Effectiveness of intramuscular gluteal glucocorticoid injection versus intra-articular glucocorticoid injection in knee osteoarthritis: design of a multicenter randomized, 24 weeks comparative parallel-group trial
Background The knee is symptomatically the most frequent affected joint in osteoarthritis and, in the Netherlands and other Western countries, is mainly managed by general practitioners (GPs). An intra-articular glucocorticoid injection is recommended in (inter) national guidelines for patients with...
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| Vydáno v: | BMC musculoskeletal disorders Ročník 21; číslo 1; s. 225 - 9 |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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London
BioMed Central
11.04.2020
BioMed Central Ltd Springer Nature B.V BMC |
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| ISSN: | 1471-2474, 1471-2474 |
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| Abstract | Background
The knee is symptomatically the most frequent affected joint in osteoarthritis and, in the Netherlands and other Western countries, is mainly managed by general practitioners (GPs). An intra-articular glucocorticoid injection is recommended in (inter) national guidelines for patients with knee osteoarthritis as an option for a flare of knee pain and/or for those who are not responding well to pain medication. An innovative approach that could replace the intra-articular injection is an intramuscular gluteal glucocorticoid injection. An intramuscular injection is easier to perform than an intra-articular injection with lesser risk of severe local adverse reactions. We hypothesize that intramuscular gluteal glucocorticoid injection is non-inferior in reducing knee pain compared to intra-articular glucocorticoid injection, with potentially a longer lasting effect than intra-articular injection.
Methods/design
The study will be a pragmatic randomized controlled non-inferiority trial with two parallel groups. A total of 140 patients aged 45 years and older with knee osteoarthritis who contacted their general practitioner and have persistent knee pain (score ≥ 3 on 0–10 numerical rating scale; 0 = no knee pain) will be included.
Patients will be randomly allocated (1:1) to an injection of 40 mg triamcinolone acetonide intra-articular in the knee joint or intramuscular in the ipsilateral ventrogluteal area.
The effect of treatment will be evaluated by questionnaires at 2, 4, 8, 12, and 24 weeks after injection. The primary outcome is patients’ reported severity of knee pain measured with the pain subscale of the Knee injury and Osteoarthritis Outcome Score 4 weeks after injection. Statistical analysis will be based on both the per-protocol and the intention-to-treat principle.
Discussion
This study will evaluate non-inferiority of intramuscular glucocorticoid injection compared to intra-articular glucocorticoid injection for knee osteoarthritis symptoms.
Trial registration
This trial is registered in the Dutch Trial Registry (number NTR6968) at 2018-01-22 (
https://www.trialregister.nl/trial/6784
). Issue date: 1 October 2019.
Trial sponsor
Erasmus MC University Medical Center Rotterdam.
PO-box 2040.
3000 CA Rotterdam.
The Netherlands. |
|---|---|
| AbstractList | The knee is symptomatically the most frequent affected joint in osteoarthritis and, in the Netherlands and other Western countries, is mainly managed by general practitioners (GPs). An intra-articular glucocorticoid injection is recommended in (inter) national guidelines for patients with knee osteoarthritis as an option for a flare of knee pain and/or for those who are not responding well to pain medication. An innovative approach that could replace the intra-articular injection is an intramuscular gluteal glucocorticoid injection. An intramuscular injection is easier to perform than an intra-articular injection with lesser risk of severe local adverse reactions. We hypothesize that intramuscular gluteal glucocorticoid injection is non-inferior in reducing knee pain compared to intra-articular glucocorticoid injection, with potentially a