Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes

Major depressive disorder (MDD) is a common, heterogenous, and potentially serious psychiatric illness. Diverse brain cell types have been implicated in MDD etiology. Significant sexual differences exist in MDD clinical presentation and outcome, and recent evidence suggests different molecular bases...

Full description

Saved in:
Bibliographic Details
Published in:Nature communications Vol. 14; no. 1; pp. 2912 - 18
Main Authors: Maitra, Malosree, Mitsuhashi, Haruka, Rahimian, Reza, Chawla, Anjali, Yang, Jennie, Fiori, Laura M., Davoli, Maria Antonietta, Perlman, Kelly, Aouabed, Zahia, Mash, Deborah C., Suderman, Matthew, Mechawar, Naguib, Turecki, Gustavo, Nagy, Corina
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 22.05.2023
Nature Publishing Group
Nature Portfolio
Subjects:
38
38/91
631/337/2019
631/378
631/378/1689/1414
Astrocytes
Brain
Brain - metabolism
Clusters
Depression - genetics
Depressive Disorder, Major - genetics
Depressive Disorder, Major - metabolism
Female
Females
Gender differences
Gene expression
Gene sequencing
Genes
Glial stem cells
Humanities and Social Sciences
Humans
Interneurons
Male
Males
Mental depression
Microglia
multidisciplinary
Parvalbumin
Prefrontal cortex
Prefrontal Cortex - metabolism
Science
Science (multidisciplinary)
Sex differences
Transcriptome - genetics
Transcriptomes
Transcriptomics
ISSN:2041-1723, 2041-1723
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Major depressive disorder (MDD) is a common, heterogenous, and potentially serious psychiatric illness. Diverse brain cell types have been implicated in MDD etiology. Significant sexual differences exist in MDD clinical presentation and outcome, and recent evidence suggests different molecular bases for male and female MDD. We evaluated over 160,000 nuclei from 71 female and male donors, leveraging new and pre-existing single-nucleus RNA-sequencing data from the dorsolateral prefrontal cortex. Cell type specific transcriptome-wide threshold-free MDD-associated gene expression patterns were similar between the sexes, but significant differentially expressed genes (DEGs) diverged. Among 7 broad cell types and 41 clusters evaluated, microglia and parvalbumin interneurons contributed the most DEGs in females, while deep layer excitatory neurons, astrocytes, and oligodendrocyte precursors were the major contributors in males. Further, the Mic1 cluster with 38% of female DEGs and the ExN10_L46 cluster with 53% of male DEGs, stood out in the meta-analysis of both sexes. Sex differences in brain transcriptomics have unknown cell type specificity. Here, authors show concordant cortical transcriptomic patterns in depression within individual cell types between sexes, but distinctly affected top cell types and genes.
AbstractList Major depressive disorder (MDD) is a common, heterogenous, and potentially serious psychiatric illness. Diverse brain cell types have been implicated in MDD etiology. Significant sexual differences exist in MDD clinical presentation and outcome, and recent evidence suggests different molecular bases for male and female MDD. We evaluated over 160,000 nuclei from 71 female and male donors, leveraging new and pre-existing single-nucleus RNA-sequencing data from the dorsolateral prefrontal cortex. Cell type specific transcriptome-wide threshold-free MDD-associated gene expression patterns were similar between the sexes, but significant differentially expressed genes (DEGs) diverged. Among 7 broad cell types and 41 clusters evaluated, microglia and parvalbumin interneurons contributed the most DEGs in females, while deep layer excitatory neurons, astrocytes, and oligodendrocyte precursors were the major contributors in males. Further, the Mic1 cluster with 38% of female DEGs and the ExN10_L46 cluster with 53% of male DEGs, stood out in the meta-analysis of both sexes.
Major depressive disorder (MDD) is a common, heterogenous, and potentially serious psychiatric illness. Diverse brain cell types have been implicated in MDD etiology. Significant sexual differences exist in MDD clinical presentation and outcome, and recent evidence suggests different molecular bases for male and female MDD. We evaluated over 160,000 nuclei from 71 female and male donors, leveraging new and pre-existing single-nucleus RNA-sequencing data from the dorsolateral prefrontal cortex. Cell type specific transcriptome-wide threshold-free MDD-associated gene expression patterns were similar between the sexes, but significant differentially expressed genes (DEGs) diverged. Among 7 broad cell types and 41 clusters evaluated, microglia and parvalbumin interneurons contributed the most DEGs in females, while deep layer excitatory neurons, astrocytes, and oligodendrocyte precursors were the major contributors in males. Further, the Mic1 cluster with 38% of female DEGs and the ExN10_L46 cluster with 53% of male DEGs, stood out in the meta-analysis of both sexes. Sex differences in brain transcriptomics have unknown cell type specificity. Here, authors show concordant cortical transcriptomic patterns in depression within individual cell types between sexes, but distinctly affected top cell types and genes.
Major depressive disorder (MDD) is a common, heterogenous, and potentially serious psychiatric illness. Diverse brain cell types have been implicated in MDD etiology. Significant sexual differences exist in MDD clinical presentation and outcome, and recent evidence suggests different molecular bases for male and female MDD. We evaluated over 160,000 nuclei from 71 female and male donors, leveraging new and pre-existing single-nucleus RNA-sequencing data from the dorsolateral prefrontal cortex. Cell type specific transcriptome-wide threshold-free MDD-associated gene expression patterns were similar between the sexes, but significant differentially expressed genes (DEGs) diverged. Among 7 broad cell types and 41 clusters evaluated, microglia and parvalbumin interneurons contributed the most DEGs in females, while deep layer excitatory neurons, astrocytes, and oligodendrocyte precursors were the major contributors in males. Further, the Mic1 cluster with 38% of female DEGs and the ExN10_L46 cluster with 53% of male DEGs, stood out in the meta-analysis of both sexes. Sex differences in brain transcriptomics have unknown cell type specificity. Here, authors show concordant cortical transcriptomic patterns in depression within individual cell types between sexes, but distinctly affected top cell types and genes.
Major depressive disorder (MDD) is a common, heterogenous, and potentially serious psychiatric illness. Diverse brain cell types have been implicated in MDD etiology. Significant sexual differences exist in MDD clinical presentation and outcome, and recent evidence suggests different molecular bases for male and female MDD. We evaluated over 160,000 nuclei from 71 female and male donors, leveraging new and pre-existing single-nucleus RNA-sequencing data from the dorsolateral prefrontal cortex. Cell type specific transcriptome-wide threshold-free MDD-associated gene expression patterns were similar between the sexes, but significant differentially expressed genes (DEGs) diverged. Among 7 broad cell types and 41 clusters evaluated, microglia and parvalbumin interneurons contributed the most DEGs in females, while deep layer excitatory neurons, astrocytes, and oligodendrocyte precursors were the major contributors in males. Further, the Mic1 cluster with 38% of female DEGs and the ExN10_L46 cluster with 53% of male DEGs, stood out in the meta-analysis of both sexes.Major depressive disorder (MDD) is a common, heterogenous, and potentially serious psychiatric illness. Diverse brain cell types have been implicated in MDD etiology. Significant sexual differences exist in MDD clinical presentation and outcome, and recent evidence suggests different molecular bases for male and female MDD. We evaluated over 160,000 nuclei from 71 female and male donors, leveraging new and pre-existing single-nucleus RNA-sequencing data from the dorsolateral prefrontal cortex. Cell type specific transcriptome-wide threshold-free MDD-associated gene expression patterns were similar between the sexes, but significant differentially expressed genes (DEGs) diverged. Among 7 broad cell types and 41 clusters evaluated, microglia and parvalbumin interneurons contributed the most DEGs in females, while deep layer excitatory neurons, astrocytes, and oligodendrocyte precursors were the major contributors in males. Further, the Mic1 cluster with 38% of female DEGs and the ExN10_L46 cluster with 53% of male DEGs, stood out in the meta-analysis of both sexes.
Abstract Major depressive disorder (MDD) is a common, heterogenous, and potentially serious psychiatric illness. Diverse brain cell types have been implicated in MDD etiology. Significant sexual differences exist in MDD clinical presentation and outcome, and recent evidence suggests different molecular bases for male and female MDD. We evaluated over 160,000 nuclei from 71 female and male donors, leveraging new and pre-existing single-nucleus RNA-sequencing data from the dorsolateral prefrontal cortex. Cell type specific transcriptome-wide threshold-free MDD-associated gene expression patterns were similar between the sexes, but significant differentially expressed genes (DEGs) diverged. Among 7 broad cell types and 41 clusters evaluated, microglia and parvalbumin interneurons contributed the most DEGs in females, while deep layer excitatory neurons, astrocytes, and oligodendrocyte precursors were the major contributors in males. Further, the Mic1 cluster with 38% of female DEGs and the ExN10_L46 cluster with 53% of male DEGs, stood out in the meta-analysis of both sexes.
ArticleNumber 2912
Author Mitsuhashi, Haruka
Nagy, Corina
Aouabed, Zahia
Fiori, Laura M.
Maitra, Malosree
Mash, Deborah C.
