Urine neutrophil gelatinase-associated lipocalin and urine output as predictors of the successful discontinuation of continuous renal replacement therapy in critically ill patients with acute kidney injury
Background Continuous renal replacement therapy (CCRT) is a frequently used modality for the support of intensive care patients with acute kidney injury (AKI). Nevertheless, there are no objective criteria for the discontinuation of CRRT. The purpose of this study was to investigate whether urine ne...
Saved in:
| Published in: | BMC nephrology Vol. 21; no. 1; pp. 375 - 10 |
|---|---|
| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
London
BioMed Central
28.08.2020
BioMed Central Ltd Springer Nature B.V BMC |
| Subjects: | |
| ISSN: | 1471-2369, 1471-2369 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Background
Continuous renal replacement therapy (CCRT) is a frequently used modality for the support of intensive care patients with acute kidney injury (AKI). Nevertheless, there are no objective criteria for the discontinuation of CRRT. The purpose of this study was to investigate whether urine neutrophil gelatinase-associated lipocalin (uNGAL) alone or in combination with urine output could be used as a diagnostic test for renal function recovery in ICU patients on CRRT.
Methods
This was a single-centre prospective observational study including patients with acute kidney failure needing CRRT. Sixty-nine patients were enrolled, and 54 completed the study. Of the 54 patients, 22 recovered renal function (REC), defined as dialysis independency at 72 h from discontinuation, while 32 patients did not (NREC). Urine NGAL was measured at 0, 6, 12, and 24 h after CRRT discontinuation. The cumulated urine output was measured for 24 h prior to discontinuation and at 6, 12, and 24 h after discontinuation. Missing uNGAL values were calculated by interpolation. The Youden’s index was used to calculate cut-off values in order to define uNGAL and urine output single variable and 2-variable diagnostic tests with the optimum prediction of successful CRRT discontinuation.
Results
Baseline characteristics at CRRT initiation were similar between groups. Compared to the NREC group, the REC group had significantly higher urine output (
p
< 0.0001) and lower uNGAL (
p
< 0.001) at all time points, except for uNGAL at 24 h (
p
< 0.24). The best uNGAL predictor for successful CRRT discontinuation was uNGAL at 6 h after discontinuation (predictive value 80%). The best single predictor was cumulated urine output 24 h before discontinuation (predictive value 85%). The combinations of uNGAL at 6 h (cut-off 1650 μg/L) with cumulated urine output 24 h prior to discontinuation (cut-off 210 ml) proved to be the superior tests (using either “or” or “and”), with predictive values of 93% (successful CRRT discontinuation) and 92% (dialysis dependency).
Conclusions
With a predictive value of 93%, the combination of uNGAL at 6 h after and the cumulated urine output 24 h prior to CRRT cessation proved to be the best diagnostic test for successful CRRT discontinuation in ICU patients.
Clinical trial registration
N/A |
|---|---|
| AbstractList | Abstract Background Continuous renal replacement therapy (CCRT) is a frequently used modality for the support of intensive care patients with acute kidney injury (AKI). Nevertheless, there are no objective criteria for the discontinuation of CRRT. The purpose of this study was to investigate whether urine neutrophil gelatinase-associated lipocalin (uNGAL) alone or in combination with urine output could be used as a diagnostic test for renal function recovery in ICU patients on CRRT. Methods This was a single-centre prospective observational study including patients with acute kidney failure needing CRRT. Sixty-nine patients were enrolled, and 54 completed the study. Of the 54 patients, 22 recovered renal function (REC), defined as dialysis independency at 72 h from discontinuation, while 32 patients did not (NREC). Urine NGAL was measured at 0, 6, 12, and 24 h after CRRT discontinuation. The cumulated urine output was measured for 24 h prior to discontinuation and at 6, 12, and 24 h after discontinuation. Missing uNGAL values were calculated by interpolation. The Youden’s index was used to calculate cut-off values in order to define uNGAL and urine output single variable and 2-variable diagnostic tests with the optimum prediction of successful CRRT discontinuation. Results Baseline characteristics at CRRT initiation were similar between groups. Compared to the NREC group, the REC group had significantly higher urine output (p < 0.0001) and lower uNGAL (p < 0.001) at all time points, except for uNGAL at 24 h (p < 0.24). The best uNGAL predictor for successful CRRT discontinuation was uNGAL at 6 h after discontinuation (predictive value 80%). The best single predictor was cumulated urine output 24 h before discontinuation (predictive value 