longer lasting effect than intra-articular injection. The study will be a pragmatic randomized controlled non-inferiority trial with two parallel groups. A total of 140 patients aged 45 years and older with knee osteoarthritis who contacted their general practitioner and have persistent knee pain (score [greater than or equai to] 3 on 0-10 numerical rating scale; 0 = no knee pain) will be included. The effect of treatment will be evaluated by questionnaires at 2, 4, 8, 12, and 24 weeks after injection. The primary outcome is patients' reported severity of knee pain measured with the pain subscale of the Knee injury and Osteoarthritis Outcome Score 4 weeks after injection. Statistical analysis will be based on both the per-protocol and the intention-to-treat principle. This study will evaluate non-inferiority of intramuscular glucocorticoid injection compared to intra-articular glucocorticoid injection for knee osteoarthritis symptoms. The knee is symptomatically the most frequent affected joint in osteoarthritis and, in the Netherlands and other Western countries, is mainly managed by general practitioners (GPs). An intra-articular glucocorticoid injection is recommended in (inter) national guidelines for patients with knee osteoarthritis as an option for a flare of knee pain and/or for those who are not responding well to pain medication. An innovative approach that could replace the intra-articular injection is an intramuscular gluteal glucocorticoid injection. An intramuscular injection is easier to perform than an intra-articular injection with lesser risk of severe local adverse reactions. We hypothesize that intramuscular gluteal glucocorticoid injection is non-inferior in reducing knee pain compared to intra-articular glucocorticoid injection, with potentially a longer lasting effect than intra-articular injection.BACKGROUNDThe knee is symptomatically the most frequent affected joint in osteoarthritis and, in the Netherlands and other Western countries, is mainly managed by general practitioners (GPs). An intra-articular glucocorticoid injection is recommended in (inter) national guidelines for patients with knee osteoarthritis as an option for a flare of knee pain and/or for those who are not responding well to pain medication. An innovative approach that could replace the intra-articular injection is an intramuscular gluteal glucocorticoid injection. An intramuscular injection is easier to perform than an intra-articular injection with lesser risk of severe local adverse reactions. We hypothesize that intramuscular gluteal glucocorticoid injection is non-inferior in reducing knee pain compared to intra-articular glucocorticoid injection, with potentially a longer lasting effect than intra-articular injection.The study will be a pragmatic randomized controlled non-inferiority trial with two parallel groups. A total of 140 patients aged 45 years and older with knee osteoarthritis who contacted their general practitioner and have persistent knee pain (score ≥ 3 on 0-10 numerical rating scale; 0 = no knee pain) will be included. Patients will be randomly allocated (1:1) to an injection of 40 mg triamcinolone acetonide intra-articular in the knee joint or intramuscular in the ipsilateral ventrogluteal area. The effect of treatment will be evaluated by questionnaires at 2, 4, 8, 12, and 24 weeks after injection. The primary outcome is patients' reported severity of knee pain measured with the pain subscale of the Knee injury and Osteoarthritis Outcome Score 4 weeks after injection. Statistical analysis will be based on both the per-protocol and the intention-to-treat principle.METHODS/DESIGNThe study will be a pragmatic randomized controlled non-inferiority trial with two parallel groups. A total of 140 patients aged 45 years and older with knee osteoarthritis who contacted their general practitioner and have persistent knee pain (score ≥ 3 on 0-10 numerical rating scale; 0 = no knee pain) will be included. Patients will be randomly allocated (1:1) to an injection of 40 mg triamcinolone acetonide intra-articular in the knee joint or intramuscular in the ipsilateral