Perlman, Kelly
Yang, Jennie
Suderman, Matthew
Mechawar, Naguib
Chawla, Anjali
Davoli, Maria Antonietta
Rahimian, Reza
Turecki, Gustavo
Author_xml – sequence: 1
  givenname: Malosree
  surname: Maitra
  fullname: Maitra, Malosree
  organization: McGill Group for Suicide Studies, Douglas Institute, Integrated Program in Neuroscience, McGill University, Douglas Institute, Department of Psychiatry, McGill University
– sequence: 2
  givenname: Haruka
  surname: Mitsuhashi
  fullname: Mitsuhashi, Haruka
  organization: McGill Group for Suicide Studies, Douglas Institute, Integrated Program in Neuroscience, McGill University, Douglas Institute, Department of Psychiatry, McGill University
– sequence: 3
  givenname: Reza
  surname: Rahimian
  fullname: Rahimian, Reza
  organization: McGill Group for Suicide Studies, Douglas Institute, Douglas Institute, Department of Psychiatry, McGill University
– sequence: 4
  givenname: Anjali
  surname: Chawla
  fullname: Chawla, Anjali
  organization: McGill Group for Suicide Studies, Douglas Institute, Integrated Program in Neuroscience, McGill University, Douglas Institute, Department of Psychiatry, McGill University
– sequence: 5
  givenname: Jennie
  surname: Yang
  fullname: Yang, Jennie
  organization: McGill Group for Suicide Studies, Douglas Institute, Douglas Institute, Department of Psychiatry, McGill University
– sequence: 6
  givenname: Laura M.
  surname: Fiori
  fullname: Fiori, Laura M.
  organization: McGill Group for Suicide Studies, Douglas Institute, Douglas Institute, Department of Psychiatry, McGill University
– sequence: 7
  givenname: Maria Antonietta
  surname: Davoli
  fullname: Davoli, Maria Antonietta
  organization: McGill Group for Suicide Studies, Douglas Institute, Douglas Institute, Department of Psychiatry, McGill University
– sequence: 8
  givenname: Kelly
  surname: Perlman
  fullname: Perlman, Kelly
  organization: McGill Group for Suicide Studies, Douglas Institute, Integrated Program in Neuroscience, McGill University, Douglas Institute, Department of Psychiatry, McGill University
– sequence: 9
  givenname: Zahia
  surname: Aouabed
  fullname: Aouabed, Zahia
  organization: McGill Group for Suicide Studies, Douglas Institute, Douglas Institute, Department of Psychiatry, McGill University
– sequence: 10
  givenname: Deborah C.
  surname: Mash
  fullname: Mash, Deborah C.
  organization: Dr. Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University
– sequence: 11
  givenname: Matthew
  orcidid: 0000-0002-2715-9930
  surname: Suderman
  fullname: Suderman, Matthew
  organization: Population Health Sciences, Bristol Medical School, University of Bristol, MRC Integrative Epidemiology Unit, University of Bristol
– sequence: 12
  givenname: Naguib
  orcidid: 0000-0003-4960-756X
  surname: Mechawar
  fullname: Mechawar, Naguib
  organization: McGill Group for Suicide Studies, Douglas Institute, Integrated Program in Neuroscience, McGill University, Douglas Institute, Department of Psychiatry, McGill University
– sequence: 13
  givenname: Gustavo
  orcidid: 0000-0003-4075-2736
  surname: Turecki
  fullname: Turecki, Gustavo
  email: gustavo.turecki@mcgill.ca
  organization: McGill Group for Suicide Studies, Douglas Institute, Integrated Program in Neuroscience, McGill University, Douglas Institute, Department of Psychiatry, McGill University
– sequence: 14
  givenname: Corina
  orcidid: 0000-0003-1439-0129
  surname: Nagy
  fullname: Nagy, Corina
  email: corina.nagy@mcgill.ca
  organization: McGill Group for Suicide Studies, Douglas Institute, Integrated Program in Neuroscience, McGill University, Douglas Institute, Department of Psychiatry, McGill University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37217515$$D View this record in MEDLINE/PubMed
BookMark eNp9ks1u1DAUhSNUREvpC7BAltiwCfg3dlYIVfxUqsQG1pbjXE89Suxge6j6JLwunqYDbRfNxo5zzqeT6_OyOQoxQNO8Jvg9wUx9yJzwTraYspYpwXArnjUnFHPSEknZ0b39cXOW8xbXh_VEcf6iOWaSEimIOGn-nMM0oXKzAMoLWO-8RSWZkG3yS4lzfR29c5AgWMjIBzTCkiBnHwPKV_EaZT_7ySS0mFIghYwGKNcAAc1mqg4TRuRg3Q-7gvy8TN6aApWbiw-2IHuIsKo3ECC_ap47M2U4u1tPm59fPv84_9Zefv96cf7psrUdlqXtgY9Dp1zfk05wq0BILJjphLKiF7bH0mAHTlrJRycYV9QQbEdn6joy2rPT5mLljtFs9ZL8bNKNjsbr24OYNtqk4u0Emql-6AwZBugIH0c3UMepgk5V2OAYq6yPK2vZDTOMFkKd5PQA-vBL8Fd6E39rgilmhItKeHdHSPHXDnLRs8_78ZgAcZc1VUTV_-uErNK3j6TbuEuhzmqvklQK2dOqenM_0r8shwJUgVoFNsWcEzhtfTGl3m5N6KcaTe_rpte66Vo3fVs3vbfSR9YD_UkTW025isMG0v_YT7j-AooC6rE
