p < 0.001). Overall, prone position induced a significant increase in PaO2/FiO2 ratio, while no change in respiratory system compliance or ventilatory ratio was observed. Seventy-eight % of the subset of 78 patients were Oxygen Responders. Non-Responders had a more severe respiratory failure and died more often in the ICU (65% vs. 38%, p = 0.047). Forty-seven % of patients were defined as Carbon Dioxide Responders. These patients were older and had more comorbidities; however, no difference in terms of ICU mortality was observed (51% vs. 37%, p = 0.189 for Carbon Dioxide Responders and Non-Responders, respectively).During the COVID-19 pandemic, prone position has been widely adopted to treat mechanically ventilated patients with respiratory failure. The majority of patients improved their oxygenation during prone position, most likely due to a better ventilation perfusion matching.CONCLUSIONSDuring the COVID-19 pandemic, prone position has been widely adopted to treat mechanically ventilated patients with respiratory failure. The majority of patients improved their oxygenation during prone position, most likely due to a better ventilation perfusion matching.clinicaltrials.gov number: NCT04388670.TRIAL REGISTRATIONclinicaltrials.gov number: NCT04388670. Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study is to investigate the use and effect of prone position in this population during the first 2020 pandemic wave. Retrospective, multicentre, national cohort study conducted between February 24 and June 14, 2020, in 24 Italian Intensive Care Units (ICU) on adult patients needing invasive mechanical ventilation for respiratory failure caused by COVID-19. Clinical data were collected on the day of ICU admission. Information regarding the use of prone position was collected daily. Follow-up for patient outcomes was performed on July 15, 2020. The respiratory effects of the first prone position were studied in a subset of 78 patients. Patients were classified as Oxygen Responders if the PaO.sub.2/FiO.sub.2 ratio increased [greater than or equai to] 20 mmHg during prone position and as Carbon Dioxide Responders if the ventilatory ratio was reduced during prone position. Of 1057 included patients, mild, moderate and severe ARDS was present in 15, 50 and 35% of patients, respectively, and had a resulting mortality of 25, 33 and 41%. Prone position was applied in 61% of the patients. Patients placed prone had a more severe disease and died significantly more (45% vs. 33%, p < 0.001). Overall, prone position induced a significant increase in PaO.sub.2/FiO.sub.2 ratio, while no change in respiratory system compliance or ventilatory ratio was observed. Seventy-eight % of the subset of 78 patients were Oxygen Responders. Non-Responders had a more severe respiratory failure and died more often in the ICU (65% vs. 38%, p = 0.047). Forty-seven % of patients were defined as Carbon Dioxide Responders. These patients were older and had more comorbidities; however, no difference in terms of ICU mortality was observed (51% vs. 37%, p = 0.189 for Carbon Dioxide Responders and Non-Responders, respectively). During the COVID-19 pandemic, prone position has been widely adopted to treat mechanically ventilated patients with respiratory failure. The majority of patients improved their oxygenation during prone position, most likely due to a better ventilation perfusion matching. Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study is to investigate the use and effect of prone position in this population during the first 2020 pandemic wave. Retrospective, multicentre, national cohort study conducted between February 24 and June 14, 2020, in 24 Italian Intensive Care Units (ICU) on adult patients needing invasive mechanical ventilation for respiratory failure caused by COVID-19. Clinical data were collected on the day of ICU admission. Information regarding the use of prone position was collected daily. Follow-up for patient outcomes was performed on July 15, 2020. The respiratory effects of the first prone position were studied in a subset of 78 patients. Patients were classified as Oxygen Responders if the PaO /FiO ratio increased ≥ 20 mmHg during prone position and as Carbon Dioxide Responders if the