SLCO4A1-AS1 promotes colorectal tumourigenesis by regulating Cdk2/c-Myc signalling

Background SLCO4A1-AS1 was found to be upregulated in several cancer types, including colorectal cancer (CRC). However, the detailed roles of SLCO4A1-AS1 in CRC remain to be elucidated. Therefore, we investigated the functions, mechanism, and clinical significance of SLCO4A1-AS1 in colorectal tumour...

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Veröffentlicht in:	Journal of biomedical science Jg. 29; H. 1; S. 4 - 17
Hauptverfasser:	Zhang, Jia, Cui, Kaisa, Huang, Liuying, Yang, Fan, Sun, Shengbai, Bian, Zehua, Wang, Xue, Li, Chaoqun, Yin, Yuan, Huang, Shengling, Zhou, Leyuan, Fei, Bojian, Huang, Zhaohui
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 17.01.2022 BioMed Central Ltd Springer Nature B.V BMC
Schlagworte:	Analysis Antibodies Biomedical and Life Sciences Biomedicine c-Myc c-Myc protein Cancer Carcinogenesis - genetics Cdk2 Cell cycle Cell growth Cell Line, Tumor Cell Movement Cell Proliferation - genetics Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Cyclin-Dependent Kinase 2 DNA methylation Gene Expression Regulation, Neoplastic Genes Heat shock proteins Hsp90 protein Humans Immunohistochemistry Immunoprecipitation In vivo methods and tests Long non-coding RNA Mass spectrometry Metastasis Methylation MicroRNAs Myc protein Pathogenesis Phosphorylation Plasmids Prognosis Proteins Proto-Oncogene Proteins c-myc Ribonucleic acid RNA RNA, Antisense RNA, Long Noncoding Scientific imaging Signal transduction Signal Transduction - genetics Signaling SLCO4A1-AS1 Therapeutic targets Tumorigenesis Tumors China United States > US SLCO4A1-AS1 c-Myc Colorectal cancer Cdk2 Long non-coding RNA
ISSN:	1423-0127, 1021-7770, 1423-0127
Online-Zugang:	Volltext
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