CitedBy_id crossref_primary_10_1038_s41380_024_02816_x
crossref_primary_10_1093_cercor_bhae197
crossref_primary_10_1002_brb3_70664
crossref_primary_10_1016_j_pnpbp_2023_110876
crossref_primary_10_1016_j_psychres_2025_116653
crossref_primary_10_1016_j_cellin_2024_100222
crossref_primary_10_14789_ejmj_JMJ25_0003_R
crossref_primary_10_1093_psyrad_kkae007
crossref_primary_10_1016_j_neures_2024_12_006
crossref_primary_10_1016_j_biopsych_2024_05_017
crossref_primary_10_3389_fpsyt_2024_1422939
crossref_primary_10_1186_s12967_023_04727_x
crossref_primary_10_1016_j_mcn_2024_103980
crossref_primary_10_1038_s41380_025_02993_3
crossref_primary_10_1038_s41380_024_02534_4
crossref_primary_10_1016_j_bbi_2024_07_037
crossref_primary_10_1016_j_jad_2025_04_161
crossref_primary_10_3390_biom14080964
crossref_primary_10_1038_s41467_025_59115_4
crossref_primary_10_1016_j_bbi_2025_05_023
crossref_primary_10_1016_j_biopsych_2024_09_021
crossref_primary_10_1126_science_adh3707
crossref_primary_10_3389_fpsyt_2024_1480438
crossref_primary_10_1016_j_jad_2025_120198
crossref_primary_10_1016_j_ghres_2024_100004
crossref_primary_10_1016_j_intimp_2023_110903
crossref_primary_10_1038_s41398_025_03497_y
crossref_primary_10_1126_science_adg5136
crossref_primary_10_1016_j_neuropharm_2025_110641
crossref_primary_10_3390_ijms252413412
crossref_primary_10_3389_fnbeh_2025_1598178
crossref_primary_10_3390_ijms26073135
crossref_primary_10_15446_rcciquifa_v52n3_111080
crossref_primary_10_1016_j_ajhg_2024_07_002
crossref_primary_10_1016_j_schres_2025_07_019
crossref_primary_10_3390_biom14091087
crossref_primary_10_1038_s41380_024_02707_1
crossref_primary_10_1002_alz_70549
crossref_primary_10_1016_j_neuroscience_2023_12_011
crossref_primary_10_1038_s44184_025_00133_x
crossref_primary_10_1186_s12974_023_02901_y
crossref_primary_10_1038_s41398_024_03128_y
crossref_primary_10_3390_cells13020177
crossref_primary_10_3390_cells13151262
crossref_primary_10_1038_s41386_025_02162_8
crossref_primary_10_1016_j_bbi_2025_106103
crossref_primary_10_1038_s44277_025_00041_0
crossref_primary_10_1093_ijnp_pyad057
crossref_primary_10_1038_s41588_025_02249_4
crossref_primary_10_1016_j_jad_2024_08_144
crossref_primary_10_1016_j_bcp_2024_116599
crossref_primary_10_3390_ijms25137391
crossref_primary_10_1007_s00109_024_02487_9
crossref_primary_10_1038_s41380_025_03088_9
crossref_primary_10_1016_j_bbi_2024_12_013
crossref_primary_10_1038_s41598_025_92030_8
crossref_primary_10_3390_ijms26052227
crossref_primary_10_3390_ijms26157611
crossref_primary_10_1038_s41386_024_02040_9
crossref_primary_10_3390_life15060921
crossref_primary_10_1016_j_ecoenv_2024_117193
crossref_primary_10_1186_s12883_024_03685_1
crossref_primary_10_1016_j_bbi_2024_08_016
crossref_primary_10_1016_j_isci_2024_111316
crossref_primary_10_1038_s41467_024_48257_6
Cites_doi 10.1016/j.drudis.2022.06.015
10.1038/s41380-020-0696-6
10.1371/journal.pone.0187631
10.1016/j.neulet.2018.10.027
10.1038/npp.2016.169
10.1001/archpsyc.58.6.545
10.1038/s41593-020-0621-y
10.1073/pnas.95.22.13290
10.1523/JNEUROSCI.1673-18.2018
10.1186/s13293-014-0017-3
10.1176/appi.ajp.162.11.2116
10.1016/j.nbd.2011.01.014
10.1126/science.aad6469
10.1038/s41380-021-01372-y
10.1016/S0140-6736(18)32279-7
10.1126/science.1169786
10.1111/gbb.12643
10.1016/j.cell.2021.04.048
10.1177/1099800418776082
10.1093/nar/gkv007
10.1038/s41598-018-27903-2
10.1016/j.biopsych.2021.02.972
10.1038/s41586-019-1195-2
10.1016/j.bbih.2021.100320
10.1186/1471-2105-15-91
10.1016/j.biopsych.2018.01.017
10.1093/nar/gkaa1074
10.3389/fpsyt.2022.871997
10.3390/biomedicines10040840
10.1038/nbt.4038
10.1038/nmeth.4407
10.1146/annurev-publhealth-031912-114409
10.1038/s41588-021-00894-z
10.1016/j.pnpbp.2017.11.017
10.1523/JNEUROSCI.1268-12.2013
10.1038/s41593-020-00787-0
10.1016/j.yhbeh.2012.02.018
10.1038/mp.2017.47
10.1038/s41598-017-17204-5
10.1038/nn.4338
10.1016/j.neuroscience.2018.02.048
10.1136/svn-2016-000012
10.1073/pnas.2008762117
10.1093/nar/gkab1028
10.1016/j.ynstr.2021.100312
10.1016/j.celrep.2020.108189
10.1038/s41592-019-0619-0
10.3389/fncel.2019.00197
10.3233/BPL-210125
10.3389/fncir.2022.875873
10.1038/s41593-018-0326-7
10.1371/journal.pone.0015463
10.1038/s41380-022-01512-y
10.1002/glia.23767
10.1038/s41467-020-14766-3
10.1016/j.celrep.2018.08.001
10.1016/j.bbi.2015.10.003
10.1126/science.aat7615
10.1186/1471-2105-9-559
10.3390/life11121376
10.1186/s12859-021-03957-4
10.1111/jnc.15262
10.31887/DCNS.2004.6.2/cstockmeier
10.1007/s00018-021-03881-z
10.1093/bioinformatics/btw777
10.1093/bioinformatics/btp616
10.1038/s41586-019-1506-7
10.3390/ijerph15071425
10.1371/journal.pone.0006585
10.1038/s41467-020-19894-4
10.1038/s41598-018-27293-5
10.1038/nri.2016.90
10.1176/appi.ajp.2017.16070759
10.1186/s12864-018-4772-0
10.1093/brain/awab446
10.1074/jbc.M109665200
10.1016/j.celrep.2017.11.058
10.1152/ajpcell.1998.275.2.C327
10.1084/jem.20202717
10.1016/j.biopsych.2020.12.025
10.1002/jnr.23854
10.1038/s41596-021-00514-4
10.1038/s41586-021-03465-8
10.1042/BJ20040424
10.1016/j.tox.2020.152404
10.1038/s41596-021-00575-5
10.1093/nar/gkaa762
10.1176/appi.ajp.2017.16111286
10.1038/nm.4386
10.1172/JCI141083
10.1038/s41586-019-0903-2
10.1093/bioinformatics/btaa956
10.1126/science.aav8130
10.1016/S0006-3223(99)00041-4
10.1093/cercor/12.4.386
10.1073/pnas.0506580102
10.1038/s41467-021-21246-9
10.1093/database/bax043
10.1093/bioinformatics/btx506
10.1101/2020.11.06.20225342
10.1126/sciadv.abn8367
10.1101/2020.07.29.227355
10.1176/appi.books.9780890425787
10.1101/653253
10.32614/CRAN.package.babelgene
10.1101/060012
ContentType Journal Article
Copyright The Author(s) 2023
2023. The Author(s).
The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2023
– notice: 2023. The Author(s).
– notice: The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/s41467-023-38530-5
DatabaseName SpringerOpen Free (Free internet resource, activated by CARLI)
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
ProQuest SciTech Premium Collection Technology Collection Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE
CrossRef


MEDLINE - Academic
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: PIMPY
  name: ProQuest Publicly Available Content Database
  url: http://search.proquest.com/publiccontent
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 18
ExternalDocumentID oai_doaj_org_article_389b6a1bbe614ddfb2f428e68a2abf33
PMC10203145
37217515
10_1038_s41467_023_38530_5
Genre Research Support, Non-U.S. Gov't
Meta-Analysis
Journal Article
GrantInformation_xml – fundername: Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada)
  grantid: FDN148374; ENP161427 (ERA-NET ERA PerMed); PJT183904
  funderid: https://doi.org/10.13039/501100000024
– fundername: NARSAD (BBRF #31204)
– fundername: Medical Research Council
  grantid: MC_UU_00011/5
– fundername: Medical Research Council
  grantid: MC_UU_00032/4
– fundername: ;
– fundername: ;
  grantid: FDN148374; ENP161427 (ERA-NET ERA PerMed); PJT183904
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
AFFHD
CITATION
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
CGR
CUY
CVF
ECM
EIF
NPM
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
SOI
7X8
PUEGO
5PM
ID FETCH-LOGICAL-c607t-9e4db68f991654c8e57053a658c595c907a0fef7c74df53482a10cdfa2a1d3293
IEDL.DBID P5Z
ISICitedReferencesCount 72
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001024186000015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 2041-1723
IngestDate Tue Oct 14 15:16:18 EDT 2025
Tue Nov 04 02:07:18 EST 2025
Thu Sep 04 19:56:43 EDT 2025
Tue Oct 07 07:14:12 EDT 2025
Mon Jul 21 06:07:03 EDT 2025
Sat Nov 29 02:11:48 EST 2025
Tue Nov 18 21:00:10 EST 2025
Fri Feb 21 02:40:00 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License 2023. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c607t-9e4db68f991654c8e57053a658c595c907a0fef7c74df53482a10cdfa2a1d3293
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Article-2
ObjectType-Feature-1
content type line 23
ORCID 0000-0002-2715-9930
0000-0003-4960-756X
0000-0003-1439-0129
0000-0003-4075-2736
OpenAccessLink https://www.proquest.com/docview/2817275792?pq-origsite=%requestingapplication%
PMID 37217515
PQID 2817275792
PQPubID 546298
PageCount 18
ParticipantIDs doaj_primary_oai_doaj_org_article_389b6a1bbe614ddfb2f428e68a2abf33
pubmedcentral_primary_oai_pubmedcentral_nih_gov_10203145
proquest_miscellaneous_2818053657
proquest_journals_2817275792
pubmed_primary_37217515
crossref_citationtrail_10_1038_s41467_023_38530_5
crossref_primary_10_1038_s41467_023_38530_5
springer_journals_10_1038_s41467_023_38530_5
PublicationCentury 2000
PublicationDate 2023-05-22
PublicationDateYYYYMMDD 2023-05-22
PublicationDate_xml – month: 05
  year: 2023
  text: 2023-05-22
  day: 22
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2023
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Bakken (CR20) 2021; 598
Mahajan (CR52) 2018; 82
Woodburn, Bollinger, Wohleb (CR48) 2021; 14
Liu, Leak, Hu (CR55) 2016; 1
Lau, Cao, Fu, Ip (CR71) 2020; 117
Velmeshev (CR15) 2019; 364
Rosmus, Lange, Ludwig, Ajami, Wieghofer (CR68) 2022; 10
Nagy (CR16) 2020; 23
Rau, Marot, Jaffrézic (CR101) 2014; 15
Subramanian (CR102) 2005; 102
Song (CR19) 2021; 49
Rahimian, Belliveau, Chen, Mechawar (CR42) 2022; 13
Rahimian, Cordeau, Kriz (CR41) 2019; 405
Blokland (CR70) 2022; 91
Howard (CR3) 2019; 22
Habib (CR90) 2017; 14
Seney (CR7) 2018; 84
Stolero, Frenkel (CR57) 2021; 158
Stockmeier, Rajkowska (CR30) 2004; 6
Gibel-Russo, Benacom, Di Nardo (CR61) 2022; 16
Kowalczyk (CR63) 2021; 11
Mathys (CR72) 2019; 570
Labonté (CR10) 2017; 23
Hodge (CR86) 2019; 573
Korsunsky (CR17) 2019; 16
Patterson-Cross, Levine, Menon (CR82) 2021; 22
Langfelder, Horvath (CR107) 2008; 9
Wu (CR110) 2021; 2
Robinson, McCarthy, Smyth (CR96) 2010; 26
Street (CR91) 2018; 19
Geraldo (CR27) 2021; 131
