Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases

A rapidly developing paradigm for modern health care is a proactive and individualized response to patients' symptoms, combining precision diagnosis and personalized treatment. Precision medicine is becoming an overarching medical discipline that will require a better understanding of biomarker...

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Veröffentlicht in:The Journal of clinical investigation Jg. 129; H. 4; S. 1493 - 1503
Hauptverfasser: Agache, Ioana, Akdis, Cezmi A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States American Society for Clinical Investigation 01.04.2019
Schlagworte:
Allergens
Allergic diseases
Allergy
Asthma
B cells
Big data
Biological markers
Biomarkers
Biomedical research
Care and treatment
Chronic illnesses
Chronic obstructive pulmonary disease
Dermatitis
Diagnosis
Disease management
Fibroblasts
Food allergies
Gene expression
Genotypes
Health care costs
Inflammation
Medical economics
Medicine
Patient outcomes
Patients
Phenotypes
Precision medicine
Review Series
Risk factors
ISSN:0021-9738, 1558-8238, 1558-8238
Online-Zugang:Volltext
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Abstract A rapidly developing paradigm for modern health care is a proactive and individualized response to patients' symptoms, combining precision diagnosis and personalized treatment. Precision medicine is becoming an overarching medical discipline that will require a better understanding of biomarkers, phenotypes, endotypes, genotypes, regiotypes, and theratypes of diseases. The 100-year-old personalized allergen-specific management of allergic diseases has particularly contributed to early awareness in precision medicine. Polyomics, big data, and systems biology have demonstrated a profound complexity and dynamic variability in allergic disease between individuals, as well as between regions. Escalating health care costs together with questionable efficacy of the current management of allergic diseases facilitated the emergence of the endotype-driven approach. We describe here a precision medicine approach that stratifies patients based on disease mechanisms to optimize management of allergic diseases.
AbstractList A rapidly developing paradigm for modern health care is a proactive and individualized response to patients' symptoms, combining precision diagnosis and personalized treatment. Precision medicine is becoming an overarching medical discipline that will require a better understanding of biomarkers, phenotypes, endotypes, genotypes, regiotypes, and theratypes of diseases. The 100-year-old personalized allergen-specific management of allergic diseases has particularly contributed to early awareness in precision medicine. Polyomics, big data, and systems biology have demonstrated a profound complexity and dynamic variability in allergic disease between individuals, as well as between regions. Escalating health care costs together with questionable efficacy of the current management of allergic diseases facilitated the emergence of the endotype-driven approach. We describe here a precision medicine approach that stratifies patients based on disease mechanisms to optimize management of allergic diseases.
A rapidly developing paradigm for modern health care is a proactive and individualized response to patients' symptoms, combining precision diagnosis and personalized treatment. Precision medicine is becoming an overarching medical discipline that will require a better understanding of biomarkers, phenotypes, endotypes, genotypes, regiotypes, and theratypes of diseases. The 100-year-old personalized allergen-specific management of allergic diseases has particularly contributed to early awareness in precision medicine. Polyomics, big data, and systems biology have demonstrated a profound complexity and dynamic variability in allergic disease between individuals, as well as between regions. Escalating health care costs together with questionable efficacy of the current management of allergic diseases facilitated the emergence of the endotype-driven approach. We describe here a precision medicine approach that stratifies patients based on disease mechanisms to optimize management of allergic diseases.A rapidly developing paradigm for modern health care is a proactive and individualized response to patients' symptoms, combining precision diagnosis and personalized treatment. Precision medicine is becoming an overarching medical discipline that will require a better understanding of biomarkers, phenotypes, endotypes, genotypes, regiotypes, and theratypes of diseases. The 100-year-old personalized allergen-specific management of allergic diseases has particularly contributed to early awareness in precision medicine. Polyomics, big data, and systems biology have demonstrated a profound complexity and dynamic variability in allergic disease between individuals, as well as between regions. Escalating health care costs together with questionable efficacy of the current management of allergic diseases facilitated the emergence of the endotype-driven approach. We describe here a precision medicine approach that stratifies patients based on disease mechanisms to optimize management of allergic diseases.
A rapidly developing paradigm for modern health care is a proactive and individualized response to patients' symptoms, combining precision diagnosis and personalized treatment. Precision medicine is becoming an overarching medical discipline that will require a better understanding of biomarkers, phenotypes, endotypes, genotypes, regiotypes, and theratypes of diseases. The 100-year-old personalized allergen-specific management of allergic diseases has particularly contributed to early awareness in precision medicine. Polyomics, big data, and systems biology have demonstrated a profound complexity and dynamic variability in allergic disease between individuals, as well as between regions. Escalating health care costs together with questionable efficacy of the current management of allergic diseases facilitated the emergence of the endotypedriven approach. We describe here a precision medicine approach that stratifies patients based on disease mechanisms to optimize management of allergic diseases.
Audience Academic
Author Akdis, Cezmi A.
Agache, Ioana
AuthorAffiliation 3 Christine Kühne – Center for Allergy Research and Education (CK-CARE), Davos, Switzerland
1 Transylvania University, Faculty of Medicine, Brasov, Romania
2 Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
AuthorAffiliation_xml – name: 3 Christine Kühne – Center for Allergy Research and Education (CK-CARE), Davos, Switzerland
– name: 2 Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
– name: 1 Transylvania University, Faculty of Medicine, Brasov, Romania
Author_xml – sequence: 1
  givenname: Ioana
  surname: Agache
  fullname: Agache, Ioana
– sequence: 2
  givenname: Cezmi A.
  orcidid: 0000-0001-8020-019X
  surname: Akdis
  fullname: Akdis, Cezmi A.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30855278$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright COPYRIGHT 2019 American Society for Clinical Investigation
Copyright American Society for Clinical Investigation Apr 2019
2019 American Society for Clinical Investigation 2019 American Society for Clinical Investigation
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Snippet A rapidly developing paradigm for modern health care is a proactive and individualized response to patients' symptoms, combining precision diagnosis and...
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SubjectTerms Allergens
Allergic diseases
Allergy
Asthma
B cells
Big data
Biological markers
Biomarkers
Biomedical research
Care and treatment
Chronic illnesses
Chronic obstructive pulmonary disease
Dermatitis
Diagnosis
Disease management
Fibroblasts
Food allergies
Gene expression
Genotypes
Health care costs
Inflammation
Medical economics
Medicine
Patient outcomes
Patients
Phenotypes
Precision medicine
Review Series
Risk factors
Title Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases
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