ventilatory ratio was reduced during prone position. Of 1057 included patients, mild, moderate and severe ARDS was present in 15, 50 and 35% of patients, respectively, and had a resulting mortality of 25, 33 and 41%. Prone position was applied in 61% of the patients. Patients placed prone had a more severe disease and died significantly more (45% vs. 33%, p < 0.001). Overall, prone position induced a significant increase in PaO /FiO ratio, while no change in respiratory system compliance or ventilatory ratio was observed. Seventy-eight % of the subset of 78 patients were Oxygen Responders. Non-Responders had a more severe respiratory failure and died more often in the ICU (65% vs. 38%, p = 0.047). Forty-seven % of patients were defined as Carbon Dioxide Responders. These patients were older and had more comorbidities; however, no difference in terms of ICU mortality was observed (51% vs. 37%, p = 0.189 for Carbon Dioxide Responders and Non-Responders, respectively). During the COVID-19 pandemic, prone position has been widely adopted to treat mechanically ventilated patients with respiratory failure. The majority of patients improved their oxygenation during prone position, most likely due to a better ventilation perfusion matching. clinicaltrials.gov number: NCT04388670. |
| ArticleNumber | 128 |
| Audience | Academic |
| Author | Pesenti, Antonio Cabrini, Luca Tardini, Francesca Grieco, Domenico Luca Forastieri, Andrea Forlini, Clarissa Langer, Thomas Carlesso, Eleonora Castelli, Gianpaolo Ranieri, Marco Guzzardella, Amedeo Previtali, Paola Girardis, Massimo Mirabella, Lucia Foti, Giuseppe De Robertis, Edoardo Favarato, Martina Rona, Roberto Fumagalli, Roberto Noseda, Valentina Brioni, Matteo Protti, Alessandro Tonetti, Tommaso Grasselli, Giacomo Dalla Corte, Francesca Zannoni, Fabio Antonelli, Massimo |
| Author_xml | – sequence: 1 givenname: Thomas surname: Langer fullname: Langer, Thomas organization: Department of Medicine and Surgery, University of Milan-Bicocca, Department of Anesthesia and Intensive Care Medicine, Niguarda Ca’ Granda – sequence: 2 givenname: Matteo surname: Brioni fullname: Brioni, Matteo organization: Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico – sequence: 3 givenname: Amedeo surname: Guzzardella fullname: Guzzardella, Amedeo organization: Department of Pathophysiology and Transplantation, University of Milan – sequence: 4 givenname: Eleonora surname: Carlesso fullname: Carlesso, Eleonora organization: Department of Pathophysiology and Transplantation, University of Milan – sequence: 5 givenname: Luca surname: Cabrini fullname: Cabrini, Luca organization: Ospedale di Circolo e Fondazione Macchi, Università degli studi dell’Insubria – sequence: 6 givenname: Gianpaolo surname: Castelli fullname: Castelli, Gianpaolo organization: Department of Anesthesiology and Intensive Care, ASST Mantova–Ospedale Carlo Poma – sequence: 7 givenname: Francesca surname: Dalla Corte fullname: Dalla Corte, Francesca organization: Department of Biomedical Sciences, Humanitas University – sequence: 8 givenname: Edoardo surname: De Robertis fullname: De Robertis, Edoardo organization: Division of Anaesthesia, Analgesia and Intensive Care, Department of Medicine and Surgery, University of Perugia – sequence: 9 givenname: Martina surname: Favarato fullname: Favarato, Martina organization: Department of Medicine and Surgery, University of Milan-Bicocca – sequence: 10 givenname: Andrea surname: Forastieri fullname: Forastieri, Andrea organization: Department of Anesthesia and Intensive Care, A. Manzoni Hospital, ASST Lecco – sequence: 11 givenname: Clarissa surname: Forlini fullname: Forlini, Clarissa organization: Department of Medicine and Surgery, University of Milan-Bicocca, Department of Anesthesia and Intensive Care Medicine, Niguarda Ca’ Granda – sequence: 12 givenname: Massimo surname: Girardis fullname: Girardis, Massimo organization: Department of Anesthesia and Intensive Care, University Hospital of Modena – sequence: 13 givenname: Domenico Luca surname: Grieco fullname: Grieco, Domenico Luca organization: Department of Anesthesiology, Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Sacred Heart Catholic University – sequence: 14 givenname: Lucia surname: Mirabella