ventrogluteal area. The effect of treatment will be evaluated by questionnaires at 2, 4, 8, 12, and 24 weeks after injection. The primary outcome is patients' reported severity of knee pain measured with the pain subscale of the Knee injury and Osteoarthritis Outcome Score 4 weeks after injection. Statistical analysis will be based on both the per-protocol and the intention-to-treat principle.This study will evaluate non-inferiority of intramuscular glucocorticoid injection compared to intra-articular glucocorticoid injection for knee osteoarthritis symptoms.DISCUSSIONThis study will evaluate non-inferiority of intramuscular glucocorticoid injection compared to intra-articular glucocorticoid injection for knee osteoarthritis symptoms.This trial is registered in the Dutch Trial Registry (number NTR6968) at 2018-01-22 (https://www.trialregister.nl/trial/6784). Issue date: 1 October 2019.TRIAL REGISTRATIONThis trial is registered in the Dutch Trial Registry (number NTR6968) at 2018-01-22 (https://www.trialregister.nl/trial/6784). Issue date: 1 October 2019.Erasmus MC University Medical Center Rotterdam. PO-box 2040. 3000 CA Rotterdam. The Netherlands.TRIAL SPONSORErasmus MC University Medical Center Rotterdam. PO-box 2040. 3000 CA Rotterdam. The Netherlands. Background The knee is symptomatically the most frequent affected joint in osteoarthritis and, in the Netherlands and other Western countries, is mainly managed by general practitioners (GPs). An intra-articular glucocorticoid injection is recommended in (inter) national guidelines for patients with knee osteoarthritis as an option for a flare of knee pain and/or for those who are not responding well to pain medication. An innovative approach that could replace the intra-articular injection is an intramuscular gluteal glucocorticoid injection. An intramuscular injection is easier to perform than an intra-articular injection with lesser risk of severe local adverse reactions. We hypothesize that intramuscular gluteal glucocorticoid injection is non-inferior in reducing knee pain compared to intra-articular glucocorticoid injection, with potentially a longer lasting effect than intra-articular injection. Methods/design The study will be a pragmatic randomized controlled non-inferiority trial with two parallel groups. A total of 140 patients aged 45 years and older with knee osteoarthritis who contacted their general practitioner and have persistent knee pain (score ≥ 3 on 0–10 numerical rating scale; 0 = no knee pain) will be included. Patients will be randomly allocated (1:1) to an injection of 40 mg triamcinolone acetonide intra-articular in the knee joint or intramuscular in the ipsilateral ventrogluteal area. The effect of treatment will be evaluated by questionnaires at 2, 4, 8, 12, and 24 weeks after injection. The primary outcome is patients’ reported severity of knee pain measured with the pain subscale of the Knee injury and Osteoarthritis Outcome Score 4 weeks after injection. Statistical analysis will be based on both the per-protocol and the intention-to-treat principle. Discussion This study will evaluate non-inferiority of intramuscular glucocorticoid injection compared to intra-articular glucocorticoid injection for knee osteoarthritis symptoms. Trial registration This trial is registered in the Dutch Trial Registry (number NTR6968) at 2018-01-22 (https://www.trialregister.nl/trial/6784). Issue date: 1 October 2019. Trial sponsor Erasmus MC University Medical Center Rotterdam. PO-box 2040. 3000 CA Rotterdam. The Netherlands. The knee is symptomatically the most frequent affected joint in osteoarthritis and, in the Netherlands and other Western countries, is mainly managed by general practitioners (GPs). An intra-articular glucocorticoid injection is recommended in (inter) national guidelines for patients with knee osteoarthritis as an option for a flare of knee pain and/or for those who are not responding well to pain medication. An innovative approach that could replace the intra-articular injection is an intramuscular gluteal glucocorticoid injection. An intramuscular injection is easier to perform