Morrison (CR51) 2019; 692
Van den Berge (CR92) 2020; 11
Gandal (CR4) 2018; 359
Burstyn-Cohen, Hochberg (CR67) 2021; 7
Bollinger (CR38) 2021; 16
McCarthy, Campbell, Lun, Wills (CR97) 2017; 33
Perez (CR109) 2021; 26
Kessler, Bromet (CR5) 2013; 34
Szklarczyk (CR26) 2021; 49
Guneykaya (CR43) 2018; 24
Dumais (CR76) 2005; 162
Maitra (CR77) 2021; 16
Lake (CR89) 2018; 36
Cotter, Mackay, Landau, Kerwin, Everall (CR32) 2001; 58
Hirohata (CR65) 2002; 277
Bhandage, Barragan (CR58) 2021; 78
Seney, Glausier, Sibille (CR22) 2022; 91
Eder (CR56) 1998; 275
Wang, Roy, Turecki, Shelton, Dwivedi (CR50) 2018; 175
Brivio, Lopez, Chen (CR69) 2020; 19
Li (CR88) 2018; 362
Bankhead (CR79) 2017; 7
Sequeira (CR35) 2009; 4
Ransohoff (CR54) 2016; 19
Chen, Colonna (CR73) 2021; 218
Pesarico (CR60) 2019; 13
Caplan, Cox, Bedi (CR44) 2017; 95
Ongür, Drevets, Price (CR34) 1998; 95
Wellman (CR59) 2018; 38
CR2
Crowell (CR95) 2020; 11
Steullet (CR62) 2017; 22
Boutej (CR24) 2017; 21
Klein, Flanagan (CR39) 2016; 16
Tanti (CR66) 2022; 27
Glessner (CR64) 2010; 5
CR83
Tang (CR18) 2021; 37
Barnes, Mondelli, Pariante (CR53) 2017; 42
Morabito (CR11) 2021; 53
CR80
James (CR1) 2018; 392
Gillespie (CR104) 2021; 50
Bollinger, Bergeon Burns, Wellman (CR47) 2016; 52
Smajić (CR12) 2022; 145
Lutz (CR37) 2017; 174
Tripp, Kota, Lewis, Sibille (CR36) 2011; 42
Bollinger, Collins, Patel, Wellman (CR49) 2017; 12
Bachmann (CR8) 2018; 15
Rajkowska (CR31) 1999; 45
Cotter (CR33) 2002; 12
Schwarz, Bilbo (CR45) 2012; 62
Hao (CR81) 2021; 184
Cahill, Huo, Tseng, Logan, Seney (CR23) 2018; 8
CR14
CR13
Seney, Sibille (CR6) 2014; 5
Labaka, Goñi-Balentziaga, Lebeña, Pérez-Tejada (CR9) 2018; 20
CR94
CR93
Maynard (CR85) 2021; 24
Kokkosis, Madeira, Mullahy, Tsirka (CR99) 2022; 27
Rahimian, Perlman, Canonne, Mechawar (CR100) 2022; 27
Gerrits, Heng, Boddeke, Eggen (CR75) 2020; 68
Ritchie (CR108) 2015; 43
Lenz, Nugent, Haliyur, McCarthy (CR46) 2013; 33
Thrupp (CR74) 2020; 32
CR25
McKenzie (CR84) 2018; 8
CR21
CR105
CR103
Porter, Clark, Kevorkian, Edwards (CR28) 2005; 386
Jin (CR29) 2021; 12
Fischer, Crow, Harris, Gillis (CR87) 2021; 16
Kriaucionis, Heintz (CR78) 2009; 324
Shi (CR40) 2020; 433-434
CR106
Jäkel (CR98) 2019; 566
C Nagy (38530_CR16) 2020; 23
T Burstyn-Cohen (38530_CR67) 2021; 7
L Song (38530_CR19) 2021; 49
J Barnes (38530_CR53) 2017; 42
D Ongür (38530_CR34) 1998; 95
H Mathys (38530_CR72) 2019; 570
I Korsunsky (38530_CR17) 2019; 16
FG Morrison (38530_CR51) 2019; 692
MD Robinson (38530_CR96) 2010; 26
S Kriaucionis (38530_CR78) 2009; 324
AK Bhandage (38530_CR58) 2021; 78
S Fischer (38530_CR87) 2021; 16
Y Chen (38530_CR73) 2021; 218
P Bankhead (38530_CR79) 2017; 7
BB Lake (38530_CR89) 2018; 36
T Wu (38530_CR110) 2021; 2
JM Schwarz (38530_CR45) 2012; 62
H Liu (38530_CR55) 2016; 1
P Steullet (38530_CR62) 2017; 22
JT Glessner (38530_CR64) 2010; 5
D-D Rosmus (38530_CR68) 2022; 10
N Habib (38530_CR90) 2017; 14
A Labaka (38530_CR9) 2018; 20
N Thrupp (38530_CR74) 2020; 32
E Gerrits (38530_CR75) 2020; 68
LH Geraldo (38530_CR27) 2021; 131
38530_CR2
38530_CR13
38530_CR14
B Labonté (38530_CR10) 2017; 23
R Rahimian (38530_CR41) 2019; 405
CL Wellman (38530_CR59) 2018; 38
R Gibel-Russo (38530_CR61) 2022; 16
S-F Lau (38530_CR71) 2020; 117
S Hirohata (38530_CR65) 2002; 277
JM Perez (38530_CR109) 2021; 26
D Cotter (38530_CR32) 2001; 58
RC Kessler (38530_CR5) 2013; 34
JL Bollinger (38530_CR38) 2021; 16
H Boutej (38530_CR24) 2017; 21
M Gillespie (38530_CR104) 2021; 50
S Bachmann (38530_CR8) 2018; 15
38530_CR21
KM Lenz (38530_CR46) 2013; 33
A Dumais (38530_CR76) 2005; 162
38530_CR25
AG Kokkosis (38530_CR99) 2022; 27
AP Pesarico (38530_CR60) 2019; 13
RM Ransohoff (38530_CR54) 2016; 19
38530_CR80
38530_CR83
A Tripp (38530_CR36) 2011; 42
S Morabito (38530_CR11) 2021; 53
AT McKenzie (38530_CR84) 2018; 8
S Jin (38530_CR29) 2021; 12
K Street (38530_CR91) 2018; 19
KM Cahill (38530_CR23) 2018; 8
JL Bollinger (38530_CR47) 2016; 52
M Tang (38530_CR18) 2021; 37
S Jäkel (38530_CR98) 2019; 566
S Smajić (38530_CR12) 2022; 145
GJ Mahajan (38530_CR52) 2018; 82
HL Crowell (38530_CR95) 2020; 11
ML Seney (38530_CR22) 2022; 91
A Subramanian (38530_CR102) 2005; 102
A Sequeira (38530_CR35) 2009; 4
38530_CR93
D Szklarczyk (38530_CR26) 2021; 49
38530_CR94
M Shi (38530_CR40) 2020; 433-434
ME Ritchie (38530_CR108) 2015; 43
Q Wang (38530_CR50) 2018; 175
P Langfelder (38530_CR107) 2008; 9
N Stolero (38530_CR57) 2021; 158
PE Lutz (38530_CR37) 2017; 174
D Cotter (38530_CR33) 2002; 12
C Eder (38530_CR56) 1998; 275
RB Patterson-Cross (38530_CR82) 2021; 22
K Van den Berge (38530_CR92) 2020; 11
SL James (38530_CR1) 2018; 392
HW Caplan (38530_CR44) 2017; 95
A Rau (38530_CR101) 2014; 15
G Rajkowska (38530_CR31) 1999; 45
JL Bollinger (38530_CR49) 2017; 12
D Velmeshev (38530_CR15) 2019; 364
ML Seney (38530_CR6) 2014; 5
M Kowalczyk (38530_CR63) 2021; 11
M Li (38530_CR88) 2018; 362
MJ Gandal (38530_CR4) 2018; 359
M Maitra (38530_CR77) 2021; 16
E Brivio (38530_CR69) 2020; 19
Y Hao (38530_CR81) 2021; 184
R Rahimian (38530_CR100) 2022; 27
A Tanti (38530_CR66) 2022; 27
KR Maynard (38530_CR85) 2021; 24
SL Klein (38530_CR39) 2016; 16
ML Seney (38530_CR7) 2018; 84
TE Bakken (38530_CR20) 2021; 598
RD Hodge (38530_CR86) 2019; 573
R Rahimian (38530_CR42) 2022; 13
SC Woodburn (38530_CR48) 2021; 14
GAM Blokland (38530_CR70) 2022; 91
CA Stockmeier (38530_CR30) 2004; 6
38530_CR105
38530_CR106
S Porter (38530_CR28) 2005; 386
D Guneykaya (38530_CR43) 2018; 24
38530_CR103
DJ McCarthy (38530_CR97) 2017; 33
DM Howard (38530_CR3) 2019; 22
References_xml – volume: 27
  start-page: 2562
  year: 2022
  end-page: 2573
  ident: CR100
  article-title: Targeting microglia-oligodendrocyte crosstalk in neurodegenerative and psychiatric disorders
  publication-title: Drug Discov. Today
  doi: 10.1016/j.drudis.2022.06.015
– volume: 26
  start-page: 2577
  year: 2021
  end-page: 2589
  ident: CR109
  article-title: Hippocampal subfield transcriptome analysis in schizophrenia psychosis
  publication-title: Mol. Psychiatry
  doi: 10.1038/s41380-020-0696-6
– volume: 12
  start-page: e0187631
  year: 2017
  ident: CR49
  article-title: Behavioral stress alters corticolimbic microglia in a sex- and brain region-specific manner
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0187631
– volume: 692
  start-page: 204
  year: 2019
  end-page: 209
  ident: CR51
  article-title: Reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression
  publication-title: Neurosci. Lett.
  doi: 10.1016/j.neulet.2018.10.027
– volume: 42
  start-page: 81
  year: 2017
  end-page: 98
  ident: CR53
  article-title: Genetic Contributions of Inflammation to Depression
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2016.169
– volume: 58
  start-page: 545
  year: 2001
  end-page: 553
  ident: CR32
  article-title: Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder
  publication-title: Arch. Gen. Psychiatry
  doi: 10.1001/archpsyc.58.6.545
– volume: 23
  start-page: 771
  year: 2020
  end-page: 781
  ident: CR16
  article-title: Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-020-0621-y
– volume: 95
  start-page: 13290
  year: 1998
  end-page: 13295
  ident: CR34
  article-title: Glial reduction in the subgenual prefrontal cortex in mood disorders
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.95.22.13290
– volume: 38
  start-page: 9423
  year: 2018
  end-page: 9432
  ident: CR59
  article-title: Sex differences in risk and resilience: stress effects on the neural substrates of emotion and motivation
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1673-18.2018
– ident: CR80
– volume: 5
  start-page: 17
  year: 2014
  ident: CR6
  article-title: Sex differences in mood disorders: perspectives from humans and rodent models
  publication-title: Biol. Sex. Differ.
  doi: 10.1186/s13293-014-0017-3
– ident: CR106
– ident: CR25
– volume: 162
  start-page: 2116
  year: 2005
  end-page: 2124
  ident: CR76
  article-title: Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.162.11.2116
– volume: 42
  start-page: 116
  year: 2011
  end-page: 124
  ident: CR36
  article-title: Reduced somatostatin in subgenual anterior cingulate cortex in major depression
  publication-title: Neurobiol. Dis.
  doi: 10.1016/j.nbd.2011.01.014
– volume: 359
  start-page: 693
  year: 2018
  end-page: 697
  ident: CR4
  article-title: Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
  publication-title: Science
  doi: 10.1126/science.aad6469
– volume: 27
  start-page: 1552
  year: 2022
  end-page: 1561
  ident: CR66
  article-title: Child abuse associates with increased recruitment of perineuronal nets in the ventromedial prefrontal cortex: a possible implication of oligodendrocyte progenitor cells
  publication-title: Mol. Psychiatry
  doi: 10.1038/s41380-021-01372-y
– volume: 392
  start-page: 1789
  year: 2018
  end-page: 1858
  ident: CR1
  article-title: Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
  publication-title: Lancet
  doi: 10.1016/S0140-6736(18)32279-7
– volume: 324
  start-page: 929
  year: 2009
  end-page: 930
  ident: CR78
  article-title: The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
  publication-title: Science
  doi: 10.1126/science.1169786
– volume: 19
  start-page: e12643
  year: 2020
  ident: CR69
  article-title: Sex differences: Transcriptional signatures of stress exposure in male and female brains
  publication-title: Genes Brain Behav.
  doi: 10.1111/gbb.12643
– volume: 184
  start-page: 3573
  year: 2021
  end-page: 3587.e3529
  ident: CR81
  article-title: Integrated analysis of multimodal single-cell data
  publication-title: Cell
  doi: 10.1016/j.cell.2021.04.048
– volume: 20
  start-page: 383
  year: 2018
  end-page: 392
  ident: CR9
  article-title: Biological sex differences in depression: a systematic review
  publication-title: Biol. Res Nurs.
