The ever growing complexity of placental epigenetics – Role in adverse pregnancy outcomes and fetal programming

As the primary interface between maternal and fetal circulations, the placenta is subject to a myriad of environmental exposures with the capacity to alter placental function and fetal development. Many of these effects are likely to be mediated by epigenetic (‘above DNA’) change, which is also in t...

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Vydáno v:	Placenta (Eastbourne) Ročník 33; číslo 12; s. 959 - 970
Hlavní autoři:	Novakovic, B., Saffery, R.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Kidlington Elsevier Ltd 01.12.2012 Elsevier
Témata:	Animals Biological and medical sciences Birth-weight Diet DNA Methylation Embryology: invertebrates and vertebrates. Teratology Environment Epigenesis, Genetic Epigenetics Female Fetal Development Fetal Diseases - etiology Fetal Diseases - metabolism Fundamental and applied biological sciences. Psychology Humans Internal Medicine Obstetrics and Gynecology Placenta Placenta - physiology Placenta - physiopathology Preeclampsia Pregnancy Pregnancy Complications - etiology Pregnancy Complications - metabolism Birth-weight Placenta Diet Preeclampsia Epigenetics DNA methylation Environment Pregnancy Vertebrata Fetal development Mammalia Prognosis Fetal membrane Fetus
ISSN:	0143-4004, 1532-3102, 1532-3102
On-line přístup:	Získat plný text
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Popis
Shrnutí:	As the primary interface between maternal and fetal circulations, the placenta is subject to a myriad of environmental exposures with the capacity to alter placental function and fetal development. Many of these effects are likely to be mediated by epigenetic (‘above DNA’) change, which is also in turn regulated by maternal and fetal genetic factors. Linking specific environmental exposures, genetic, and epigenetic variation to maternal and fetal outcomes may provide valuable mechanistic insights into the role of placental dysfunction in pregnancy-associated disease and later health. The complexities are manifold but are rapidly being overcome by technological advances and emerging analytical approaches. Although focussing on recent genome-scale and gene-specific DNA methylation studies in the human placenta, this review also discusses the potential of a future broader exploration of combined environmental, genetic and epigenomic approaches, encompassing higher order epigenetic modifications, for unravelling the molecular mechanisms underlying gene-environment interaction at the fetomaternal interface.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0143-4004 1532-3102 1532-3102
DOI:	10.1016/j.placenta.2012.10.003