than an intra-articular injection with lesser risk of severe local adverse reactions. We hypothesize that intramuscular gluteal glucocorticoid injection is non-inferior in reducing knee pain compared to intra-articular glucocorticoid injection, with potentially a longer lasting effect than intra-articular injection. The study will be a pragmatic randomized controlled non-inferiority trial with two parallel groups. A total of 140 patients aged 45 years and older with knee osteoarthritis who contacted their general practitioner and have persistent knee pain (score ≥ 3 on 0-10 numerical rating scale; 0 = no knee pain) will be included. Patients will be randomly allocated (1:1) to an injection of 40 mg triamcinolone acetonide intra-articular in the knee joint or intramuscular in the ipsilateral ventrogluteal area. The effect of treatment will be evaluated by questionnaires at 2, 4, 8, 12, and 24 weeks after injection. The primary outcome is patients' reported severity of knee pain measured with the pain subscale of the Knee injury and Osteoarthritis Outcome Score 4 weeks after injection. Statistical analysis will be based on both the per-protocol and the intention-to-treat principle. This study will evaluate non-inferiority of intramuscular glucocorticoid injection compared to intra-articular glucocorticoid injection for knee osteoarthritis symptoms. This trial is registered in the Dutch Trial Registry (number NTR6968) at 2018-01-22 (https://www.trialregister.nl/trial/6784). Issue date: 1 October 2019. Erasmus MC University Medical Center Rotterdam. PO-box 2040. 3000 CA Rotterdam. The Netherlands. Background The knee is symptomatically the most frequent affected joint in osteoarthritis and, in the Netherlands and other Western countries, is mainly managed by general practitioners (GPs). An intra-articular glucocorticoid injection is recommended in (inter) national guidelines for patients with knee osteoarthritis as an option for a flare of knee pain and/or for those who are not responding well to pain medication. An innovative approach that could replace the intra-articular injection is an intramuscular gluteal glucocorticoid injection. An intramuscular injection is easier to perform than an intra-articular injection with lesser risk of severe local adverse reactions. We hypothesize that intramuscular gluteal glucocorticoid injection is non-inferior in reducing knee pain compared to intra-articular glucocorticoid injection, with potentially a longer lasting effect than intra-articular injection. Methods/design The study will be a pragmatic randomized controlled non-inferiority trial with two parallel groups. A total of 140 patients aged 45 years and older with knee osteoarthritis who contacted their general practitioner and have persistent knee pain (score [greater than or equai to] 3 on 0-10 numerical rating scale; 0 = no knee pain) will be included. Patients will be randomly allocated (1:1) to an injection of 40 mg triamcinolone acetonide intra-articular in the knee joint or intramuscular in the ipsilateral ventrogluteal area. The effect of treatment will be evaluated by questionnaires at 2, 4, 8, 12, and 24 weeks after injection. The primary outcome is patients' reported severity of knee pain measured with the pain subscale of the Knee injury and Osteoarthritis Outcome Score 4 weeks after injection. Statistical analysis will be based on both the per-protocol and the intention-to-treat principle. Discussion This study will evaluate non-inferiority of intramuscular glucocorticoid injection compared to intra-articular glucocorticoid injection for knee osteoarthritis symptoms. Trial registration This trial is registered in the Dutch Trial Registry (number NTR6968) at 2018-01-22 ( Trial sponsor Erasmus MC University Medical Center Rotterdam. PO-box 2040. 