  doi: 10.1177/1099800418776082
– volume: 43
  start-page: e47
  year: 2015
  end-page: e47
  ident: CR108
  article-title: limma powers differential expression analyses for RNA-sequencing and microarray studies
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv007
– volume: 8
  year: 2018
  ident: CR23
  article-title: Improved identification of concordant and discordant gene expression signatures using an updated rank-rank hypergeometric overlap approach
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-27903-2
– volume: 91
  start-page: 102
  year: 2022
  end-page: 117
  ident: CR70
  article-title: Sex-dependent shared and nonshared genetic architecture across mood and psychotic disorders
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2021.02.972
– volume: 570
  start-page: 332
  year: 2019
  end-page: 337
  ident: CR72
  article-title: Single-cell transcriptomic analysis of Alzheimer’s disease
  publication-title: Nature
  doi: 10.1038/s41586-019-1195-2
– volume: 16
  start-page: 100320
  year: 2021
  ident: CR38
  article-title: Uncovering microglial pathways driving sex-specific neurobiological effects in stress and depression
  publication-title: Brain Behav., Immun. - Health
  doi: 10.1016/j.bbih.2021.100320
– volume: 15
  year: 2014
  ident: CR101
  article-title: Differential meta-analysis of RNA-seq data from multiple studies
  publication-title: BMC Bioinforma.
  doi: 10.1186/1471-2105-15-91
– volume: 84
  start-page: 18
  year: 2018
  end-page: 27
  ident: CR7
  article-title: Opposite molecular signatures of depression in men and women
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2018.01.017
– volume: 49
  start-page: D605
  year: 2021
  end-page: d612
  ident: CR26
  article-title: The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa1074
– volume: 13
  start-page: 871997
  year: 2022
  ident: CR42
  article-title: Microglial inflammatory-metabolic pathways and their potential therapeutic implication in major depressive disorder
  publication-title: Front. Psychiatry
  doi: 10.3389/fpsyt.2022.871997
– volume: 10
  start-page: 840
  year: 2022
  ident: CR68
  article-title: The role of osteopontin in microglia biology: current concepts and future perspectives
  publication-title: Biomedicines
  doi: 10.3390/biomedicines10040840
– volume: 36
  start-page: 70
  year: 2018
  end-page: 80
  ident: CR89
  article-title: Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4038
– volume: 14
  start-page: 955
  year: 2017
  ident: CR90
  article-title: Massively parallel single-nucleus RNA-seq with DroNc-seq
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.4407
– volume: 34
  start-page: 119
  year: 2013
  end-page: 138
  ident: CR5
  article-title: The epidemiology of depression across cultures
  publication-title: Annu. Rev. Public Health
  doi: 10.1146/annurev-publhealth-031912-114409
– volume: 53
  start-page: 1143
  year: 2021
  end-page: 1155
  ident: CR11
  article-title: Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer’s disease
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-021-00894-z
– volume: 82
  start-page: 177
  year: 2018
  end-page: 186
  ident: CR52
  article-title: Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder
  publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2017.11.017
– volume: 33
  start-page: 2761
  year: 2013
  end-page: 2772
  ident: CR46
  article-title: Microglia are essential to masculinization of brain and behavior
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1268-12.2013
– volume: 24
  start-page: 425
  year: 2021
  end-page: 436
  ident: CR85
  article-title: Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-020-00787-0
– ident: CR94
– volume: 62
  start-page: 243
  year: 2012
  end-page: 253
  ident: CR45
  article-title: Sex, glia, and development: interactions in health and disease
  publication-title: Horm. Behav.
  doi: 10.1016/j.yhbeh.2012.02.018
– ident: CR103
– volume: 22
  start-page: 936
  year: 2017
  end-page: 943
  ident: CR62
  article-title: Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2017.47
– ident: CR13
– volume: 7
  year: 2017
  ident: CR79
  article-title: QuPath: Open source software for digital pathology image analysis
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-17204-5
– volume: 19
  start-page: 987
  year: 2016
  end-page: 991
  ident: CR54
  article-title: A polarizing question: do M1 and M2 microglia exist?
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4338
– ident: CR83
– volume: 405
  start-page: 14
  year: 2019
  end-page: 23
  ident: CR41
  article-title: Brain response to injuries: when microglia go sexist
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2018.02.048
– volume: 1
  start-page: 52
  year: 2016
  end-page: 58
  ident: CR55
  article-title: Neurotransmitter receptors on microglia
  publication-title: Stroke Vasc. Neurol.
  doi: 10.1136/svn-2016-000012
– volume: 117
  start-page: 25800
  year: 2020
  end-page: 25809
  ident: CR71
  article-title: Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.2008762117
– volume: 50
  start-page: D687
  year: 2021
  end-page: D692
  ident: CR104
  article-title: The reactome pathway knowledgebase 2022
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkab1028
– volume: 14
  start-page: 100312
  year: 2021
  ident: CR48
  article-title: Synaptic and behavioral effects of chronic stress are linked to dynamic and sex-specific changes in microglia function and astrocyte dystrophy
  publication-title: Neurobiol. Stress
  doi: 10.1016/j.ynstr.2021.100312
– ident: CR93
– volume: 32
  start-page: 108189
  year: 2020
  ident: CR74
  article-title: Single-nucleus RNA-Seq is not suitable for detection of microglial activation genes in humans
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2020.108189
– volume: 16
  start-page: 1289
  year: 2019
  end-page: 1296
  ident: CR17
  article-title: Fast, sensitive and accurate integration of single-cell data with Harmony
  publication-title: Nat. Methods
  doi: 10.1038/s41592-019-0619-0
– volume: 13
  start-page: 197
  year: 2019
  ident: CR60
  article-title: Chronic stress modulates interneuronal plasticity: effects on PSA-NCAM and perineuronal nets in cortical and extracortical regions
  publication-title: Front. Cell. Neurosci.
  doi: 10.3389/fncel.2019.00197
– volume: 7
  start-page: 33
  year: 2021
  end-page: 46
  ident: CR67
  article-title: TAM signaling in the nervous system
  publication-title: Brain Plasticity
  doi: 10.3233/BPL-210125
– volume: 16
  start-page: 875873
  year: 2022
  ident: CR61
  article-title: Non-cell-autonomous factors implicated in parvalbumin interneuron maturation and critical periods
  publication-title: Front. Neural Circuits
  doi: 10.3389/fncir.2022.875873
– volume: 22
  start-page: 343
  year: 2019
  end-page: 352
  ident: CR3
  article-title: Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-018-0326-7
– volume: 5
  start-page: e15463
  year: 2010
  ident: CR64
  article-title: Duplication of the SLIT3 locus on 5q35.1 predisposes to major depressive disorder
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0015463
– volume: 27
  start-page: 2833
  year: 2022
  end-page: 2848
  ident: CR99
  article-title: Chronic stress disrupts the homeostasis and progeny progression of oligodendroglial lineage cells, associating immune oligodendrocytes with prefrontal cortex hypomyelination
  publication-title: Mol. Psychiatry
  doi: 10.1038/s41380-022-01512-y
– volume: 68
  start-page: 740
  year: 2020
  end-page: 755
  ident: CR75
  article-title: Transcriptional profiling of microglia; current state of the art and future perspectives
  publication-title: Glia
  doi: 10.1002/glia.23767
– volume: 11
  year: 2020
  ident: CR92
  article-title: Trajectory-based differential expression analysis for single-cell sequencing data
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-14766-3
– volume: 24
  start-page: 2773
  year: 2018
  end-page: 2783.e2776
  ident: CR43
  article-title: Transcriptional and translational differences of microglia from male and female brains
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.08.001
– ident: CR21
– volume: 52
  start-page: 88
  year: 2016
  end-page: 97
  ident: CR47
  article-title: Differential effects of stress on microglial cell activation in male and female medial prefrontal cortex
  publication-title: Brain Behav. Immun.
  doi: 10.1016/j.bbi.2015.10.003
– volume: 362
  start-page: eaat7615
  year: 2018
  ident: CR88
  article-title: Integrative functional genomic analysis of human brain development and neuropsychiatric risks
  publication-title: Science
  doi: 10.1126/science.aat7615
– volume: 9
  year: 2008
  ident: CR107
  article-title: WGCNA: an R package for weighted correlation network analysis
  publication-title: BMC Bioinforma.
  doi: 10.1186/1471-2105-9-559
– volume: 11
  start-page: 1376
  year: 2021
  ident: CR63
  article-title: Cellular response to unfolded proteins in depression
  publication-title: Life
  doi: 10.3390/life11121376
– volume: 22
  year: 2021
  ident: CR82
  article-title: Selecting single cell clustering parameter values using subsampling-based robustness metrics
  publication-title: BMC Bioinforma.
  doi: 10.1186/s12859-021-03957-4
– volume: 158
  start-page: 1412
  year: 2021
  end-page: 1424
  ident: CR57
  article-title: The dialog between neurons and microglia in Alzheimer’s disease: the neurotransmitters view
  publication-title: J. Neurochem.
  doi: 10.1111/jnc.15262
– volume: 6
  start-page: 185
  year: 2004
  end-page: 197
  ident: CR30
  article-title: Cellular abnormalities in depression: evidence from postmortem brain tissue
  publication-title: Dialogues Clin. Neurosci.