fullname: Mirabella, Lucia organization: Department of Medical and Surgical Sciences, Intensive Care Unit, University of Foggia – sequence: 15 givenname: Valentina surname: Noseda fullname: Noseda, Valentina organization: Department of Medicine and Surgery, University of Milan-Bicocca – sequence: 16 givenname: Paola surname: Previtali fullname: Previtali, Paola organization: Department of Anesthesia and Intensive Care Medicine, Niguarda Ca’ Granda – sequence: 17 givenname: Alessandro surname: Protti fullname: Protti, Alessandro organization: Department of Biomedical Sciences, Humanitas University, Department of Anaesthesia and Intensive Care, Humanitas Clinical and Research Center-IRCCS – sequence: 18 givenname: Roberto surname: Rona fullname: Rona, Roberto organization: Department of Anesthesia and Intensive Care Medicine, San Gerardo Hospital ASST Monza – sequence: 19 givenname: Francesca surname: Tardini fullname: Tardini, Francesca organization: Department of Anesthesia and Intensive Care Medicine, Niguarda Ca’ Granda – sequence: 20 givenname: Tommaso surname: Tonetti fullname: Tonetti, Tommaso organization: Anesthesia and Intensive Care Medicine, Policlinico di Sant’Orsola, Alma Mater Studiorum University of Bologna – sequence: 21 givenname: Fabio surname: Zannoni fullname: Zannoni, Fabio organization: Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Pathophysiology and Transplantation, University of Milan – sequence: 22 givenname: Massimo surname: Antonelli fullname: Antonelli, Massimo organization: Department of Anesthesiology, Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Sacred Heart Catholic University – sequence: 23 givenname: Giuseppe surname: Foti fullname: Foti, Giuseppe organization: Department of Medicine and Surgery, University of Milan-Bicocca, Department of Anesthesia and Intensive Care Medicine, San Gerardo Hospital ASST Monza – sequence: 24 givenname: Marco surname: Ranieri fullname: Ranieri, Marco organization: Anesthesia and Intensive Care Medicine, Policlinico di Sant’Orsola, Alma Mater Studiorum University of Bologna – sequence: 25 givenname: Antonio surname: Pesenti fullname: Pesenti, Antonio organization: Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Pathophysiology and Transplantation, University of Milan – sequence: 26 givenname: Roberto surname: Fumagalli fullname: Fumagalli, Roberto organization: Department of Medicine and Surgery, University of Milan-Bicocca, Department of Anesthesia and Intensive Care Medicine, Niguarda Ca’ Granda – sequence: 27 givenname: Giacomo orcidid: 0000-0002-1735-1400 surname: Grasselli fullname: Grasselli, Giacomo email: giacomo.grasselli@unimi.it organization: Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Pathophysiology and Transplantation, University of Milan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33823862$$D View this record in MEDLINE/PubMed |
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Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of... Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study... Background Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of... Abstract Background Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19... |
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| SubjectTerms | Aged Artificial respiration Carbon dioxide Care and treatment Clinical outcomes Cohort Studies Coronaviruses COVID-19 COVID-19 - therapy Critical care Critical Care - standards Critical Care Medicine Data collection Emergency Medicine Epidemics Female Gases Hospital patients Humans Intensive Intubation Intubation - standards Italy Laboratories Length of stay Male Mechanical ventilation Medicine Medicine & Public Health Middle Aged Patient outcomes Patient positioning Patient Positioning - standards Patients Positioning Practice Guidelines as Topic Prone Position Prone positioning Refractory hypoxemia Respiration, Artificial - standards Respiratory failure Retrospective Studies Severe acute respiratory syndrome coronavirus 2 Software Supine Position Trachea Variance analysis Ventilators |
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| Title | Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients |
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