3000 CA Rotterdam. The Netherlands. Keywords: Knee osteoarthritis, Glucocorticoid injection, Intra-articular, Intramuscular, Randomized controlled trial, Non-inferiority, Primary care, General practice Background The knee is symptomatically the most frequent affected joint in osteoarthritis and, in the Netherlands and other Western countries, is mainly managed by general practitioners (GPs). An intra-articular glucocorticoid injection is recommended in (inter) national guidelines for patients with knee osteoarthritis as an option for a flare of knee pain and/or for those who are not responding well to pain medication. An innovative approach that could replace the intra-articular injection is an intramuscular gluteal glucocorticoid injection. An intramuscular injection is easier to perform than an intra-articular injection with lesser risk of severe local adverse reactions. We hypothesize that intramuscular gluteal glucocorticoid injection is non-inferior in reducing knee pain compared to intra-articular glucocorticoid injection, with potentially a longer lasting effect than intra-articular injection. Methods/design The study will be a pragmatic randomized controlled non-inferiority trial with two parallel groups. A total of 140 patients aged 45 years and older with knee osteoarthritis who contacted their general practitioner and have persistent knee pain (score ≥ 3 on 0–10 numerical rating scale; 0 = no knee pain) will be included. Patients will be randomly allocated (1:1) to an injection of 40 mg triamcinolone acetonide intra-articular in the knee joint or intramuscular in the ipsilateral ventrogluteal area. The effect of treatment will be evaluated by questionnaires at 2, 4, 8, 12, and 24 weeks after injection. The primary outcome is patients’ reported severity of knee pain measured with the pain subscale of the Knee injury and Osteoarthritis Outcome Score 4 weeks after injection. Statistical analysis will be based on both the per-protocol and the intention-to-treat principle. Discussion This study will evaluate non-inferiority of intramuscular glucocorticoid injection compared to intra-articular glucocorticoid injection for knee osteoarthritis symptoms. Trial registration This trial is registered in the Dutch Trial Registry (number NTR6968) at 2018-01-22 ( https://www.trialregister.nl/trial/6784 ). Issue date: 1 October 2019. Trial sponsor Erasmus MC University Medical Center Rotterdam. PO-box 2040. 3000 CA Rotterdam. The Netherlands. Abstract Background The knee is symptomatically the most frequent affected joint in osteoarthritis and, in the Netherlands and other Western countries, is mainly managed by general practitioners (GPs). An intra-articular glucocorticoid injection is recommended in (inter) national guidelines for patients with knee osteoarthritis as an option for a flare of knee pain and/or for those who are not responding well to pain medication. An innovative approach that could replace the intra-articular injection is an intramuscular gluteal glucocorticoid injection. An intramuscular injection is easier to perform than an intra-articular injection with lesser risk of severe local adverse reactions. We hypothesize that intramuscular gluteal glucocorticoid injection is non-inferior in reducing knee pain compared to intra-articular glucocorticoid injection, with potentially a longer lasting effect than intra-articular injection. Methods/design The study will be a pragmatic randomized controlled non-inferiority trial with two parallel groups. A total of 140 patients aged 45 years and older with knee osteoarthritis who contacted their general practitioner and have persistent knee pain (score ≥ 3 on 0–10 numerical rating scale; 0 = no knee pain) will be included. Patients will be randomly allocated (1:1) to an injection of 40 mg triamcinolone acetonide intra-articular in the knee joint or intramuscular in the ipsilateral ventrogluteal area. The effect of treatment will be evaluated by questionnaires at 2, 4, 8, 12, and 24 weeks after injection. The primary outcome is patients’ reported severity of knee pain measured with the pain subscale of the Knee injury and Osteoarthritis Outcome Score 4 weeks after injection. Statistical analysis will be based on both the per-protocol and the intention-to-treat principle. Discussion This study will evaluate non-inferiority of intramuscular glucocorticoid injection compared to intra-articular glucocorticoid injection for knee osteoarthritis symptoms. Trial registration This trial is registered in the Dutch Trial Registry (number NTR6968) at 2018-01-22 ( https://www.trialregister.nl/trial/6784 ). Issue date: 1 October 2019. Trial sponsor Erasmus MC University Medical Center Rotterdam. PO-box 2040. 3000 CA Rotterdam. The Netherlands. |