  doi: 10.31887/DCNS.2004.6.2/cstockmeier
– volume: 78
  start-page: 5667
  year: 2021
  end-page: 5679
  ident: CR58
  article-title: GABAergic signaling by cells of the immune system: more the rule than the exception
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-021-03881-z
– volume: 33
  start-page: 1179
  year: 2017
  end-page: 1186
  ident: CR97
  article-title: Scater: pre-processing, quality control, normalization and visualization of single-cell RNA-seq data in R
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btw777
– ident: CR105
– volume: 26
  start-page: 139
  year: 2010
  end-page: 140
  ident: CR96
  article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp616
– volume: 573
  start-page: 61
  year: 2019
  end-page: 68
  ident: CR86
  article-title: Conserved cell types with divergent features in human versus mouse cortex
  publication-title: Nature
  doi: 10.1038/s41586-019-1506-7
– volume: 15
  start-page: 1425
  year: 2018
  ident: CR8
  article-title: Epidemiology of suicide and the psychiatric perspective
  publication-title: Int. J. Environ. Res. Public Health
  doi: 10.3390/ijerph15071425
– volume: 4
  start-page: e6585
  year: 2009
  ident: CR35
  article-title: Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0006585
– volume: 11
  year: 2020
  ident: CR95
  article-title: muscat detects subpopulation-specific state transitions from multi-sample multi-condition single-cell transcriptomics data
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-19894-4
– volume: 8
  year: 2018
  ident: CR84
  article-title: Brain cell type specific gene expression and co-expression network architectures
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-27293-5
– ident: CR14
– volume: 16
  start-page: 626
  year: 2016
  end-page: 638
  ident: CR39
  article-title: Sex differences in immune responses
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri.2016.90
– ident: CR2
– volume: 175
  start-page: 262
  year: 2018
  end-page: 274
  ident: CR50
  article-title: Role of complex epigenetic switching in tumor necrosis factor-α upregulation in the prefrontal cortex of suicide subjects
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.2017.16070759
– volume: 19
  year: 2018
  ident: CR91
  article-title: Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics
  publication-title: BMC Genomics
  doi: 10.1186/s12864-018-4772-0
– volume: 145
  start-page: 964
  year: 2022
  end-page: 978
  ident: CR12
  article-title: Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state
  publication-title: Brain
  doi: 10.1093/brain/awab446
– volume: 277
  start-page: 12182
  year: 2002
  end-page: 12189
  ident: CR65
  article-title: Punctin, a Novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109665200
– volume: 21
  start-page: 3220
  year: 2017
  end-page: 3233
  ident: CR24
  article-title: Diverging mRNA and protein networks in activated microglia reveal SRSF3 suppresses translation of highly upregulated innate immune transcripts
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2017.11.058
– volume: 275
  start-page: C327
  year: 1998
  end-page: C342
  ident: CR56
  article-title: Ion channels in microglia (brain macrophages)
  publication-title: Am. J. Physiol.-Cell Physiol.
  doi: 10.1152/ajpcell.1998.275.2.C327
– volume: 218
  start-page: e20202717
  year: 2021
  ident: CR73
  article-title: Microglia in Alzheimer’s disease at single-cell level. Are there common patterns in humans and mice?
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20202717
– volume: 91
  start-page: 14
  year: 2022
  end-page: 24
  ident: CR22
  article-title: Large-scale transcriptomics studies provide insight into sex differences in depression
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2020.12.025
– volume: 95
  start-page: 509
  year: 2017
  end-page: 517
  ident: CR44
  article-title: Do microglia play a role in sex differences in TBI?
  publication-title: J. Neurosci. Res.
  doi: 10.1002/jnr.23854
– volume: 16
  start-page: 2788
  year: 2021
  end-page: 2801
  ident: CR77
  article-title: Extraction of nuclei from archived postmortem tissues for single-nucleus sequencing applications
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-021-00514-4
– volume: 598
  start-page: 111
  year: 2021
  end-page: 119
  ident: CR20
  article-title: Comparative cellular analysis of motor cortex in human, marmoset and mouse
  publication-title: Nature
  doi: 10.1038/s41586-021-03465-8
– volume: 386
  start-page: 15
  year: 2005
  end-page: 27
  ident: CR28
  article-title: The ADAMTS metalloproteinases
  publication-title: Biochem. J.
  doi: 10.1042/BJ20040424
– volume: 433-434
  start-page: 152404
  year: 2020
  ident: CR40
  article-title: Estrogen receptor-regulated SOCS3 modulation via JAK2/STAT3 pathway is involved in BPF-induced M1 polarization of macrophages
  publication-title: Toxicology
  doi: 10.1016/j.tox.2020.152404
– volume: 16
  start-page: 4031
  year: 2021
  end-page: 4067
  ident: CR87
  article-title: Scaling up reproducible research for single-cell transcriptomics using MetaNeighbor
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-021-00575-5
– volume: 49
  start-page: D1029
  year: 2021
  end-page: d1037
  ident: CR19
  article-title: STAB: a spatio-temporal cell atlas of the human brain
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa762
– volume: 174
  start-page: 1185
  year: 2017
  end-page: 1194
  ident: CR37
  article-title: Association of a history of child abuse with impaired myelination in the anterior cingulate cortex: convergent epigenetic, transcriptional, and morphological evidence
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.2017.16111286
– volume: 23
  start-page: 1102
  year: 2017
  end-page: 1111
  ident: CR10
  article-title: Sex-specific transcriptional signatures in human depression
  publication-title: Nat. Med.
  doi: 10.1038/nm.4386
– volume: 131
  start-page: e141083
  year: 2021
  ident: CR27
  article-title: SLIT2/ROBO signaling in tumor-associated microglia and macrophages drives glioblastoma immunosuppression and vascular dysmorphia
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI141083
– volume: 566
  start-page: 543
  year: 2019
  end-page: 547
  ident: CR98
  article-title: Altered human oligodendrocyte heterogeneity in multiple sclerosis
  publication-title: Nature
  doi: 10.1038/s41586-019-0903-2
– volume: 2
  start-page: 100141
  year: 2021
  ident: CR110
  article-title: clusterProfiler 4.0: a universal enrichment tool for interpreting omics data
  publication-title: Innovation
– volume: 37
  start-page: 2212
  year: 2021
  end-page: 2214
  ident: CR18
  article-title: Evaluating single-cell cluster stability using the Jaccard similarity index
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btaa956
– volume: 364
  start-page: 685
  year: 2019
  ident: CR15
  article-title: Single-cell genomics identifies cell type–specific molecular changes in autism
  publication-title: Science
  doi: 10.1126/science.aav8130
– volume: 45
  start-page: 1085
  year: 1999
  end-page: 1098
  ident: CR31
  article-title: Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression
  publication-title: Biol. Psychiatry
  doi: 10.1016/S0006-3223(99)00041-4
– volume: 12
  start-page: 386
  year: 2002
  end-page: 394
  ident: CR33
  article-title: Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder
  publication-title: Cereb. Cortex
  doi: 10.1093/cercor/12.4.386
– volume: 102
  start-page: 15545
  year: 2005
  end-page: 15550
  ident: CR102
  article-title: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0506580102
– volume: 12
  year: 2021
  ident: CR29
  article-title: Inference and analysis of cell-cell communication using CellChat
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-21246-9
– volume: 91
  start-page: 102
  year: 2022
  ident: 38530_CR70
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2021.02.972
– volume: 22
  year: 2021
  ident: 38530_CR82
  publication-title: BMC Bioinforma.
  doi: 10.1186/s12859-021-03957-4
– volume: 38
  start-page: 9423
  year: 2018
  ident: 38530_CR59
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1673-18.2018
– volume: 16
  start-page: 875873
  year: 2022
  ident: 38530_CR61
  publication-title: Front. Neural Circuits
  doi: 10.3389/fncir.2022.875873
– volume: 184
  start-page: 3573
  year: 2021
  ident: 38530_CR81
  publication-title: Cell
  doi: 10.1016/j.cell.2021.04.048
– volume: 45
  start-page: 1085
  year: 1999
  ident: 38530_CR31
  publication-title: Biol. Psychiatry
  doi: 10.1016/S0006-3223(99)00041-4
– volume: 324
  start-page: 929
  year: 2009
  ident: 38530_CR78
  publication-title: Science
  doi: 10.1126/science.1169786
– volume: 24
  start-page: 2773
  year: 2018
  ident: 38530_CR43
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.08.001
– volume: 573
  start-page: 61
  year: 2019
  ident: 38530_CR86
  publication-title: Nature
  doi: 10.1038/s41586-019-1506-7
– volume: 19
  start-page: e12643
  year: 2020
  ident: 38530_CR69
  publication-title: Genes Brain Behav.
  doi: 10.1111/gbb.12643
– volume: 91
  start-page: 14
  year: 2022
  ident: 38530_CR22
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2020.12.025
– volume: 21
  start-page: 3220
  year: 2017
  ident: 38530_CR24
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2017.11.058
– ident: 38530_CR25
  doi: 10.1093/database/bax043
– volume: 12
  start-page: e0187631
  year: 2017
  ident: 38530_CR49
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0187631
– volume: 22
  start-page: 936
  year: 2017
  ident: 38530_CR62
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2017.47
– ident: 38530_CR106
  doi: 10.1093/bioinformatics/btx506
– volume: 9
  year: 2008
  ident: 38530_CR107
  publication-title: BMC Bioinforma.
  doi: 10.1186/1471-2105-9-559
– volume: 11
  start-page: 1376
  year: 2021
  ident: 38530_CR63
  publication-title: Life
  doi: 10.3390/life11121376
– volume: 11
  year: 2020
  ident: 38530_CR95
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-19894-4
– volume: 26
  start-page: 2577
  year: 2021
  ident: 38530_CR109
  publication-title: Mol. Psychiatry
  doi: 10.1038/s41380-020-0696-6
– volume: 23
  start-page: 771
  year: 2020
  ident: 38530_CR16
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-020-0621-y
– volume: 7
  year: 2017
  ident: 38530_CR79
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-17204-5
– ident: 38530_CR14
  doi: 10.1101/2020.11.06.20225342
– volume: 33
  start-page: 2761
  year: 2013
  ident: 38530_CR46
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1268-12.2013
– volume: 42
  start-page: 81
  year: 2017
  ident: 38530_CR53
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2016.169
– volume: 275
  start-page: C327
  year: 1998
  ident: 38530_CR56
  publication-title: Am. J. Physiol.-Cell Physiol.
  doi: 10.1152/ajpcell.1998.275.2.C327
– volume: 11
  year: 2020
  ident: 38530_CR92
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-14766-3
– volume: 692
  start-page: 204
  year: 2019
  ident: 38530_CR51
  publication-title: Neurosci. Lett.
