Hypoxia at 3D organoid establishment selects essential subclones within heterogenous pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is especially hypoxic and composed of heterogeneous cell populations containing hypoxia-adapted cells. Hypoxia as a microenvironment of PDAC is known to cause epithelial-mesenchymal transition (EMT) and resistance to therapy. Therefore, cells adapted to hypoxi...

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Vydáno v:	Frontiers in cell and developmental biology Ročník 12; s. 1327772
Hlavní autoři:	Kumano, Koichiro, Nakahashi, Hiromitsu, Louphrasitthiphol, Pakavarin, Kuroda, Yukihito, Miyazaki, Yoshihiro, Shimomura, Osamu, Hashimoto, Shinji, Akashi, Yoshimasa, Mathis, Bryan J., Kim, Jaejeong, Owada, Yohei, Goding, Colin R., Oda, Tatsuya
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland Frontiers Media SA 01.02.2024 Frontiers Media S.A
Témata:	3D organoid Adenocarcinoma Cell and Developmental Biology Cell culture Cell growth Chemotherapy Gene expression Hypoxia Microenvironments Organoids Pancreatic cancer selection bias Transcriptomes tumor heterogeneity Tumors selection bias hypoxia pancreatic cancer 3D organoid tumor heterogeneity
ISSN:	2296-634X, 2296-634X
On-line přístup:	Získat plný text
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