| ArticleNumber | 225 |
| Audience | Academic |
| Author | Bos, P. Koen Dorleijn, Desirée M. J. Gussekloo, Jacobijn Mol, Marianne F. Bindels, Patrick J. E. Bierma-Zeinstra, Sita M. A. Runhaar, Jos Vis, Marijn |
| Author_xml | – sequence: 1 givenname: Marianne F. surname: Mol fullname: Mol, Marianne F. organization: Department of General Practice, Erasmus MC University Medical Center Rotterdam – sequence: 2 givenname: Jos surname: Runhaar fullname: Runhaar, Jos email: j.runhaar@erasmusmc.nl organization: Department of General Practice, Erasmus MC University Medical Center Rotterdam – sequence: 3 givenname: P. Koen surname: Bos fullname: Bos, P. Koen organization: Department of Orthopaedic Surgery, Erasmus MC University Medical Center Rotterdam – sequence: 4 givenname: Desirée M. J. surname: Dorleijn fullname: Dorleijn, Desirée M. J. organization: Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen – sequence: 5 givenname: Marijn surname: Vis fullname: Vis, Marijn organization: Department of Rheumatology, Erasmus MC University Medical Center Rotterdam – sequence: 6 givenname: Jacobijn surname: Gussekloo fullname: Gussekloo, Jacobijn organization: Department of Public Health and Primary Care, Leiden University Medical Center, Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center – sequence: 7 givenname: Patrick J. E. surname: Bindels fullname: Bindels, Patrick J. E. organization: Department of General Practice, Erasmus MC University Medical Center Rotterdam – sequence: 8 givenname: Sita M. A. surname: Bierma-Zeinstra fullname: Bierma-Zeinstra, Sita M. A. organization: Department of General Practice, Erasmus MC University Medical Center Rotterdam, Department of Orthopaedic Surgery, Erasmus MC University Medical Center Rotterdam |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32278346$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1080_10255842_2023_2268232 crossref_primary_10_1136_bmjopen_2024_087785 crossref_primary_10_1155_2021_7218067 crossref_primary_10_1016_j_jddst_2025_106719 crossref_primary_10_3390_ijms22052697 crossref_primary_10_1093_rheumatology_keac707 crossref_primary_10_1111_bph_15780 crossref_primary_10_1001_jamanetworkopen_2022_4852 crossref_primary_10_3390_jcm9061880 |
| Cites_doi | 10.1001/jamainternmed.2015.0461 10.1136/ard.2006.053538 10.1186/s12966-015-0162-z 10.1093/rheumatology/keh683 10.1371/journal.pone.0146117 10.3899/jrheum.171385 10.1002/acr.22783 10.1136/bmj.38039.573970.7C 10.1136/bmjopen-2016-012594 10.1186/1471-2474-7-48 10.1001/jama.2017.5283 10.1111/j.1742-1241.2009.02177.x 10.1007/s10067-003-0757-7 10.1016/j.carj.2018.11.002 10.1016/j.joca.2004.02.001 10.2106/JBJS.18.00454 10.1007/s11136-011-9903-x 10.1016/j.joca.2007.12.004 10.1249/01.MSS.0000078924.61453.FB 10.1136/ard.16.4.494 10.1111/jocn.13923 10.1177/0300060514531924 10.1016/j.arth.2015.08.032 10.1016/j.joca.2019.06.011 10.1016/j.joca.2016.01.983 10.1002/art.1780380817 10.1002/art.1780290816 10.1016/j.joca.2019.01.007 10.1136/bmj.a3112 10.3899/jrheum.150398 10.1016/j.semarthrit.2011.02.007 10.1370/afm.1232 10.1186/1471-2296-14-195 10.1002/art.40515 10.1016/j.joca.2019.02.799 10.1177/1941738117702585 10.1016/j.joca.2009.04.003 10.1016/j.jval.2016.01.003 |
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| Keywords | Glucocorticoid injection Intra-articular Knee osteoarthritis Non-inferiority General practice Intramuscular Randomized controlled trial Primary care |
| Language | English |
| License | Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
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| References | PS Emrani (3255_CR25) 2008; 16 CP Charalambous (3255_CR11) 2003; 22 TA Larkin (3255_CR31) 2018; 27 M Versteegh (3255_CR35) 2016; 19 SS Richardson (3255_CR22) 2019; 101 P Juni (3255_CR9) 2015; 10 AL Waterbrook (3255_CR20) 2017; 9 JH Kellgren (3255_CR26) 1957; 16 3255_CR39 B Arroll (3255_CR19) 2004; 328 PG Conaghan (3255_CR14) 2019; 27 M Herdman (3255_CR34) 2011; 20 A Brinks (3255_CR43) 2011; 9 C Zeng (3255_CR13) 2019; 27 OM Ekeberg (3255_CR16) 2009; 338 SH Liu (3255_CR10) 2018; 45 J Hermans (3255_CR28) 2011; 41 M Reijman (3255_CR32) 2007; 66 KA Mills (3255_CR42) 2016; 43 P Mishra (3255_CR29) 2010; 64 T Pham (3255_CR38) 2004; 12 BC Werner (3255_CR23) 2016; 31 M van Middelkoop (3255_CR47) 2016; 24 MR de Boer (3255_CR45) 2015; 12 W Rienstra (3255_CR36) 2015; 10 AW Aleem (3255_CR21) 2017; 5 TE McAlindon (3255_CR12) 2017; 317 JA Singh (3255_CR17) 2016; 68 H Jung Kim (3255_CR30) 2014; 42 M Henriksen (3255_CR40) 2015; 175 Z Paskins (3255_CR3) 2013; 14 SA Oliveria (3255_CR1) 1995; 38 RR Bannuru (3255_CR8) 2019; 27 3255_CR7 S Rehal (3255_CR46) 2016; 6 T Rosemann (3255_CR4) 2006; 7 WG Liddell (3255_CR15) 2005; 44 JF Maillefert (3255_CR33) 2009; 17 DG Altman (3255_CR44) 1985; 34 3255_CR2 DMJ Dorleijn (3255_CR18) 2018; 77 R Altman (3255_CR24) 1986; 29 A Shah (3255_CR27) 2019; 70 3255_CR6 3255_CR5 CL Craig (3255_CR37) 2003; 35 3255_CR41 |
| References_xml | – volume: 175 start-page: 923 issue: 6 year: 2015 ident: 3255_CR40 publication-title: JAMA Intern Med doi: 10.1001/jamainternmed.2015.0461 – volume: 66 start-page: 158 issue: 2 year: 2007 ident: 3255_CR32 publication-title: Ann Rheum Dis doi: 10.1136/ard.2006.053538 – volume: 12 start-page: 4 year: 2015 ident: 3255_CR45 publication-title: Int J Behav Nutr Phys Act doi: 10.1186/s12966-015-0162-z – volume: 44 start-page: 1043 issue: 8 year: 2005 ident: 3255_CR15 publication-title: Rheumatology (Oxford) doi: 10.1093/rheumatology/keh683 – volume: 10 issue: 12 year: 2015 ident: 3255_CR36 publication-title: PLoS One doi: 10.1371/journal.pone.0146117 – volume: 45 start-page: 1316 issue: 9 year: 2018 ident: 3255_CR10 publication-title: J Rheumatol doi: 10.3899/jrheum.171385 – volume: 68 start-page: 1 issue: 1 year: 2016 ident: 3255_CR17 publication-title: Arthritis Care Res (Hoboken) doi: 10.1002/acr.22783 – volume: 328 start-page: 869 issue: 7444 year: 2004 ident: 3255_CR19 publication-title: Bmj doi: 10.1136/bmj.38039.573970.7C – volume: 6 issue: 10 year: 2016 ident: 3255_CR46 publication-title: BMJ Open doi: 10.1136/bmjopen-2016-012594 – volume: 7 start-page: 48 year: 2006 ident: 3255_CR4 publication-title: BMC Musculoskelet Disord doi: 10.1186/1471-2474-7-48 – volume: 317 start-page: 1967 issue: 19 year: 2017 ident: 3255_CR12 publication-title: JAMA doi: 10.1001/jama.2017.5283 – volume: 64 start-page: 1573 issue: 11 year: 2010 ident: 3255_CR29 publication-title: Int J Clin Pract doi: 10.1111/j.1742-1241.2009.02177.x – volume: 22 start-page: 386 issue: 6 year: 2003 ident: 3255_CR11 publication-title: Clin Rheumatol doi: 10.1007/s10067-003-0757-7 – volume: 70 start-page: 29 issue: 1 year: 2019 ident: 3255_CR27 publication-title: Can Assoc Radiol J doi: 10.1016/j.carj.2018.11.002 – volume: 5 start-page: 315 issue: 5 year: 2017 ident: 3255_CR21 publication-title: Arch Bone Jt Surg – ident: 3255_CR7 – volume: 12 start-page: 389 issue: 5 year: 2004 ident: 3255_CR38 publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2004.02.001 – ident: 3255_CR39 – volume: 101 start-page: 112 issue: 2 year: 2019 ident: 3255_CR22 publication-title: J Bone Joint Surg Am doi: 10.2106/JBJS.18.00454 – volume: 20 start-page: 1727 issue: 10 year: 2011 ident: 3255_CR34 publication-title: Qual Life Res doi: 10.1007/s11136-011-9903-x – volume: 16 start-page: 873 issue: 8 year: 2008 ident: 3255_CR25 publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2007.12.004 – volume: 35 start-page: 1381 issue: 8 year: 2003 ident: 3255_CR37 publication-title: Med Sci Sports Exerc doi: 10.1249/01.MSS.0000078924.61453.FB – volume: 16 start-page: 494 issue: 4 year: 1957 ident: 3255_CR26 publication-title: Ann Rheum Dis doi: 10.1136/ard.16.4.494 – volume: 27 start-page: e242 issue: 1–2 year: 2018 ident: 3255_CR31 publication-title: J Clin Nurs doi: 10.1111/jocn.13923 – volume: 42 start-page: 887 issue: 4 year: 2014 ident: 3255_CR30 publication-title: J Int Med Res doi: 10.1177/0300060514531924 – volume: 31 start-page: 820 issue: 4 year: 2016 ident: 3255_CR23 publication-title: J Arthroplast doi: 10.1016/j.arth.2015.08.032 – volume: 27 start-page: 1578 issue: 11 year: 2019 ident: 3255_CR8 publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2019.06.011 – volume: 24 start-page: 1143 issue: 7 year: 2016 ident: 3255_CR47 publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2016.01.983 – ident: 3255_CR41 – volume: 38 start-page: 1134 issue: 8 year: 1995 ident: 3255_CR1 publication-title: Arthritis Rheum doi: 10.1002/art.1780380817 – volume: 29 start-page: 1039 issue: 8 year: 1986 ident: 3255_CR24 publication-title: Arthritis Rheum doi: 10.1002/art.1780290816 – ident: 3255_CR2 – volume: 77 start-page: 875 issue: 6 year: 2018 ident: 3255_CR18 publication-title: Ann Rheum Dis – volume: 27 start-page: 855 issue: 6 year: 2019 ident: 3255_CR13 publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2019.01.007 – volume: 338 start-page: a3112 year: 2009 ident: 3255_CR16 publication-title: BMJ doi: 10.1136/bmj.a3112 – volume: 43 start-page: 395 issue: 2 year: 2016 ident: 3255_CR42 publication-title: J Rheumatol doi: 10.3899/jrheum.150398 – volume: 34 start-page: 125 issue: 1 year: 1985 ident: 3255_CR44 publication-title: J R Stat Soc Ser D-Stat – volume: 41 start-page: 106 issue: 2 year: 2011 ident: 3255_CR28 publication-title: Semin Arthritis Rheum doi: 10.1016/j.semarthrit.2011.02.007 – volume: 10 year: 2015 ident: 3255_CR9 publication-title: Cochrane Database Syst Rev – volume: 9 start-page: 226 issue: 3 year: 2011 ident: 3255_CR43 publication-title: Ann Fam Med doi: 10.1370/afm.1232 – volume: 14 start-page: 195 year: 2013 ident: 3255_CR3 publication-title: BMC Fam Pract doi: 10.1186/1471-2296-14-195 – ident: 3255_CR5 doi: 10.1002/art.40515 – volume: 27 start-page: e5 issue: 6 year: 2019 ident: 3255_CR14 publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2019.02.799 – ident: 3255_CR6 – volume: 9 start-page: 372 issue: 4 year: 2017 ident: 3255_CR20 publication-title: Sports Health doi: 10.1177/1941738117702585 – volume: 17 start-page: 1293 issue: 10 year: 2009 ident: 3255_CR33 publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2009.04.003 – volume: 19 start-page: 343 issue: 4 year: 2016 ident: 3255_CR35 publication-title: Value Health doi: 10.1016/j.jval.2016.01.003 |
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The knee is symptomatically the most frequent affected joint in osteoarthritis and, in the Netherlands and other Western countries, is mainly... The knee is symptomatically the most frequent affected joint in osteoarthritis and, in the Netherlands and other Western countries, is mainly managed by... Background The knee is symptomatically the most frequent affected joint in osteoarthritis and, in the Netherlands and other Western countries, is mainly... Abstract Background The knee is symptomatically the most frequent affected joint in osteoarthritis and, in the Netherlands and other Western countries, is... |
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| SubjectTerms | Analgesics Arthritis Cartilage Clinical rheumatology and osteoporosis Comparative analysis Consent Double-Blind Method Epidemiology Glucocorticoid injection Glucocorticoids Glucocorticoids - administration & dosage Humans Injection Injections, Intra-Articular Injections, Intramuscular Internal Medicine Intra-articular Intramuscular Joint surgery Knee Knee Joint - physiopathology Knee osteoarthritis Medical ethics Medical research Medicine Medicine & Public Health Multicenter Studies as Topic Musculoskeletal diseases Netherlands Non-inferiority Orthopedics Osteoarthritis Osteoarthritis, Knee - drug therapy Pain Pain - drug therapy Pain management Pain Measurement Patient safety Patients Pragmatic Clinical Trials as Topic Questionnaires Randomized controlled trial Rehabilitation Rheumatology Severity of Illness Index Sports Medicine Statistical analysis Studies Study Protocol Surveys and Questionnaires Time Factors Treatment Outcome Triamcinolone Triamcinolone acetonide Triamcinolone Acetonide - administration & dosage |
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