  doi: 10.1016/j.neulet.2018.10.027
– volume: 16
  start-page: 2788
  year: 2021
  ident: 38530_CR77
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-021-00514-4
– volume: 4
  start-page: e6585
  year: 2009
  ident: 38530_CR35
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0006585
– volume: 68
  start-page: 740
  year: 2020
  ident: 38530_CR75
  publication-title: Glia
  doi: 10.1002/glia.23767
– volume: 277
  start-page: 12182
  year: 2002
  ident: 38530_CR65
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109665200
– volume: 5
  start-page: 17
  year: 2014
  ident: 38530_CR6
  publication-title: Biol. Sex. Differ.
  doi: 10.1186/s13293-014-0017-3
– volume: 43
  start-page: e47
  year: 2015
  ident: 38530_CR108
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv007
– volume: 14
  start-page: 955
  year: 2017
  ident: 38530_CR90
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.4407
– volume: 33
  start-page: 1179
  year: 2017
  ident: 38530_CR97
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btw777
– volume: 175
  start-page: 262
  year: 2018
  ident: 38530_CR50
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.2017.16070759
– volume: 16
  start-page: 626
  year: 2016
  ident: 38530_CR39
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri.2016.90
– volume: 392
  start-page: 1789
  year: 2018
  ident: 38530_CR1
  publication-title: Lancet
  doi: 10.1016/S0140-6736(18)32279-7
– volume: 27
  start-page: 1552
  year: 2022
  ident: 38530_CR66
  publication-title: Mol. Psychiatry
  doi: 10.1038/s41380-021-01372-y
– volume: 36
  start-page: 70
  year: 2018
  ident: 38530_CR89
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4038
– ident: 38530_CR94
– ident: 38530_CR21
  doi: 10.1126/sciadv.abn8367
– volume: 49
  start-page: D1029
  year: 2021
  ident: 38530_CR19
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa762
– volume: 22
  start-page: 343
  year: 2019
  ident: 38530_CR3
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-018-0326-7
– volume: 78
  start-page: 5667
  year: 2021
  ident: 38530_CR58
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-021-03881-z
– ident: 38530_CR13
  doi: 10.1101/2020.07.29.227355
– volume: 158
  start-page: 1412
  year: 2021
  ident: 38530_CR57
  publication-title: J. Neurochem.
  doi: 10.1111/jnc.15262
– ident: 38530_CR80
– ident: 38530_CR2
  doi: 10.1176/appi.books.9780890425787
– volume: 364
  start-page: 685
  year: 2019
  ident: 38530_CR15
  publication-title: Science
  doi: 10.1126/science.aav8130
– volume: 53
  start-page: 1143
  year: 2021
  ident: 38530_CR11
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-021-00894-z
– volume: 174
  start-page: 1185
  year: 2017
  ident: 38530_CR37
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.2017.16111286
– volume: 362
  start-page: eaat7615
  year: 2018
  ident: 38530_CR88
  publication-title: Science
  doi: 10.1126/science.aat7615
– volume: 27
  start-page: 2562
  year: 2022
  ident: 38530_CR100
  publication-title: Drug Discov. Today
  doi: 10.1016/j.drudis.2022.06.015
– volume: 13
  start-page: 871997
  year: 2022
  ident: 38530_CR42
  publication-title: Front. Psychiatry
  doi: 10.3389/fpsyt.2022.871997
– volume: 34
  start-page: 119
  year: 2013
  ident: 38530_CR5
  publication-title: Annu. Rev. Public Health
  doi: 10.1146/annurev-publhealth-031912-114409
– volume: 15
  start-page: 1425
  year: 2018
  ident: 38530_CR8
  publication-title: Int. J. Environ. Res. Public Health
  doi: 10.3390/ijerph15071425
– volume: 23
  start-page: 1102
  year: 2017
  ident: 38530_CR10
  publication-title: Nat. Med.
  doi: 10.1038/nm.4386
– volume: 10
  start-page: 840
  year: 2022
  ident: 38530_CR68
  publication-title: Biomedicines
  doi: 10.3390/biomedicines10040840
– volume: 1
  start-page: 52
  year: 2016
  ident: 38530_CR55
  publication-title: Stroke Vasc. Neurol.
  doi: 10.1136/svn-2016-000012
– volume: 95
  start-page: 509
  year: 2017
  ident: 38530_CR44
  publication-title: J. Neurosci. Res.
  doi: 10.1002/jnr.23854
– volume: 24
  start-page: 425
  year: 2021
  ident: 38530_CR85
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-020-00787-0
– ident: 38530_CR93
– volume: 12
  start-page: 386
  year: 2002
  ident: 38530_CR33
  publication-title: Cereb. Cortex
  doi: 10.1093/cercor/12.4.386
– volume: 145
  start-page: 964
  year: 2022
  ident: 38530_CR12
  publication-title: Brain
  doi: 10.1093/brain/awab446
– volume: 2
  start-page: 100141
  year: 2021
  ident: 38530_CR110
  publication-title: Innovation
– volume: 62
  start-page: 243
  year: 2012
  ident: 38530_CR45
  publication-title: Horm. Behav.
  doi: 10.1016/j.yhbeh.2012.02.018
– volume: 50
  start-page: D687
  year: 2021
  ident: 38530_CR104
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkab1028
– volume: 16
  start-page: 100320
  year: 2021
  ident: 38530_CR38
  publication-title: Brain Behav., Immun. - Health
  doi: 10.1016/j.bbih.2021.100320
– ident: 38530_CR83
  doi: 10.1101/653253
– volume: 19
  year: 2018
  ident: 38530_CR91
  publication-title: BMC Genomics
  doi: 10.1186/s12864-018-4772-0
– volume: 95
  start-page: 13290
  year: 1998
  ident: 38530_CR34
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.95.22.13290
– volume: 82
  start-page: 177
  year: 2018
  ident: 38530_CR52
  publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2017.11.017
– volume: 117
  start-page: 25800
  year: 2020
  ident: 38530_CR71
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.2008762117
– volume: 359
  start-page: 693
  year: 2018
  ident: 38530_CR4
  publication-title: Science
  doi: 10.1126/science.aad6469
– volume: 52
  start-page: 88
  year: 2016
  ident: 38530_CR47
  publication-title: Brain Behav. Immun.
  doi: 10.1016/j.bbi.2015.10.003
– volume: 162
  start-page: 2116
  year: 2005
  ident: 38530_CR76
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.162.11.2116
– ident: 38530_CR105
  doi: 10.32614/CRAN.package.babelgene
– ident: 38530_CR103
  doi: 10.1101/060012
– volume: 12
  year: 2021
  ident: 38530_CR29
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-21246-9
– volume: 13
  start-page: 197
  year: 2019
  ident: 38530_CR60
  publication-title: Front. Cell. Neurosci.
  doi: 10.3389/fncel.2019.00197
– volume: 8
  year: 2018
  ident: 38530_CR23
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-27903-2
– volume: 27
  start-page: 2833
  year: 2022
  ident: 38530_CR99
  publication-title: Mol. Psychiatry
  doi: 10.1038/s41380-022-01512-y
– volume: 433-434
  start-page: 152404
  year: 2020
  ident: 38530_CR40
  publication-title: Toxicology
  doi: 10.1016/j.tox.2020.152404
– volume: 131
  start-page: e141083
  year: 2021
  ident: 38530_CR27
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI141083
– volume: 49
  start-page: D605
  year: 2021
  ident: 38530_CR26
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa1074
– volume: 6
  start-page: 185
  year: 2004
  ident: 38530_CR30
  publication-title: Dialogues Clin. Neurosci.
  doi: 10.31887/DCNS.2004.6.2/cstockmeier
– volume: 16
  start-page: 4031
  year: 2021
  ident: 38530_CR87
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-021-00575-5
– volume: 16
  start-page: 1289
  year: 2019
  ident: 38530_CR17
  publication-title: Nat. Methods
  doi: 10.1038/s41592-019-0619-0
– volume: 405
  start-page: 14
  year: 2019
  ident: 38530_CR41
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2018.02.048
– volume: 26
  start-page: 139
  year: 2010
  ident: 38530_CR96
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp616
– volume: 14
  start-page: 100312
  year: 2021
  ident: 38530_CR48
  publication-title: Neurobiol. Stress
  doi: 10.1016/j.ynstr.2021.100312
– volume: 58
  start-page: 545
  year: 2001
  ident: 38530_CR32
  publication-title: Arch. Gen. Psychiatry
  doi: 10.1001/archpsyc.58.6.545
– volume: 42
  start-page: 116
  year: 2011
  ident: 38530_CR36
  publication-title: Neurobiol. Dis.
  doi: 10.1016/j.nbd.2011.01.014
– volume: 37
  start-page: 2212
  year: 2021
  ident: 38530_CR18
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btaa956
– volume: 5
  start-page: e15463
  year: 2010
  ident: 38530_CR64
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0015463
– volume: 7
  start-page: 33
  year: 2021
  ident: 38530_CR67
  publication-title: Brain Plasticity
  doi: 10.3233/BPL-210125
– volume: 218
  start-page: e20202717
  year: 2021
  ident: 38530_CR73
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20202717
– volume: 386
  start-page: 15
  year: 2005
  ident: 38530_CR28
  publication-title: Biochem. J.
  doi: 10.1042/BJ20040424
– volume: 32
  start-page: 108189
  year: 2020
  ident: 38530_CR74
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2020.108189
– volume: 84
  start-page: 18
  year: 2018
  ident: 38530_CR7
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2018.01.017
– volume: 566
  start-page: 543
  year: 2019
  ident: 38530_CR98
  publication-title: Nature
  doi: 10.1038/s41586-019-0903-2
– volume: 8
  year: 2018
  ident: 38530_CR84
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-27293-5
– volume: 20
  start-page: 383
  year: 2018
  ident: 38530_CR9
  publication-title: Biol. Res Nurs.
  doi: 10.1177/1099800418776082
– volume: 598
  start-page: 111
  year: 2021
  ident: 38530_CR20
  publication-title: Nature
  doi: 10.1038/s41586-021-03465-8
– volume: 570
  start-page: 332
  year: 2019
  ident: 38530_CR72
  publication-title: Nature
  doi: 10.1038/s41586-019-1195-2
– volume: 19
  start-page: 987
  year: 2016
  ident: 38530_CR54
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4338
– volume: 15
  year: 2014
  ident: 38530_CR101
  publication-title: BMC Bioinforma.
  doi: 10.1186/1471-2105-15-91
– volume: 102
  start-page: 15545
  year: 2005
  ident: 38530_CR102
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0506580102
SSID ssj0000391844
Score 2.629181
SecondaryResourceType review_article
Snippet Major depressive disorder (MDD) is a common, heterogenous, and potentially serious psychiatric illness. Diverse brain cell types have been implicated in MDD...