85%). The combinations of uNGAL at 6 h (cut-off 1650 μg/L) with cumulated urine output 24 h prior to discontinuation (cut-off 210 ml) proved to be the superior tests (using either “or” or “and”), with predictive values of 93% (successful CRRT discontinuation) and 92% (dialysis dependency). Conclusions With a predictive value of 93%, the combination of uNGAL at 6 h after and the cumulated urine output 24 h prior to CRRT cessation proved to be the best diagnostic test for successful CRRT discontinuation in ICU patients. Clinical trial registration N/A Continuous renal replacement therapy (CCRT) is a frequently used modality for the support of intensive care patients with acute kidney injury (AKI). Nevertheless, there are no objective criteria for the discontinuation of CRRT. The purpose of this study was to investigate whether urine neutrophil gelatinase-associated lipocalin (uNGAL) alone or in combination with urine output could be used as a diagnostic test for renal function recovery in ICU patients on CRRT. This was a single-centre prospective observational study including patients with acute kidney failure needing CRRT. Sixty-nine patients were enrolled, and 54 completed the study. Of the 54 patients, 22 recovered renal function (REC), defined as dialysis independency at 72 h from discontinuation, while 32 patients did not (NREC). Urine NGAL was measured at 0, 6, 12, and 24 h after CRRT discontinuation. The cumulated urine output was measured for 24 h prior to discontinuation and at 6, 12, and 24 h after discontinuation. Missing uNGAL values were calculated by interpolation. The Youden's index was used to calculate cut-off values in order to define uNGAL and urine output single variable and 2-variable diagnostic tests with the optimum prediction of successful CRRT discontinuation. Baseline characteristics at CRRT initiation were similar between groups. Compared to the NREC group, the REC group had significantly higher urine output (p < 0.0001) and lower uNGAL (p < 0.001) at all time points, except for uNGAL at 24 h (p < 0.24). The best uNGAL predictor for successful CRRT discontinuation was uNGAL at 6 h after discontinuation (predictive value 80%). The best single predictor was cumulated urine output 24 h before discontinuation (predictive value 85%). The combinations of uNGAL at 6 h (cut-off 1650 [mu]g/L) with cumulated urine output 24 h prior to discontinuation (cut-off 210 ml) proved to be the superior tests (using either "or" or "and"), with predictive values of 93% (successful CRRT discontinuation) and 92% (dialysis dependency). With a predictive value of 93%, the combination of uNGAL at 6 h after and the cumulated urine output 24 h prior to CRRT cessation proved to be the best diagnostic test for successful CRRT discontinuation in ICU patients. Continuous renal replacement therapy (CCRT) is a frequently used modality for the support of intensive care patients with acute kidney injury (AKI). Nevertheless, there are no objective criteria for the discontinuation of CRRT. The purpose of this study was to investigate whether urine neutrophil gelatinase-associated lipocalin (uNGAL) alone or in combination with urine output could be used as a diagnostic test for renal function recovery in ICU patients on CRRT. This was a single-centre prospective observational study including patients with acute kidney failure needing CRRT. Sixty-nine patients were enrolled, and 54 completed the study. Of the 54 patients, 22 recovered renal function (REC), defined as dialysis independency at 72 h from discontinuation, while 32 patients did not (NREC). Urine NGAL was measured at 0, 6, 12, and 24 h after CRRT discontinuation. The cumulated urine output was measured for 24 h prior to discontinuation and at 6, 12, and 24 h after discontinuation. Missing uNGAL values were calculated by interpolation. The Youden's index was used to calculate cut-off values in order to define uNGAL and urine output single variable and 2-variable diagnostic tests with the optimum prediction of successful CRRT discontinuation. Baseline characteristics at CRRT initiation were similar between groups. Compared to the NREC group, the REC group had significantly higher urine output (p < 0.0001) and lower uNGAL (p < 0.001) at all time points, except for uNGAL at 24 h (p < 0.24). The best uNGAL predictor for successful CRRT discontinuation was uNGAL at 6 h after discontinuation (predictive value 80%). The best single predictor was cumulated urine output 24 h before discontinuation (predictive value 85%). The combinations of uNGAL at 6 h (cut-off 1650 μg/L) with cumulated urine output 24 h prior to discontinuation (cut-off 210 ml) proved to be the superior tests (using either "or" or "and"), with predictive values of 93% (successful CRRT discontinuation) and 92% (dialysis dependency). With a predictive value of 93%, the combination of uNGAL at 6 h after and the cumulated urine output 24 h prior to CRRT cessation proved to be the best diagnostic test for successful CRRT discontinuation in ICU patients. N/A. Background Continuous renal replacement therapy (CCRT) is a frequently used modality for the support of intensive care patients with acute kidney injury (AKI). Nevertheless, there are no objective criteria for the discontinuation of CRRT. The purpose of this study was to investigate whether urine neutrophil gelatinase-associated lipocalin (uNGAL) alone or in combination with urine output could be used as a diagnostic test for renal function recovery in ICU patients on CRRT. Methods This was a single-centre prospective observational study including patients with acute kidney failure needing CRRT. Sixty-nine patients were enrolled, and 54 completed the study. Of the 54 patients, 22 recovered renal function (REC), defined as dialysis independency at 72 h from discontinuation, while 32 patients did not (NREC). Urine NGAL was measured at 0, 6, 12, and 24 h after CRRT discontinuation. The cumulated urine output was measured for 24 h prior to discontinuation and at 6, 12, and 24 h after discontinuation. Missing uNGAL values were calculated by interpolation. The Youden's index was used to calculate cut-off values in order to define uNGAL and urine output single variable and 2-variable diagnostic tests with the optimum prediction of successful CRRT discontinuation. Results Baseline characteristics at CRRT initiation were similar between groups. Compared to the NREC group, the REC group had significantly higher urine output (p < 0.0001) and lower uNGAL (p < 0.001) at all time points, except for uNGAL at 24 h (p < 0.24). The best uNGAL predictor for successful CRRT discontinuation was uNGAL at 6 h after discontinuation (predictive value 80%). The best single predictor was cumulated urine output 24 h before discontinuation (predictive value 85%). The combinations of uNGAL at 6 h (cut-off 1650 [mu]g/L) with cumulated urine output 24 h prior to discontinuation (cut-off 210 ml) proved to be the superior tests (using either "or" or "and"), with predictive values of 93% (successful CRRT discontinuation) and 92% (dialysis dependency). Conclusions With a predictive value of 93%, the combination of uNGAL at 6 h after and the cumulated urine output 24 h prior to CRRT cessation proved to be the best diagnostic test for successful CRRT discontinuation in ICU patients. Clinical trial registration N/A Keywords: Renal replacement therapy, Critical care, Acute kidney injury, Intensive care unit, Dialysis, Urine neutrophil gelatinase-associated lipocalin Continuous renal replacement therapy (CCRT) is a frequently used modality for the support of intensive care patients with acute kidney injury (AKI). Nevertheless, there are no objective criteria for the discontinuation of CRRT. The purpose of this study was to investigate whether urine neutrophil gelatinase-associated lipocalin (uNGAL) alone or in combination with urine output could be used as a diagnostic test for renal function recovery in ICU patients on CRRT.BACKGROUNDContinuous renal replacement therapy (CCRT) is a frequently used modality for the support of intensive care patients with acute kidney injury (AKI). Nevertheless, there are no objective criteria for the discontinuation of CRRT. The purpose of this study was to investigate whether urine neutrophil gelatinase-associated lipocalin (uNGAL) alone or in combination with urine output could be used as a diagnostic test for renal function recovery in ICU patients on CRRT.This was a single-centre prospective observational study including patients with acute kidney failure needing CRRT. Sixty-nine patients were enrolled, and 54 completed the study. Of the 54 patients, 22 recovered renal function (REC), defined as dialysis independency at 72 h from discontinuation, while 32 patients did not (NREC). Urine NGAL was measured at 0, 6, 12, and 24 h after CRRT discontinuation. The cumulated urine output was measured for 24 h prior to discontinuation and at 6, 12, and 24 h after discontinuation. Missing uNGAL values were calculated by interpolation. The Youden's index was used to calculate cut-off values in order to define uNGAL and urine output single variable and 2-variable diagnostic tests with the optimum prediction of successful CRRT discontinuation.METHODSThis was a single-centre prospective observational study including patients with acute kidney failure needing CRRT. Sixty-nine patients were enrolled, and 54 completed the study. Of the 54 patients, 22 recovered renal function (REC), defined as dialysis independency at 72 h from discontinuation, while 32 patients did not (NREC). Urine NGAL was measured at 0, 6, 12, and 24 h after CRRT discontinuation. The cumulated urine output was measured for 24 h prior to discontinuation and at 6, 12, and 24 h after discontinuation. Missing uNGAL values were calculated by interpolation. The Youden's index was used to calculate cut-off values in order to define uNGAL and urine output single variable and 2-variable diagnostic tests with the optimum prediction of successful CRRT discontinuation.Baseline characteristics at CRRT initiation were similar between groups. Compared to the NREC group, the REC group had significantly higher urine output (p < 0.0001) and lower uNGAL (p < 0.001) at all time points, except for uNGAL at 24 h (p < 0.24). The best uNGAL predictor for successful CRRT discontinuation was uNGAL at 6 h after discontinuation (predictive value 80%). The best single predictor was cumulated urine output 24 h before discontinuation (predictive value 85%). The combinations of uNGAL at 6 h (cut-off 1650 μg/L) with cumulated urine output 24 h prior to discontinuation (cut-off 210 ml) proved to be the superior tests (using either "or" or "and"), with predictive values of 93% (successful CRRT discontinuation) and 92% (dialysis dependency).RESULTSBaseline characteristics at CRRT initiation were similar between groups. Compared to the NREC group, the REC group had significantly higher urine output (p < 0.0001) and lower uNGAL (p < 0.001) at all time points, except for uNGAL at 24 h (p < 0.24). The best uNGAL predictor for successful CRRT discontinuation was uNGAL at 6 h after discontinuation (predictive value 80%). The best single predictor was cumulated urine output 24 h before discontinuation (predictive value 85%). The combinations of uNGAL at 6 h (cut-off 1650 μg/L) with cumulated urine output 24 h prior to discontinuation (cut-off 210 ml) proved to be the superior tests (using either "or" or "and"), with predictive values of 93% (successful CRRT discontinuation) and 92% (dialysis dependency).With a predictive value of 93%, the combination of uNGAL at 6 h after and the cumulated urine output 24 h prior to CRRT cessation proved to be the best diagnostic test for successful CRRT discontinuation in ICU patients.CONCLUSIONSWith a predictive value of 93%, the combination of uNGAL at 6 h after and the cumulated urine output 24 h prior to CRRT cessation proved to be the best diagnostic test for successful CRRT discontinuation in ICU patients.N/A.CLINICAL TRIAL REGISTRATIONN/A. Background Continuous renal replacement therapy (CCRT) is a frequently used modality for the support of intensive care patients with acute kidney injury (AKI). Nevertheless, there are no objective criteria for the discontinuation of CRRT. The purpose of this study was to investigate whether urine neutrophil gelatinase-associated lipocalin (uNGAL) alone or in combination with urine output could be used as a diagnostic test for renal function recovery in ICU patients on CRRT. Methods This was a single-centre prospective observational study including patients with acute kidney failure needing CRRT. Sixty-nine patients were enrolled, and 54 completed the study. Of the 54 patients, 22 recovered renal function (REC), defined as dialysis independency at 72 h from discontinuation, while 32 patients did not (NREC). Urine NGAL was measured at 0, 6, 12, and 24 h after CRRT discontinuation. The cumulated urine output was measured for 24 h prior to discontinuation and at 6, 12, and 24 h after discontinuation. Missing uNGAL values were calculated by interpolation. The Youden’s index was used to calculate cut-off values in order to define uNGAL and urine output single variable and 2-variable diagnostic tests with the optimum prediction of successful CRRT discontinuation. Results Baseline characteristics at CRRT initiation were similar between groups. Compared to the NREC group, the REC group had significantly higher urine output ( p < 0.0001) and lower uNGAL ( p < 0.001) at all time points, except for uNGAL at 24 h ( p < 0.24). The best uNGAL predictor for successful CRRT discontinuation was uNGAL at 6 h after discontinuation (predictive value 80%). The best single predictor was cumulated urine output 24 h before discontinuation (predictive value 85%). The combinations of uNGAL at 6 h (cut-off 1650 μg/L) with cumulated urine output 24 h prior to discontinuation (cut-off 210 ml) proved to be the superior tests (using either “or” or “and”), with predictive values of 93% (successful CRRT discontinuation) and 92% (dialysis dependency). Conclusions With a predictive value of 93%, the combination of uNGAL at 6 h after and the cumulated urine output 24 h prior to CRRT cessation proved to be the best diagnostic test for successful CRRT discontinuation in ICU patients. Clinical trial registration N/A Background Continuous renal replacement therapy (CCRT) is a frequently used modality for the support of intensive care patients with acute kidney injury (AKI). Nevertheless, there are no objective criteria for the discontinuation of CRRT. The purpose of this study was to investigate whether urine neutrophil gelatinase-associated lipocalin (uNGAL) alone or in combination with urine output could be used as a diagnostic test for renal function recovery in ICU patients on CRRT. Methods This was a single-centre prospective observational study including patients with acute kidney failure needing CRRT. Sixty-nine patients were enrolled, and 54 completed the study. Of the 54 patients, 22 recovered renal function (REC), defined as dialysis independency at 72 h from discontinuation, while 32 patients did not (NREC). Urine NGAL was measured at 0, 6, 12, and 24 h after CRRT discontinuation. The cumulated urine output was measured for 24 h prior to discontinuation and at 6, 12, and 24 h after discontinuation. Missing uNGAL values were calculated by interpolation. The Youden’s index was used to calculate cut-off values in order to define uNGAL and urine output single variable and 2-variable diagnostic tests with the optimum prediction of successful CRRT discontinuation. Results Baseline characteristics at CRRT initiation were similar between groups. Compared to the NREC group, the REC group had significantly higher urine output (p < 0.0001) and lower uNGAL (p < 0.001) at all time points, except for uNGAL at 24 h (p < 0.24). The best uNGAL predictor for successful CRRT discontinuation was uNGAL at 6 h after discontinuation (predictive value 80%). The best single predictor was cumulated urine output 24 h before discontinuation (predictive value 85%). The combinations of uNGAL at 6 h (cut-off 1650 μg/L) with cumulated urine output 24 h prior to discontinuation (cut-off 210 ml) proved to be the superior tests (using either “or” or “and”), with predictive values of 93% (successful CRRT discontinuation) and 92% (dialysis dependency). Conclusions With a predictive value of 93%, the combination of uNGAL at 6 h after and the cumulated urine output 24 h prior to CRRT cessation proved to be the best diagnostic test for successful CRRT discontinuation in ICU patients. Clinical trial registration N/A |
| ArticleNumber | 375 |
| Audience | Academic |
| Author | Toft, Palle Thomsen, Josefine Sprogøe, Ulrik |
| Author_xml | – sequence: 1 givenname: Josefine orcidid: 0000-0001-7536-8553 surname: Thomsen fullname: Thomsen, Josefine email: Josefine.thomsen@rsyd.dk organization: Department of Anaesthesiology and Intensive Care, Odense University Hospital – sequence: 2 givenname: Ulrik surname: Sprogøe fullname: Sprogøe, Ulrik organization: Department of Clinical Immunology, Odense University Hospital – sequence: 3 givenname: Palle surname: Toft fullname: Toft, Palle organization: Department of Anaesthesiology and Intensive Care, Odense University Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32859163$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9ksluFDEURUsoiAzwAyyQJTZsKpRd8wYpihgiRWJD1pbLfu5247YLD0T5SP6JV90JGYSiUg227z2u93yPiwPnHRTFW1qdUjp0HyNlw8DKilXLXbfl9YviiDY9LVndjQcPvg-L4xg3VUX7oaleFYc1G9qRdvVR8ecqGAfEQU7Bz2tjyQqsSMaJCKWI0UsjEihizeylsMYR4RTJO5PPac6JiEjmAMrI5EMkXpO0BhKzlBCjzpYoE6V3iMzI9W5R3I59jiSAExafsxUStuDSYg9iviG4lwwmGdzW4shaMiMAFZFcm7QmQuYE5KdRDhbxJoeb18VLLWyEN7fvk-Lqy-cf59_Ky-9fL87PLkvZVX0qJwoAU9OJQUnJxq6jqm5BjdXY19OocZEJyvQ0TWyUQtf9qKZJKRjHXg0w6PqkuNhzlRcbPgezFeGGe2H4bsKHFRcB_9wC15L1su4byRrV9BoZTE7VBFoLEG3bIOvTnjXnaQtKYoFB2EfQxyvOrPnK_-Z902I1C-DDLSD4Xxli4lvsOFgrHGCHOWvqoeubrluk759INz4HPIBF1TQUAzOye9VKYAHGaY_7ygXKz7q6rSimj6Lq9D8qvBRsDR4waIPzjwzvHhb6r8K7MKJg2Atk8DEG0FyatMsMko3ltOJL7vk-9xwzz3e559doZU-sd_RnTfXeFFHsVhDuu_GM6y9zeB4- |
| CitedBy_id | crossref_primary_10_1080_14737159_2021_1917384 crossref_primary_10_7759_cureus_81783 crossref_primary_10_1007_s40291_020_00498_z crossref_primary_10_1186_s13054_025_05451_2 crossref_primary_10_1007_s00063_025_01293_6 crossref_primary_10_1186_s40560_023_00659_2 crossref_primary_10_3390_jcm13020579 crossref_primary_10_1016_j_clinsp_2023_100280 crossref_primary_10_1159_000539787 crossref_primary_10_3390_biomedicines10071628 crossref_primary_10_1016_j_jcrc_2024_154929 crossref_primary_10_1186_s13613_023_01137_6 |
| Cites_doi | 10.1186/1749-8090-7-6 10.1159/000485609 10.1007/978-3-319-99713-1_8 10.1093/ejcts/ezv199 10.1016/S0140-6736(05)74811-X 10.1007/s00134-007-0813-x 10.2215/CJN.11261210 10.1053/j.ajkd.2009.07.020 10.1111/hdi.12532 10.1016/j.jtcvs.2017.05.005 10.1186/s13054-016-1212-x 10.1186/s12882-019-1327-9 10.1007/s00134-015-3934-7 10.1097/CCM.0b013e3181a38241 10.2215/CJN.04010907 10.1016/j.jcrc.2012.08.012 10.1177/0310057X1604400401 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2020 COPYRIGHT 2020 BioMed Central Ltd. 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2020 – notice: COPYRIGHT 2020 BioMed Central Ltd. – notice: 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION NPM 3V. 7QP 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S M1P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA |
| DOI | 10.1186/s12882-020-02035-w |
| DatabaseName | Springer Nature OA Free Journals (WRLC) CrossRef PubMed ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni Edition) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) Medical Database ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database (ProQuest) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1471-2369 |
| EndPage | 10 |
| ExternalDocumentID | oai_doaj_org_article_fc27c374c24d47fe992cb0beffaea554 PMC7456074 A635011181 32859163 10_1186_s12882_020_02035_w |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Denmark |
| GeographicLocations_xml | – name: Denmark |
| GrantInformation_xml | – fundername: Odense Universitetshospital grantid: DK 10.000 funderid: http://dx.doi.org/10.13039/501100004196 – fundername: Odense Universitetshospital grantid: DK 10.000 – fundername: ; grantid: DK 10.000 |
| GroupedDBID | --- 0R~ 23N 2WC 53G 5GY 5VS 6J9 6PF 7X7 88E 8FI 8FJ AAFWJ AAJSJ AASML AAWTL ABUWG ACGFO ACGFS ACIHN ACPRK ADBBV ADRAZ ADUKV AEAQA AENEX AFKRA AFPKN AHBYD AHMBA AHYZX ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS BAPOH BAWUL BCNDV BENPR BFQNJ BMC BPHCQ BVXVI C6C CCPQU CS3 DIK DU5 E3Z EBD EBLON EBS EMB EMOBN F5P FYUFA GROUPED_DOAJ GX1 HMCUK HYE IAO IHR INH INR ITC KQ8 M1P M48 M~E O5R O5S OK1 OVT P2P PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQQKQ PROAC PSQYO PUEGO RBZ RNS ROL RPM RSV SMD SOJ SV3 TR2 UKHRP W2D WOQ WOW XSB AAYXX AFFHD CITATION -A0 3V. ACRMQ ADINQ ALIPV C24 NPM 7QP 7XB 8FK AZQEC DWQXO K9. PKEHL PQEST PQUKI PRINS 7X8 5PM |
| ID | FETCH-LOGICAL-c607t-b1eeeb46a8dcc29661d35ed90973b9feee2a12fbbb29caf379dbbdde997d8e8f3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 13 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000566945200002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1471-2369 |
| IngestDate | Mon Nov 10 04:30:41 EST 2025 Tue Nov 04 01:50:48 EST 2025 Sun Nov 09 12:41:14 EST 2025 Thu Oct 09 21:52:06 EDT 2025 Tue Nov 11 10:17:42 EST 2025 Tue Nov 04 17:51:05 EST 2025 Thu Jan 02 22:58:50 EST 2025 Tue Nov 18 22:34:20 EST 2025 Sat Nov 29 03:42:12 EST 2025 Sat Sep 06 07:21:51 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Critical care Dialysis Urine neutrophil gelatinase-associated lipocalin Renal replacement therapy Acute kidney injury Intensive care unit |
| Language | English |
| License | Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c607t-b1eeeb46a8dcc29661d35ed90973b9feee2a12fbbb29caf379dbbdde997d8e8f3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 |
| ORCID | 0000-0001-7536-8553 |
| OpenAccessLink | https://doaj.org/article/fc27c374c24d47fe992cb0beffaea554 |
| PMID | 32859163 |
| PQID | 2444114792 |
| PQPubID | 44769 |
| PageCount | 10 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_fc27c374c24d47fe992cb0beffaea554 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7456074 proquest_miscellaneous_2438674664 proquest_journals_2444114792 gale_infotracmisc_A635011181 gale_infotracacademiconefile_A635011181 pubmed_primary_32859163 crossref_citationtrail_10_1186_s12882_020_02035_w crossref_primary_10_1186_s12882_020_02035_w springer_journals_10_1186_s12882_020_02035_w |
| PublicationCentury | 2000 |
| PublicationDate | 2020-08-28 |
| PublicationDateYYYYMMDD | 2020-08-28 |
| PublicationDate_xml | – month: 08 year: 2020 text: 2020-08-28 day: 28 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | BMC nephrology |
| PublicationTitleAbbrev | BMC Nephrol |
| PublicationTitleAlternate | BMC Nephrol |
| PublicationYear | 2020 |
| Publisher | BioMed Central BioMed Central Ltd Springer Nature B.V BMC |
| Publisher_xml | – name: BioMed Central – name: BioMed Central Ltd – name: Springer Nature B.V – name: BMC |
| References | VC Wu (2035_CR4) 2008; 34 J Mishra (2035_CR11) 2005; 365 HR de Geus (2035_CR8) 2017; 154 D Heise (2035_CR5) 2012; 7 2035_CR7 N Srisawat (2035_CR15) 2011; 6 2035_CR12 FJWM Dankers (2035_CR17) 2019 S Katayama (2035_CR2) 2016; 44 G Romero-González (2035_CR3) 2018; 194 S Stads (2035_CR16) 2019; 20 A Zhang (2035_CR9) 2016; 20 M Bennett (2035_CR13) 2008; 3 F Zhou (2035_CR10) 2016; 49 T Yang (2035_CR14) 2018; 22 S Uchino (2035_CR6) 2009; 37 EA Hoste (2035_CR1) 2015; 41 |
| References_xml | – volume: 7 start-page: 6 year: 2012 ident: 2035_CR5 publication-title: J Cardiothorac Surg doi: 10.1186/1749-8090-7-6 – volume: 194 start-page: 118 year: 2018 ident: 2035_CR3 publication-title: Contrib Nephrol doi: 10.1159/000485609 – volume-title: Prediction modeling methodology year: 2019 ident: 2035_CR17 doi: 10.1007/978-3-319-99713-1_8 – volume: 49 start-page: 746 year: 2016 ident: 2035_CR10 publication-title: Eur J Cardiothorac Surg doi: 10.1093/ejcts/ezv199 – volume: 365 start-page: 1231 year: 2005 ident: 2035_CR11 publication-title: Lancet. doi: 10.1016/S0140-6736(05)74811-X – volume: 34 start-page: 101 year: 2008 ident: 2035_CR4 publication-title: Intensive Care Med doi: 10.1007/s00134-007-0813-x – volume: 6 start-page: 1815 year: 2011 ident: 2035_CR15 publication-title: Clin J Am Soc Nephrol doi: 10.2215/CJN.11261210 – ident: 2035_CR12 doi: 10.1053/j.ajkd.2009.07.020 – volume: 22 start-page: 56 year: 2018 ident: 2035_CR14 publication-title: Hemodial Int doi: 10.1111/hdi.12532 – volume: 154 start-page: 939 year: 2017 ident: 2035_CR8 publication-title: J Thorac Cardiovasc Surg doi: 10.1016/j.jtcvs.2017.05.005 – volume: 20 start-page: 41 year: 2016 ident: 2035_CR9 publication-title: Crit Care doi: 10.1186/s13054-016-1212-x – volume: 20 start-page: 129 year: 2019 ident: 2035_CR16 publication-title: BMC Nephrol doi: 10.1186/s12882-019-1327-9 – volume: 41 start-page: 1411 year: 2015 ident: 2035_CR1 publication-title: Intensive Care Med doi: 10.1007/s00134-015-3934-7 – volume: 37 start-page: 2576 year: 2009 ident: 2035_CR6 publication-title: Crit Care Med doi: 10.1097/CCM.0b013e3181a38241 – volume: 3 start-page: 665 year: 2008 ident: 2035_CR13 publication-title: Clin J Am Soc Nephrol doi: 10.2215/CJN.04010907 – ident: 2035_CR7 doi: 10.1016/j.jcrc.2012.08.012 – volume: 44 start-page: 453 year: 2016 ident: 2035_CR2 publication-title: Anaesth Intensive Care doi: 10.1177/0310057X1604400401 |
| SSID | ssj0017840 |
| Score | 2.284177 |
| Snippet | Background
Continuous renal replacement therapy (CCRT) is a frequently used modality for the support of intensive care patients with acute kidney injury (AKI).... Continuous renal replacement therapy (CCRT) is a frequently used modality for the support of intensive care patients with acute kidney injury (AKI).... Background Continuous renal replacement therapy (CCRT) is a frequently used modality for the support of intensive care patients with acute kidney injury (AKI).... Abstract Background Continuous renal replacement therapy (CCRT) is a frequently used modality for the support of intensive care patients with acute kidney... |
| SourceID | doaj pubmedcentral proquest gale pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 375 |
| SubjectTerms | Acute kidney failure Acute kidney injury Biomarkers Care and treatment Catheters Clinical Research Creatinine Critical care Diagnostic tests Dialysis Evaluation Gelatinase Health aspects Hemodialysis Hospital patients Intensive care unit Internal Medicine Kidneys Laboratories Lipocalin Medical examination Medicine Medicine & Public Health Nephrology Neutrophils Patient outcomes Patients Physiology Renal failure Renal function Renal replacement therapy Research Article Transport proteins Urinalysis Urine Urine neutrophil gelatinase-associated lipocalin Variables |
| SummonAdditionalLinks | – databaseName: ProQuest Central dbid: BENPR link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Jb9UwELbgFSEu7EugICMhcYCoL8uLnRNqUSsOUFWISr1FXttAlIQsVPxI_hMzjt8rKaIXjonHiScZz4w9nm8IebVMmJFymYQC7FuYapuEOZM81CtE_wb_NuEuUfgjOzzkJyf5kd9w6_2xyrVOdIpaNwr3yHfADKXgu7M8ftd-D7FqFEZXfQmN62QLkcrSBdna2z88-ryJIzBYv6xTZXi204M2Bo8Sl0wYgVuF5zNz5FD7_9bNfxinywcnL0VPnVE6uPO_7Nwlt707Sncn-blHrpn6Prn5yQfcH5Bfx5gdSGszDl3TnpUVPXWn52owfqHwv9ZoWpUtGsWypqLWdHSdmnFox4GKnrYdPhDr-tDGUnA5aT-6Qo12rCjmBTdYr2ICHUcKf92MPe0Mjq8z7uwY7mTSKWPsJ4V3KV-noYKrqqIeI7anuLlMhRoHQ7-VujZI_BWE5yE5Ptj_8v5D6CtAhCpbsiGUkTFGppngWqkYVmaRTlZG54gxJHMLjbGIYiuljHMlbMJyLSUo7Dxnmhtuk0dkUTe1eUJoFIuVibRBqHQw3Ct4tLZc4nqPm6VSAYnWglAoD4-OVTqqwi2TeFZMwlOA4BROeIrzgLzZ9GkncJArqfdQvjaUCOztbjTdaeH1RGFVzFTCUhWnOmUWOImVXEpjrTACXL-AvEbpLFD9wPCU8FkUwCQCeRW7GUaKMZs4INszSlAbat68FszCq62-uJDKgLzcNGNPPIpXG_jvQJPwjGFVgoA8nqbDhqXEwSFmSUDYbKLMeJ631OWZAzVn4MmDOxuQt-spdTGsf3_Tp1dz8Yzcit1kB2vAt8li6EbznNxQP4ay7154ZfEbrjZ6kA priority: 102 providerName: ProQuest – databaseName: SpringerLINK Contemporary 1997-Present dbid: RSV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Jb9UwELagIMSFfQkUZCQkDhDxsrzYORZExQEqBBRxs7y2gSh5ykLFj-Q_MeM4D1IWCY55HufFGc-W8XxDyMNVxqxSqyyWYN_i3LgsLpnisVkj-jf4txn3hcKv2MEB__ixfBOKwvr5tPuckvSa2os1L572oEnBG8RwB7Nn6_jkLDkH5o6jOL5992GbO2AQs8zlMb-dtzBBHqn_V338k0E6fVjyVMbUG6L9y_-3hCvkUnA86d60U66SM7a5Ri68Dqn16-TbIdYB0saOQ9dujquaHvlzcg2YuVgGJlpD62qD5q9qqGwMHf2kdhw240BlTzcd3hA7-NDWUXAuaT_6loxurClWALfYmWKCF0eKcN2OPe0sPl9n_Skx_GZJp9qwrxT-S4eODDVc1TUNaLA9xc_IVOpxsPRzZRqLxJ9gm9wgh_sv3j9_GYdeD7EuVmyIVWKtVXkhudE6hRgsMdnamhLRhFTpYDCVSeqUUmmppctYaZQC1VyWzHDLXXaT7DRtY28TmqRybRNjERQdTPQabm0cVxjZcbvSOiLJzH6hAxA69uOohQ-IeCEmPgngkfB8EicRebyds5lgQP5K_Qx31ZYSIbz9D213JIJGEE6nTGcs12lucuZgJalWK2Wdk1aCkxeRR7gnBSoaeDwtQ70ELBIhu8RegTlhrBuOyO6CEhSEXg7Pu1oEBdUL8OpyCIVZmUbkwXYYZ-Khu8YC34Em4wXD_gMRuTUJwXZJmQc-LLKIsIV4LNa8HGmqYw9fzsBnB8c1Ik9mIfnxWH9-p3f-jfwuuZh6OQM7wHfJztCN9h45r78MVd_d9wrjOzG2cBQ priority: 102 providerName: Springer Nature |
| Title | Urine neutrophil gelatinase-associated lipocalin and urine output as predictors of the successful discontinuation of continuous renal replacement therapy in critically ill patients with acute kidney injury |
| URI | https://link.springer.com/article/10.1186/s12882-020-02035-w https://www.ncbi.nlm.nih.gov/pubmed/32859163 https://www.proquest.com/docview/2444114792 https://www.proquest.com/docview/2438674664 https://pubmed.ncbi.nlm.nih.gov/PMC7456074 https://doaj.org/article/fc27c374c24d47fe992cb0beffaea554 |
| Volume | 21 |
| WOSCitedRecordID | wos000566945200002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVADU databaseName: BioMedCentral customDbUrl: eissn: 1471-2369 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017840 issn: 1471-2369 databaseCode: RBZ dateStart: 20000101 isFulltext: true titleUrlDefault: https://www.biomedcentral.com/search/ providerName: BioMedCentral – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1471-2369 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017840 issn: 1471-2369 databaseCode: DOA dateStart: 20000101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1471-2369 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017840 issn: 1471-2369 databaseCode: M~E dateStart: 20000101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1471-2369 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017840 issn: 1471-2369 databaseCode: 7X7 dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1471-2369 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017840 issn: 1471-2369 databaseCode: BENPR dateStart: 20090101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1471-2369 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017840 issn: 1471-2369 databaseCode: PIMPY dateStart: 20090101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVAVX databaseName: SpringerLINK Contemporary 1997-Present customDbUrl: eissn: 1471-2369 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017840 issn: 1471-2369 databaseCode: RSV dateStart: 20001201 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagIMQF8SZQVkZC4gBRN4-NnWOLWoFEV6tC0XKy4hcNRMkqDyp-JP-JGce7dIuAC5eVvLYT2zOeR-z5hpDn04QZKadJWIB-C1NtkzBnkod6hujfYN8m3AUKv2PzOV8u88WFVF94J2yEBx4Xbs-qmKmEpSpOdcqsyfNYyak01hamAF2I0hesnrUz5c8PGPgt6xAZnu11IIXBkkRXCU_eZuH5lhpyaP2_y-QLSunyhclLp6ZOGR3dJre8FUn3x9HfIVdMfZfcOPbn5PfIj1MM6qO1Gfq2WZ2VFf3sLr3VoLPCwlPEaFqVK9RlZU2LWtPBdWqGfjX0tOjoqsUHYjoe2lgKliLtBpdf0Q4VxXDeBtNMjFjh2MKXm6GjrcHxtcZd-cIPkHQM9PpO4V3Kp1eooFRV1EO7dhS_CdNCDb2hX0tdG2z8BWh-n5weHX54_Sb0iRtClU1ZH8rIGCPTrOBaqRgcqkgnM6NzhAaSuYXKuIhiK6WMc1XYhOVaSpCzec40N9wmD8hO3dTmEaFRXMxMpA0inIO-ncGjteUS3TRupkoFJFrTUSiPao7JNSrhvBueiZH2AuguHO3FeUBebvqsRkyPv7Y-QPbYtEQ8bvcHcKnwXCr-xaUBeYHMJVBqwPBU4YMfYJKIvyX2MzzgxSDggOxutYTdrrar1-wpvLTpBJhoKfi1LI8D8mxTjT3xBl1tgO7QJuEZw2QCAXk4cvNmSolDMcySgLAtPt-a83ZNXZ45LHIGBjhYoQF5td4Rv4b15zV9_D_W9Am5GbsdDaKe75Kdvh3MU3JdfevLrp2Qq2zJ3C-fkGsHh_PFycTJCCgt3h4vPkHp5P3Hn9AIcw0 |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1R3JbtQw1CpTBFzYl0ABI4E4QNSZJBM7B4TKUnXUmVEPrdSeTLykHYiSIQuj_hR_wj_xnpNMmSJ664Fj4mfHdt5qv4WQl32fGSn7vhuDfHMDnfhuxCR39RCzf4N-63MbKDxm0yk_PIz21sjPLhYG3So7nmgZtc4VnpFvghgKQHdnkfd-_t3FqlF4u9qV0GjQYtecLsBkK9-NPsH_feV525_3P-64bVUBV4V9VrlyYIyRQRhzrZQH2v5A-0OjI8xbI6MEGr144CVSSi9SceKzSEsJTCCKmOaGJz6Me4WsB4DsvEfW90aTvaPlvQUDe6kLzeHhZgncHzRYNNHwxm_oLlbEn60S8Lcs-EMYnnfUPHdba4Xg9q3_bftuk5utuk23Gvq4Q9ZMdpdcm7QOBffIrwOMfqSZqasin5_MUnpsvQMzEO5u3KKu0TSdzVHozzIaZ5rWtlNeV_O6onFJ5wUOiHWLaJ5QUKlpWdtClEmdUox7zrEeR5NUHSHa57wuaWFwfoWxvnF4UkubiLhTCt9SbR2KFJ7SlLY5cEuKh-c0VnVl6LeZzgwCfwXiuE8OLmUzH5BelmfmEaEDLx6agTaYCh4UkyEMrRMu0Z7lpq-UQwYd4gnVpn_HKiSpsGYgD0WDrAIQVVhkFQuHvFn2mTfJTy6E_oD4vITExOX2RV4ci5YPikR5TPksUF6gA5bASjwl-9IkSWxiUG0d8hqpQSB7hempuI0SgUViojKxFeJNOEZLO2RjBRLYolpt7ghBtGy5FGdU4JAXy2bsia6GmYH_DjA-DxlWXXDIw4b8lkvybbrH0HcIWyHMlTWvtmSzE5u0nYGlAuq6Q952JHw2rX_v6eOLV_GcXN_Zn4zFeDTdfUJueJbRgOTjG6RXFbV5Sq6qH9WsLJ61jIqSL5dN3L8B1T3dVg |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Zb9QwELagoIoX7kKggJGQeICom2Nj57EcFYiyqgRFfbN8tgtREuWg4kfyn5hxsktTDgnxmHic2PF4joznG0KezBJmlZoloQT9FqbGJWHOFA_NHNG_wb5NuE8U3meLBT86yg_OZPH70-6rkOSQ04AoTWW3Uxs3bHGe7bQgVcEyRNcHI2nz8PQiuZRi0SD01z98WscRGPgvq1SZ3_abqCOP2v-rbD6jnM4fnDwXPfVKae_a_0_nOrk6GqR0d-CgG-SCLW-SzfdjyP0W-X6I-YG0tH3XVPXJsqDH_vxcCeovlOPiWkOLZY1qcVlSWRra-05V39V9R2VL6wYfiJV9aOUoGJ207X2pRtcXFDODK6xYMcCOI8V4XfUtbSyOr7H-9Bj-y6RDztg3Cu_SY6WGAq6Kgo4osS3F38tU6r6z9MvSlBaJPwP73CaHe68_vnwTjjUgQp3NWBeqyFqr0kxyo3UMvllkkrk1OaIMqdxBYyyj2Cml4lxLl7DcKAUiO8-Z4Za7ZItslFVp7xIaxXJuI2MRLB1U9xwebRxX6PFxO9M6INGKFYQeAdKxTkchvKPEMzGsk4A1En6dxGlAnq371AM8yF-pXyCHrSkR2tvfqJpjMUoK4XTMdMJSHacmZQ5mEms1U9Y5aSUYfwF5ivwpUADB8LQc8yhgkgjlJXYzjBVjPnFAtieUIDj0tHnF4WIUXK0Aay8FF5nlcUAer5uxJx7GKy2sO9AkPGNYlyAgd4YNsZ5S4gERsyQgbLJVJnOetpTLEw9rzsCWB4M2IM9XG-bnsP78Te_9G_kjsnnwak_sv128u0-uxH7Lgarg22Sja3r7gFzWX7tl2zz0cuQH5AV73A |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Urine+neutrophil+gelatinase-associated+lipocalin+and+urine+output+as+predictors+of+the+successful+discontinuation+of+continuous+renal+replacement+therapy+in+critically+ill+patients+with+acute+kidney+injury&rft.jtitle=BMC+nephrology&rft.au=Thomsen%2C+Josefine&rft.au=Sprog%C3%B8e%2C+Ulrik&rft.au=Toft%2C+Palle&rft.date=2020-08-28&rft.issn=1471-2369&rft.eissn=1471-2369&rft.volume=21&rft.issue=1&rft.spage=375&rft_id=info:doi/10.1186%2Fs12882-020-02035-w&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1471-2369&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1471-2369&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1471-2369&client=summon |