Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes

Major depressive disorder (MDD) is a common, heterogenous, and potentially serious psychiatric illness. Diverse brain cell types have been implicated in MDD etiology. Significant sexual differences exist in MDD clinical presentation and outcome, and recent evidence suggests different molecular bases...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; pp. 2912 - 18
Main Authors:	Maitra, Malosree, Mitsuhashi, Haruka, Rahimian, Reza, Chawla, Anjali, Yang, Jennie, Fiori, Laura M., Davoli, Maria Antonietta, Perlman, Kelly, Aouabed, Zahia, Mash, Deborah C., Suderman, Matthew, Mechawar, Naguib, Turecki, Gustavo, Nagy, Corina
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 22.05.2023 Nature Publishing Group Nature Portfolio
Subjects:	38 38/91 631/337/2019 631/378 631/378/1689/1414 Astrocytes Brain Brain - metabolism Clusters Depression - genetics Depressive Disorder, Major - genetics Depressive Disorder, Major - metabolism Female Females Gender differences Gene expression Gene sequencing Genes Glial stem cells Humanities and Social Sciences Humans Interneurons Male Males Mental depression Microglia multidisciplinary Parvalbumin Prefrontal cortex Prefrontal Cortex - metabolism Science Science (multidisciplinary) Sex differences Transcriptome - genetics Transcriptomes Transcriptomics
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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