Abstract Major depressive disorder (MDD) is a common, heterogenous, and potentially serious psychiatric illness. Diverse brain cell types have been implicated...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 2912
SubjectTerms 38
38/91
631/337/2019
631/378
631/378/1689/1414
Astrocytes
Brain
Brain - metabolism
Clusters
Depression - genetics
Depressive Disorder, Major - genetics
Depressive Disorder, Major - metabolism
Female
Females
Gender differences
Gene expression
Gene sequencing
Genes
Glial stem cells
Humanities and Social Sciences
Humans
Interneurons
Male
Males
Mental depression
Microglia
multidisciplinary
Parvalbumin
Prefrontal cortex
Prefrontal Cortex - metabolism
Science
Science (multidisciplinary)
Sex differences
Transcriptome - genetics
Transcriptomes
Transcriptomics
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Jb9QwFLZQVSQuiJ1Ai4zEDaImXhLnSCsqDqjiAKg3yyuNNPVUTQbEL-Hv8mwnaYf1wm00cUbWW783fv4eQi8qQ4irIstno23JqG5KYbUpO86N0VC26HRv7dO79uREnJ5276-N-oo9YZkeOAvuABKqblSttYNEYq3XxANido1QRGlPE88noJ5rxVSKwbSD0oVNt2QqKg4GlmICpKiSQoqqSr6ViRJh_-9Q5q_Nkj-dmKZEdHwH3Z4QJH6dd34X3XDhHrqZZ0p-u4--H7nVCsd_VnG8RRk7gfAYE1IKD_EOMp6HokCIwH3ASzNswMPZ-ise-vMe6l18kag3w4CnXi58DslkwCpY7F3-rDcj7qeedAe_C_EimBGbeQt59ecYTx-gj8dvPhy9LafpC6VpqnYsO8esboSPAJIzIxxvwWEVIBbDO26gqFaVd741LbOeR44cVVfGetBLbSmgiIdoJ6yDe4ywr5mzykA884Qpo0BxitCu0QAGa-VpgepZE9JM1ORxQsZKpiNyKmTWngTtyaQ9yQv0cnnnIhNz_HX1YVTwsjKSaqcvwNTkZGryX6ZWoL3ZPOTk6YMkIkJA3nakQM-Xx-CjUdQquPUmrREgu4a3BXqUrWnZCYUSvAVQWSCxZWdbW91-EvqzxANex1PkmsGrr2aTvNrXn2Xx5H_I4im6RaIvVbwkZA_tjJcbt492zZexHy6fJWf8AaiSO84
  priority: 102
  providerName: Directory of Open Access Journals
Title Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes
URI https://link.springer.com/article/10.1038/s41467-023-38530-5
https://www.ncbi.nlm.nih.gov/pubmed/37217515
https://www.proquest.com/docview/2817275792
https://www.proquest.com/docview/2818053657
https://pubmed.ncbi.nlm.nih.gov/PMC10203145
https://doaj.org/article/389b6a1bbe614ddfb2f428e68a2abf33
Volume 14
WOSCitedRecordID wos001024186000015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: DOA
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: M~E
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVPQU
  databaseName: Advanced Technologies & Aerospace Database
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: P5Z
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/hightechjournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: M7P
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: 7X7
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: BENPR
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Publicly Available Content Database
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: PIMPY
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpR3ZbtNAcEVbkHjhPgIlWiTewKqvtddPiFatQILIQoACL9aeraXUCbED4kv4XWbWa1fh6AsvSZQdW7O7c-_sDCHPQhXHJsQqn5nUQZrILOBaqqBgTCkJbot099Y-vc1nMz6fF6UPuLU-rXKQiU5Q66XCGPlBzFHVsryIX66-Btg1Ck9XfQuNHbKHVRKQMUv2ZYyxYPVznqb-rkyY8IM2dZIBFFWQgKIKA7alj1zZ_r_Zmn-mTP52burU0cnN_53ILXLDG6L0VU85t8kV09wh1_rWlD_ukp9HZrGgGKCleBkTE4poh3rNSRm8ykyH3iogaWjd0DGntqHt2fI7bevzGtxmunIVPJuW-pQweg46qaWi0dSa_rfcdLT2qe0G3gtip1EdVQMKPfQpiuV75OPJ8Yej14Fv4hCoLMy7oDCplhm3aIeyVHHDcuB7AYaPYgVT4JuL0BqbqzzVlmGpHRGFSlsB3zoBY-Q-2W2WjXlIqI1So4UCsWjjVCghJEAlRSbBpoyETSYkGrayUr7COTbaWFTupD3hVb_9FWx_5ba_YhPyfHxm1df3uBT6EClkhMTa3O6P5fq08qwOsIXMRCSlAdNHaytjCz6eyThMSdoE0NwfCKPyAqOtLqhiQp6Ow8DquNSiMcuNg-GwdhnLJ-RBT44jJgl48jnYphPCtwh1C9XtkaY-c-XEIzyMjlJ49MVA0xd4_XstHl0-jcfkeoxsFrIgjvfJbrfemCfkqvrW1e16Snbyee4--ZTsHR7PyvdTFw6ZYvJtOXV8DCPlm3fl51-Bo0_q
linkProvider ProQuest
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELaqAoIL78dCASPBCaImThw7B4SgULXqsuJQUG_Bduw20ja7bLJU_SX8C34jM86jWh699cBpV5vJajIZfzNjz4OQ56FhzIbY5TPVRZDEOg1koU2QcW6MhrBF-7q1L2MxmciDg-zTGvnZ18JgWmWPiR6oi5nBPfJNJtHUcpGxN_NvAU6NwtPVfoRGqxZ79vQEQrb69e57eL8vGNv-sL-1E3RTBQKThqIJMpsUOpUOHSOeGGm5AEVUYIkNz7iBYFGFzjphRFI4jr1fVBSawin4LGKGzZcA8i8BjgtMIRMHYtjTwW7rMkm62pwwlpt14pEIDGMQg2EMA75i__yYgL_5tn-maP52TuvN3_aN_01wN8n1ztGmb9uVcYus2eo2udKO3jy9Q35s2emU4gY0xWJTTJiiDdptj6JYqk372TGApLSs6JAzXNH6aHZC6_K4nKoFnfsOpVVNu5Q3egw2t6aqKqiz7Xe9bGjZpe5b-F-A1co01PQstNSHaHbuks8XIpV7ZL2aVfYBoS5KbKEMwL5jiTJKaaCKs1SDzxwpF49I1KtObroO7jhIZJr7TIJY5q265aBuuVe3nI_Iy-Geedu_5Fzqd6iRAyX2Hvc_zBaHeQdlQJvpVEVaW3DtisJp5iCGtamER9IuBjY3ekXMO0Cs8zMtHJFnw2WAMhS1quxs6WkkyC7lYkTut-o_cBILiJ3B9x4RubIwVlhdvVKVR75deoSH7VECt77q19AZX_-WxcPzH-Mpubqz_3Gcj3cne4_INYZLPOQBYxtkvVks7WNy2XxvynrxxGMEJV8vem39ArxCpRg
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Zb9NAEF5V5RAv3EegwCLBE1ix114fDwhBS0TVKsoDoIoXs2drKbVD7FD1l_Bf-HXMrI8qHH3rA0-J4nE0Xs98M7M7ByHPfcWY8bHLZyy1F4Uy9lItlZdxrpSEsEW6urXP-8l0mh4cZLMN8rOvhcG0yh4THVDrSuEe-ZilaGp5krGx7dIiZjuTN4tvHk6QwpPWfpxGKyJ75vQEwrf69e4OvOsXjE3ef9z-4HUTBjwV-0njZSbSMk4tOkk8UqnhCQilAKuseMYVBI7Ct8YmKom05dgHRgS-0lbApw4ZNmIC-L-UQIyJgd-Mfxn2d7DzehpFXZ2OH6bjOnKoBEbSC8FI-h5fs4VuZMDf_Nw_0zV_O7N1pnBy439exJvkeueA07etxtwiG6a8Ta60IzlP75Af22Y-p7gxTbEIFROpaIP23KErlnDTfqYMICwtSjrkEpe0PqpOaF0cF3OxpAvXubSsaZcKR4_BFtdUlJpa036Xq4YWXUq_gf8FuC1VQ1XPQkt9iOboLvl0Iatyj2yWVWkeEGqDyGihwBxYFgklhASqMIsl-NKBsOGIBL0Y5arr7I4DRua5yzAI07wVvRxEL3eil_MReTncs2j7mpxL_Q6lc6DEnuTuh2p5mHcQB7SZjEUgpQGXT2srmYXY1sQpPJK0IbC51Qtl3gFlnZ9J5Ig8Gy4DxOFSi9JUK0eTwtrFPBmR-60qDJyECcTU4JOPSLqmJGusrl8piyPXRj3AQ_gggltf9fp0xte_1-Lh-Y_xlFwFlcr3d6d7j8g1htruc4-xLbLZLFfmMbmsvjdFvXzi4IKSrxetWr8Ad36uCw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cell+type+specific+transcriptomic+differences+in+depression+show+similar+patterns+between+males+and+females+but+implicate+distinct+cell+types+and+genes&rft.jtitle=Nature+communications&rft.au=Maitra%2C+Malosree&rft.au=Mitsuhashi%2C+Haruka&rft.au=Rahimian%2C+Reza&rft.au=Chawla%2C+Anjali&rft.date=2023-05-22&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2041-1723&rft.volume=14&rft.issue=1&rft_id=info:doi/10.1038%2Fs41467-023-38530-5&rft.externalDocID=10_1038_s41467_023_38530_5
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon